5f7v - Revision history

OCA at 12:30, 6 March 2024

2024-03-06T12:30:41Z

←Older revision		Revision as of 12:30, 6 March 2024
Line 10:		Line 10:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/Q8YAE9_LISMO Q8YAE9_LISMO]		[https://www.uniprot.org/uniprot/Q8YAE9_LISMO Q8YAE9_LISMO]
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Here we employ a 'systems structural biology' approach to functionally characterize an unconventional alpha-glucan metabolic pathway from the food-borne pathogen Listeria monocytogenes (Lm). Crystal structure determination coupled with basic biochemical and biophysical assays allowed for the identification of anabolic, transport, catabolic and regulatory portions of the cycloalternan pathway. These findings provide numerous insights into cycloalternan pathway function and reveal the mechanism of repressor, open reading frame, kinase (ROK) transcription regulators. Moreover, by developing a structural overview we were able to anticipate the cycloalternan pathway's role in the metabolism of partially hydrolysed starch derivatives and demonstrate its involvement in Lm pathogenesis. These findings suggest that the cycloalternan pathway plays a role in interspecies resource competition-potentially within the host gastrointestinal tract-and establish the methodological framework for characterizing bacterial systems of unknown function.
-
-	Structure to function of an alpha-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis.,Light SH, Cahoon LA, Halavaty AS, Freitag NE, Anderson WF Nat Microbiol. 2016 Nov 7;2:16202. doi: 10.1038/nmicrobiol.2016.202. PMID:27819654<ref>PMID:27819654</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5f7v" style="background-color:#fffaf0;"></div>
-	== References ==
-	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:41, 19 July 2023

2023-07-19T06:41:32Z

←Older revision		Revision as of 06:41, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='5f7v' size='340' side='right'caption='[[5f7v]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='5f7v' size='340' side='right'caption='[[5f7v]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f7v]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lismo Lismo~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F7V OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5F7V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f7v]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5F7V FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=GLC:ALPHA~~-~~D-GLUCOSE'>GLC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5f7q\|5f7q]], [[5f7r\|5f7r]], [[5f7p\|5f7p]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">lmo0181 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=169963 LISMO])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5f7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f7v OCA], [https://pdbe.org/5f7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5f7v RCSB], [https://www.ebi.ac.uk/pdbsum/5f7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5f7v ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5f7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f7v OCA], [~~http~~://pdbe.org/5f7v PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5f7v RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5f7v PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5f7v ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q8YAE9_LISMO Q8YAE9_LISMO]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lismo~~]]	+	[[Category: Listeria monocytogenes EGD-e]]
-	[[Category: Anderson~~, W F]]~~	+	[[Category: Anderson WF]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Light SH]]
-	[[Category: Light~~, S H]]~~	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Cycloalternan binding protein]]~~	+
-	~~[[Category: Substrate-binding protein~~]]	+

OCA at 08:03, 29 April 2020

2020-04-29T08:03:43Z

←Older revision		Revision as of 08:03, 29 April 2020
Line 1:		Line 1:

	==ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with cycloalternan==		==ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with cycloalternan==
-	<StructureSection load='5f7v' size='340' side='right' caption='[[5f7v]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='5f7v' size='340' side='right'caption='[[5f7v]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5f7v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F7V OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5F7V FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5f7v]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lismo Lismo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F7V OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5F7V FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f7q\|5f7q]], [[5f7r\|5f7r]], [[5f7p\|5f7p]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f7q\|5f7q]], [[5f7r\|5f7r]], [[5f7p\|5f7p]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5f7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f7v OCA], [http://pdbe.org/5f7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f7v RCSB], [http://www.ebi.ac.uk/pdbsum/5f7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f7v ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">lmo0181 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=169963 LISMO])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5f7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f7v OCA], [http://pdbe.org/5f7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f7v RCSB], [http://www.ebi.ac.uk/pdbsum/5f7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f7v ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lismo]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 11:05, 10 December 2016

