5ezn - Revision history

OCA at 08:36, 12 July 2023

2023-07-12T08:36:23Z

←Older revision		Revision as of 08:36, 12 July 2023
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	<StructureSection load='5ezn' size='340' side='right'caption='[[5ezn]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='5ezn' size='340' side='right'caption='[[5ezn]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ezn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5EZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ezn]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5EZN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [~~http~~://pdbe.org/5ezn PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.51Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [https://pdbe.org/5ezn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [https://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/CYRPA_PLAF7 CYRPA_PLAF7] Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:22593616, PubMed:25583518, PubMed:27374406, PubMed:28195530, PubMed:28195038). Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes (PubMed:25583518, PubMed:28186186, PubMed:28195530, PubMed:28195038, PubMed:30542156). This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte (PubMed:27374406, PubMed:28186186, PubMed:30542156).<ref>PMID:22593616</ref> <ref>PMID:25583518</ref> <ref>PMID:27374406</ref> <ref>PMID:28186186</ref> <ref>PMID:28195038</ref> <ref>PMID:28195530</ref> <ref>PMID:30542156</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Favuzza, P~~]]	+	[[Category: Plasmodium falciparum 3D7]]
-	[[Category: ~~Pluschke, G~~]]	+	[[Category: Favuzza P]]
-	[[Category: ~~Rudolph, M~~ G]]	+	[[Category: Pluschke G]]
-	[[Category: ~~Cyrpa]]~~	+	[[Category: Rudolph MG]]
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Immune system]]~~	+
-	~~[[Category: Malaria inhibitory antibody~~]]	+

OCA at 07:52, 29 April 2020

2020-04-29T07:52:37Z

←Older revision		Revision as of 07:52, 29 April 2020
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	==Crystal Structure of PfCyRPA==		==Crystal Structure of PfCyRPA==
-	<StructureSection load='5ezn' size='340' side='right' caption='[[5ezn]], [[Resolution\|resolution]] 2.51Å' scene=''>	+	<StructureSection load='5ezn' size='340' side='right'caption='[[5ezn]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ezn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5EZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ezn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5EZN FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [http://pdbe.org/5ezn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [http://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [http://pdbe.org/5ezn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [http://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Favuzza, P]]		[[Category: Favuzza, P]]
	[[Category: Pluschke, G]]		[[Category: Pluschke, G]]

OCA at 07:37, 27 April 2017

2017-04-27T07:37:39Z

←Older revision		Revision as of 07:37, 27 April 2017
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	<StructureSection load='5ezn' size='340' side='right' caption='[[5ezn]], [[Resolution\|resolution]] 2.51Å' scene=''>		<StructureSection load='5ezn' size='340' side='right' caption='[[5ezn]], [[Resolution\|resolution]] 2.51Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ezn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EZN FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ezn]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EZN FirstGlance]. <br>
	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [http://pdbe.org/5ezn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [http://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>		</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [http://pdbe.org/5ezn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [http://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) is a crucial component of a ternary complex, including Reticulocyte binding-like Homologous protein 5 (PfRH5) and the RH5-interacting protein (PfRipr), essential for erythrocyte invasion. Here we present the crystal structure of PfCyRPA and of its complex with the antigen-binding fragment of a parasite growth inhibitory antibody. While PfCyRPA adopts a 6-bladed beta-propeller structure with similarity to the classic sialidase fold, it possesses no sialidase activity, indicating that it fulfills a non-enzymatic function. Characterization of the epitope recognized by protective antibodies will facilitate design of peptidomimetics that focus vaccine responses on protective epitopes. Both in vitro and in vivo anti-PfCyRPA and anti-PfRH5 antibodies showed more potent parasite growth inhibitory activity in combination than on their own, supporting a combined delivery of PfCyRPA and PfRH5 in vaccines.
		+
		+	Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody.,Favuzza P, Guffart E, Tamborrini M, Scherer B, Dreyer AM, Rufer AC, Erny J, Hoernschemeyer J, Thoma R, Schmid G, Gsell B, Lamelas A, Benz J, Joseph C, Matile H, Pluschke G, Rudolph MG Elife. 2017 Feb 14;6. pii: e20383. doi: 10.7554/eLife.20383. PMID:28195038<ref>PMID:28195038</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ezn" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Favuzza, A]]	+	[[Category: Favuzza, P]]
	[[Category: Pluschke, G]]		[[Category: Pluschke, G]]
	[[Category: Rudolph, M G]]		[[Category: Rudolph, M G]]

OCA at 09:28, 2 January 2017

2017-01-02T09:28:36Z

←Older revision		Revision as of 09:28, 2 January 2017
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	[[Category: Pluschke, G]]		[[Category: Pluschke, G]]
	[[Category: Rudolph, M G]]		[[Category: Rudolph, M G]]
		+	[[Category: Cyrpa]]
	[[Category: Fab]]		[[Category: Fab]]
	[[Category: Immune system]]		[[Category: Immune system]]
	[[Category: Malaria inhibitory antibody]]		[[Category: Malaria inhibitory antibody]]

OCA at 02:09, 11 December 2016

2016-12-11T02:09:03Z

←Older revision		Revision as of 02:09, 11 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ezn is ~~ON HOLD~~	+	==Crystal Structure of PfCyRPA==
-		+	<StructureSection load='5ezn' size='340' side='right' caption='[[5ezn]], [[Resolution\|resolution]] 2.51Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ezn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EZN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EZN FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ezn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ezn OCA], [http://pdbe.org/5ezn PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ezn RCSB], [http://www.ebi.ac.uk/pdbsum/5ezn PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ezn ProSAT]</span></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Favuzza, A]]
		+	[[Category: Pluschke, G]]
		+	[[Category: Rudolph, M G]]
		+	[[Category: Fab]]
		+	[[Category: Immune system]]
		+	[[Category: Malaria inhibitory antibody]]

OCA at 12:41, 15 May 2016

2016-05-15T12:41:26Z

←Older revision		Revision as of 12:41, 15 May 2016
Line 3:		Line 3:
	The entry 5ezn is ON HOLD		The entry 5ezn is ON HOLD

-	Authors: ~~Favuzza, A., Pluschke, G., Rudolph, M.G.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Favuzza, A]]
-	[[Category: Pluschke, G]]
-	[[Category: Rudolph, M.G]]

OCA: Protected "5ezn" [edit=sysop:move=sysop]

2015-12-02T15:13:09Z

Protected "5ezn" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:13, 2 December 2015

OCA: New page: '''Unreleased structure''' The entry 5ezn is ON HOLD Authors: Favuzza, A., Pluschke, G., Rudolph, M.G. Description: Category: Unreleased Structures Category: Favuzza, A [[Cate...

2015-12-02T15:13:08Z

New page: '''Unreleased structure''' The entry 5ezn is ON HOLD Authors: Favuzza, A., Pluschke, G., Rudolph, M.G. Description: Category: Unreleased Structures Category: Favuzza, A [[Cate...

New page

'''Unreleased structure'''

The entry 5ezn is ON HOLD

Authors: Favuzza, A., Pluschke, G., Rudolph, M.G.

Description:
[[Category: Unreleased Structures]]
[[Category: Favuzza, A]]
[[Category: Pluschke, G]]
[[Category: Rudolph, M.G]]