5ev6 - Revision history

OCA at 11:20, 3 January 2024

2024-01-03T11:20:52Z

←Older revision		Revision as of 11:20, 3 January 2024
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	<StructureSection load='5ev6' size='340' side='right'caption='[[5ev6]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='5ev6' size='340' side='right'caption='[[5ev6]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ev6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/~~"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus~~ marcescens~~" (bizio 1823) trevisan in de toni and trevisan 1889~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ev6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EV6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.984Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [https://pdbe.org/5ev6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ev6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev6 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [https://pdbe.org/5ev6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ev6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.	+	[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Beta-lactamase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Hinchliffe, P~~]]	+	[[Category: Serratia marcescens]]
-	[[Category: ~~Spencer, J~~]]	+	[[Category: Hinchliffe P]]
-	[[Category: ~~Antibiotic resistance]]~~	+	[[Category: Spencer J]]
-	~~[[Category: Carbapenemase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Inhibitor~~]]	+

OCA at 10:53, 30 March 2022

2022-03-30T10:53:54Z

←Older revision		Revision as of 10:53, 30 March 2022
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	<StructureSection load='5ev6' size='340' side='right'caption='[[5ev6]], [[Resolution\|resolution]] 1.98Å' scene=''>		<StructureSection load='5ev6' size='340' side='right'caption='[[5ev6]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ev6]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV6 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ev6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EV6 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [~~http~~://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [~~http~~://pdbe.org/5ev6 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ev6 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [https://pdbe.org/5ev6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [https://www.ebi.ac.uk/pdbsum/5ev6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.	+	[[https://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==

OCA at 07:46, 29 April 2020

2020-04-29T07:46:16Z

←Older revision		Revision as of 07:46, 29 April 2020
Line 1:		Line 1:

	==Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1==		==Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1==
-	<StructureSection load='5ev6' size='340' side='right' caption='[[5ev6]], [[Resolution\|resolution]] 1.98Å' scene=''>	+	<StructureSection load='5ev6' size='340' side='right'caption='[[5ev6]], [[Resolution\|resolution]] 1.98Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ev6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV6 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EV6 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ev6]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_marcescens"_(bizio_1823)_trevisan_in_de_toni_and_trevisan_1889 "bacillus marcescens" (bizio 1823) trevisan in de toni and trevisan 1889]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV6 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EV6 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [http://pdbe.org/5ev6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev6 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [http://pdbe.org/5ev6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5ev6" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ev6" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-lactamase 3D structures\|Beta-lactamase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Beta-lactamase]]		[[Category: Beta-lactamase]]
		+	[[Category: Large Structures]]
	[[Category: Hinchliffe, P]]		[[Category: Hinchliffe, P]]
	[[Category: Spencer, J]]		[[Category: Spencer, J]]

