5deg - Revision history

OCA at 11:26, 10 January 2024

2024-01-10T11:26:00Z

←Older revision		Revision as of 11:26, 10 January 2024
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5deg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DEG FirstGlance]. <br>		<table><tr><td colspan='2'>[[5deg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DEG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.83Å</td></tr>
		+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5deg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5deg OCA], [https://pdbe.org/5deg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5deg RCSB], [https://www.ebi.ac.uk/pdbsum/5deg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5deg ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5deg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5deg OCA], [https://pdbe.org/5deg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5deg RCSB], [https://www.ebi.ac.uk/pdbsum/5deg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5deg ProSAT]</span></td></tr>
	</table>		</table>

OCA at 10:32, 21 June 2023

2023-06-21T10:32:09Z

←Older revision		Revision as of 10:32, 21 June 2023
Line 3:		Line 3:
	<StructureSection load='5deg' size='340' side='right'caption='[[5deg]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='5deg' size='340' side='right'caption='[[5deg]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5deg]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DEG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5deg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DEG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>~~</td></tr>~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1of2\|1of2]], [[1ogt\|1ogt]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5deg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5deg OCA], [https://pdbe.org/5deg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5deg RCSB], [https://www.ebi.ac.uk/pdbsum/5deg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5deg ProSAT]</span></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5deg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5deg OCA], [~~http~~://pdbe.org/5deg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5deg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5deg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5deg ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/~~B2MG_HUMAN B2MG_HUMAN~~]~~] Defects in B2M are the cause~~ of ~~hypercatabolic hypoproteinemia (HYCATHYP) [MIM~~:~~[http://omim~~.~~org/~~entry~~/241600 241600]]~~. ~~Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due~~ to ~~rapid degradation~~.<ref>PMID:~~16549777~~</ref> ~~Note=Beta~~-2-~~microglobulin may adopt the fibrillar configuration~~ of ~~amyloid~~ in ~~certain pathologic states~~. The ~~capacity~~ to ~~assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis~~ in ~~patients on long-term hemodialysis~~.<ref>PMID:~~3532124~~</ref> <ref>PMID:~~1336137~~</ref> ~~<ref>PMID~~:~~7554280</ref> <ref>PMID~~:~~4586824</ref> <ref>PMID~~:~~8084451<~~/~~ref> <ref>PMID:12119416<~~/~~ref> <ref>PMID:12796775<~~/~~ref> <ref>PMID:16901902<~~/~~ref>~~ <ref>PMID:~~16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224~~</ref> <ref>PMID:~~19284997~~</ref>	+	[https://www.uniprot.org/uniprot/HLAB_HUMAN HLAB_HUMAN] Prediction of allopurinol toxicity;NON RARE IN EUROPE: Ankylosing spondylitis;Prediction of flucloxacilline toxicity;Giant cell arteritis;Takayasu arteritis;Reactive arthritis;Behcet disease;Stevens-Johnson syndrome;Prediction of phenytoin or carbamazepine toxicity;Pulmonary arterial hypertension associated with connective tissue disease;Prediction of abacavir toxicity. Disease susceptibility is associated with variants affecting the gene represented in this entry. Increased susceptibility to Stevens-Johnson syndrome is conferred by allele B15:02.<ref>PMID:15057820</ref> Disease susceptibility is associated with variants affecting the gene represented in this entry. A restricted number of HLA-B27 subtypes can be associated with ankylosing spondylitis and other B27-related diseases, and an elevated frequency of the B27:02 allele in ankylosing spondylitis patients is identified. The allele B27:07 seems to have a protective role in some populations because it was found only in the healthy controls.