5fl1 - Revision history

OCA at 06:55, 19 July 2023

2023-07-19T06:55:53Z

←Older revision		Revision as of 06:55, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='5fl1' size='340' side='right'caption='[[5fl1]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5fl1' size='340' side='right'caption='[[5fl1]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fl1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_thetaiotaomicron"_distaso_1912 "bacillus~~ thetaiotaomicron~~" distaso 1912~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FL1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacteroides_thetaiotaomicron Bacteroides thetaiotaomicron]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FL1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DV1:(3~{A}~{R},5~{R},6~{S},7~{R},7~{A}~{R})-5-(HYDROXYMETHYL)-2-(PROP-2-ENYLAMINO)-5,6,7,7~{A}-TETRAHYDRO-3~{A}~{H}-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>DV1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.95Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fky\|5fky]], [[5fl0\|5fl0]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DV1:(3~{A}~{R},5~{R},6~{S},7~{R},7~{A}~{R})-5-(HYDROXYMETHYL)-2-(PROP-2-ENYLAMINO)-5,6,7,7~{A}-TETRAHYDRO-3~{A}~{H}-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>DV1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_O-GlcNAcase Protein O-GlcNAcase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.169 3.2.1.169] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fl1 OCA], [https://pdbe.org/5fl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fl1 RCSB], [https://www.ebi.ac.uk/pdbsum/5fl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fl1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fl1 OCA], [~~http~~://pdbe.org/5fl1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fl1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fl1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fl1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/OGA_BACTN OGA_BACTN]] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins.	+	[https://www.uniprot.org/uniprot/OGA_BACTN OGA_BACTN] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 20:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5fl1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fl1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[O-GlcNAcase\|O-GlcNAcase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacillus~~ thetaiotaomicron ~~distaso 1912~~]]	+	[[Category: Bacteroides thetaiotaomicron]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	~~[[Category: Protein O-GlcNAcase]]~~	+	[[Category: Cekic N]]
-	[[Category: Cekic, N]]	+	[[Category: Davies GJ]]
-	[[Category: Davies~~, G J~~]]	+	[[Category: Heinonen JE]]
-	[[Category: Heinonen~~, J E~~]]	+	[[Category: McEachern EJ]]
-	[[Category: McEachern~~, E J~~]]	+	[[Category: Roth C]]
-	[[Category: Roth, C]]	+	[[Category: Stubbs KA]]
-	[[Category: Stubbs~~, K A~~]]	+	[[Category: Vocadlo DJ]]
-	[[Category: Vocadlo~~, D J]]~~	+
-	~~[[Category: Hydrolase~~]]	+

OCA at 07:04, 3 June 2020

2020-06-03T07:04:22Z

←Older revision		Revision as of 07:04, 3 June 2020
Line 1:		Line 1:

	==Structure of a hydrolase with an inhibitor==		==Structure of a hydrolase with an inhibitor==
-	<StructureSection load='5fl1' size='340' side='right' caption='[[5fl1]], [[Resolution\|resolution]] 1.95Å' scene=''>	+	<StructureSection load='5fl1' size='340' side='right'caption='[[5fl1]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FL1 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FL1 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FL1 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DV1:(3~{A}~{R},5~{R},6~{S},7~{R},7~{A}~{R})-5-(HYDROXYMETHYL)-2-(PROP-2-ENYLAMINO)-5,6,7,7~{A}-TETRAHYDRO-3~{A}~{H}-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>DV1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DV1:(3~{A}~{R},5~{R},6~{S},7~{R},7~{A}~{R})-5-(HYDROXYMETHYL)-2-(PROP-2-ENYLAMINO)-5,6,7,7~{A}-TETRAHYDRO-3~{A}~{H}-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>DV1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fky\|5fky]], [[5fl0\|5fl0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fky\|5fky]], [[5fl0\|5fl0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_O-GlcNAcase Protein O-GlcNAcase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.169 3.2.1.169] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_O-GlcNAcase Protein O-GlcNAcase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.169 3.2.1.169] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fl1 OCA], [http://pdbe.org/5fl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fl1 RCSB], [http://www.ebi.ac.uk/pdbsum/5fl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fl1 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fl1 OCA], [http://pdbe.org/5fl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fl1 RCSB], [http://www.ebi.ac.uk/pdbsum/5fl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fl1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 25:		Line 25:
	</StructureSection>		</StructureSection>
	[[Category: Bacillus thetaiotaomicron distaso 1912]]		[[Category: Bacillus thetaiotaomicron distaso 1912]]
		+	[[Category: Large Structures]]
	[[Category: Protein O-GlcNAcase]]		[[Category: Protein O-GlcNAcase]]
	[[Category: Cekic, N]]		[[Category: Cekic, N]]

