5em9 - Revision history

OCA at 06:33, 5 July 2023

2023-07-05T06:33:59Z

←Older revision		Revision as of 06:33, 5 July 2023
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	<StructureSection load='5em9' size='340' side='right'caption='[[5em9]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5em9' size='340' side='right'caption='[[5em9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5em9]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EM9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5em9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EM9 FirstGlance]. <br>
-	</td></tr><tr id='~~NonStdRes~~'><td class="sblockLbl"><b>[[~~Non-Standard_Residue~~\|~~NonStd Res~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z8j\|4z8j]]~~, [[~~5elq~~\|~~5elq]], [[5ema\|5ema]], [[5emb\|5emb~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~Snx27, Mrt1 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5em9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em9 OCA], [https://pdbe.org/5em9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5em9 RCSB], [https://www.ebi.ac.uk/pdbsum/5em9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5em9 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5em9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em9 OCA], [~~http~~://pdbe.org/5em9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5em9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5em9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5em9 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/SNX27_RAT SNX27_RAT]] Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes (By similarity).	+	[https://www.uniprot.org/uniprot/SNX27_RAT SNX27_RAT] Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Sorting nexin\|Sorting nexin]]	+	*[[Sorting nexin 3D structures\|Sorting nexin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Buffalo rat~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Clairfeuille, T~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Collins, B M~~]]	+	[[Category: Clairfeuille T]]
-	[[Category: ~~Endosome]]~~	+	[[Category: Collins BM]]
-	~~[[Category: Pdz domain]]~~	+
-	~~[[Category: Protein transport]]~~	+
-	~~[[Category: Sorting nexin~~]]	+

OCA at 08:02, 8 January 2020

2020-01-08T08:02:06Z

←Older revision		Revision as of 08:02, 8 January 2020
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	==Crystal structure of the SNX27 PDZ domain bound to the phosphorylated C-terminal 5HT4(a)R PDZ binding motif==		==Crystal structure of the SNX27 PDZ domain bound to the phosphorylated C-terminal 5HT4(a)R PDZ binding motif==
-	<StructureSection load='5em9' size='340' side='right' caption='[[5em9]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5em9' size='340' side='right'caption='[[5em9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5em9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EM9 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5em9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EM9 FirstGlance]. <br>
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	</div>		</div>
	<div class="pdbe-citations 5em9" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5em9" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Sorting nexin\|Sorting nexin]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Clairfeuille, T]]		[[Category: Clairfeuille, T]]
	[[Category: Collins, B M]]		[[Category: Collins, B M]]

OCA at 12:38, 6 November 2017

2017-11-06T12:38:53Z

←Older revision		Revision as of 12:38, 6 November 2017
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	<StructureSection load='5em9' size='340' side='right' caption='[[5em9]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5em9' size='340' side='right' caption='[[5em9]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5em9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EM9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5em9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EM9 FirstGlance]. <br>
	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>		</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z8j\|4z8j]], [[5elq\|5elq]], [[5ema\|5ema]], [[5emb\|5emb]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z8j\|4z8j]], [[5elq\|5elq]], [[5ema\|5ema]], [[5emb\|5emb]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Snx27, Mrt1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5em9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em9 OCA], [http://pdbe.org/5em9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5em9 RCSB], [http://www.ebi.ac.uk/pdbsum/5em9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5em9 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5em9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em9 OCA], [http://pdbe.org/5em9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5em9 RCSB], [http://www.ebi.ac.uk/pdbsum/5em9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5em9 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Clairfeuille, T]]		[[Category: Clairfeuille, T]]
	[[Category: Collins, B M]]		[[Category: Collins, B M]]

