5dnl - Revision history

OCA at 21:51, 28 June 2023

2023-06-28T21:51:24Z

←Older revision		Revision as of 21:51, 28 June 2023
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	<StructureSection load='5dnl' size='340' side='right'caption='[[5dnl]], [[Resolution\|resolution]] 1.53Å' scene=''>		<StructureSection load='5dnl' size='340' side='right'caption='[[5dnl]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dnl]] is a 3 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_43587 Atcc 43587~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DNL OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5DNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dnl]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus Pyrococcus furiosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DNL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5DNL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5DL:[(2S)-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]PHOSPHONIC+ACID'>5DL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.53Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hisB, PF1660 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5DL:[(2S)-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]PHOSPHONIC+ACID'>5DL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Imidazoleglycerol-phosphate_dehydratase Imidazoleglycerol-phosphate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.19 4.2.1.19] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5dnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnl OCA], [https://pdbe.org/5dnl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5dnl RCSB], [https://www.ebi.ac.uk/pdbsum/5dnl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnl ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5dnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnl OCA], [~~http~~://pdbe.org/5dnl PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5dnl RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5dnl PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnl ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/HIS7_PYRFU HIS7_PYRFU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 43587]]
-	[[Category: Imidazoleglycerol-phosphate dehydratase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Baker~~, P J~~]]	+	[[Category: Pyrococcus furiosus]]
-	[[Category: Bisson, C]]	+	[[Category: Baker PJ]]
-	[[Category: Britton~~, K L~~]]	+	[[Category: Bisson C]]
-	[[Category: Eadsforth~~, T C~~]]	+	[[Category: Britton KL]]
-	[[Category: Hawkes~~, T R~~]]	+	[[Category: Eadsforth TC]]
-	[[Category: Rice~~, D W~~]]	+	[[Category: Hawkes TR]]
-	[[Category: Rodgers~~, H F~~]]	+	[[Category: Rice DW]]
-	[[Category: Sedelnikova~~, S E~~]]	+	[[Category: Rodgers HF]]
-	[[Category: Viner~~, R C]]~~	+	[[Category: Sedelnikova SE]]
-	~~[[Category: Complex]]~~	+	[[Category: Viner RC]]
-	~~[[Category: Cytoplasmic]]~~	+
-	~~[[Category: Dehydratase]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Lyase~~]]	+

OCA at 08:11, 8 April 2020

2020-04-08T08:11:40Z

←Older revision		Revision as of 08:11, 8 April 2020
Line 1:		Line 1:

	==Crystal structure of IGPD from Pyrococcus furiosus in complex with (S)-C348==		==Crystal structure of IGPD from Pyrococcus furiosus in complex with (S)-C348==
-	<StructureSection load='5dnl' size='340' side='right' caption='[[5dnl]], [[Resolution\|resolution]] 1.53Å' scene=''>	+	<StructureSection load='5dnl' size='340' side='right'caption='[[5dnl]], [[Resolution\|resolution]] 1.53Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5dnl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DNL OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5DNL FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5dnl]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_43587 Atcc 43587]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DNL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5DNL FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5DL:[(2S)-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]PHOSPHONIC+ACID'>5DL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5DL:[(2S)-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]PHOSPHONIC+ACID'>5DL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">hisB, PF1660 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2261 ATCC 43587])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Imidazoleglycerol-phosphate_dehydratase Imidazoleglycerol-phosphate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.19 4.2.1.19] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Imidazoleglycerol-phosphate_dehydratase Imidazoleglycerol-phosphate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.19 4.2.1.19] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5dnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnl OCA], [http://pdbe.org/5dnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dnl RCSB], [http://www.ebi.ac.uk/pdbsum/5dnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnl ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5dnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnl OCA], [http://pdbe.org/5dnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dnl RCSB], [http://www.ebi.ac.uk/pdbsum/5dnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnl ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 43587]]
	[[Category: Imidazoleglycerol-phosphate dehydratase]]		[[Category: Imidazoleglycerol-phosphate dehydratase]]
		+	[[Category: Large Structures]]
	[[Category: Baker, P J]]		[[Category: Baker, P J]]
	[[Category: Bisson, C]]		[[Category: Bisson, C]]

OCA at 09:41, 19 October 2016

2016-10-19T09:41:38Z

←Older revision		Revision as of 09:41, 19 October 2016
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnl OCA], [http://pdbe.org/5dnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dnl RCSB], [http://www.ebi.ac.uk/pdbsum/5dnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnl ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnl OCA], [http://pdbe.org/5dnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dnl RCSB], [http://www.ebi.ac.uk/pdbsum/5dnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnl ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Programs of drug discovery generally exploit one enantiomer of a chiral compound for lead development following the principle that enantiomer recognition is central to biological specificity. However, chiral promiscuity has been identified for a number of enzyme families, which have shown that mirror-image packing can enable opposite enantiomers to be accommodated in an enzyme's active site. Reported here is a series of crystallographic studies of complexes between an enzyme and a potent experimental herbicide whose chiral center forms an essential part of the inhibitor pharmacophore. Initial studies with a racemate at 1.85 A resolution failed to identify the chirality of the bound inhibitor, however, by extending the resolution to 1.1 A and by analyzing high-resolution complexes with the enantiopure compounds, we determined that both enantiomers make equivalent pseudosymmetric interactions in the active site, thus mimicking an achiral reaction intermediate.
		+
		+	Mirror-Image Packing Provides a Molecular Basis for the Nanomolar Equipotency of Enantiomers of an Experimental Herbicide.,Bisson C, Britton KL, Sedelnikova SE, Rodgers HF, Eadsforth TC, Viner RC, Hawkes TR, Baker PJ, Rice DW Angew Chem Int Ed Engl. 2016 Oct 17;55(43):13485-13489. doi:, 10.1002/anie.201607185. Epub 2016 Sep 26. PMID:27717128<ref>PMID:27717128</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5dnl" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 17:03, 3 October 2016

