5eub - Revision history

OCA at 08:24, 12 July 2023

2023-07-12T08:24:39Z

←Older revision		Revision as of 08:24, 12 July 2023
Line 3:		Line 3:
	<StructureSection load='5eub' size='340' side='right'caption='[[5eub]], [[Resolution\|resolution]] 1.81Å' scene=''>		<StructureSection load='5eub' size='340' side='right'caption='[[5eub]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eub]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EUB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eub]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EUB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5S7:(2~{R},3~{R},4~{S},5~{S})-2-[2,6-BIS(AZANYL)PURIN-9-YL]-5-(METHYLSULFANYLMETHYL)OXOLANE-3,4-DIOL'>5S7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.81Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ozc\|3ozc]], [[3ozd\|3ozd]], [[1k27\|1k27]], [[3oze\|3oze]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5S7:(2~{R},3~{R},4~{S},5~{S})-2-[2,6-BIS(AZANYL)PURIN-9-YL]-5-(METHYLSULFANYLMETHYL)OXOLANE-3,4-DIOL'>5S7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTAP, MSAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5eub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eub OCA], [https://pdbe.org/5eub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5eub RCSB], [https://www.ebi.ac.uk/pdbsum/5eub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5eub ProSAT]</span></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5eub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eub OCA], [~~http~~://pdbe.org/5eub PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5eub RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5eub PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5eub ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Defects in MTAP are the cause of diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH) [MIM:[~~http~~://omim.org/entry/112250 112250]]. An autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. Some patients show a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma. Note=DMSMFH causing mutations found in MTAP exon 9 result in exon skipping and dysregulated alternative splicing of all MTAP isoforms (PubMed:22464254).<ref>PMID:22464254</ref> Note=Loss of MTAP activity may play a role in human cancer. MTAP loss has been reported in a number of cancers, including osteosarcoma, malignant melanoma and gastric cancer.[HAMAP-Rule:MF_03155]	+	[https://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN] Defects in MTAP are the cause of diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH) [MIM:[https://omim.org/entry/112250 112250]. An autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. Some patients show a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma. Note=DMSMFH causing mutations found in MTAP exon 9 result in exon skipping and dysregulated alternative splicing of all MTAP isoforms (PubMed:22464254).<ref>PMID:22464254</ref> Note=Loss of MTAP activity may play a role in human cancer. MTAP loss has been reported in a number of cancers, including osteosarcoma, malignant melanoma and gastric cancer.[HAMAP-Rule:MF_03155]
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>	+	[https://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>

	==See Also==		==See Also==
Line 21:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: S-methyl-5'-thioadenosine phosphorylase]]~~	+	[[Category: Almo SC]]
-	[[Category: Almo~~, S C~~]]	+	[[Category: Cameron SA]]
-	[[Category: Cameron~~, S A~~]]	+	[[Category: Firestone RS]]
-	[[Category: Firestone~~, R S~~]]	+	[[Category: Schramm VL]]
-	[[Category: Schramm~~, V L]]~~	+
-	~~[[Category: Phosphorylase]]~~	+
-	~~[[Category: Transferase-transferase substrate complex~~]]	+

OCA at 09:02, 4 December 2019

2019-12-04T09:02:29Z

←Older revision		Revision as of 09:02, 4 December 2019
Line 1:		Line 1:

	==Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate==		==Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate==
-	<StructureSection load='5eub' size='340' side='right' caption='[[5eub]], [[Resolution\|resolution]] 1.81Å' scene=''>	+	<StructureSection load='5eub' size='340' side='right'caption='[[5eub]], [[Resolution\|resolution]] 1.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5eub]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EUB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5eub]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EUB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5S7:(2~{R},3~{R},4~{S},5~{S})-2-[2,6-BIS(AZANYL)PURIN-9-YL]-5-(METHYLSULFANYLMETHYL)OXOLANE-3,4-DIOL'>5S7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5S7:(2~{R},3~{R},4~{S},5~{S})-2-[2,6-BIS(AZANYL)PURIN-9-YL]-5-(METHYLSULFANYLMETHYL)OXOLANE-3,4-DIOL'>5S7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ozc\|3ozc]], [[3ozd\|3ozd]], [[1k27\|1k27]], [[3oze\|3oze]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ozc\|3ozc]], [[3ozd\|3ozd]], [[1k27\|1k27]], [[3oze\|3oze]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTAP, MSAP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eub OCA], [http://pdbe.org/5eub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eub RCSB], [http://www.ebi.ac.uk/pdbsum/5eub PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eub ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eub OCA], [http://pdbe.org/5eub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eub RCSB], [http://www.ebi.ac.uk/pdbsum/5eub PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eub ProSAT]</span></td></tr>
Line 13:		Line 14:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>		[[http://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>
		+
		+	==See Also==
		+	*[[5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures\|5'-deoxy-5'-methylthioadenosine phosphorylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: S-methyl-5'-thioadenosine phosphorylase]]		[[Category: S-methyl-5'-thioadenosine phosphorylase]]
	[[Category: Almo, S C]]		[[Category: Almo, S C]]

