5ehm - Revision history

OCA at 06:28, 5 July 2023

2023-07-05T06:28:23Z

←Older revision		Revision as of 06:28, 5 July 2023
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	<StructureSection load='5ehm' size='340' side='right'caption='[[5ehm]], [[Resolution\|resolution]] 1.28Å' scene=''>		<StructureSection load='5ehm' size='340' side='right'caption='[[5ehm]], [[Resolution\|resolution]] 1.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ehm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Drome Drome~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EHM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ehm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EHM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=OEM:N~~-~~METHYL-D-ASPARTIC+ACID'>OEM</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.281Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5ehk\|5ehk]], [[5ehs\|5ehs]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OEM:N-METHYL-D-ASPARTIC+ACID'>OEM</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">CG3822, Dmel_CG3822 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ehm OCA], [https://pdbe.org/5ehm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ehm RCSB], [https://www.ebi.ac.uk/pdbsum/5ehm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ehm ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ehm OCA], [~~http~~://pdbe.org/5ehm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ehm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ehm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ehm ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8MS48_DROME Q8MS48_DROME] [https://www.uniprot.org/uniprot/Q9VDH5_DROME Q9VDH5_DROME]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Drome~~]]	+	[[Category: Drosophila melanogaster]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dharkar, P]]	+	[[Category: Dharkar P]]
-	[[Category: Mayer~~, M L]]~~	+	[[Category: Mayer ML]]
-	~~[[Category: Membrane protein~~]]	+

OCA at 06:58, 22 April 2020

2020-04-22T06:58:27Z

←Older revision		Revision as of 06:58, 22 April 2020
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	==Crystal structure of the Drosophila CG3822 KaiR1D ligand binding domain complex with NMDA==		==Crystal structure of the Drosophila CG3822 KaiR1D ligand binding domain complex with NMDA==
-	<StructureSection load='5ehm' size='340' side='right' caption='[[5ehm]], [[Resolution\|resolution]] 1.28Å' scene=''>	+	<StructureSection load='5ehm' size='340' side='right'caption='[[5ehm]], [[Resolution\|resolution]] 1.28Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ehm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EHM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ehm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Drome Drome]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EHM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OEM:N-METHYL-D-ASPARTIC+ACID'>OEM</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OEM:N-METHYL-D-ASPARTIC+ACID'>OEM</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ehk\|5ehk]], [[5ehs\|5ehs]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ehk\|5ehk]], [[5ehs\|5ehs]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ehm OCA], [http://pdbe.org/5ehm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ehm RCSB], [http://www.ebi.ac.uk/pdbsum/5ehm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ehm ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">CG3822, Dmel_CG3822 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 DROME])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ehm OCA], [http://pdbe.org/5ehm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ehm RCSB], [http://www.ebi.ac.uk/pdbsum/5ehm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ehm ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Drome]]
		+	[[Category: Large Structures]]
	[[Category: Dharkar, P]]		[[Category: Dharkar, P]]
	[[Category: Mayer, M L]]		[[Category: Mayer, M L]]
	[[Category: Membrane protein]]		[[Category: Membrane protein]]

OCA at 14:34, 22 December 2016

2016-12-22T14:34:44Z

←Older revision		Revision as of 14:34, 22 December 2016
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ehm OCA], [http://pdbe.org/5ehm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ehm RCSB], [http://www.ebi.ac.uk/pdbsum/5ehm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ehm ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ehm OCA], [http://pdbe.org/5ehm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ehm RCSB], [http://www.ebi.ac.uk/pdbsum/5ehm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ehm ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Phylogenetic analysis reveals AMPA, kainate, and NMDA receptor families in insect genomes, suggesting conserved functional properties corresponding to their vertebrate counterparts. However, heterologous expression of the Drosophila kainate receptor DKaiR1D and the AMPA receptor DGluR1A revealed novel ligand selectivity at odds with the classification used for vertebrate glutamate receptor ion channels (iGluRs). DKaiR1D forms a rapidly activating and desensitizing receptor that is inhibited by both NMDA and the NMDA receptor antagonist AP5; crystallization of the KaiR1D ligand-binding domain reveals that these ligands stabilize open cleft conformations, explaining their action as antagonists. Surprisingly, the AMPA receptor DGluR1A shows weak activation by its namesake agonist AMPA and also by quisqualate. Crystallization of the DGluR1A ligand-binding domain reveals amino acid exchanges that interfere with binding of these ligands. The unexpected ligand-binding profiles of insect iGluRs allows classical tools to be used in novel approaches for the study of synaptic regulation. VIDEO ABSTRACT.
		+
		+	Novel Functional Properties of Drosophila CNS Glutamate Receptors.,Li Y, Dharkar P, Han TH, Serpe M, Lee CH, Mayer ML Neuron. 2016 Dec 7;92(5):1036-1048. doi: 10.1016/j.neuron.2016.10.058. Epub 2016 , Nov 23. PMID:27889096<ref>PMID:27889096</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ehm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 19:45, 9 December 2016

2016-12-09T19:45:11Z

←Older revision		Revision as of 19:45, 9 December 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5ehm is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the Drosophila CG3822 KaiR1D ligand binding domain complex with NMDA==
-		+	<StructureSection load='5ehm' size='340' side='right' caption='[[5ehm]], [[Resolution\|resolution]] 1.28Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ehm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EHM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EHM FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OEM:N-METHYL-D-ASPARTIC+ACID'>OEM</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ehk\|5ehk]], [[5ehs\|5ehs]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ehm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ehm OCA], [http://pdbe.org/5ehm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ehm RCSB], [http://www.ebi.ac.uk/pdbsum/5ehm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ehm ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dharkar, P]]
		+	[[Category: Mayer, M L]]
		+	[[Category: Membrane protein]]

OCA at 12:24, 15 May 2016

2016-05-15T12:24:23Z

←Older revision		Revision as of 12:24, 15 May 2016
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	The entry 5ehm is ON HOLD until Paper Publication		The entry 5ehm is ON HOLD until Paper Publication

-	Authors: ~~Dharkar, P., Mayer, M.L.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Dharkar, P]]
-	[[Category: Mayer, M.L]]

OCA at 14:40, 2 December 2015

2015-12-02T14:40:45Z

←Older revision		Revision as of 14:40, 2 December 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ehm is ON HOLD	+	The entry 5ehm is ON HOLD until Paper Publication

	Authors: Dharkar, P., Mayer, M.L.		Authors: Dharkar, P., Mayer, M.L.

OCA: Protected "5ehm" [edit=sysop:move=sysop]

2015-12-01T02:51:20Z

Protected "5ehm" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:51, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5ehm is ON HOLD Authors: Dharkar, P., Mayer, M.L. Description: Category: Unreleased Structures Category: Dharkar, P [[Category: Mayer, M.L...

2015-12-01T02:51:18Z

New page: '''Unreleased structure''' The entry 5ehm is ON HOLD Authors: Dharkar, P., Mayer, M.L. Description: Category: Unreleased Structures Category: Dharkar, P [[Category: Mayer, M.L...

New page

'''Unreleased structure'''

The entry 5ehm is ON HOLD

Authors: Dharkar, P., Mayer, M.L.

Description:
[[Category: Unreleased Structures]]
[[Category: Dharkar, P]]
[[Category: Mayer, M.L]]