5em0 - Revision history

OCA at 06:33, 5 July 2023

2023-07-05T06:33:40Z

←Older revision		Revision as of 06:33, 5 July 2023
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	<StructureSection load='5em0' size='340' side='right'caption='[[5em0]], [[Resolution\|resolution]] 1.10Å' scene=''>		<StructureSection load='5em0' size='340' side='right'caption='[[5em0]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5em0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Artvu Artvu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EM0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5em0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Artemisia_vulgaris Artemisia vulgaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EM0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)~~-1~~-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.1Å</td></tr>
-	<tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene><~~/td~~></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-	<~~tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[5em1\|5em1]]~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em0 OCA], [https://pdbe.org/5em0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5em0 RCSB], [https://www.ebi.ac.uk/pdbsum/5em0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5em0 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em0 OCA], [~~http~~://pdbe.org/5em0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5em0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5em0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5em0 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/PROF1_ARTVU PROF1_ARTVU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Artvu~~]]	+	[[Category: Artemisia vulgaris]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Chruszcz, M]]	+	[[Category: Chruszcz M]]
-	[[Category: Offermann~~, L R~~]]	+	[[Category: Offermann LR]]
-	[[Category: Perdue~~, M L]]~~	+	[[Category: Perdue ML]]
-	~~[[Category: Allergen~~]]	+

OCA at 07:05, 22 April 2020

2020-04-22T07:05:02Z

←Older revision		Revision as of 07:05, 22 April 2020
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	==Crystal structure of mugwort allergen Art v 4==		==Crystal structure of mugwort allergen Art v 4==
-	<StructureSection load='5em0' size='340' side='right' caption='[[5em0]], [[Resolution\|resolution]] 1.10Å' scene=''>	+	<StructureSection load='5em0' size='340' side='right'caption='[[5em0]], [[Resolution\|resolution]] 1.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5em0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EM0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5em0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Artvu Artvu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EM0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em1\|5em1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em1\|5em1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em0 OCA], [http://pdbe.org/5em0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5em0 RCSB], [http://www.ebi.ac.uk/pdbsum/5em0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5em0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em0 OCA], [http://pdbe.org/5em0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5em0 RCSB], [http://www.ebi.ac.uk/pdbsum/5em0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5em0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5em0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5em0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Profilin 3D Structures\|Profilin 3D Structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Artvu]]
		+	[[Category: Large Structures]]
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
	[[Category: Offermann, L R]]		[[Category: Offermann, L R]]
	[[Category: Perdue, M L]]		[[Category: Perdue, M L]]
	[[Category: Allergen]]		[[Category: Allergen]]

OCA at 08:19, 10 August 2016

2016-08-10T08:19:12Z

←Older revision		Revision as of 08:19, 10 August 2016
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	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em1\|5em1]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em1\|5em1]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em0 OCA], [http://pdbe.org/5em0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5em0 RCSB], [http://www.ebi.ac.uk/pdbsum/5em0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em0 OCA], [http://pdbe.org/5em0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5em0 RCSB], [http://www.ebi.ac.uk/pdbsum/5em0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5em0 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 15:22, 20 June 2016

2016-06-20T15:22:02Z

←Older revision		Revision as of 15:22, 20 June 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5em0 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of mugwort allergen Art v 4==
		+	<StructureSection load='5em0' size='340' side='right' caption='[[5em0]], [[Resolution\|resolution]] 1.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5em0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EM0 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5em1\|5em1]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5em0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em0 OCA], [http://pdbe.org/5em0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5em0 RCSB], [http://www.ebi.ac.uk/pdbsum/5em0 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ragweed allergens affect several million people in the USA and Canada. To date, only two ragweed allergens, Amb t 5 and Amb a 11, have their structures determined and deposited to the Protein Data Bank. Here, we present structures of methylated ragweed allergen Amb a 8, Amb a 8 in the presence of poly-L-proline and Art v 4 (mugwort allergen). Amb a 8 and Art v 4 are panallergens belonging to the profilin family of proteins. They share significant sequence and structural similarities which results in cross-recognition by IgE antibodies. Molecular and immunological properties of Amb a 8 and Art v 4 are compared to those of Bet v 2 (birch pollen allergen), as well as to other allergenic profilins. We purified recombinant allergens that are recognized by patient IgE and are highly cross-reactive. It was determined that the analyzed allergens are relatively unstable. Structures of Amb a 8 in complex with poly-L-proline10 or poly-L-proline14 are the first structures of the plant profilin in complex with proline-rich peptides. Amb a 8 binds the poly-L-proline in a mode similar to that observed in human, mouse and P. falciparum profilin-peptide complexes. However, only some of residues that form the peptide binding site are conserved.

-	~~Authors: Offermann~~, ~~L.R~~., Perdue, ~~M.L.~~, ~~Chruszcz~~, M.	+	Structural, functional and immunological characterization of profilin panallergens amb a 8, Art v 4, and Bet v 2.,Offermann LR, Schlachter CR, Perdue ML, Majorek KA, He JZ, Booth WT, Garrett J, Kowal K, Chruszcz M J Biol Chem. 2016 May 26. pii: jbc.M116.733659. PMID:27231348<ref>PMID:27231348</ref>

-	~~Description: Crystal structure~~ of ~~mugwort allergen Art v 4~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Perdue, M.L]]~~	+	<div class="pdbe-citations 5em0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Chruszcz, M]]		[[Category: Chruszcz, M]]
-	[[Category: Offermann, L.R]]	+	[[Category: Offermann, L R]]
		+	[[Category: Perdue, M L]]
		+	[[Category: Allergen]]

OCA: Protected "5em0" [edit=sysop:move=sysop]

2015-12-01T03:02:15Z

Protected "5em0" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:02, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5em0 is ON HOLD until Paper Publication Authors: Offermann, L.R., Perdue, M.L., Chruszcz, M. Description: Crystal structure of mugwort allergen Art...

2015-12-01T03:02:13Z

New page: '''Unreleased structure''' The entry 5em0 is ON HOLD until Paper Publication Authors: Offermann, L.R., Perdue, M.L., Chruszcz, M. Description: Crystal structure of mugwort allergen Art...

New page

'''Unreleased structure'''

The entry 5em0 is ON HOLD until Paper Publication

Authors: Offermann, L.R., Perdue, M.L., Chruszcz, M.

Description: Crystal structure of mugwort allergen Art v 4
[[Category: Unreleased Structures]]
[[Category: Perdue, M.L]]
[[Category: Chruszcz, M]]
[[Category: Offermann, L.R]]