<ref>PMID:15603872</ref> There is evidence that HLA-B51 is associated with susceptibility to Behcet disease (BD). However, it is not certain whether HLA-B51 itself or a closely linked gene is responsible for susceptibility. The world distribution of HLA-B51 in healthy people corresponds to the global distribution of BD; in Southern hemisphere countries (Africa, South Pacific, etc.) and in some parts of Europe, the prevalence of HLA-B51 in healthy people is low or null, corresponding to a low prevalence of BD. The wide variation that exists in the relative risk of HLA-B51 would support other nongenetic risk factors.<ref>PMID:23291587</ref> The presence of allele B57:01 is associated with increased susceptibility to abacavir hypersensitivity [MIM:[https://omim.org/entry/142830 142830] in HIV-1 patients.<ref>PMID:11888582</ref> Allele group B08 is associated with increased susceptibility to rheumatoid arthritis, where affected individuals have antibodies to cyclic citrullinated peptide (anti-CCP-positive rheumatoid arthritis).<ref>PMID:22286218</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~Q7YQB0_HUMAN Q7YQB0_HUMAN~~]~~] Involved in~~ the ~~presentation~~ of ~~foreign~~ antigens to the ~~immune system~~.~~[SAAS~~:~~SAAS00281819] [[http~~://~~www~~.~~uniprot~~.~~org~~/~~uniprot~~/~~B2MG_HUMAN B2MG_HUMAN]] Component~~ of the ~~class I major histocompatibility~~ complex (~~MHC~~). ~~Involved~~ in the ~~presentation~~ of peptide ~~antigens~~ to the ~~immune system~~.	+	[https://www.uniprot.org/uniprot/HLAB_HUMAN HLAB_HUMAN] Antigen-presenting major histocompatibility complex class I (MHCI) molecule. In complex with B2M/beta 2 microglobulin displays primarily viral and tumor-derived peptides on antigen-presenting cells for recognition by alpha-beta T cell receptor (TCR) on HLA-B-restricted CD8-positive T cells, guiding antigen-specific T cell immune response to eliminate infected or transformed cells (PubMed:25808313, PubMed:29531227, PubMed:9620674, PubMed:23209413). May also present self-peptides derived from the signal sequence of secreted or membrane proteins, although T cells specific for these peptides are usually inactivated to prevent autoreactivity (PubMed:7743181, PubMed:18991276). Both the peptide and the MHC molecule are recognized by TCR, the peptide is responsible for the fine specificity of antigen recognition and MHC residues account for the MHC restriction of T cells (PubMed:29531227, PubMed:9620674, PubMed:24600035). Typically presents intracellular peptide antigens of 8 to 13 amino acids that arise from cytosolic proteolysis via constitutive proteasome and IFNG-induced immunoproteasome (PubMed:23209413). Can bind different peptides containing allele-specific binding motifs, which are mainly defined by anchor residues at position 2 and 9 (PubMed:25808313, PubMed:29531227).<ref>PMID:18991276</ref> <ref>PMID:23209413</ref> <ref>PMID:24600035</ref> <ref>PMID:25808313</ref> <ref>PMID:29531227</ref> <ref>PMID:7743181</ref> <ref>PMID:9620674</ref> Allele B07:02: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and mainly a Leu anchor residue at the C-terminus (PubMed:7743181). Presents a long peptide (APRGPHGGAASGL) derived from the cancer-testis antigen CTAG1A/NY-ESO-1, eliciting a polyclonal CD8-positive T cell response against tumor cells (PubMed:29531227). Presents viral epitopes derived from HIV-1 gag-pol (TPQDLNTML) and Nef (RPQVPLRPM) (PubMed:25808313). Presents an immunodominant epitope derived from SARS-CoV-2 N/nucleoprotein (SPRWYFYYL) (PubMed:32887977). Displays self-peptides including a peptide derived from the signal sequence of HLA-DPB1 (APRTVALTA) (PubMed:7743181).<ref>PMID:25808313</ref> <ref>PMID:29531227</ref> <ref>PMID:32887977</ref> <ref>PMID:7743181</ref> Allele B08:01: Presents to CD8-positive T cells viral epitopes derived from EBV/HHV-4 EBNA3 (QAKWRLQTL), eliciting cytotoxic T cell response.<ref>PMID:9620674</ref> Allele B13:02: Presents multiple HIV-1 epitopes derived from gag (RQANFLGKI, GQMREPRGSDI), nef (RQDILDLWI), gag-pol (RQYDQILIE, GQGQWTYQI) and rev (LQLPPLERL), all having in common a Gln residue at position 2 and mainly hydrophobic amino acids Leu, Ile or Val at the C-terminus. Associated with succesful control of HIV-1 infection.<ref>PMID:17251285</ref> Allele B18:01: Preferentially presents octomeric and nonameric peptides sharing a common motif, namely a Glu at position 2 and Phe or Tyr anchor residues at the C-terminus (PubMed:14978097, PubMed:23749632, PubMed:18991276). Presents an EBV/HHV-4 epitope derived from BZLF1 (SELEIKRY) (PubMed:23749632). May present to CD8-positive T cells an antigenic peptide derived from MAGEA3 (MEVDPIGHLY), triggering an anti-tumor immune response (PubMed:12366779). May display a broad repertoire of self-peptides with a preference for peptides derived from RNA-binding proteins (PubMed:14978097).