2016-12-10T11:05:01Z

←Older revision		Revision as of 11:05, 10 December 2016
Line 8:		Line 8:
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f7v OCA], [http://pdbe.org/5f7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f7v RCSB], [http://www.ebi.ac.uk/pdbsum/5f7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f7v ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f7v OCA], [http://pdbe.org/5f7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f7v RCSB], [http://www.ebi.ac.uk/pdbsum/5f7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f7v ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Here we employ a 'systems structural biology' approach to functionally characterize an unconventional alpha-glucan metabolic pathway from the food-borne pathogen Listeria monocytogenes (Lm). Crystal structure determination coupled with basic biochemical and biophysical assays allowed for the identification of anabolic, transport, catabolic and regulatory portions of the cycloalternan pathway. These findings provide numerous insights into cycloalternan pathway function and reveal the mechanism of repressor, open reading frame, kinase (ROK) transcription regulators. Moreover, by developing a structural overview we were able to anticipate the cycloalternan pathway's role in the metabolism of partially hydrolysed starch derivatives and demonstrate its involvement in Lm pathogenesis. These findings suggest that the cycloalternan pathway plays a role in interspecies resource competition-potentially within the host gastrointestinal tract-and establish the methodological framework for characterizing bacterial systems of unknown function.
		+
		+	Structure to function of an alpha-glucan metabolic pathway that promotes Listeria monocytogenes pathogenesis.,Light SH, Cahoon LA, Halavaty AS, Freitag NE, Anderson WF Nat Microbiol. 2016 Nov 7;2:16202. doi: 10.1038/nmicrobiol.2016.202. PMID:27819654<ref>PMID:27819654</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5f7v" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:04, 10 September 2016

2016-09-10T21:04:54Z

←Older revision		Revision as of 21:04, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5f7v is ~~ON HOLD until Paper Publication~~	+	==ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with cycloalternan==
-		+	<StructureSection load='5f7v' size='340' side='right' caption='[[5f7v]], [[Resolution\|resolution]] 1.40Å' scene=''>
-	~~Authors~~: ~~Light~~, S.H., ~~Anderson~~, W.F., ~~Center for Structural Genomics of Infectious Diseases (CSGID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5f7v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F7V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F7V FirstGlance]. <br>
-	~~Description~~: ~~ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with cycloalternan~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5f7q\|5f7q]], [[5f7r\|5f7r]], [[5f7p\|5f7p]]</td></tr>
-	[[Category: Light, S.H]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f7v OCA], [http://pdbe.org/5f7v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f7v RCSB], [http://www.ebi.ac.uk/pdbsum/5f7v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5f7v ProSAT]</span></td></tr>
-	[[Category: ~~Anderson, W.F~~]]	+	</table>
-	[[Category: ~~Center For Structural Genomics Of Infectious Diseases (Csgid)~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Anderson, W F]]
		+	[[Category: Structural genomic]]
		+	[[Category: Light, S H]]
		+	[[Category: Csgid]]
		+	[[Category: Cycloalternan binding protein]]
		+	[[Category: Substrate-binding protein]]

OCA at 17:37, 30 December 2015

2015-12-30T17:37:05Z

←Older revision		Revision as of 17:37, 30 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5f7v is ON HOLD	+	The entry 5f7v is ON HOLD until Paper Publication

	Authors: Light, S.H., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)		Authors: Light, S.H., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

OCA at 11:17, 23 December 2015

2015-12-23T11:17:05Z

←Older revision		Revision as of 11:17, 23 December 2015
Line 3:		Line 3:
	The entry 5f7v is ON HOLD		The entry 5f7v is ON HOLD

-	Authors: Light, S.H., Anderson, W.F.	+	Authors: Light, S.H., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

	Description: ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with cycloalternan		Description: ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with cycloalternan
Line 9:		Line 9:
	[[Category: Light, S.H]]		[[Category: Light, S.H]]
	[[Category: Anderson, W.F]]		[[Category: Anderson, W.F]]
		+	[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]

OCA: Protected "5f7v" [edit=sysop:move=sysop]

2015-12-16T12:40:38Z

Protected "5f7v" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:40, 16 December 2015

OCA: New page: '''Unreleased structure''' The entry 5f7v is ON HOLD Authors: Light, S.H., Anderson, W.F. Description: ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with...

2015-12-16T12:40:37Z

New page: '''Unreleased structure''' The entry 5f7v is ON HOLD Authors: Light, S.H., Anderson, W.F. Description: ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with...

New page

'''Unreleased structure'''

The entry 5f7v is ON HOLD

Authors: Light, S.H., Anderson, W.F.

Description: ABC substrate-binding protein Lmo0181 from Listeria monocytogenes in complex with cycloalternan
[[Category: Unreleased Structures]]
[[Category: Light, S.H]]
[[Category: Anderson, W.F]]