OCA at 21:36, 22 December 2016

2016-12-22T21:36:45Z

←Older revision		Revision as of 21:36, 22 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5eub is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate==
-		+	<StructureSection load='5eub' size='340' side='right' caption='[[5eub]], [[Resolution\|resolution]] 1.81Å' scene=''>
-	~~Authors~~: ~~Cameron~~, S.A., ~~Firestone, R~~.S., ~~Schramm~~, V.L., ~~Almo~~, S.C.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5eub]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EUB FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure~~ of human 5'-~~deoxy~~-5'-~~methylthioadenosine phosphorylase in complex with 2~~-~~amino~~-MTA ~~and sulfate~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5S7:(2~{R},3~{R},4~{S},5~{S})-2-[2,6-BIS(AZANYL)PURIN-9-YL]-5-(METHYLSULFANYLMETHYL)OXOLANE-3,4-DIOL'>5S7</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[3ozc\|3ozc]], [[3ozd\|3ozd]], [[1k27\|1k27]], [[3oze\|3oze]]</td></tr>
-	[[Category: Almo, S.C]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/S-methyl-5'-thioadenosine_phosphorylase S-methyl-5'-thioadenosine phosphorylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.28 2.4.2.28] </span></td></tr>
-	[[Category: ~~Schramm~~, ~~V.L~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eub OCA], [http://pdbe.org/5eub PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eub RCSB], [http://www.ebi.ac.uk/pdbsum/5eub PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5eub ProSAT]</span></td></tr>
-	[[Category: ~~Cameron~~, S.A]]	+	</table>
-	[[Category: ~~Firestone~~, ~~R.S~~]]	+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Defects in MTAP are the cause of diaphyseal medullary stenosis with malignant fibrous histiocytoma (DMSMFH) [MIM:[http://omim.org/entry/112250 112250]]. An autosomal dominant bone dysplasia characterized by pathologic fractures due to abnormal cortical growth and diaphyseal medullary stenosis. The fractures heal poorly, and there is progressive bowing of the lower extremities. Some patients show a limb-girdle myopathy, with muscle weakness and atrophy. Approximately 35% of affected individuals develop an aggressive form of bone sarcoma consistent with malignant fibrous histiocytoma or osteosarcoma. Note=DMSMFH causing mutations found in MTAP exon 9 result in exon skipping and dysregulated alternative splicing of all MTAP isoforms (PubMed:22464254).<ref>PMID:22464254</ref> Note=Loss of MTAP activity may play a role in human cancer. MTAP loss has been reported in a number of cancers, including osteosarcoma, malignant melanoma and gastric cancer.[HAMAP-Rule:MF_03155]
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MTAP_HUMAN MTAP_HUMAN]] Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.<ref>PMID:3091600</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: S-methyl-5'-thioadenosine phosphorylase]]
		+	[[Category: Almo, S C]]
		+	[[Category: Cameron, S A]]
		+	[[Category: Firestone, R S]]
		+	[[Category: Schramm, V L]]
		+	[[Category: Phosphorylase]]
		+	[[Category: Transferase-transferase substrate complex]]

OCA at 15:01, 2 December 2015

2015-12-02T15:01:08Z

←Older revision		Revision as of 15:01, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5eub is ON HOLD	+	The entry 5eub is ON HOLD until Paper Publication

	Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C.		Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C.

OCA: Protected "5eub" [edit=sysop:move=sysop]

2015-12-01T03:22:42Z

Protected "5eub" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:22, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5eub is ON HOLD Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C. Description: Crystal structure of human 5'-deoxy-5'-methylthioad...

2015-12-01T03:22:41Z

New page: '''Unreleased structure''' The entry 5eub is ON HOLD Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C. Description: Crystal structure of human 5'-deoxy-5'-methylthioad...

New page

'''Unreleased structure'''

The entry 5eub is ON HOLD

Authors: Cameron, S.A., Firestone, R.S., Schramm, V.L., Almo, S.C.

Description: Crystal structure of human 5'-deoxy-5'-methylthioadenosine phosphorylase in complex with 2-amino-MTA and sulfate
[[Category: Unreleased Structures]]
[[Category: Almo, S.C]]
[[Category: Schramm, V.L]]
[[Category: Cameron, S.A]]
[[Category: Firestone, R.S]]