5f1n - Revision history

OCA at 08:40, 12 July 2023

2023-07-12T08:40:29Z

←Older revision		Revision as of 08:40, 12 July 2023
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	==MHC complexed to 11mer peptide==		==MHC complexed to 11mer peptide==
-	<StructureSection load='5f1n' size='340' side='right' caption='[[5f1n]], [[Resolution\|resolution]] 2.00Å' scene=''>	+	<StructureSection load='5f1n' size='340' side='right'caption='[[5f1n]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f1n]] is a 6 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Canlf Canlf~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1N OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F1N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f1n]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Canis_lupus_familiaris Canis lupus familiaris]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F1N FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5f1i\|5f1i]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">DLA-88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9615 CANLF]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1n OCA], [https://pdbe.org/5f1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f1n RCSB], [https://www.ebi.ac.uk/pdbsum/5f1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f1n ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1n OCA], [~~http~~://pdbe.org/5f1n PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f1n RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f1n PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f1n ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~E2RN10_CANLF E2RN10_CANLF]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.[SAAS:SAAS00359208~~]	+	[https://www.uniprot.org/uniprot/J9UGS3_CANLF J9UGS3_CANLF]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5f1n" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5f1n" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Beta-2 microglobulin 3D structures\|Beta-2 microglobulin 3D structures]]
		+	*[[MHC 3D structures\|MHC 3D structures]]
		+	*[[MHC I 3D structures\|MHC I 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Canlf~~]]	+	[[Category: Canis lupus familiaris]]
-	[[Category: ~~Chai, Y~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Gao, G F~~]]	+	[[Category: Chai Y]]
-	[[Category: ~~Liu, J~~]]	+	[[Category: Gao GF]]
-	[[Category: ~~Qi,~~ J]]	+	[[Category: Liu J]]
-	[[Category: ~~Immune system]]~~	+	[[Category: Qi J]]
-	~~[[Category: Mhc~~]]	+

OCA at 10:07, 15 November 2017

2017-11-15T10:07:37Z

←Older revision		Revision as of 10:07, 15 November 2017
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	<StructureSection load='5f1n' size='340' side='right' caption='[[5f1n]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5f1n' size='340' side='right' caption='[[5f1n]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f1n]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F1N FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f1n]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Canlf Canlf]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F1N FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1i\|5f1i]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1i\|5f1i]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DLA-88 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9615 CANLF])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1n OCA], [http://pdbe.org/5f1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f1n RCSB], [http://www.ebi.ac.uk/pdbsum/5f1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f1n ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1n OCA], [http://pdbe.org/5f1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f1n RCSB], [http://www.ebi.ac.uk/pdbsum/5f1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f1n ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Canlf]]
	[[Category: Chai, Y]]		[[Category: Chai, Y]]
	[[Category: Gao, G F]]		[[Category: Gao, G F]]

OCA at 14:38, 22 December 2016

2016-12-22T14:38:08Z

←Older revision		Revision as of 14:38, 22 December 2016
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-	==MHC ~~comlexed~~ to 11mer peptide==	+	==MHC complexed to 11mer peptide==
	<StructureSection load='5f1n' size='340' side='right' caption='[[5f1n]], [[Resolution\|resolution]] 2.00Å' scene=''>		<StructureSection load='5f1n' size='340' side='right' caption='[[5f1n]], [[Resolution\|resolution]] 2.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==

OCA at 18:31, 10 December 2016

2016-12-10T18:31:50Z

←Older revision		Revision as of 18:31, 10 December 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5f1n is ~~ON HOLD until Paper~~ Publication	+	==MHC comlexed to 11mer peptide==
		+	<StructureSection load='5f1n' size='340' side='right' caption='[[5f1n]], [[Resolution\|resolution]] 2.00Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5f1n]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F1N FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f1i\|5f1i]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f1n OCA], [http://pdbe.org/5f1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f1n RCSB], [http://www.ebi.ac.uk/pdbsum/5f1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f1n ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/E2RN10_CANLF E2RN10_CANLF]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.[SAAS:SAAS00359208]
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Canines represent a crucial animal model for studying human diseases and organ transplantation, as well as the evolution of domestic animals. MHCs, with a central role in cellular immunity, are commonly used in the study of dog population genetics and genome evolution. However, the molecular basis for the peptide presentation of dog MHC remains largely unknown. In this study, peptide presentation by canine MHC class I DLA-8850801 was structurally determined, revealing diversified anchoring modes of the binding peptides. Flexible and large pockets composed of both hydrophobic and hydrophilic residues can accommodate pathogen-derived peptides with diverse anchor residues, as confirmed by thermostability measurements. Furthermore, DLA-8850801 contains an unusual alpha2 helix with a large coil in the TCR contact region. These results further our understanding of canine T cell immunity through peptide presentation of MHC class I and shed light on the molecular basis for vaccine development for canine infectious diseases, for example, canine distemper virus.

-	~~Authors~~:	+	Diversified Anchoring Features the Peptide Presentation of DLA-88*50801: First Structural Insight into Domestic Dog MHC Class I.,Xiao J, Xiang W, Chai Y, Haywood J, Qi J, Ba L, Qi P, Wang M, Liu J, Gao GF J Immunol. 2016 Sep 15;197(6):2306-15. doi: 10.4049/jimmunol.1600887. Epub 2016, Aug 10. PMID:27511732<ref>PMID:27511732</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5f1n" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chai, Y]]
		+	[[Category: Gao, G F]]
		+	[[Category: Liu, J]]
		+	[[Category: Qi, J]]
		+	[[Category: Immune system]]
		+	[[Category: Mhc]]

OCA at 12:43, 15 May 2016

2016-05-15T12:43:57Z

←Older revision		Revision as of 12:43, 15 May 2016
Line 3:		Line 3:
	The entry 5f1n is ON HOLD until Paper Publication		The entry 5f1n is ON HOLD until Paper Publication

-	Authors: ~~Liu, J., Chai, Y., Qi, J., Gao, G.F.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Gao, G.F]]
-	[[Category: Liu, J]]
-	[[Category: Chai, Y]]
-	[[Category: Qi, J]]

OCA at 22:39, 10 May 2016

2016-05-10T22:39:32Z

←Older revision		Revision as of 22:39, 10 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5f1n is ON HOLD	+	The entry 5f1n is ON HOLD until Paper Publication

	Authors: Liu, J., Chai, Y., Qi, J., Gao, G.F.		Authors: Liu, J., Chai, Y., Qi, J., Gao, G.F.

OCA: Protected "5f1n" [edit=sysop:move=sysop]

2015-12-09T12:29:16Z

Protected "5f1n" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:29, 9 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f1n is ON HOLD Authors: Liu, J., Chai, Y., Qi, J., Gao, G.F. Description: Category: Unreleased Structures Category: Gao, G.F [[Category: ...

2015-12-09T12:29:14Z

New page: '''Unreleased structure''' The entry 5f1n is ON HOLD Authors: Liu, J., Chai, Y., Qi, J., Gao, G.F. Description: Category: Unreleased Structures Category: Gao, G.F [[Category: ...

New page

'''Unreleased structure'''

The entry 5f1n is ON HOLD

Authors: Liu, J., Chai, Y., Qi, J., Gao, G.F.

Description:
[[Category: Unreleased Structures]]
[[Category: Gao, G.F]]
[[Category: Liu, J]]
[[Category: Chai, Y]]
[[Category: Qi, J]]