5eld - Revision history

OCA at 06:32, 5 July 2023

2023-07-05T06:32:50Z

←Older revision		Revision as of 06:32, 5 July 2023
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	<StructureSection load='5eld' size='340' side='right'caption='[[5eld]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='5eld' size='340' side='right'caption='[[5eld]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eld]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Vibrio_cholerae_01~~ Vibrio cholerae 01]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ELD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eld]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Vibrio_cholerae_O1 Vibrio cholerae O1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ELD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene><~~/td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	~~<tr id~~='~~gene'><td class~~=~~"sblockLbl"><b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">ctxB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=127906 Vibrio cholerae 01])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=PRD_900128:Blood+group+A+Lewis+Y+antigen,+alpha+anomer'>PRD_900128</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eld OCA], [~~http~~://pdbe.org/5eld PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5eld RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5eld PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5eld ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eld OCA], [https://pdbe.org/5eld PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eld RCSB], [https://www.ebi.ac.uk/pdbsum/5eld PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eld ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/D6R7L2_VIBCL D6R7L2_VIBCL]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Vibrio cholerae 01]]	+	[[Category: Vibrio cholerae O1]]
-	[[Category: Burschowsky, D]]	+	[[Category: Burschowsky D]]
-	[[Category: Heggelund~~, J E~~]]	+	[[Category: Heggelund JE]]
-	[[Category: Krengel, U]]	+	[[Category: Krengel U]]
-	~~[[Category: A lewis-y]]~~	+
-	~~[[Category: Blood group oligosaccharide/antigen]]~~	+
-	~~[[Category: Cholera toxin b-pentamer]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Toxin~~]]	+

OCA at 07:04, 22 April 2020

2020-04-22T07:04:15Z

←Older revision		Revision as of 07:04, 22 April 2020
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	==Cholera toxin classical B-pentamer in complex with A Lewis-y==		==Cholera toxin classical B-pentamer in complex with A Lewis-y==
-	<StructureSection load='5eld' size='340' side='right' caption='[[5eld]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='5eld' size='340' side='right'caption='[[5eld]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eld]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ELD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eld]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Vibrio_cholerae_01 Vibrio cholerae 01]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ELD FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eld OCA], [http://pdbe.org/5eld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eld RCSB], [http://www.ebi.ac.uk/pdbsum/5eld PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ctxB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=127906 Vibrio cholerae 01])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eld OCA], [http://pdbe.org/5eld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eld RCSB], [http://www.ebi.ac.uk/pdbsum/5eld PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eld ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5eld" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5eld" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cholera toxin 3D structures\|Cholera toxin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Vibrio cholerae 01]]
	[[Category: Burschowsky, D]]		[[Category: Burschowsky, D]]
	[[Category: Heggelund, J E]]		[[Category: Heggelund, J E]]

OCA at 15:55, 10 May 2016

2016-05-10T15:55:20Z

←Older revision		Revision as of 15:55, 10 May 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5eld is ~~ON HOLD until Paper~~ Publication	+	==Cholera toxin classical B-pentamer in complex with A Lewis-y==
		+	<StructureSection load='5eld' size='340' side='right' caption='[[5eld]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5eld]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ELD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ELD FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=GLA:ALPHA+D-GALACTOSE'>GLA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eld FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eld OCA], [http://pdbe.org/5eld PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eld RCSB], [http://www.ebi.ac.uk/pdbsum/5eld PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cholera is the prime example of blood-group-dependent diseases, with individuals of blood group O experiencing the most severe symptoms. The cholera toxin is the main suspect to cause this relationship. We report the high-resolution crystal structures (1.1-1.6 A) of the native cholera toxin B-pentamer for both classical and El Tor biotypes, in complexes with relevant blood group determinants and a fragment of its primary receptor, the GM1 ganglioside. The blood group A determinant binds in the opposite orientation compared to previously published structures of the cholera toxin, whereas the blood group H determinant, characteristic of blood group O, binds in both orientations. H-determinants bind with higher affinity than A-determinants, as shown by surface plasmon resonance. Together, these findings suggest why blood group O is a risk factor for severe cholera.

-	~~Authors: Heggelund, J.E~~., ~~Burschowsky~~, D., ~~Krengel~~, U.	+	High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.,Heggelund JE, Burschowsky D, Bjornestad VA, Hodnik V, Anderluh G, Krengel U PLoS Pathog. 2016 Apr 15;12(4):e1005567. doi: 10.1371/journal.ppat.1005567., eCollection 2016 Apr. PMID:27082955<ref>PMID:27082955</ref>

-	~~Description:~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category: Heggelund~~, J.~~E]]~~	+	<div class="pdbe-citations 5eld" style="background-color:#fffaf0;"></div>
-	~~[[Category~~: ~~Krengel, U]]~~	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Burschowsky, D]]		[[Category: Burschowsky, D]]
		+	[[Category: Heggelund, J E]]
		+	[[Category: Krengel, U]]
		+	[[Category: A lewis-y]]
		+	[[Category: Blood group oligosaccharide/antigen]]
		+	[[Category: Cholera toxin b-pentamer]]
		+	[[Category: Complex]]
		+	[[Category: Toxin]]

OCA at 11:01, 2 March 2016

2016-03-02T11:01:09Z

←Older revision		Revision as of 11:01, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5eld is ON HOLD	+	The entry 5eld is ON HOLD until Paper Publication

	Authors: Heggelund, J.E., Burschowsky, D., Krengel, U.		Authors: Heggelund, J.E., Burschowsky, D., Krengel, U.

OCA: Protected "5eld" [edit=sysop:move=sysop]

2015-12-01T03:00:54Z

Protected "5eld" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:00, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5eld is ON HOLD Authors: Heggelund, J.E., Burschowsky, D., Krengel, U. Description: Category: Unreleased Structures [[Category: Heggelund, J.E...

2015-12-01T03:00:53Z

New page: '''Unreleased structure''' The entry 5eld is ON HOLD Authors: Heggelund, J.E., Burschowsky, D., Krengel, U. Description: Category: Unreleased Structures [[Category: Heggelund, J.E...

New page

'''Unreleased structure'''

The entry 5eld is ON HOLD

Authors: Heggelund, J.E., Burschowsky, D., Krengel, U.

Description:
[[Category: Unreleased Structures]]
[[Category: Heggelund, J.E]]
[[Category: Krengel, U]]
[[Category: Burschowsky, D]]