5d7k - Revision history

OCA at 08:44, 27 September 2023

2023-09-27T08:44:00Z

←Older revision		Revision as of 08:44, 27 September 2023
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	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5d7k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D7K FirstGlance]. <br>		<table><tr><td colspan='2'>[[5d7k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D7K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [https://pdbe.org/5d7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [https://www.ebi.ac.uk/pdbsum/5d7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7k ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [https://pdbe.org/5d7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [https://www.ebi.ac.uk/pdbsum/5d7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7k ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:24, 21 June 2023

2023-06-21T10:24:41Z

←Older revision		Revision as of 10:24, 21 June 2023
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	<StructureSection load='5d7k' size='340' side='right'caption='[[5d7k]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5d7k' size='340' side='right'caption='[[5d7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d7k]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7K OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5D7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d7k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5D7K FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5d5m\|5d5m]], [[5d7i\|5d7i]], [[5d7j\|5d7j]], [[5d7l\|5d7l]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [https://pdbe.org/5d7k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [https://www.ebi.ac.uk/pdbsum/5d7k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7k ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRBV/TRBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [~~http~~://pdbe.org/5d7k PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5d7k PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7k ProSAT]</span></td></tr>	+
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 22:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Keller~~, A N~~]]	+	[[Category: Keller AN]]
-	[[Category: Rossjohn, J]]	+	[[Category: Rossjohn J]]
-	~~[[Category: Antigen]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Receptor~~]]	+

OCA at 10:41, 1 April 2020

2020-04-01T10:41:40Z

←Older revision		Revision as of 10:41, 1 April 2020
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		+
	==Structure of MR1-reactive MAV36 TCR==		==Structure of MR1-reactive MAV36 TCR==
-	<StructureSection load='5d7k' size='340' side='right' caption='[[5d7k]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5d7k' size='340' side='right'caption='[[5d7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5d7k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7K FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5d7k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7K FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5d5m\|5d5m]], [[5d7i\|5d7i]], [[5d7j\|5d7j]], [[5d7l\|5d7l]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5d5m\|5d5m]], [[5d7i\|5d7i]], [[5d7j\|5d7j]], [[5d7l\|5d7l]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [http://pdbe.org/5d7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [http://www.ebi.ac.uk/pdbsum/5d7k PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">TRBV/TRBC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [http://pdbe.org/5d7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [http://www.ebi.ac.uk/pdbsum/5d7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d7k ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Keller, A N]]		[[Category: Keller, A N]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]

OCA at 07:56, 3 February 2016

2016-02-03T07:56:31Z

←Older revision		Revision as of 07:56, 3 February 2016
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [http://pdbe.org/5d7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [http://www.ebi.ac.uk/pdbsum/5d7k PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [http://pdbe.org/5d7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [http://www.ebi.ac.uk/pdbsum/5d7k PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A characteristic of mucosal-associated invariant T (MAIT) cells is the expression of TRAV1-2(+) T cell receptors (TCRs) that are activated by riboflavin metabolite-based antigens (Ag) presented by the MHC-I related molecule, MR1. Whether the MR1-restricted T cell repertoire and associated Ag responsiveness extends beyond these cells remains unclear. Here, we describe MR1 autoreactivity and folate-derivative reactivity in a discrete subset of TRAV1-2(+) MAIT cells. This recognition was attributable to CDR3beta loop-mediated effects within a consensus TRAV1-2(+) TCR-MR1-Ag footprint. Furthermore, we have demonstrated differential folate- and riboflavin-derivative reactivity by a diverse population of "atypical" TRAV1-2(-) MR1-restricted T cells. We have shown that TRAV1-2(-) T cells are phenotypically heterogeneous and largely distinct from TRAV1-2(+) MAIT cells. A TRAV1-2(-) TCR docks more centrally on MR1, thereby adopting a markedly different molecular footprint to the TRAV1-2(+) TCR. Accordingly, diversity within the MR1-restricted T cell repertoire leads to differing MR1-restricted Ag specificity.
		+
		+	Diversity of T Cells Restricted by the MHC Class I-Related Molecule MR1 Facilitates Differential Antigen Recognition.,Gherardin NA, Keller AN, Woolley RE, Le Nours J, Ritchie DS, Neeson PJ, Birkinshaw RW, Eckle SB, Waddington JN, Liu L, Fairlie DP, Uldrich AP, Pellicci DG, McCluskey J, Godfrey DI, Rossjohn J Immunity. 2016 Jan 19;44(1):32-45. doi: 10.1016/j.immuni.2015.12.005. Epub 2016, Jan 12. PMID:26795251<ref>PMID:26795251</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5d7k" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 02:34, 28 January 2016

2016-01-28T02:34:16Z

←Older revision		Revision as of 02:34, 28 January 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Structure of MR1-reactive MAV36 TCR==
-		+	<StructureSection load='5d7k' size='340' side='right' caption='[[5d7k]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~The entry~~ 5d7k is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5d7k]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7K FirstGlance]. <br>
-	~~Authors~~: ~~Keller~~, A.N., ~~Rossjohn~~, J.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5d5m\|5d5m]], [[5d7i\|5d7i]], [[5d7j\|5d7j]], [[5d7l\|5d7l]]</td></tr>
-	~~Description:~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7k OCA], [http://pdbe.org/5d7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7k RCSB], [http://www.ebi.ac.uk/pdbsum/5d7k PDBsum]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Keller, A N]]
	[[Category: Rossjohn, J]]		[[Category: Rossjohn, J]]
-	[[Category: ~~Keller, A.N~~]]	+	[[Category: Antigen]]
		+	[[Category: Immune system]]
		+	[[Category: Receptor]]

OCA at 12:45, 30 September 2015

2015-09-30T12:45:08Z

←Older revision		Revision as of 12:45, 30 September 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5d7k is ON HOLD	+	The entry 5d7k is ON HOLD until Paper Publication

	Authors: Keller, A.N., Rossjohn, J.		Authors: Keller, A.N., Rossjohn, J.

OCA at 11:17, 2 September 2015

2015-09-02T11:17:35Z

←Older revision		Revision as of 11:17, 2 September 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5d7k is ON HOLD ~~until sometime in the future~~	+	The entry 5d7k is ON HOLD

	Authors: Keller, A.N., Rossjohn, J.		Authors: Keller, A.N., Rossjohn, J.

OCA at 12:30, 26 August 2015

2015-08-26T12:30:41Z

←Older revision		Revision as of 12:30, 26 August 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5d7k is ON HOLD	+	The entry 5d7k is ON HOLD until sometime in the future

	Authors: Keller, A.N., Rossjohn, J.		Authors: Keller, A.N., Rossjohn, J.

OCA: Protected "5d7k" [edit=sysop:move=sysop]

2015-08-20T11:29:08Z

Protected "5d7k" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:29, 20 August 2015

OCA: New page: '''Unreleased structure''' The entry 5d7k is ON HOLD Authors: Keller, A.N., Rossjohn, J. Description: Category: Unreleased Structures Category: Rossjohn, J [[Category: Keller,...

2015-08-20T11:29:06Z

New page: '''Unreleased structure''' The entry 5d7k is ON HOLD Authors: Keller, A.N., Rossjohn, J. Description: Category: Unreleased Structures Category: Rossjohn, J [[Category: Keller,...

New page

'''Unreleased structure'''

The entry 5d7k is ON HOLD

Authors: Keller, A.N., Rossjohn, J.

Description:
[[Category: Unreleased Structures]]
[[Category: Rossjohn, J]]
[[Category: Keller, A.N]]