5e61 - Revision history

OCA at 12:27, 6 March 2024

2024-03-06T12:27:25Z

←Older revision		Revision as of 12:27, 6 March 2024
Line 7:		Line 7:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [https://pdbe.org/5e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [https://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [https://pdbe.org/5e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [https://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr>
	</table>		</table>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Structural studies of amyloidogenic segments by X-ray crystallography have revealed a novel packing motif, consisting of out-of-register beta sheets, that may constitute one of the toxic species in aggregation related diseases. Here we sought to determine the presence of such a motif in Islet amyloid polypeptide (IAPP), whose amyloidogenic properties are associated with Type 2 Diabetes. We determined four new crystal structures of segments within IAPP all forming steric zippers. Most interestingly, one of the segments in the fibril core of IAPP forms an out-of-register steric zipper. Analysis of this structure reveals several commonalities with previously solved out-of-register fibrils. Our results provide evidence that out-of-register beta sheets may be a common structural motif in amyloid aggregates and may be associated with toxicity.
-
-	Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.,Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D J Phys Chem B. 2015 Dec 2. PMID:26629790<ref>PMID:26629790</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5e61" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:14, 5 July 2023

2023-07-05T06:14:15Z

←Older revision		Revision as of 06:14, 5 July 2023
Line 3:		Line 3:
	<StructureSection load='5e61' size='340' side='right'caption='[[5e61]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='5e61' size='340' side='right'caption='[[5e61]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E61 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5E61 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e61]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E61 FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5e5v\|5e5v]]~~, [[~~5e5x~~\|~~5e5x]], [[5e5z\|5e5z~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.79Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [~~http~~://pdbe.org/5e61 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [https://pdbe.org/5e61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [https://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Eisenberg, D]]	+	[[Category: Eisenberg D]]
-	[[Category: Soriaga~~, A B]]~~	+	[[Category: Soriaga AB]]
-	~~[[Category: Amyloid-like protofibril]]~~	+
-	~~[[Category: De novo protein]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Protein fibril~~]]	+

OCA at 06:45, 22 April 2020

2020-04-22T06:45:19Z

←Older revision		Revision as of 06:45, 22 April 2020
Line 1:		Line 1:

	==Structure of amyloid-forming peptide FGAILSS (residues 23-29) from islet amyloid polypeptide==		==Structure of amyloid-forming peptide FGAILSS (residues 23-29) from islet amyloid polypeptide==
-	<StructureSection load='5e61' size='340' side='right' caption='[[5e61]], [[Resolution\|resolution]] 1.79Å' scene=''>	+	<StructureSection load='5e61' size='340' side='right'caption='[[5e61]], [[Resolution\|resolution]] 1.79Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E61 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5E61 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E61 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5E61 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e5v\|5e5v]], [[5e5x\|5e5x]], [[5e5z\|5e5z]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e5v\|5e5v]], [[5e5x\|5e5x]], [[5e5z\|5e5z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [http://pdbe.org/5e61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [http://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [http://pdbe.org/5e61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [http://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 20:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
	[[Category: Soriaga, A B]]		[[Category: Soriaga, A B]]

OCA at 06:51, 26 July 2016

2016-07-26T06:51:48Z

←Older revision		Revision as of 06:51, 26 July 2016
Line 1:		Line 1:
		+
	==Structure of amyloid-forming peptide FGAILSS (residues 23-29) from islet amyloid polypeptide==		==Structure of amyloid-forming peptide FGAILSS (residues 23-29) from islet amyloid polypeptide==
	<StructureSection load='5e61' size='340' side='right' caption='[[5e61]], [[Resolution\|resolution]] 1.79Å' scene=''>		<StructureSection load='5e61' size='340' side='right' caption='[[5e61]], [[Resolution\|resolution]] 1.79Å' scene=''>
Line 4:		Line 5:
	<table><tr><td colspan='2'>[[5e61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E61 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5e61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E61 FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e5v\|5e5v]], [[5e5x\|5e5x]], [[5e5z\|5e5z]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e5v\|5e5v]], [[5e5x\|5e5x]], [[5e5z\|5e5z]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [http://pdbe.org/5e61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [http://www.ebi.ac.uk/pdbsum/5e61 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [http://pdbe.org/5e61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [http://www.ebi.ac.uk/pdbsum/5e61 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e61 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 13:50, 16 December 2015

