5e62 - Revision history

OCA at 06:14, 5 July 2023

2023-07-05T06:14:16Z

←Older revision		Revision as of 06:14, 5 July 2023
Line 1:		Line 1:

	==HEF-mut with Tr323 complex==		==HEF-mut with Tr323 complex==
-	<StructureSection load='5e62' size='340' side='right' caption='[[5e62]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5e62' size='340' side='right'caption='[[5e62]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e62]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Influenza_c_virus_~~(c/swine/~~oklahoma~~/1334/2011) Influenza c virus (c/swine/~~oklahoma~~/1334/2011)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E62 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5E62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e62]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_D_virus_(D/swine/Oklahoma/1334/2011) Influenza D virus (D/swine/Oklahoma/1334/2011)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5E62 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5N6:(2~{R},4~{S},5~{R},6~{R})-5-ACETAMIDO-6-[(1~{R},2~{R})-3-ACETYLOXY-1,2-BIS(OXIDANYL)PROPYL]-2,4-BIS(OXIDANYL)OXANE-2-CARBOXYLIC+ACID'>5N6</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z3Q:2-AZIDOETHYL+2-(ACETYLAMINO)-2-DEOXY-BETA-D-GLUCOPYRANOSIDE'>Z3Q</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.203Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e66\|5e66]], [[5e5w\|5e5w]], [[5e64\|5e64]], [[5e65\|5e65]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5N6:(2~{R},4~{S},5~{R},6~{R})-5-ACETAMIDO-6-[(1~{R},2~{R})-3-ACETYLOXY-1,2-BIS(OXIDANYL)PROPYL]-2,4-BIS(OXIDANYL)OXANE-2-CARBOXYLIC+ACID'>5N6</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z3Q:2-AZIDOETHYL+2-(ACETYLAMINO)-2-DEOXY-BETA-D-GLUCOPYRANOSIDE'>Z3Q</scene></td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1173138 Influenza C virus (C/swine/Oklahoma/1334/2011)])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5e62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e62 OCA], [https://pdbe.org/5e62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5e62 RCSB], [https://www.ebi.ac.uk/pdbsum/5e62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5e62 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5e62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e62 OCA], [~~http~~://pdbe.org/5e62 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5e62 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5e62 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5e62 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/K9LG83_9ORTO K9LG83_9ORTO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 21:

	==See Also==		==See Also==
-	*[[Hemagglutinin-esterase\|Hemagglutinin-esterase]]	+	*[[Hemagglutinin-esterase 3D structures\|Hemagglutinin-esterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Gao~~, G F~~]]	+	[[Category: Large Structures]]
-	[[Category: Qi, J]]	+	[[Category: Gao GF]]
-	[[Category: Shi, Y]]	+	[[Category: Qi J]]
-	[[Category: Song, H]]	+	[[Category: Shi Y]]
-	~~[[Category: Complex]]~~	+	[[Category: Song H]]
-	~~[[Category: Hef]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Influenza~~]]	+

OCA at 10:20, 5 September 2018

2018-09-05T10:20:06Z

←Older revision		Revision as of 10:20, 5 September 2018
Line 3:		Line 3:
	<StructureSection load='5e62' size='340' side='right' caption='[[5e62]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5e62' size='340' side='right' caption='[[5e62]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5e62]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E62 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5e62]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Influenza_c_virus_(c/swine/oklahoma/1334/2011) Influenza c virus (c/swine/oklahoma/1334/2011)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E62 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5N6:(2~{R},4~{S},5~{R},6~{R})-5-ACETAMIDO-6-[(1~{R},2~{R})-3-ACETYLOXY-1,2-BIS(OXIDANYL)PROPYL]-2,4-BIS(OXIDANYL)OXANE-2-CARBOXYLIC+ACID'>5N6</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z3Q:2-AZIDOETHYL+2-(ACETYLAMINO)-2-DEOXY-BETA-D-GLUCOPYRANOSIDE'>Z3Q</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5N6:(2~{R},4~{S},5~{R},6~{R})-5-ACETAMIDO-6-[(1~{R},2~{R})-3-ACETYLOXY-1,2-BIS(OXIDANYL)PROPYL]-2,4-BIS(OXIDANYL)OXANE-2-CARBOXYLIC+ACID'>5N6</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z3Q:2-AZIDOETHYL+2-(ACETYLAMINO)-2-DEOXY-BETA-D-GLUCOPYRANOSIDE'>Z3Q</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e66\|5e66]], [[5e5w\|5e5w]], [[5e64\|5e64]], [[5e65\|5e65]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e66\|5e66]], [[5e5w\|5e5w]], [[5e64\|5e64]], [[5e65\|5e65]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e62 OCA], [http://pdbe.org/5e62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e62 RCSB], [http://www.ebi.ac.uk/pdbsum/5e62 PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEF ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1173138 Influenza C virus (C/swine/Oklahoma/1334/2011)])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e62 OCA], [http://pdbe.org/5e62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e62 RCSB], [http://www.ebi.ac.uk/pdbsum/5e62 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5e62 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
-	~~[This corrects~~ the ~~article DOI: 10~~.~~1371/journal~~.~~ppat~~.~~1005411~~.].	+	Influenza viruses cause seasonal flu each year and pandemics or epidemic sporadically, posing a major threat to public health. Recently, a new influenza D virus (IDV) was isolated from pigs and cattle. Here, we reveal that the IDV utilizes 9-O-acetylated sialic acids as its receptor for virus entry. Then, we determined the crystal structures of hemagglutinin-esterase-fusion glycoprotein (HEF) of IDV both in its free form and in complex with the receptor and enzymatic substrate analogs. The IDV HEF shows an extremely similar structural fold as the human-infecting influenza C virus (ICV) HEF. However, IDV HEF has an open receptor-binding cavity to accommodate diverse extended glycan moieties. This structural difference provides an explanation for the phenomenon that the IDV has a broad cell tropism. As IDV HEF is structurally and functionally similar to ICV HEF, our findings highlight the potential threat of the virus to public health.

