5fhb - Revision history

OCA at 06:51, 19 July 2023

2023-07-19T06:51:15Z

←Older revision		Revision as of 06:51, 19 July 2023
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	<StructureSection load='5fhb' size='340' side='right'caption='[[5fhb]], [[Resolution\|resolution]] 1.97Å' scene=''>		<StructureSection load='5fhb' size='340' side='right'caption='[[5fhb]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fhb]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FHB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FHB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fhb]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FHB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>~~, ~~<scene name='pdbligand=EDO:~~1~~,2-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.973Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5fha\|5fha]]~~, ~~[[5fhc\|5fhc]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fhb OCA], [~~http~~://pdbe.org/5fhb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fhb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fhb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fhb ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fhb OCA], [https://pdbe.org/5fhb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fhb RCSB], [https://www.ebi.ac.uk/pdbsum/5fhb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fhb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	==See Also==		==See Also==
	*[[Antibody 3D structures\|Antibody 3D structures]]		*[[Antibody 3D structures\|Antibody 3D structures]]
		+	*[[Sandbox 20009\|Sandbox 20009]]
		+	*[[3D structures of human antibody\|3D structures of human antibody]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gilman~~, M S.A~~]]	+	[[Category: Gilman MSA]]
-	[[Category: McLellan~~, J S]]~~	+	[[Category: McLellan JS]]
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Ig domain]]~~	+
-	~~[[Category: Immune system~~]]	+

OCA at 07:19, 6 May 2020

2020-05-06T07:19:42Z

←Older revision		Revision as of 07:19, 6 May 2020
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	==Crystal Structure of Protective Ebola Virus Antibody 100==		==Crystal Structure of Protective Ebola Virus Antibody 100==
-	<StructureSection load='5fhb' size='340' side='right' caption='[[5fhb]], [[Resolution\|resolution]] 1.97Å' scene=''>	+	<StructureSection load='5fhb' size='340' side='right'caption='[[5fhb]], [[Resolution\|resolution]] 1.97Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fhb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FHB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FHB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fhb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FHB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FHB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fha\|5fha]], [[5fhc\|5fhc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fha\|5fha]], [[5fhc\|5fhc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fhb OCA], [http://pdbe.org/5fhb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fhb RCSB], [http://www.ebi.ac.uk/pdbsum/5fhb PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fhb OCA], [http://pdbe.org/5fhb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fhb RCSB], [http://www.ebi.ac.uk/pdbsum/5fhb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fhb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5fhb" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fhb" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Antibody 3D structures\|Antibody 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gilman, M S.A]]		[[Category: Gilman, M S.A]]
	[[Category: McLellan, J S]]		[[Category: McLellan, J S]]

OCA at 17:35, 10 May 2016

2016-05-10T17:35:48Z

←Older revision		Revision as of 17:35, 10 May 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5fhb is ~~ON HOLD~~	+	==Crystal Structure of Protective Ebola Virus Antibody 100==
		+	<StructureSection load='5fhb' size='340' side='right' caption='[[5fhb]], [[Resolution\|resolution]] 1.97Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fhb]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FHB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FHB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fha\|5fha]], [[5fhc\|5fhc]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fhb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fhb OCA], [http://pdbe.org/5fhb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fhb RCSB], [http://www.ebi.ac.uk/pdbsum/5fhb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Ebola virus causes hemorrhagic fever with a high case fatality rate for which there is no approved therapy. Two human monoclonal antibodies, mAb100 and mAb114, in combination, protect nonhuman primates against all signs of Ebola virus disease, including viremia. Here, we demonstrate that mAb100 recognizes the base of the Ebola virus glycoprotein (GP) trimer, occludes access to the cathepsin-cleavage loop, and prevents the proteolytic cleavage of GP that is required for virus entry. We show that mAb114 interacts with the glycan cap and inner chalice of GP, remains associated after proteolytic removal of the glycan cap, and inhibits binding of cleaved GP to its receptor. These results define the basis of neutralization for two protective antibodies and may facilitate development of therapies and vaccines.

-	~~Authors:~~ Gilman, M~~.S.~~A., ~~McLellan~~, J.S.	+	Structural and molecular basis for Ebola virus neutralization by protective human antibodies.,Misasi J, Gilman MS, Kanekiyo M, Gui M, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS, Xiang Y, Sullivan NJ, McLellan JS Science. 2016 Mar 18;351(6279):1343-6. doi: 10.1126/science.aad6117. Epub 2016, Feb 25. PMID:26917592<ref>PMID:26917592</ref>

-	~~Description: Crystal Structure~~ of ~~Protective Ebola Virus Antibody 100~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Mclellan~~, J.S]]	+	<div class="pdbe-citations 5fhb" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Gilman, M.S.A~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gilman, M S.A]]
		+	[[Category: McLellan, J S]]
		+	[[Category: Fab]]
		+	[[Category: Ig domain]]
		+	[[Category: Immune system]]

OCA at 14:37, 20 January 2016

2016-01-20T14:37:47Z

←Older revision		Revision as of 14:37, 20 January 2016
Line 5:		Line 5:
	Authors: Gilman, M.S.A., McLellan, J.S.		Authors: Gilman, M.S.A., McLellan, J.S.

-	Description: Crystal Structure of Protective Ebola ~~virus~~ Antibody 100	+	Description: Crystal Structure of Protective Ebola Virus Antibody 100
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Mclellan, J.S]]		[[Category: Mclellan, J.S]]
	[[Category: Gilman, M.S.A]]		[[Category: Gilman, M.S.A]]

OCA: Protected "5fhb" [edit=sysop:move=sysop]

2015-12-30T17:57:29Z

Protected "5fhb" [edit=sysop:move=sysop]

←Older revision

Revision as of 17:57, 30 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fhb is ON HOLD Authors: Gilman, M.S.A., McLellan, J.S. Description: Crystal Structure of Protective Ebola virus Antibody 100 [[Category: Unrelease...

2015-12-30T17:57:28Z

New page: '''Unreleased structure''' The entry 5fhb is ON HOLD Authors: Gilman, M.S.A., McLellan, J.S. Description: Crystal Structure of Protective Ebola virus Antibody 100 [[Category: Unrelease...

New page

'''Unreleased structure'''

The entry 5fhb is ON HOLD

Authors: Gilman, M.S.A., McLellan, J.S.

Description: Crystal Structure of Protective Ebola virus Antibody 100
[[Category: Unreleased Structures]]
[[Category: Mclellan, J.S]]
[[Category: Gilman, M.S.A]]