5f3x - Revision history

OCA at 08:45, 12 July 2023

2023-07-12T08:45:13Z

←Older revision		Revision as of 08:45, 12 July 2023
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	<StructureSection load='5f3x' size='340' side='right'caption='[[5f3x]], [[Resolution\|resolution]] 2.65Å' scene=''>		<StructureSection load='5f3x' size='340' side='right'caption='[[5f3x]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f3x]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~] and [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3X OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5F3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f3x]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F3X FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.649Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5f3y\|5f3y]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td><td class="sblockDat">USH1C, AIE75 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Anks4b, Harp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3x OCA], [https://pdbe.org/5f3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f3x RCSB], [https://www.ebi.ac.uk/pdbsum/5f3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f3x ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5f3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3x OCA], [~~http~~://pdbe.org/5f3x PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f3x RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f3x PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f3x ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/USH1C_HUMAN USH1C_HUMAN]] Defects in USH1C are the cause of Usher syndrome type 1C (USH1C) [MIM:[~~http~~://omim.org/entry/276904 276904]]; also known as Usher syndrome type I Acadian variety. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:10973247</ref> Defects in USH1C are the cause of deafness, autosomal recessive, 18A (DFNB18A) [MIM:[~~http~~://omim.org/entry/602092 602092]]. A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:12107438</ref>	+	[https://www.uniprot.org/uniprot/USH1C_HUMAN USH1C_HUMAN] Defects in USH1C are the cause of Usher syndrome type 1C (USH1C) [MIM:[https://omim.org/entry/276904 276904]; also known as Usher syndrome type I Acadian variety. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:10973247</ref> Defects in USH1C are the cause of deafness, autosomal recessive, 18A (DFNB18A) [MIM:[https://omim.org/entry/602092 602092]. A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:12107438</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/USH1C_HUMAN USH1C_HUMAN]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity). [[http://www.uniprot.org/uniprot/ANS4B_MOUSE ANS4B_MOUSE]] As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (By similarity). May play a role in cellular response to endoplasmic reticulum stress (PubMed:22589549).[UniProtKB:Q8N8V4]<ref>PMID:22589549</ref>	+	[https://www.uniprot.org/uniprot/USH1C_HUMAN USH1C_HUMAN] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: He, Y]]	+	[[Category: He Y]]
-	[[Category: Li, J]]	+	[[Category: Li J]]
-	[[Category: Lu, Q]]	+	[[Category: Lu Q]]
-	[[Category: Zhang, M]]	+	[[Category: Zhang M]]
-	~~[[Category: Complex]]~~	+
-	~~[[Category: Protein binding]]~~	+
-	~~[[Category: Structural protein]]~~	+
-	~~[[Category: Structural protein-protein binding complex~~]]	+

OCA at 07:58, 29 April 2020

2020-04-29T07:58:37Z

←Older revision		Revision as of 07:58, 29 April 2020
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	==Crystal structure of Harmonin NPDZ1 in complex with ANKS4B SAM-PBM==		==Crystal structure of Harmonin NPDZ1 in complex with ANKS4B SAM-PBM==
-	<StructureSection load='5f3x' size='340' side='right' caption='[[5f3x]], [[Resolution\|resolution]] 2.65Å' scene=''>	+	<StructureSection load='5f3x' size='340' side='right'caption='[[5f3x]], [[Resolution\|resolution]] 2.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f3x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3X OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F3X FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f3x]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human] and [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3X OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5F3X FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f3y\|5f3y]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f3y\|5f3y]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3x OCA], [http://pdbe.org/5f3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f3x RCSB], [http://www.ebi.ac.uk/pdbsum/5f3x PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">USH1C, AIE75 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), Anks4b, Harp ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5f3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3x OCA], [http://pdbe.org/5f3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f3x RCSB], [http://www.ebi.ac.uk/pdbsum/5f3x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f3x ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
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	</div>		</div>
	<div class="pdbe-citations 5f3x" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5f3x" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Harmonin\|Harmonin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: He, Y]]		[[Category: He, Y]]
	[[Category: Li, J]]		[[Category: Li, J]]