<ref>PMID:12366779</ref> <ref>PMID:14978097</ref> <ref>PMID:18991276</ref> <ref>PMID:23749632</ref> Allele B27:05: Presents to CD8-positive T cells immunodominant viral epitopes derived from HCV POLG (ARMILMTHF), HIV-1 gag (KRWIILGLNK), IAV NP (SRYWAIRTR), SARS-CoV-2 N/nucleoprotein (QRNAPRITF), EBV/HHV-4 EBNA4 (HRCQAIRKK) and EBV/HHV-4 EBNA6 (RRIYDLIEL), confering longterm protection against viral infection (PubMed:19139562, PubMed:18385228, PubMed:15113903, PubMed:9620674, PubMed:32887977). Can present self-peptides derived from cytosolic and nuclear proteins. All peptides carry an Arg at position 2 (PubMed:1922338). The peptide-bound form interacts with NK cell inhibitory receptor KIR3DL1 and inhibits NK cell activation in a peptide-specific way, being particularly sensitive to the nature of the amino acid side chain at position 8 of the antigenic peptide (PubMed:8879234, PubMed:15657948). KIR3DL1 fails to recognize HLA-B27:05 in complex with B2M and EBV/HHV-4 EBNA6 (RRIYDLIEL) peptide, which can lead to increased activation of NK cells during infection (PubMed:15657948). May present an altered repertoire of peptides in the absence of TAP1-TAP2 and TAPBPL (PubMed:9620674).<ref>PMID:15113903</ref> <ref>PMID:15657948</ref> <ref>PMID:18385228</ref> <ref>PMID:19139562</ref> <ref>PMID:1922338</ref> <ref>PMID:8879234</ref> <ref>PMID:9620674</ref> Allele B40:01: Presents immunodominant viral epitopes derived from EBV/HHV-4 LMP2 (IEDPPFNSL) and SARS-CoV-2 N/nucleoprotein (MEVTPSGTWL), triggering memory CD8-positive T cell response (PubMed:18991276, PubMed:32887977). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and a Leu anchor residue at the C-terminus (PubMed:18991276).<ref>PMID:18991276</ref> <ref>PMID:32887977</ref> Allele B41:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.<ref>PMID:18991276</ref> Allele B44:02: Presents immunodominant viral epitopes derived from EBV/HHV-4 EBNA4 (VEITPYKPTW) and EBNA6 (AEGGVGWRHW, EENLLDFVRF), triggering memory CD8-positive T cell response (PubMed:9620674, PubMed:18991276). Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Phe, Tyr or Trp anchor residues at the C-terminus (PubMed:18991276).<ref>PMID:18991276</ref> <ref>PMID:9620674</ref> Allele B45:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.<ref>PMID:18991276</ref> Allele B46:01: Preferentially presents nonameric peptides sharing a signature motif, namely Ala and Leu at position 2 and Tyr, Phe, Leu, or Met anchor residues at the C-terminus. The peptide-bound form interacts with KIR2DL3 and inhibits NK cell cytotoxic response in a peptide-specific way.<ref>PMID:28514659</ref> Allele B47:01: Displays self-peptides sharing a signature motif, namely an Asp at position 2 and Leu or Met anchor residues at the C-terminus.<ref>PMID:18991276</ref> Allele B49:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ile or Val anchor residues at the C-terminus.<ref>PMID:18991276</ref> Allele B50:01: Displays self-peptides sharing a signature motif, namely a Glu at position 2 and Ala or Pro anchor residues at the C-terminus.<ref>PMID:18991276</ref> Allele B51:01: Presents an octomeric HIV-1 epitope derived from gag-pol (TAFTIPSI) to the public TRAV17/TRBV7-3 TCR clonotype, strongly suppressing HIV-1 replication.<ref>PMID:24600035</ref> Allele B54:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.<ref>PMID:7743181</ref> Allele B55:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.<ref>PMID:7743181</ref> Allele B56:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Ala anchor residue at the C-terminus.<ref>PMID:7743181</ref> Allele B57:01: The peptide-bound form recognizes KIR3DL1 and inhibits NK cell cytotoxic response.<ref>PMID:22020283</ref> <ref>PMID:25480565</ref> Allele B67:01: Displays peptides sharing a common signature motif, namely a Pro residue at position 2 and Leu anchor residue at the C-terminus.<ref>PMID:7743181</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 29:		Line 27:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fabian, H]]	+	[[Category: Fabian H]]
-	[[Category: Hee~~, C S~~]]	+	[[Category: Hee CS]]
-	[[Category: Huser, H]]	+	[[Category: Huser H]]
-	[[Category: Loll, B]]	+	[[Category: Loll B]]
-	[[Category: Uchanska-Ziegler, B]]	+	[[Category: Uchanska-Ziegler B]]
-	[[Category: Ziegler, A]]	+	[[Category: Ziegler A]]
-	~~[[Category: Hla- b*2706]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immune system-complex~~]]	+