OCA at 06:23, 26 July 2016

2016-07-26T06:23:55Z

←Older revision		Revision as of 06:23, 26 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [http://pdbe.org/5ev6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev6 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [http://pdbe.org/5ev6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ev6 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.		[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Metallo-beta-lactamases (MBLs) hydrolyze almost all beta-lactam antibiotics and are unaffected by clinically available beta-lactamase inhibitors (betaLIs). Active-site architecture divides MBLs into three classes (B1, B2, and B3), complicating development of betaLIs effective against all enzymes. Bisthiazolidines (BTZs) are carboxylate-containing, bicyclic compounds, considered as penicillin analogs with an additional free thiol. Here, we show both l- and d-BTZ enantiomers are micromolar competitive betaLIs of all MBL classes in vitro, with Kis of 6-15 microM or 36-84 microM for subclass B1 MBLs (IMP-1 and BcII, respectively), and 10-12 microM for the B3 enzyme L1. Against the B2 MBL Sfh-I, the l-BTZ enantiomers exhibit 100-fold lower Kis (0.26-0.36 microM) than d-BTZs (26-29 microM). Importantly, cell-based time-kill assays show BTZs restore beta-lactam susceptibility of Escherichia coli-producing MBLs (IMP-1, Sfh-1, BcII, and GOB-18) and, significantly, an extensively drug-resistant Stenotrophomonas maltophilia clinical isolate expressing L1. BTZs therefore inhibit the full range of MBLs and potentiate beta-lactam activity against producer pathogens. X-ray crystal structures reveal insights into diverse BTZ binding modes, varying with orientation of the carboxylate and thiol moieties. BTZs bind the di-zinc centers of B1 (IMP-1; BcII) and B3 (L1) MBLs via the free thiol, but orient differently depending upon stereochemistry. In contrast, the l-BTZ carboxylate dominates interactions with the monozinc B2 MBL Sfh-I, with the thiol uninvolved. d-BTZ complexes most closely resemble beta-lactam binding to B1 MBLs, but feature an unprecedented disruption of the D120-zinc interaction. Cross-class MBL inhibition therefore arises from the unexpected versatility of BTZ binding.
		+
		+	Cross-class metallo-beta-lactamase inhibition by bisthiazolidines reveals multiple binding modes.,Hinchliffe P, Gonzalez MM, Mojica MF, Gonzalez JM, Castillo V, Saiz C, Kosmopoulou M, Tooke CL, Llarrull LI, Mahler G, Bonomo RA, Vila AJ, Spencer J Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):E3745-54. doi:, 10.1073/pnas.1601368113. Epub 2016 Jun 14. PMID:27303030<ref>PMID:27303030</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ev6" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:07, 2 June 2016

2016-06-02T06:07:33Z

←Older revision		Revision as of 06:07, 2 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5ev6 is ON HOLD until Paper Publication~~	+	==Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1==
-		+	<StructureSection load='5ev6' size='340' side='right' caption='[[5ev6]], [[Resolution\|resolution]] 1.98Å' scene=''>
-	~~Authors: Spencer, J., Hinchliffe, P.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ev6]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EV6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EV6 FirstGlance]. <br>
-	~~Description:~~ Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-lactamase Beta-lactamase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.2.6 3.5.2.6] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ev6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ev6 OCA], [http://pdbe.org/5ev6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ev6 RCSB], [http://www.ebi.ac.uk/pdbsum/5ev6 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BLAB_SERMA BLAB_SERMA]] Confers resistance to imipenem and broad-spectrum beta-lactams. Also hydrolyzes carbapenems.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-lactamase]]
		+	[[Category: Hinchliffe, P]]
	[[Category: Spencer, J]]		[[Category: Spencer, J]]
-	[[Category: ~~Hinchliffe, P~~]]	+	[[Category: Antibiotic resistance]]
		+	[[Category: Carbapenemase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Inhibitor]]

OCA at 15:02, 2 December 2015

2015-12-02T15:02:35Z

←Older revision		Revision as of 15:02, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ev6 is ON HOLD	+	The entry 5ev6 is ON HOLD until Paper Publication

	Authors: Spencer, J., Hinchliffe, P.		Authors: Spencer, J., Hinchliffe, P.

OCA: Protected "5ev6" [edit=sysop:move=sysop]

2015-12-01T03:25:49Z

Protected "5ev6" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:25, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5ev6 is ON HOLD Authors: Spencer, J., Hinchliffe, P. Description: Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1 [[Category:...

2015-12-01T03:25:48Z

New page: '''Unreleased structure''' The entry 5ev6 is ON HOLD Authors: Spencer, J., Hinchliffe, P. Description: Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1 [[Category:...

New page

'''Unreleased structure'''

The entry 5ev6 is ON HOLD

Authors: Spencer, J., Hinchliffe, P.

Description: Crystal structure of the native, di-zinc metallo-beta-lactamase IMP-1
[[Category: Unreleased Structures]]
[[Category: Spencer, J]]
[[Category: Hinchliffe, P]]