-	~~Correction:~~ An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.,Song H, Qi J, Khedri Z, Diaz S, Yu H, Chen X, Varki A, Shi Y, Gao GF PLoS Pathog. 2016 ~~Mar 8~~;12(3):~~e1005505~~. doi: 10.1371/journal.ppat.~~1005505~~., eCollection 2016 ~~Mar~~. PMID:~~26954772~~<ref>PMID:~~26954772~~</ref>	+	An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.,Song H, Qi J, Khedri Z, Diaz S, Yu H, Chen X, Varki A, Shi Y, Gao GF PLoS Pathog. 2016 Jan 27;12(1):e1005411. doi: 10.1371/journal.ppat.1005411., eCollection 2016 Jan. PMID:26816272<ref>PMID:26816272</ref>

	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>		From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
	</div>		</div>
	<div class="pdbe-citations 5e62" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5e62" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Hemagglutinin-esterase\|Hemagglutinin-esterase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 13:02, 11 May 2016

2016-05-11T13:02:39Z

←Older revision		Revision as of 13:02, 11 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5e62 is ~~ON HOLD until Oct 09 2017~~	+	==HEF-mut with Tr323 complex==
		+	<StructureSection load='5e62' size='340' side='right' caption='[[5e62]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5e62]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E62 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E62 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5N6:(2~{R},4~{S},5~{R},6~{R})-5-ACETAMIDO-6-[(1~{R},2~{R})-3-ACETYLOXY-1,2-BIS(OXIDANYL)PROPYL]-2,4-BIS(OXIDANYL)OXANE-2-CARBOXYLIC+ACID'>5N6</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=Z3Q:2-AZIDOETHYL+2-(ACETYLAMINO)-2-DEOXY-BETA-D-GLUCOPYRANOSIDE'>Z3Q</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5e66\|5e66]], [[5e5w\|5e5w]], [[5e64\|5e64]], [[5e65\|5e65]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e62 OCA], [http://pdbe.org/5e62 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e62 RCSB], [http://www.ebi.ac.uk/pdbsum/5e62 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	[This corrects the article DOI: 10.1371/journal.ppat.1005411.].

-	~~Authors~~: ~~Song~~, H., Qi, J., ~~Shi~~, Y., Gao~~, G~~.F.	+	Correction: An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism.,Song H, Qi J, Khedri Z, Diaz S, Yu H, Chen X, Varki A, Shi Y, Gao GF PLoS Pathog. 2016 Mar 8;12(3):e1005505. doi: 10.1371/journal.ppat.1005505., eCollection 2016 Mar. PMID:26954772<ref>PMID:26954772</ref>

-	~~Description: HEF~~-~~mut with Tr323 complex~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: Gao, G.F]]	+	<div class="pdbe-citations 5e62" style="background-color:#fffaf0;"></div>
-	~~[[Category: Song, H]]~~	+	== References ==
-	~~[[Category: Shi, Y~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gao, G F]]
	[[Category: Qi, J]]		[[Category: Qi, J]]
		+	[[Category: Shi, Y]]
		+	[[Category: Song, H]]
		+	[[Category: Complex]]
		+	[[Category: Hef]]
		+	[[Category: Hydrolase]]
		+	[[Category: Influenza]]

OCA at 02:27, 1 December 2015

2015-12-01T02:27:09Z

←Older revision		Revision as of 02:27, 1 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5e62 is ON HOLD	+	The entry 5e62 is ON HOLD until Oct 09 2017

-	Authors: ~~Hao~~ Song, ~~Jianxun~~ Qi, Yi Shi, ~~George F~~ Gao	+	Authors: Song, H., Qi, J., Shi, Y., Gao, G.F.

	Description: HEF-mut with Tr323 complex		Description: HEF-mut with Tr323 complex
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Hao~~ Song, ~~Jianxun Qi, Yi~~ Shi, ~~George F Gao~~]]	+	[[Category: Gao, G.F]]
		+	[[Category: Song, H]]
		+	[[Category: Shi, Y]]
		+	[[Category: Qi, J]]

OCA: Protected "5e62" [edit=sysop:move=sysop]

2015-10-16T03:03:41Z

Protected "5e62" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:03, 16 October 2015

OCA: New page: '''Unreleased structure''' The entry 5e62 is ON HOLD Authors: Hao Song, Jianxun Qi, Yi Shi, George F Gao Description: HEF-mut with Tr323 complex Category: Unreleased Structures [[C...

2015-10-16T03:03:39Z

New page: '''Unreleased structure''' The entry 5e62 is ON HOLD Authors: Hao Song, Jianxun Qi, Yi Shi, George F Gao Description: HEF-mut with Tr323 complex Category: Unreleased Structures [[C...

New page

'''Unreleased structure'''

The entry 5e62 is ON HOLD

Authors: Hao Song, Jianxun Qi, Yi Shi, George F Gao

Description: HEF-mut with Tr323 complex
[[Category: Unreleased Structures]]
[[Category: Hao Song, Jianxun Qi, Yi Shi, George F Gao]]