5djz - Revision history

OCA at 21:45, 28 June 2023

2023-06-28T21:45:08Z

←Older revision		Revision as of 21:45, 28 June 2023
Line 1:		Line 1:

	==Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V==		==Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V==
-	<StructureSection load='5djz' size='340' side='right' caption='[[5djz]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5djz' size='340' side='right'caption='[[5djz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5djz]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJZ OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DJZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5djz]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DJZ FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5di8\|5di8]], [[5dj0\|5dj0]], [[5dj2\|5dj2]], [[5dj6\|5dj6]], [[5dj8\|5dj8]], [[5dja\|5dja]], [[5djc\|5djc]], [[5djd\|5djd]], [[5djx\|5djx]], [[5djy\|5djy]], [[5dk0\|5dk0]], [[5dk2\|5dk2]], [[5dvk\|5dvk]], [[5dvl\|5dvl]], [[5dvm\|5dvm]], [[5dvn\|5dvn]], [[5dvo\|5dvo]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5djz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djz OCA], [https://pdbe.org/5djz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5djz RCSB], [https://www.ebi.ac.uk/pdbsum/5djz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5djz ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5djz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djz OCA], [~~http~~://pdbe.org/5djz PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5djz RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5djz PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5djz ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[~~http~~://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.	+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[https://omim.org/entry/254500 254500]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 24:		Line 25:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: Aldaz, H]]	+	[[Category: Large Structures]]
-	[[Category: Atwell, S]]	+	[[Category: Synthetic construct]]
-	[[Category: Chamberlain~~, A K~~]]	+	[[Category: Aldaz H]]
-	[[Category: Demarest~~, S J~~]]	+	[[Category: Atwell S]]
-	[[Category: Dhanani~~, S H~~]]	+	[[Category: Chamberlain AK]]
-	[[Category: Fitchett~~, J R~~]]	+	[[Category: Demarest SJ]]
-	[[Category: Froning~~, K J~~]]	+	[[Category: Dhanani SH]]
-	[[Category: Gutierrez, B]]	+	[[Category: Fitchett JR]]
-	[[Category: Hendle, J]]	+	[[Category: Froning KJ]]
-	[[Category: Huang, F]]	+	[[Category: Gutierrez B]]
-	[[Category: Kuhlman, B]]	+	[[Category: Hendle J]]
-	[[Category: Leaver-Fay, A]]	+	[[Category: Huang F]]
-	[[Category: Lu, F]]	+	[[Category: Kuhlman B]]
-	[[Category: Pustilnik, A]]	+	[[Category: Leaver-Fay A]]
-	[[Category: Yuan, R]]	+	[[Category: Lu F]]
-	~~[[Category: Bispecific antibody]]~~	+	[[Category: Pustilnik A]]
-	~~[[Category: Ch3]]~~	+	[[Category: Yuan R]]
-	~~[[Category: Fc]]~~	+
-	~~[[Category: Heterodimer]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Immunoglobulin~~]]	+

OCA at 09:52, 22 November 2017

2017-11-22T09:52:43Z

←Older revision		Revision as of 09:52, 22 November 2017
Line 3:		Line 3:
	<StructureSection load='5djz' size='340' side='right' caption='[[5djz]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5djz' size='340' side='right' caption='[[5djz]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5djz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJZ FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5djz]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJZ FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5di8\|5di8]], [[5dj0\|5dj0]], [[5dj2\|5dj2]], [[5dj6\|5dj6]], [[5dj8\|5dj8]], [[5dja\|5dja]], [[5djc\|5djc]], [[5djd\|5djd]], [[5djx\|5djx]], [[5djy\|5djy]], [[5dk0\|5dk0]], [[5dk2\|5dk2]], [[5dvk\|5dvk]], [[5dvl\|5dvl]], [[5dvm\|5dvm]], [[5dvn\|5dvn]], [[5dvo\|5dvo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5di8\|5di8]], [[5dj0\|5dj0]], [[5dj2\|5dj2]], [[5dj6\|5dj6]], [[5dj8\|5dj8]], [[5dja\|5dja]], [[5djc\|5djc]], [[5djd\|5djd]], [[5djx\|5djx]], [[5djy\|5djy]], [[5dk0\|5dk0]], [[5dk2\|5dk2]], [[5dvk\|5dvk]], [[5dvl\|5dvl]], [[5dvm\|5dvm]], [[5dvn\|5dvn]], [[5dvo\|5dvo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5djz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djz OCA], [http://pdbe.org/5djz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5djz RCSB], [http://www.ebi.ac.uk/pdbsum/5djz PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">IGHG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5djz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djz OCA], [http://pdbe.org/5djz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5djz RCSB], [http://www.ebi.ac.uk/pdbsum/5djz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5djz ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Aldaz, H]]		[[Category: Aldaz, H]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]

