5d60 - Revision history

OCA at 11:24, 10 January 2024

2024-01-10T11:24:50Z

←Older revision		Revision as of 11:24, 10 January 2024
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D60 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D60 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [https://pdbe.org/5d60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [https://www.ebi.ac.uk/pdbsum/5d60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d60 ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [https://pdbe.org/5d60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [https://www.ebi.ac.uk/pdbsum/5d60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d60 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 10:23, 21 June 2023

2023-06-21T10:23:12Z

←Older revision		Revision as of 10:23, 21 June 2023
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	<StructureSection load='5d60' size='340' side='right'caption='[[5d60]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5d60' size='340' side='right'caption='[[5d60]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Cbs_144.50 Cbs 144.50~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5D60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum Chaetomium thermophilum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D60 FirstGlance]. <br>
-	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [https://pdbe.org/5d60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [https://www.ebi.ac.uk/pdbsum/5d60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d60 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [~~http~~://pdbe.org/5d60 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5d60 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5d60 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/SKN7_CHATD SKN7_CHATD] Transcription factor that is part of a SLN1-YPD1-SKN7 two-component regulatory system, which controls gene expression in response to changes in the osmolarity of the extracellular environment. Under low osmotic conditions, phosphorylated and activated by the phosphorelay intermediate protein YPD1. Also activated in response to oxidative stress, independent on the two-component regulatory system. Regulates heat shock genes in response to oxidative stress and genes involved in cell wall integrity in response to osmotic changes.[UniProtKB:P38889]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Cbs 144 50~~]]	+	[[Category: Chaetomium thermophilum]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Bracher, A]]	+	[[Category: Bracher A]]
-	[[Category: Hartl~~, F U~~]]	+	[[Category: Hartl FU]]
-	[[Category: Hayer-Hartl, M]]	+	[[Category: Hayer-Hartl M]]
-	[[Category: Neudegger, T]]	+	[[Category: Neudegger T]]
-	[[Category: Verghese, J]]	+	[[Category: Verghese J]]
-	~~[[Category: Coiled-coil]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 10:39, 1 April 2020

2020-04-01T10:39:34Z

←Older revision		Revision as of 10:39, 1 April 2020
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	==Structure of Chaetomium thermophilum Skn7 coiled-coil domain, crystal form III==		==Structure of Chaetomium thermophilum Skn7 coiled-coil domain, crystal form III==
-	<StructureSection load='5d60' size='340' side='right' caption='[[5d60]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5d60' size='340' side='right'caption='[[5d60]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Cbs_144.50 Cbs 144.50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D60 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [http://pdbe.org/5d60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [http://www.ebi.ac.uk/pdbsum/5d60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d60 ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CTHT_0048700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=209285 CBS 144.50])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [http://pdbe.org/5d60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [http://www.ebi.ac.uk/pdbsum/5d60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d60 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Cbs 144 50]]
		+	[[Category: Large Structures]]
	[[Category: Bracher, A]]		[[Category: Bracher, A]]
	[[Category: Hartl, F U]]		[[Category: Hartl, F U]]

OCA at 02:24, 13 July 2016

2016-07-13T02:24:22Z

←Older revision		Revision as of 02:24, 13 July 2016
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D60 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D60 FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [http://pdbe.org/5d60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [http://www.ebi.ac.uk/pdbsum/5d60 PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [http://pdbe.org/5d60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [http://www.ebi.ac.uk/pdbsum/5d60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d60 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 23:07, 23 June 2016

2016-06-23T23:07:28Z

←Older revision		Revision as of 23:07, 23 June 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5d60 is ~~ON HOLD until Paper~~ Publication	+	==Structure of Chaetomium thermophilum Skn7 coiled-coil domain, crystal form III==
		+	<StructureSection load='5d60' size='340' side='right' caption='[[5d60]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5d60]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D60 FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d60 OCA], [http://pdbe.org/5d60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d60 RCSB], [http://www.ebi.ac.uk/pdbsum/5d60 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Heat-shock transcription factor 1 (HSF1) has a central role in mediating the protective response to protein conformational stresses in eukaryotes. HSF1 consists of an N-terminal DNA-binding domain (DBD), a coiled-coil oligomerization domain, a regulatory domain and a transactivation domain. Upon stress, HSF1 trimerizes via its coiled-coil domain and binds to the promoters of heat shock protein-encoding genes. Here, we present cocrystal structures of the human HSF1 DBD in complex with cognate DNA. A comparative analysis of the HSF1 paralog Skn7 from Chaetomium thermophilum showed that single amino acid changes in the DBD can switch DNA binding specificity, thus revealing the structural basis for the interaction of HSF1 with cognate DNA. We used a crystal structure of the coiled-coil domain of C. thermophilum Skn7 to develop a model of the active human HSF1 trimer in which HSF1 embraces the heat-shock-element DNA.

-	~~Authors~~:	+	Structure of human heat-shock transcription factor 1 in complex with DNA.,Neudegger T, Verghese J, Hayer-Hartl M, Hartl FU, Bracher A Nat Struct Mol Biol. 2016 Jan 4. doi: 10.1038/nsmb.3149. PMID:26727489<ref>PMID:26727489</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5d60" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Bracher, A]]
		+	[[Category: Hartl, F U]]
		+	[[Category: Hayer-Hartl, M]]
		+	[[Category: Neudegger, T]]
		+	[[Category: Verghese, J]]
		+	[[Category: Coiled-coil]]
		+	[[Category: Transcription]]

OCA at 11:46, 15 May 2016

2016-05-15T11:46:02Z

←Older revision		Revision as of 11:46, 15 May 2016
Line 3:		Line 3:
	The entry 5d60 is ON HOLD until Paper Publication		The entry 5d60 is ON HOLD until Paper Publication

-	Authors: ~~Bracher, A.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bracher, A]]

OCA at 12:27, 26 August 2015

2015-08-26T12:27:54Z

←Older revision		Revision as of 12:27, 26 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5d60 is ON HOLD	+	The entry 5d60 is ON HOLD until Paper Publication

	Authors: Bracher, A.		Authors: Bracher, A.

OCA: Protected "5d60" [edit=sysop:move=sysop]

2015-08-20T11:24:56Z

Protected "5d60" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:24, 20 August 2015

OCA: New page: '''Unreleased structure''' The entry 5d60 is ON HOLD Authors: Bracher, A. Description: Category: Unreleased Structures Category: Bracher, A

2015-08-20T11:24:55Z

New page: '''Unreleased structure''' The entry 5d60 is ON HOLD Authors: Bracher, A. Description: Category: Unreleased Structures Category: Bracher, A

New page

'''Unreleased structure'''

The entry 5d60 is ON HOLD

Authors: Bracher, A.

Description:
[[Category: Unreleased Structures]]
[[Category: Bracher, A]]