2016-10-03T17:03:34Z

←Older revision		Revision as of 17:03, 3 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5dnl is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of IGPD from Pyrococcus furiosus in complex with (S)-C348==
-		+	<StructureSection load='5dnl' size='340' side='right' caption='[[5dnl]], [[Resolution\|resolution]] 1.53Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5dnl]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5DNL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5DNL FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5DL:[(2S)-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL]PHOSPHONIC+ACID'>5DL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Imidazoleglycerol-phosphate_dehydratase Imidazoleglycerol-phosphate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.19 4.2.1.19] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5dnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5dnl OCA], [http://pdbe.org/5dnl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5dnl RCSB], [http://www.ebi.ac.uk/pdbsum/5dnl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5dnl ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Imidazoleglycerol-phosphate dehydratase]]
		+	[[Category: Baker, P J]]
		+	[[Category: Bisson, C]]
		+	[[Category: Britton, K L]]
		+	[[Category: Eadsforth, T C]]
		+	[[Category: Hawkes, T R]]
		+	[[Category: Rice, D W]]
		+	[[Category: Rodgers, H F]]
		+	[[Category: Sedelnikova, S E]]
		+	[[Category: Viner, R C]]
		+	[[Category: Complex]]
		+	[[Category: Cytoplasmic]]
		+	[[Category: Dehydratase]]
		+	[[Category: Inhibitor]]
		+	[[Category: Lyase]]

OCA at 11:58, 15 May 2016

2016-05-15T11:58:33Z

←Older revision		Revision as of 11:58, 15 May 2016
Line 3:		Line 3:
	The entry 5dnl is ON HOLD until Paper Publication		The entry 5dnl is ON HOLD until Paper Publication

-	Authors: ~~Bisson, C., Britton, K.L., Sedelnikova, S.E., Rodgers, H.F., Eadsforth, T.C., Viner, R.C., Hawkes, T.R., Baker, P.J., Rice, D.W.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bisson, C]]
-	[[Category: Baker, P.J]]
-	[[Category: Britton, K.L]]
-	[[Category: Sedelnikova, S.E]]
-	[[Category: Hawkes, T.R]]
-	[[Category: Viner, R.C]]
-	[[Category: Rodgers, H.F]]
-	[[Category: Rice, D.W]]
-	[[Category: Eadsforth, T.C]]

OCA at 11:16, 16 December 2015

2015-12-16T11:16:19Z

←Older revision		Revision as of 11:16, 16 December 2015
Line 9:		Line 9:
	[[Category: Bisson, C]]		[[Category: Bisson, C]]
	[[Category: Baker, P.J]]		[[Category: Baker, P.J]]
-	[[Category: Viner, R.C]]
-	[[Category: Rodgers, H.F]]
-	[[Category: Rice, D.W]]
	[[Category: Britton, K.L]]		[[Category: Britton, K.L]]
	[[Category: Sedelnikova, S.E]]		[[Category: Sedelnikova, S.E]]
	[[Category: Hawkes, T.R]]		[[Category: Hawkes, T.R]]
		+	[[Category: Viner, R.C]]
		+	[[Category: Rodgers, H.F]]
		+	[[Category: Rice, D.W]]
	[[Category: Eadsforth, T.C]]		[[Category: Eadsforth, T.C]]

OCA: Protected "5dnl" [edit=sysop:move=sysop]

2015-09-30T13:13:49Z

Protected "5dnl" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:13, 30 September 2015

OCA: New page: '''Unreleased structure''' The entry 5dnl is ON HOLD until Paper Publication Authors: Bisson, C., Britton, K.L., Sedelnikova, S.E., Rodgers, H.F., Eadsforth, T.C., Viner, R.C., Hawkes, ...

2015-09-30T13:13:47Z

New page: '''Unreleased structure''' The entry 5dnl is ON HOLD until Paper Publication Authors: Bisson, C., Britton, K.L., Sedelnikova, S.E., Rodgers, H.F., Eadsforth, T.C., Viner, R.C., Hawkes, ...

New page

'''Unreleased structure'''

The entry 5dnl is ON HOLD until Paper Publication

Authors: Bisson, C., Britton, K.L., Sedelnikova, S.E., Rodgers, H.F., Eadsforth, T.C., Viner, R.C., Hawkes, T.R., Baker, P.J., Rice, D.W.

Description:
[[Category: Unreleased Structures]]
[[Category: Bisson, C]]
[[Category: Baker, P.J]]
[[Category: Viner, R.C]]
[[Category: Rodgers, H.F]]
[[Category: Rice, D.W]]
[[Category: Britton, K.L]]
[[Category: Sedelnikova, S.E]]
[[Category: Hawkes, T.R]]
[[Category: Eadsforth, T.C]]