OCA at 19:39, 10 May 2016

2016-05-10T19:39:34Z

←Older revision		Revision as of 19:39, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5djz is ~~ON HOLD until Paper~~ Publication	+	==Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V==
		+	<StructureSection load='5djz' size='340' side='right' caption='[[5djz]], [[Resolution\|resolution]] 1.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5djz]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DJZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DJZ FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5di8\|5di8]], [[5dj0\|5dj0]], [[5dj2\|5dj2]], [[5dj6\|5dj6]], [[5dj8\|5dj8]], [[5dja\|5dja]], [[5djc\|5djc]], [[5djd\|5djd]], [[5djx\|5djx]], [[5djy\|5djy]], [[5dk0\|5dk0]], [[5dk2\|5dk2]], [[5dvk\|5dvk]], [[5dvl\|5dvl]], [[5dvm\|5dvm]], [[5dvn\|5dvn]], [[5dvo\|5dvo]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5djz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5djz OCA], [http://pdbe.org/5djz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5djz RCSB], [http://www.ebi.ac.uk/pdbsum/5djz PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/IGHG1_HUMAN IGHG1_HUMAN]] Defects in IGHG1 are a cause of multiple myeloma (MM) [MIM:[http://omim.org/entry/254500 254500]]. MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. Note=A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	A challenge in the structure-based design of specificity is modeling the negative states, i.e., the complexes that you do not want to form. This is a difficult problem because mutations predicted to destabilize the negative state might be accommodated by small conformational rearrangements. To overcome this challenge, we employ an iterative strategy that cycles between sequence design and protein docking in order to build up an ensemble of alternative negative state conformations for use in specificity prediction. We have applied our technique to the design of heterodimeric CH3 interfaces in the Fc region of antibodies. Combining computationally and rationally designed mutations produced unique designs with heterodimer purities greater than 90%. Asymmetric Fc crystallization was able to resolve the interface mutations; the heterodimer structures confirmed that the interfaces formed as designed. With these CH3 mutations, and those made at the heavy-/light-chain interface, we demonstrate one-step synthesis of four fully IgG-bispecific antibodies.

-	~~Authors: Atwell, S~~., Leaver-Fay, A., Froning, ~~K.J.~~, Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R~~., Dhanani~~, S~~.H.~~, Chamberlain~~, A.K.~~, Fitchett, ~~J.R., Gutierrez~~, B.~~, Hendle, J~~.~~, Demarest, S~~.J., ~~Kuhlman, B~~.	+	Computationally Designed Bispecific Antibodies using Negative State Repertoires.,Leaver-Fay A, Froning KJ, Atwell S, Aldaz H, Pustilnik A, Lu F, Huang F, Yuan R, Hassanali S, Chamberlain AK, Fitchett JR, Demarest SJ, Kuhlman B Structure. 2016 Apr 5;24(4):641-51. doi: 10.1016/j.str.2016.02.013. Epub 2016 Mar, 17. PMID:26996964<ref>PMID:26996964</ref>

