5f19 - Revision history

OCA at 08:39, 12 July 2023

2023-07-12T08:39:47Z

←Older revision		Revision as of 08:39, 12 July 2023
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	<StructureSection load='5f19' size='340' side='right'caption='[[5f19]], [[Resolution\|resolution]] 2.04Å' scene=''>		<StructureSection load='5f19' size='340' side='right'caption='[[5f19]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f19]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F19 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F19 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.04Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene~~></td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene></td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1a\|5f1a]]</td></tr>~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f19 OCA], [https://pdbe.org/5f19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f19 RCSB], [https://www.ebi.ac.uk/pdbsum/5f19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f19 ProSAT]</span></td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTGS2, COX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>	+
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f19 OCA], [~~http~~://pdbe.org/5f19 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f19 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f19 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f19 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/PGH2_HUMAN PGH2_HUMAN]] Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<ref>PMID:16373578</ref>	+	[https://www.uniprot.org/uniprot/PGH2_HUMAN PGH2_HUMAN] Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<ref>PMID:16373578</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Prostaglandin-endoperoxide synthase]]~~	+	[[Category: Lucido MJ]]
-	[[Category: Lucido~~, M J~~]]	+	[[Category: Malkowski MG]]
-	[[Category: Malkowski~~, M G~~]]	+	[[Category: Orlando BJ]]
-	[[Category: Orlando~~, B J]]~~	+
-	~~[[Category: Aspirin]]~~	+
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Covalent inhibitor]]~~	+
-	~~[[Category: Cyclooxygenase]]~~	+
-	~~[[Category: Cyxlooxygenase-2]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Monotopic]]~~	+
-	~~[[Category: Oxidoreductase-inhibitor complex~~]]	+

OCA at 11:36, 25 December 2019

2019-12-25T11:36:49Z

←Older revision		Revision as of 11:36, 25 December 2019
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	==The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2==		==The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2==
-	<StructureSection load='5f19' size='340' side='right' caption='[[5f19]], [[Resolution\|resolution]] 2.04Å' scene=''>	+	<StructureSection load='5f19' size='340' side='right'caption='[[5f19]], [[Resolution\|resolution]] 2.04Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f19]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F19 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F19 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1a\|5f1a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1a\|5f1a]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTGS2, COX2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f19 OCA], [http://pdbe.org/5f19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f19 RCSB], [http://www.ebi.ac.uk/pdbsum/5f19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f19 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f19 OCA], [http://pdbe.org/5f19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f19 RCSB], [http://www.ebi.ac.uk/pdbsum/5f19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f19 ProSAT]</span></td></tr>
Line 21:		Line 22:
	</div>		</div>
	<div class="pdbe-citations 5f19" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5f19" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclooxygenase 3D structures\|Cyclooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Prostaglandin-endoperoxide synthase]]		[[Category: Prostaglandin-endoperoxide synthase]]
	[[Category: Lucido, M J]]		[[Category: Lucido, M J]]

OCA at 12:40, 6 November 2017

2017-11-06T12:40:32Z

←Older revision		Revision as of 12:40, 6 November 2017
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5f19" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5f19" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Cyclooxygenase\|Cyclooxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 09:26, 27 September 2017

2017-09-27T09:26:41Z

←Older revision		Revision as of 09:26, 27 September 2017
Line 8:		Line 8:
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1a\|5f1a]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1a\|5f1a]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f19 OCA], [http://pdbe.org/5f19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f19 RCSB], [http://www.ebi.ac.uk/pdbsum/5f19 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f19 OCA], [http://pdbe.org/5f19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f19 RCSB], [http://www.ebi.ac.uk/pdbsum/5f19 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f19 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:
	</div>		</div>
	<div class="pdbe-citations 5f19" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5f19" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cyclooxygenase\|Cyclooxygenase]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 03:49, 11 May 2016

