5f6i - Revision history

OCA at 06:40, 19 July 2023

2023-07-19T06:40:04Z

←Older revision		Revision as of 06:40, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='5f6i' size='340' side='right'caption='[[5f6i]], [[Resolution\|resolution]] 2.32Å' scene=''>		<StructureSection load='5f6i' size='340' side='right'caption='[[5f6i]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f6i]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Macmu Macmu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F6I OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5F6I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f6i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Macaca_mulatta Macaca mulatta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F6I FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5f6h\|5f6h]]~~, [[~~5f6j~~\|~~5f6j~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.32Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f6i OCA], [~~http~~://pdbe.org/5f6i PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f6i RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f6i PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f6i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f6i OCA], [https://pdbe.org/5f6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f6i RCSB], [https://www.ebi.ac.uk/pdbsum/5f6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f6i ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 19:		Line 19:
	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
Line 24:		Line 26:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Macmu~~]]	+	[[Category: Macaca mulatta]]
-	[[Category: Fera, D]]	+	[[Category: Fera D]]
-	[[Category: Harrison~~, S C]]~~	+	[[Category: Harrison SC]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Fab fragment]]~~	+
-	~~[[Category: Hiv-1]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 08:01, 29 April 2020

2020-04-29T08:01:52Z

←Older revision		Revision as of 08:01, 29 April 2020
Line 1:		Line 1:

	==Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque==		==Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque==
-	<StructureSection load='5f6i' size='340' side='right' caption='[[5f6i]], [[Resolution\|resolution]] 2.32Å' scene=''>	+	<StructureSection load='5f6i' size='340' side='right'caption='[[5f6i]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f6i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F6I OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F6I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f6i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F6I OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5F6I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f6h\|5f6h]], [[5f6j\|5f6j]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f6h\|5f6h]], [[5f6j\|5f6j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f6i OCA], [http://pdbe.org/5f6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f6i RCSB], [http://www.ebi.ac.uk/pdbsum/5f6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f6i ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f6i OCA], [http://pdbe.org/5f6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f6i RCSB], [http://www.ebi.ac.uk/pdbsum/5f6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f6i ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 18:		Line 18:

	==See Also==		==See Also==
-	*[[3D structures ~~of antibody~~\|3D structures ~~of antibody~~]]	+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Macmu]]		[[Category: Macmu]]
	[[Category: Fera, D]]		[[Category: Fera, D]]

OCA at 07:55, 16 November 2017

2017-11-16T07:55:20Z

←Older revision		Revision as of 07:55, 16 November 2017
Line 1:		Line 1:
		+
	==Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque==		==Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque==
	<StructureSection load='5f6i' size='340' side='right' caption='[[5f6i]], [[Resolution\|resolution]] 2.32Å' scene=''>		<StructureSection load='5f6i' size='340' side='right' caption='[[5f6i]], [[Resolution\|resolution]] 2.32Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f6i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F6I FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f6i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Macmu Macmu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F6I FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f6h\|5f6h]], [[5f6j\|5f6j]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f6h\|5f6h]], [[5f6j\|5f6j]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f6i OCA], [http://pdbe.org/5f6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f6i RCSB], [http://www.ebi.ac.uk/pdbsum/5f6i PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f6i OCA], [http://pdbe.org/5f6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f6i RCSB], [http://www.ebi.ac.uk/pdbsum/5f6i PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f6i ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 15:		Line 16:
	</div>		</div>
	<div class="pdbe-citations 5f6i" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5f6i" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[3D structures of antibody\|3D structures of antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Macmu]]
	[[Category: Fera, D]]		[[Category: Fera, D]]
	[[Category: Harrison, S C]]		[[Category: Harrison, S C]]

OCA at 20:07, 13 January 2016

2016-01-13T20:07:35Z

←Older revision		Revision as of 20:07, 13 January 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque==
		+	<StructureSection load='5f6i' size='340' side='right' caption='[[5f6i]], [[Resolution\|resolution]] 2.32Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5f6i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F6I FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f6h\|5f6h]], [[5f6j\|5f6j]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f6i OCA], [http://pdbe.org/5f6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f6i RCSB], [http://www.ebi.ac.uk/pdbsum/5f6i PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Antibodies that neutralize autologous transmitted/founder (TF) HIV occur in most HIV-infected individuals and can evolve to neutralization breadth. Autologous neutralizing antibodies (nAbs) against neutralization-resistant (Tier-2) viruses are rarely induced by vaccination. Whereas broadly neutralizing antibody (bnAb)-HIV-Envelope structures have been defined, the structures of autologous nAbs have not. Here, we show that immunization with TF mutant Envs gp140 oligomers induced high-titer, V5-dependent plasma neutralization for a Tier-2 autologous TF evolved mutant virus. Structural analysis of autologous nAb DH427 revealed binding to V5, demonstrating the source of narrow nAb specificity and explaining the failure to acquire breadth. Thus, oligomeric TF Envs can elicit autologous nAbs to Tier-2 HIVs, but induction of bnAbs will require targeting of precursors of B cell lineages that can mature to heterologous neutralization.

-	~~The entry 5f6i is ON HOLD until Paper Publication~~	+	Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.,Bradley T, Fera D, Bhiman J, Eslamizar L, Lu X, Anasti K, Zhang R, Sutherland LL, Scearce RM, Bowman CM, Stolarchuk C, Lloyd KE, Parks R, Eaton A, Foulger A, Nie X, Karim SS, Barnett S, Kelsoe G, Kepler TB, Alam SM, Montefiori DC, Moody MA, Liao HX, Morris L, Santra S, Harrison SC, Haynes BF Cell Rep. 2016 Jan 5;14(1):43-54. doi: 10.1016/j.celrep.2015.12.017. Epub 2015, Dec 24. PMID:26725118<ref>PMID:26725118</ref>

-	~~Authors: Fera~~, D.~~, Harrison,~~ S.C.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque~~	+	<div class="pdbe-citations 5f6i" style="background-color:#fffaf0;"></div>
-	~~[[Category: Unreleased Structures]]~~	+	== References ==
-	~~[[Category: Harrison, S.C]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Fera, D]]		[[Category: Fera, D]]
		+	[[Category: Harrison, S C]]
		+	[[Category: Antibody]]
		+	[[Category: Fab fragment]]
		+	[[Category: Hiv-1]]
		+	[[Category: Immune system]]

OCA: Protected "5f6i" [edit=sysop:move=sysop]

2015-12-16T12:37:25Z

Protected "5f6i" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:37, 16 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f6i is ON HOLD until Paper Publication Authors: Fera, D., Harrison, S.C. Description: Crystal Structure of Tier 2 Neutralizing Antibody DH428 from...

2015-12-16T12:37:24Z

New page: '''Unreleased structure''' The entry 5f6i is ON HOLD until Paper Publication Authors: Fera, D., Harrison, S.C. Description: Crystal Structure of Tier 2 Neutralizing Antibody DH428 from...

New page

'''Unreleased structure'''

The entry 5f6i is ON HOLD until Paper Publication

Authors: Fera, D., Harrison, S.C.

Description: Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque
[[Category: Unreleased Structures]]
[[Category: Harrison, S.C]]
[[Category: Fera, D]]