-	~~Description: Fc Heterodimer Design 7~~.~~8 D399M~~/~~Y407A + T366V/K409V~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Leaver-Fay, A]]~~	+	<div class="pdbe-citations 5djz" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Aldaz, H]]		[[Category: Aldaz, H]]
-	[[Category: Gutierrez, B]]
-	[[Category: Fitchett, J.R]]
-	[[Category: Dhanani, S.H]]
-	[[Category: Kuhlman, B]]
-	[[Category: Froning, K.J]]
-	[[Category: Demarest, S.J]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]
		+	[[Category: Chamberlain, A K]]
		+	[[Category: Demarest, S J]]
		+	[[Category: Dhanani, S H]]
		+	[[Category: Fitchett, J R]]
		+	[[Category: Froning, K J]]
		+	[[Category: Gutierrez, B]]
	[[Category: Hendle, J]]		[[Category: Hendle, J]]
-	[[Category: Yuan, R]]
-	[[Category: Lu, F]]
	[[Category: Huang, F]]		[[Category: Huang, F]]
-	[[Category: ~~Chamberlain~~, A.K]]	+	[[Category: Kuhlman, B]]
		+	[[Category: Leaver-Fay, A]]
		+	[[Category: Lu, F]]
	[[Category: Pustilnik, A]]		[[Category: Pustilnik, A]]
		+	[[Category: Yuan, R]]
		+	[[Category: Bispecific antibody]]
		+	[[Category: Ch3]]
		+	[[Category: Fc]]
		+	[[Category: Heterodimer]]
		+	[[Category: Immune system]]
		+	[[Category: Immunoglobulin]]

OCA at 22:16, 27 January 2016

2016-01-27T22:16:13Z

←Older revision		Revision as of 22:16, 27 January 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5djz is ON HOLD	+	The entry 5djz is ON HOLD until Paper Publication

	Authors: Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.		Authors: Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.

OCA at 11:12, 16 December 2015

2015-12-16T11:12:12Z

←Older revision		Revision as of 11:12, 16 December 2015
Line 7:		Line 7:
	Description: Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V		Description: Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
		+	[[Category: Leaver-Fay, A]]
		+	[[Category: Aldaz, H]]
		+	[[Category: Gutierrez, B]]
	[[Category: Fitchett, J.R]]		[[Category: Fitchett, J.R]]
	[[Category: Dhanani, S.H]]		[[Category: Dhanani, S.H]]
Line 12:		Line 15:
	[[Category: Froning, K.J]]		[[Category: Froning, K.J]]
	[[Category: Demarest, S.J]]		[[Category: Demarest, S.J]]
-	[[Category: Yuan, R]]
-	[[Category: Leaver-Fay, A]]
-	[[Category: Aldaz, H]]
-	[[Category: Gutierrez, B]]
	[[Category: Atwell, S]]		[[Category: Atwell, S]]
	[[Category: Hendle, J]]		[[Category: Hendle, J]]
		+	[[Category: Yuan, R]]
	[[Category: Lu, F]]		[[Category: Lu, F]]
	[[Category: Huang, F]]		[[Category: Huang, F]]
	[[Category: Chamberlain, A.K]]		[[Category: Chamberlain, A.K]]
	[[Category: Pustilnik, A]]		[[Category: Pustilnik, A]]

OCA: Protected "5djz" [edit=sysop:move=sysop]

2015-09-09T10:19:33Z

Protected "5djz" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:19, 9 September 2015

OCA: New page: '''Unreleased structure''' The entry 5djz is ON HOLD Authors: Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlai...

2015-09-09T10:19:32Z

New page: '''Unreleased structure''' The entry 5djz is ON HOLD Authors: Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlai...

New page

'''Unreleased structure'''

The entry 5djz is ON HOLD

Authors: Atwell, S., Leaver-Fay, A., Froning, K.J., Aldaz, H., Pustilnik, A., Lu, F., Huang, F., Yuan, R., Dhanani, S.H., Chamberlain, A.K., Fitchett, J.R., Gutierrez, B., Hendle, J., Demarest, S.J., Kuhlman, B.

Description: Fc Heterodimer Design 7.8 D399M/Y407A + T366V/K409V
[[Category: Unreleased Structures]]
[[Category: Fitchett, J.R]]
[[Category: Dhanani, S.H]]
[[Category: Kuhlman, B]]
[[Category: Froning, K.J]]
[[Category: Demarest, S.J]]
[[Category: Yuan, R]]
[[Category: Leaver-Fay, A]]
[[Category: Aldaz, H]]
[[Category: Gutierrez, B]]
[[Category: Atwell, S]]
[[Category: Hendle, J]]
[[Category: Lu, F]]
[[Category: Huang, F]]
[[Category: Chamberlain, A.K]]
[[Category: Pustilnik, A]]