2016-05-11T03:49:20Z

←Older revision		Revision as of 03:49, 11 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	The ~~entry~~ 5f19 is ~~ON HOLD~~	+	==The Crystal Structure of Aspirin Acetylated Human Cyclooxygenase-2==
		+	<StructureSection load='5f19' size='340' side='right' caption='[[5f19]], [[Resolution\|resolution]] 2.04Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5f19]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F19 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F19 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AKR:ACRYLIC+ACID'>AKR</scene>, <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=COH:PROTOPORPHYRIN+IX+CONTAINING+CO'>COH</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=OAS:O-ACETYLSERINE'>OAS</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1a\|5f1a]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Prostaglandin-endoperoxide_synthase Prostaglandin-endoperoxide synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.99.1 1.14.99.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f19 OCA], [http://pdbe.org/5f19 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f19 RCSB], [http://www.ebi.ac.uk/pdbsum/5f19 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/PGH2_HUMAN PGH2_HUMAN]] Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.<ref>PMID:16373578</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Aspirin and other nonsteroidal anti-inflammatory drugs target the cyclooxygenase enzymes (COX-1 and COX-2) to block the formation of prostaglandins. Aspirin is unique in that it covalently modifies each enzyme by acetylating Ser-530 within the cyclooxygenase active site. Acetylation of COX-1 leads to complete loss of activity, while acetylation of COX-2 results in the generation of the monooxygenated product 15(R)-hydroxyeicosatetraenoic acid (15R-HETE). Ser-530 has also been shown to influence the stereochemistry for the addition of oxygen to the prostaglandin product. We determined the crystal structures of S530T murine (mu) COX-2, aspirin-acetylated human (hu) COX-2, and huCOX-2 in complex with salicylate to 1.9, 2.0, and 2.4 A, respectively. The structures reveal that (1) the acetylated Ser-530 completely blocks access to the hydrophobic groove, (2) the observed binding pose of salicylate is reflective of the enzyme-inhibitor complex prior to acetylation, and (3) the observed Thr-530 rotamer in the S530T muCOX-2 crystal structure does not impede access to the hydrophobic groove. On the basis of these structural observations, along with functional analysis of the S530T/G533V double mutant, we propose a working hypothesis for the generation of 15R-HETE by aspirin-acetylated COX-2. We also observe differential acetylation of COX-2 purified in various detergent systems and nanodiscs, indicating that detergent and lipid binding within the membrane-binding domain of the enzyme alters the rate of the acetylation reaction in vitro.

-	~~Authors~~: ~~Lucido, M.J~~., Orlando, ~~B.J.~~, Malkowski~~, M~~.G.	+	Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry.,Lucido MJ, Orlando BJ, Vecchio AJ, Malkowski MG Biochemistry. 2016 Mar 1;55(8):1226-38. doi: 10.1021/acs.biochem.5b01378. Epub, 2016 Feb 19. PMID:26859324<ref>PMID:26859324</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Lucido, M.J]]	+	<div class="pdbe-citations 5f19" style="background-color:#fffaf0;"></div>
-	[[Category: Orlando, B.J]]	+	== References ==
-	[[Category: ~~Malkowski, M.G~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Prostaglandin-endoperoxide synthase]]
		+	[[Category: Lucido, M J]]
		+	[[Category: Malkowski, M G]]
		+	[[Category: Orlando, B J]]
		+	[[Category: Aspirin]]
		+	[[Category: Complex]]
		+	[[Category: Covalent inhibitor]]
		+	[[Category: Cyclooxygenase]]
		+	[[Category: Cyxlooxygenase-2]]
		+	[[Category: Membrane protein]]
		+	[[Category: Monotopic]]
		+	[[Category: Oxidoreductase-inhibitor complex]]

OCA: Protected "5f19" [edit=sysop:move=sysop]

2015-12-09T12:28:12Z

Protected "5f19" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:28, 9 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f19 is ON HOLD Authors: Lucido, M.J., Orlando, B.J., Malkowski, M.G. Description: Category: Unreleased Structures Category: Lucido, M.J [...

2015-12-09T12:28:11Z

New page: '''Unreleased structure''' The entry 5f19 is ON HOLD Authors: Lucido, M.J., Orlando, B.J., Malkowski, M.G. Description: Category: Unreleased Structures Category: Lucido, M.J [...

New page

'''Unreleased structure'''

The entry 5f19 is ON HOLD

Authors: Lucido, M.J., Orlando, B.J., Malkowski, M.G.

Description:
[[Category: Unreleased Structures]]
[[Category: Lucido, M.J]]
[[Category: Orlando, B.J]]
[[Category: Malkowski, M.G]]