2015-12-16T13:50:42Z

←Older revision		Revision as of 13:50, 16 December 2015
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Structure of amyloid-forming peptide FGAILSS (residues 23-29) from islet amyloid polypeptide==
		+	<StructureSection load='5e61' size='340' side='right' caption='[[5e61]], [[Resolution\|resolution]] 1.79Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5e61]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E61 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E61 FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e5v\|5e5v]], [[5e5x\|5e5x]], [[5e5z\|5e5z]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e61 OCA], [http://pdbe.org/5e61 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e61 RCSB], [http://www.ebi.ac.uk/pdbsum/5e61 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Structural studies of amyloidogenic segments by X-ray crystallography have revealed a novel packing motif, consisting of out-of-register beta sheets, that may constitute one of the toxic species in aggregation related diseases. Here we sought to determine the presence of such a motif in Islet amyloid polypeptide (IAPP), whose amyloidogenic properties are associated with Type 2 Diabetes. We determined four new crystal structures of segments within IAPP all forming steric zippers. Most interestingly, one of the segments in the fibril core of IAPP forms an out-of-register steric zipper. Analysis of this structure reveals several commonalities with previously solved out-of-register fibrils. Our results provide evidence that out-of-register beta sheets may be a common structural motif in amyloid aggregates and may be associated with toxicity.

-	~~The entry 5e61 is ON HOLD until Paper Publication~~	+	Crystal Structures of IAPP Amyloidogenic Segments Reveal a Novel Packing Motif of Out-of-Register Beta Sheets.,Soriaga AB, Sangwan S, Macdonald R, Sawaya MR, Eisenberg D J Phys Chem B. 2015 Dec 2. PMID:26629790<ref>PMID:26629790</ref>

-	~~Authors: Soriaga~~, A.B.~~, Eisenberg, D~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: Structure of amyloid~~-~~forming peptide FGAILSS (residues 23~~-~~29) from islet amyloid polypeptide~~	+	<div class="pdbe-citations 5e61" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	== References ==
-	~~[[Category: Soriaga, A.B]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Eisenberg, D]]		[[Category: Eisenberg, D]]
		+	[[Category: Soriaga, A B]]
		+	[[Category: Amyloid-like protofibril]]
		+	[[Category: De novo protein]]
		+	[[Category: Membrane protein]]
		+	[[Category: Protein fibril]]

OCA at 02:27, 1 December 2015

2015-12-01T02:27:06Z

←Older revision		Revision as of 02:27, 1 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5e61 is ON HOLD	+	The entry 5e61 is ON HOLD until Paper Publication

	Authors: Soriaga, A.B., Eisenberg, D.		Authors: Soriaga, A.B., Eisenberg, D.

OCA: Protected "5e61" [edit=sysop:move=sysop]

2015-10-16T03:03:37Z

Protected "5e61" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:03, 16 October 2015

OCA: New page: '''Unreleased structure''' The entry 5e61 is ON HOLD Authors: Soriaga, A.B., Eisenberg, D. Description: Structure of amyloid-forming peptide FGAILSS (residues 23-29) from islet amyloid...

2015-10-16T03:03:36Z

New page: '''Unreleased structure''' The entry 5e61 is ON HOLD Authors: Soriaga, A.B., Eisenberg, D. Description: Structure of amyloid-forming peptide FGAILSS (residues 23-29) from islet amyloid...

New page

'''Unreleased structure'''

The entry 5e61 is ON HOLD

Authors: Soriaga, A.B., Eisenberg, D.

Description: Structure of amyloid-forming peptide FGAILSS (residues 23-29) from islet amyloid polypeptide
[[Category: Unreleased Structures]]
[[Category: Soriaga, A.B]]
[[Category: Eisenberg, D]]