OCA at 08:47, 18 December 2019

2019-12-18T08:47:53Z

←Older revision		Revision as of 08:47, 18 December 2019
Line 1:		Line 1:

	==Crystal structure of B*27:06 bound to the pVIPR peptide==		==Crystal structure of B*27:06 bound to the pVIPR peptide==
-	<StructureSection load='5deg' size='340' side='right' caption='[[5deg]], [[Resolution\|resolution]] 1.83Å' scene=''>	+	<StructureSection load='5deg' size='340' side='right'caption='[[5deg]], [[Resolution\|resolution]] 1.83Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5deg]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DEG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5deg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DEG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1of2\|1of2]], [[1ogt\|1ogt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1of2\|1of2]], [[1ogt\|1ogt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5deg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5deg OCA], [http://pdbe.org/5deg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5deg RCSB], [http://www.ebi.ac.uk/pdbsum/5deg PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HLA-B ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), B2M, CDABP0092, HDCMA22P ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5deg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5deg OCA], [http://pdbe.org/5deg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5deg RCSB], [http://www.ebi.ac.uk/pdbsum/5deg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5deg ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 5deg" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5deg" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Fabian, H]]		[[Category: Fabian, H]]
	[[Category: Hee, C S]]		[[Category: Hee, C S]]

OCA at 17:52, 10 May 2016

2016-05-10T17:52:31Z

←Older revision		Revision as of 17:52, 10 May 2016
Line 1:		Line 1:
		+
	==Crystal structure of B*27:06 bound to the pVIPR peptide==		==Crystal structure of B*27:06 bound to the pVIPR peptide==
	<StructureSection load='5deg' size='340' side='right' caption='[[5deg]], [[Resolution\|resolution]] 1.83Å' scene=''>		<StructureSection load='5deg' size='340' side='right' caption='[[5deg]], [[Resolution\|resolution]] 1.83Å' scene=''>

OCA at 08:55, 20 January 2016

2016-01-20T08:55:47Z

←Older revision		Revision as of 08:55, 20 January 2016
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/Q7YQB0_HUMAN Q7YQB0_HUMAN]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00281819] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.		[[http://www.uniprot.org/uniprot/Q7YQB0_HUMAN Q7YQB0_HUMAN]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00281819] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	OBJECTIVE: Dissimilarities in antigen processing and presentation are known to contribute to the differential association of HLA-B27 subtypes with the inflammatory rheumatic disease ankylosing spondylitis (AS). In support of this contention, previous X-ray crystallographic data showed that peptides can be displayed by almost identical HLA-B27 molecules in a subtype-dependent manner, allowing cytotoxic T lymphocytes to distinguish between these subtypes. For example, the human self-peptide pVIPR (RRKWRRWHL) is displayed in a single conformation by B27:09 (not AS-associated), while B27:05 (AS-associated) presents the peptide in a dual binding mode. In addition, differences in conformational flexibility between these subtypes might affect their stability or antigen presentation capability. We investigated B27:04 and B27:06, another pair of minimally distinct HLA-B27 subtypes, to assess whether dual peptide conformations or structural dynamics could play a role in the initiation of AS. METHODS: Using X-ray crystallography, we solved the structures of pVIPR-B27:04 and pVIPR-B27:06 and employed isotope-edited infrared (IR) spectroscopy to probe the dynamics of these HLA-B27 subtypes. RESULTS: As opposed to B27:05 and B27:09, B27:04 (AS-associated) displays pVIPR conventionally and B27:06 (not AS-associated) presents the peptide in a dual conformation. On the other hand, the comparison of the four HLA-B27 subtypes using IR spectroscopy revealed that B27:04 and B27:05 exhibit elevated molecular dynamics when compared to the non-associated subtypes B27:06 and B27:09. CONCLUSION: Our results demonstrate that an increase in conformational flexibility characterizes the disease-associated subtypes B27:04 and B*27:05. This article is protected by copyright. All rights reserved.
		+
		+	Increased conformational flexibility characterizes HLA-B*27 subtypes associated with ankylosing spondylitis.,Loll B, Fabian H, Huser H, Hee CS, Ziegler A, Uchanska-Ziegler B, Ziegler A Arthritis Rheumatol. 2016 Jan 8. doi: 10.1002/art.39567. PMID:26748477<ref>PMID:26748477</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5deg" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 19:00, 1 December 2015