OCA at 03:49, 11 May 2016

2016-05-11T03:49:50Z

←Older revision		Revision as of 03:49, 11 May 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5f3x is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Crystal structure of Harmonin NPDZ1 in complex with ANKS4B SAM-PBM==
		+	<StructureSection load='5f3x' size='340' side='right' caption='[[5f3x]], [[Resolution\|resolution]] 2.65Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5f3x]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F3X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F3X FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f3y\|5f3y]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f3x OCA], [http://pdbe.org/5f3x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f3x RCSB], [http://www.ebi.ac.uk/pdbsum/5f3x PDBsum]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/USH1C_HUMAN USH1C_HUMAN]] Defects in USH1C are the cause of Usher syndrome type 1C (USH1C) [MIM:[http://omim.org/entry/276904 276904]]; also known as Usher syndrome type I Acadian variety. USH is a genetically heterogeneous condition characterized by the association of retinitis pigmentosa and sensorineural deafness. Age at onset and differences in auditory and vestibular function distinguish Usher syndrome type 1 (USH1), Usher syndrome type 2 (USH2) and Usher syndrome type 3 (USH3). USH1 is characterized by profound congenital sensorineural deafness, absent vestibular function and prepubertal onset of progressive retinitis pigmentosa leading to blindness.<ref>PMID:10973247</ref> Defects in USH1C are the cause of deafness, autosomal recessive, 18A (DFNB18A) [MIM:[http://omim.org/entry/602092 602092]]. A form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:12107438</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/USH1C_HUMAN USH1C_HUMAN]] Required for normal development and maintenance of cochlear hair cell bundles. Anchoring/scaffolding protein that is a part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing (By similarity). [[http://www.uniprot.org/uniprot/ANS4B_MOUSE ANS4B_MOUSE]] As part of the intermicrovillar adhesion complex/IMAC plays a role in epithelial brush border differentiation, controlling microvilli organization and length. Plays a role in assembly of the complex (By similarity). May play a role in cellular response to endoplasmic reticulum stress (PubMed:22589549).[UniProtKB:Q8N8V4]<ref>PMID:22589549</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Brush border microvilli are actin-based protrusions lining the apical surface of epithelial cells in intestines and proximal tubules of kidneys. While brush border microvilli resemble the relatively well-characterized stereocilia of hair cells, the mechanistic basis of tip-link complex organization in microvilli is poorly understood. Here, we have biochemically and structurally characterized the following pairs of interactions: protocadherin 24 and Harmonin (also known as USH1C or AIE-75), Harmonin and myosin VIIb (MYO7B), Harmonin and ANKS4B, and ANKS4B and MYO7B. We show that Harmonin, ANKS4B, and MYO7B form a stable ternary complex for anchoring microvilli tip-link cadherins. Despite having only Harmonin in common, the microvilli and the stereocilia tip-link complexes are formed via strikingly similar interaction modes. These results not only provide insight into the mechanistic bases of brush border microvilli formation and maintenance but may also be valuable for understanding some gut and/or kidney diseases caused by perturbations of brush border microvilli structures.

-	~~Authors: Li~~, J., He, Y., Lu, Q., Zhang, M.	+	Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex.,Li J, He Y, Lu Q, Zhang M Dev Cell. 2016 Jan 25;36(2):179-89. doi: 10.1016/j.devcel.2015.12.020. PMID:26812017<ref>PMID:26812017</ref>

-	~~Description:~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Li, J]]~~	+	<div class="pdbe-citations 5f3x" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: He, Y]]		[[Category: He, Y]]
-	[[Category: ~~Zhang~~, M]]	+	[[Category: Li, J]]
	[[Category: Lu, Q]]		[[Category: Lu, Q]]
		+	[[Category: Zhang, M]]
		+	[[Category: Complex]]
		+	[[Category: Protein binding]]
		+	[[Category: Structural protein]]
		+	[[Category: Structural protein-protein binding complex]]

OCA at 12:31, 16 December 2015

2015-12-16T12:31:29Z

←Older revision		Revision as of 12:31, 16 December 2015
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5f3x is ON HOLD	+	The entry 5f3x is ON HOLD until Paper Publication

	Authors: Li, J., He, Y., Lu, Q., Zhang, M.		Authors: Li, J., He, Y., Lu, Q., Zhang, M.

OCA: Protected "5f3x" [edit=sysop:move=sysop]

2015-12-09T12:35:22Z

Protected "5f3x" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:35, 9 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f3x is ON HOLD Authors: Li, J., He, Y., Lu, Q., Zhang, M. Description: Category: Unreleased Structures Category: Li, J [[Category: He, Y]...

2015-12-09T12:35:21Z

New page: '''Unreleased structure''' The entry 5f3x is ON HOLD Authors: Li, J., He, Y., Lu, Q., Zhang, M. Description: Category: Unreleased Structures Category: Li, J [[Category: He, Y]...

New page

'''Unreleased structure'''

The entry 5f3x is ON HOLD

Authors: Li, J., He, Y., Lu, Q., Zhang, M.

Description:
[[Category: Unreleased Structures]]
[[Category: Li, J]]
[[Category: He, Y]]
[[Category: Zhang, M]]
[[Category: Lu, Q]]