OCA at 06:18, 21 September 2016

2016-09-21T06:18:57Z

←Older revision		Revision as of 06:18, 21 September 2016
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/SNX27_RAT SNX27_RAT]] Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes (By similarity).		[[http://www.uniprot.org/uniprot/SNX27_RAT SNX27_RAT]] Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recycling of internalized receptors from endosomal compartments is essential for the receptors' cell-surface homeostasis. Sorting nexin 27 (SNX27) cooperates with the retromer complex in the recycling of proteins containing type I PSD95-Dlg-ZO1 (PDZ)-binding motifs. Here we define specific acidic amino acid sequences upstream of the PDZ-binding motif required for high-affinity engagement of the human SNX27 PDZ domain. However, a subset of SNX27 ligands, such as the beta2 adrenergic receptor and N-methyl-D-aspartate (NMDA) receptor, lack these sequence determinants. Instead, we identified conserved sites of phosphorylation that substitute for acidic residues and dramatically enhance SNX27 interactions. This newly identified mechanism suggests a likely regulatory switch for PDZ interaction and protein transport by the SNX27-retromer complex. Defining this SNX27 binding code allowed us to classify more than 400 potential SNX27 ligands with broad functional implications in signal transduction, neuronal plasticity and metabolite transport.
		+
		+	A molecular code for endosomal recycling of phosphorylated cargos by the SNX27-retromer complex.,Clairfeuille T, Mas C, Chan AS, Yang Z, Tello-Lafoz M, Chandra M, Widagdo J, Kerr MC, Paul B, Merida I, Teasdale RD, Pavlos NJ, Anggono V, Collins BM Nat Struct Mol Biol. 2016 Sep 5. doi: 10.1038/nsmb.3290. PMID:27595347<ref>PMID:27595347</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5em9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:04, 10 September 2016

2016-09-10T21:04:26Z

←Older revision		Revision as of 21:04, 10 September 2016
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-	'''Unreleased structure'''

-	~~The entry 5em9 is ON HOLD until Paper Publication~~	+	==Crystal structure of the SNX27 PDZ domain bound to the phosphorylated C-terminal 5HT4(a)R PDZ binding motif==
-		+	<StructureSection load='5em9' size='340' side='right' caption='[[5em9]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors: Collins, B.M., Clairfeuille, T.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5em9]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EM9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EM9 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the SNX27 PDZ domain bound to the phosphorylated C-terminal 5HT4(a)R PDZ binding motif	+	</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4z8j\|4z8j]], [[5elq\|5elq]], [[5ema\|5ema]], [[5emb\|5emb]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5em9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5em9 OCA], [http://pdbe.org/5em9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5em9 RCSB], [http://www.ebi.ac.uk/pdbsum/5em9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5em9 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/SNX27_RAT SNX27_RAT]] Involved in endocytic trafficking (By similarity). In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes (By similarity).
		+	__TOC__
		+	</StructureSection>
	[[Category: Clairfeuille, T]]		[[Category: Clairfeuille, T]]
-	[[Category: Collins, B.M]]	+	[[Category: Collins, B M]]
		+	[[Category: Endosome]]
		+	[[Category: Pdz domain]]
		+	[[Category: Protein transport]]
		+	[[Category: Sorting nexin]]

OCA at 12:01, 9 December 2015

2015-12-09T12:01:51Z

←Older revision		Revision as of 12:01, 9 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5em9 is ON HOLD	+	The entry 5em9 is ON HOLD until Paper Publication

	Authors: Collins, B.M., Clairfeuille, T.		Authors: Collins, B.M., Clairfeuille, T.

-	Description: Crystal structure of the SNX27 PDZ domain bound to the C-terminal ~~DGKzeta~~ PDZ binding motif	+	Description: Crystal structure of the SNX27 PDZ domain bound to the phosphorylated C-terminal 5HT4(a)R PDZ binding motif
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Clairfeuille, T]]		[[Category: Clairfeuille, T]]
	[[Category: Collins, B.M]]		[[Category: Collins, B.M]]

OCA: Protected "5em9" [edit=sysop:move=sysop]

2015-12-01T03:02:41Z

Protected "5em9" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:02, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5em9 is ON HOLD Authors: Collins, B.M., Clairfeuille, T. Description: Crystal structure of the SNX27 PDZ domain bound to the C-terminal DGKzeta PDZ...

2015-12-01T03:02:40Z

New page: '''Unreleased structure''' The entry 5em9 is ON HOLD Authors: Collins, B.M., Clairfeuille, T. Description: Crystal structure of the SNX27 PDZ domain bound to the C-terminal DGKzeta PDZ...

New page

'''Unreleased structure'''

The entry 5em9 is ON HOLD

Authors: Collins, B.M., Clairfeuille, T.

Description: Crystal structure of the SNX27 PDZ domain bound to the C-terminal DGKzeta PDZ binding motif
[[Category: Unreleased Structures]]
[[Category: Clairfeuille, T]]
[[Category: Collins, B.M]]