5e55 - Revision history

OCA at 06:13, 5 July 2023

2023-07-05T06:13:17Z

←Older revision		Revision as of 06:13, 5 July 2023
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	<StructureSection load='5e55' size='340' side='right'caption='[[5e55]], [[Resolution\|resolution]] 2.70Å' scene=''>		<StructureSection load='5e55' size='340' side='right'caption='[[5e55]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e55]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E55 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5E55 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e55]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E55 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E55 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5e4q\|5e4q]], [[5e4s\|5e4s]], [[5e4i\|5e4i]], [[5e52\|5e52]], [[5e53\|5e53]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.702Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Cntn6 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e55 OCA], [https://pdbe.org/5e55 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e55 RCSB], [https://www.ebi.ac.uk/pdbsum/5e55 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e55 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5e55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e55 OCA], [~~http~~://pdbe.org/5e55 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5e55 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5e55 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5e55 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/CNTN6_MOUSE CNTN6_MOUSE]] Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination.<ref>PMID:12884264</ref>	+	[https://www.uniprot.org/uniprot/CNTN6_MOUSE CNTN6_MOUSE] Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination.<ref>PMID:12884264</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5e55" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5e55" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Contactin\|Contactin]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Bouyain, S]]	+	[[Category: Bouyain S]]
-	[[Category: Nikolaienko~~, R M]]~~	+	[[Category: Nikolaienko RM]]
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Fibronectin type iii domain]]~~	+
-	~~[[Category: Neural cell adhesion molecule~~]]	+

OCA at 11:30, 25 December 2019

2019-12-25T11:30:22Z

←Older revision		Revision as of 11:30, 25 December 2019
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	==Crystal structure of mouse CNTN6 FN1-FN3 domains==		==Crystal structure of mouse CNTN6 FN1-FN3 domains==
-	<StructureSection load='5e55' size='340' side='right' caption='[[5e55]], [[Resolution\|resolution]] 2.70Å' scene=''>	+	<StructureSection load='5e55' size='340' side='right'caption='[[5e55]], [[Resolution\|resolution]] 2.70Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e55]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E55 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e55]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E55 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4q\|5e4q]], [[5e4s\|5e4s]], [[5e4i\|5e4i]], [[5e52\|5e52]], [[5e53\|5e53]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4q\|5e4q]], [[5e4s\|5e4s]], [[5e4i\|5e4i]], [[5e52\|5e52]], [[5e53\|5e53]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Cntn6 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e55 OCA], [http://pdbe.org/5e55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e55 RCSB], [http://www.ebi.ac.uk/pdbsum/5e55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e55 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e55 OCA], [http://pdbe.org/5e55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e55 RCSB], [http://www.ebi.ac.uk/pdbsum/5e55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e55 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Bouyain, S]]		[[Category: Bouyain, S]]
	[[Category: Nikolaienko, R M]]		[[Category: Nikolaienko, R M]]

OCA at 09:33, 27 September 2017

2017-09-27T09:33:10Z

←Older revision		Revision as of 09:33, 27 September 2017
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5e55" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5e55" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Contactin\|Contactin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:54, 10 September 2016

2016-09-10T13:54:34Z

←Older revision		Revision as of 13:54, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5e55 is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of mouse CNTN6 FN1-FN3 domains==
		+	<StructureSection load='5e55' size='340' side='right' caption='[[5e55]], [[Resolution\|resolution]] 2.70Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5e55]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E55 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e4q\|5e4q]], [[5e4s\|5e4s]], [[5e4i\|5e4i]], [[5e52\|5e52]], [[5e53\|5e53]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e55 OCA], [http://pdbe.org/5e55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e55 RCSB], [http://www.ebi.ac.uk/pdbsum/5e55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e55 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/CNTN6_MOUSE CNTN6_MOUSE]] Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus (By similarity). Involved in motor coordination.<ref>PMID:12884264</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein tyrosine phosphatase receptor type G (RPTPgamma/PTPRG) interacts in vitro with contactin-3-6 (CNTN3-6), a group of glycosylphosphatidyl-anchored cell adhesion molecules involved in the wiring of the nervous system. In addition to PTPRG, CNTNs associate with multiple transmembrane proteins and signal inside the cell via cis-binding partners to alleviate the absence of an intracellular region. Here, we use comprehensive biochemical and structural analyses to demonstrate that PTPRG[middot]CNTN3-6 complexes share similar binding affinities and a conserved arrangement. Furthermore, as a first step to identifying PTPRG.CNTN complexes in vivo, we found that PTPRG and CNTN3 associate in the outer segments of mouse rod photoreceptor cells. In particular, PTPRG and CNTN3 form cis-complexes at the surface of photoreceptors, yet interact in trans when expressed on the surfaces of apposing cells. Further structural analyses suggest that all CNTN ectodomains adopt a bent conformation and might lie parallel to the cell surface to accommodate these cis and trans binding modes. Taken together, these studies identify a PTPRG.CNTN complex in vivo and provide novel insights into PTPRG- and CNTN- mediated signaling.

-	~~Authors:~~ Nikolaienko, R.M., ~~Bouyain~~, S.	+	Structural Basis for Interactions Between Contactin Family Members and Protein Tyrosine Phosphatase Receptor Type G in Neural Tissues.,Nikolaienko RM, Hammel M, Dubreuil V, Zalmai R, Hall DR, Mehzabeen N, Karuppan SJ, Harroch S, Stella SL, Bouyain S J Biol Chem. 2016 Aug 18. pii: jbc.M116.742163. PMID:27539848<ref>PMID:27539848</ref>

-	~~Description: Crystal structure~~ of ~~mouse CNTN6 FN1-FN3 domains~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Nikolaienko, R.M]]~~	+	<div class="pdbe-citations 5e55" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Bouyain, S]]		[[Category: Bouyain, S]]
		+	[[Category: Nikolaienko, R M]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Fibronectin type iii domain]]
		+	[[Category: Neural cell adhesion molecule]]

OCA at 04:21, 22 October 2015

2015-10-22T04:21:58Z

←Older revision		Revision as of 04:21, 22 October 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5e55 is ON HOLD	+	The entry 5e55 is ON HOLD until Paper Publication

	Authors: Nikolaienko, R.M., Bouyain, S.		Authors: Nikolaienko, R.M., Bouyain, S.

OCA: Protected "5e55" [edit=sysop:move=sysop]

2015-10-16T03:00:54Z

Protected "5e55" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:00, 16 October 2015

OCA: New page: '''Unreleased structure''' The entry 5e55 is ON HOLD Authors: Nikolaienko, R.M., Bouyain, S. Description: Crystal structure of mouse CNTN6 FN1-FN3 domains [[Category: Unreleased Struct...

2015-10-16T03:00:53Z

New page: '''Unreleased structure''' The entry 5e55 is ON HOLD Authors: Nikolaienko, R.M., Bouyain, S. Description: Crystal structure of mouse CNTN6 FN1-FN3 domains [[Category: Unreleased Struct...

New page

'''Unreleased structure'''

The entry 5e55 is ON HOLD

Authors: Nikolaienko, R.M., Bouyain, S.

Description: Crystal structure of mouse CNTN6 FN1-FN3 domains
[[Category: Unreleased Structures]]
[[Category: Nikolaienko, R.M]]
[[Category: Bouyain, S]]