2015-12-01T19:00:36Z

←Older revision		Revision as of 19:00, 1 December 2015
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of B*27:06 bound to the pVIPR peptide==
-		+	<StructureSection load='5deg' size='340' side='right' caption='[[5deg]], [[Resolution\|resolution]] 1.83Å' scene=''>
-	~~The entry~~ 5deg is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5deg]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DEG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DEG FirstGlance]. <br>
-	~~Authors~~: ~~Loll~~, B.~~, Fabian, H~~.~~, Hee, C~~.S., ~~Huser, H~~.~~, Uchanska~~-~~Ziegler~~, B., ~~Ziegler~~, A.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
-		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1of2\|1of2]], [[1ogt\|1ogt]]</td></tr>
-	~~Description~~:	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5deg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5deg OCA], [http://pdbe.org/5deg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5deg RCSB], [http://www.ebi.ac.uk/pdbsum/5deg PDBsum]</span></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[http://omim.org/entry/241600 241600]]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/Q7YQB0_HUMAN Q7YQB0_HUMAN]] Involved in the presentation of foreign antigens to the immune system.[SAAS:SAAS00281819] [[http://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Fabian, H]]		[[Category: Fabian, H]]
-	[[Category: Hee, C.S]]	+	[[Category: Hee, C S]]
-	[[Category: ~~Uchanska-Ziegler~~, B]]	+	[[Category: Huser, H]]
	[[Category: Loll, B]]		[[Category: Loll, B]]
		+	[[Category: Uchanska-Ziegler, B]]
	[[Category: Ziegler, A]]		[[Category: Ziegler, A]]
-	[[Category: ~~Huser, H~~]]	+	[[Category: Hla- b*2706]]
		+	[[Category: Immune system]]
		+	[[Category: Immune system-complex]]

OCA at 12:10, 7 October 2015

2015-10-07T12:10:55Z

←Older revision		Revision as of 12:10, 7 October 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5deg is ON HOLD	+	The entry 5deg is ON HOLD until Paper Publication

	Authors: Loll, B., Fabian, H., Hee, C.S., Huser, H., Uchanska-Ziegler, B., Ziegler, A.		Authors: Loll, B., Fabian, H., Hee, C.S., Huser, H., Uchanska-Ziegler, B., Ziegler, A.

OCA: Protected "5deg" [edit=sysop:move=sysop]

2015-09-02T11:32:44Z

Protected "5deg" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:32, 2 September 2015

OCA: New page: '''Unreleased structure''' The entry 5deg is ON HOLD Authors: Loll, B., Fabian, H., Hee, C.S., Huser, H., Uchanska-Ziegler, B., Ziegler, A. Description: [[Category: Unreleased Structu...

2015-09-02T11:32:43Z

New page: '''Unreleased structure''' The entry 5deg is ON HOLD Authors: Loll, B., Fabian, H., Hee, C.S., Huser, H., Uchanska-Ziegler, B., Ziegler, A. Description: [[Category: Unreleased Structu...

New page

'''Unreleased structure'''

The entry 5deg is ON HOLD

Authors: Loll, B., Fabian, H., Hee, C.S., Huser, H., Uchanska-Ziegler, B., Ziegler, A.

Description:
[[Category: Unreleased Structures]]
[[Category: Fabian, H]]
[[Category: Hee, C.S]]
[[Category: Uchanska-Ziegler, B]]
[[Category: Loll, B]]
[[Category: Ziegler, A]]
[[Category: Huser, H]]