OCA at 07:46, 29 August 2018

2018-08-29T07:46:33Z

←Older revision		Revision as of 07:46, 29 August 2018
Line 3:		Line 3:
	<StructureSection load='5fl1' size='340' side='right' caption='[[5fl1]], [[Resolution\|resolution]] 1.95Å' scene=''>		<StructureSection load='5fl1' size='340' side='right' caption='[[5fl1]], [[Resolution\|resolution]] 1.95Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fl1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FL1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fl1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_thetaiotaomicron"_distaso_1912 "bacillus thetaiotaomicron" distaso 1912]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FL1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DV1:(3~{A}~{R},5~{R},6~{S},7~{R},7~{A}~{R})-5-(HYDROXYMETHYL)-2-(PROP-2-ENYLAMINO)-5,6,7,7~{A}-TETRAHYDRO-3~{A}~{H}-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>DV1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DV1:(3~{A}~{R},5~{R},6~{S},7~{R},7~{A}~{R})-5-(HYDROXYMETHYL)-2-(PROP-2-ENYLAMINO)-5,6,7,7~{A}-TETRAHYDRO-3~{A}~{H}-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>DV1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fky\|5fky]], [[5fl0\|5fl0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fky\|5fky]], [[5fl0\|5fl0]]</td></tr>
Line 11:		Line 11:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/OGA_BACTN OGA_BACTN]] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins.		[[http://www.uniprot.org/uniprot/OGA_BACTN OGA_BACTN]] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The modification of nucleocytoplasmic proteins with O-linked N-acetylglucosamine (O-GlcNAc) plays diverse roles in multicellular organisms. Inhibitors of O-GlcNAc hydrolase (OGA), the enzyme that removes O-GlcNAc from proteins, lead to increased O-GlcNAc levels in cells and are seeing widespread adoption in the field as a research tool used in cells and in vivo. Here we synthesize and study a series of tight binding carbohydrate-based inhibitors of human OGA (hOGA). The most potent of these 2'-aminothiazolines binds with a sub-nanomolar Ki value to hOGA (510 +/- 50 pM) and the most selective has greater than 1 800 000-fold selectivity for hOGA over mechanistically related human lysosomal beta-hexosaminidase. Structural data of inhibitors in complex with an hOGA homologue reveals the basis for variation in binding among these compounds. Using linear free energy analyses, we show binding of these 2'-aminothiazoline inhibitors depends on the pKa of the aminothiazoline ring system, revealing the protonation state of the inhibitor is a key driver of binding. Using series of inhibitors and synthetic substrates, we show that 2'-aminothiazoline inhibitors are transition state analogues of hOGA that bind to the enzyme up to 1-million fold more tightly than the substrate. These collective data support an oxazoline, rather than a protonated oxazolinium ion, intermediate being formed along the reaction pathway. Inhibitors from this series will prove generally useful tools for the study of O-GlcNAc. The new insights gained here, into the catalytic mechanism of hOGA and the fundamental drivers of potency and selectivity of OGA inhibitors, should enable tuning of hOGA inhibitors with desirable properties.
		+
		+	Analysis of transition state mimicry by tight binding aminothiazoline inhibitors provides insight into catalysis by human O-GlcNAcase.,Cekic N, Heinonen JE, Stubbs KA, Roth C, He Y, Bennet AJ, McEachern EJ, Davies GJ, Vocadlo DJ Chem Sci. 2016 Jun 1;7(6):3742-3750. doi: 10.1039/c6sc00370b. Epub 2016 Feb 15. PMID:29997861<ref>PMID:29997861</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5fl1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus thetaiotaomicron distaso 1912]]
	[[Category: Protein O-GlcNAcase]]		[[Category: Protein O-GlcNAcase]]
	[[Category: Cekic, N]]		[[Category: Cekic, N]]

OCA at 13:55, 10 September 2016

2016-09-10T13:55:13Z

←Older revision		Revision as of 13:55, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fl1 ~~is ON HOLD until Paper Publication~~	+	==Structure of a hydrolase with an inhibitor==
-		+	<StructureSection load='5fl1' size='340' side='right' caption='[[5fl1]], [[Resolution\|resolution]] 1.95Å' scene=''>
-	~~Authors~~: ~~Cekic, N~~.~~, Heinonen, J~~.E., ~~Stubbs~~, K.A., ~~Roth~~, C., ~~McEachern~~, E.J., ~~Davies~~, G.J., ~~Vocadlo~~, D.J.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fl1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FL1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FL1 FirstGlance]. <br>
-	~~Description: Structure of a hydrolase with an inhibitor~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DV1:(3~{A}~{R},5~{R},6~{S},7~{R},7~{A}~{R})-5-(HYDROXYMETHYL)-2-(PROP-2-ENYLAMINO)-5,6,7,7~{A}-TETRAHYDRO-3~{A}~{H}-PYRANO[3,2-D][1,3]THIAZOLE-6,7-DIOL'>DV1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	[[~~Category~~: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fky\|5fky]], [[5fl0\|5fl0]]</td></tr>
-	[[Category: ~~Davies, G.J~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein_O-GlcNAcase Protein O-GlcNAcase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.169 3.2.1.169] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fl1 OCA], [http://pdbe.org/5fl1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fl1 RCSB], [http://www.ebi.ac.uk/pdbsum/5fl1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fl1 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/OGA_BACTN OGA_BACTN]] Biological function unknown. Capable of hydrolyzing the glycosidic link of O-GlcNAcylated proteins.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Protein O-GlcNAcase]]
	[[Category: Cekic, N]]		[[Category: Cekic, N]]
-	[[Category: ~~Vocadlo~~, D.J]]	+	[[Category: Davies, G J]]
		+	[[Category: Heinonen, J E]]
		+	[[Category: McEachern, E J]]
	[[Category: Roth, C]]		[[Category: Roth, C]]
-	[[Category: ~~Mceachern~~, ~~E.J~~]]	+	[[Category: Stubbs, K A]]
-	[[Category: ~~Stubbs~~, ~~K.A~~]]	+	[[Category: Vocadlo, D J]]
-	[[Category: ~~Heinonen, J.E~~]]	+	[[Category: Hydrolase]]

OCA: Protected "5fl1" [edit=sysop:move=sysop]

2015-12-01T03:31:50Z

Protected "5fl1" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:31, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fl1 is ON HOLD until Paper Publication Authors: Cekic, N., Heinonen, J.E., Stubbs, K.A., Roth, C., McEachern, E.J., Davies, G.J., Vocadlo, D.J. De...

2015-12-01T03:31:49Z

New page: '''Unreleased structure''' The entry 5fl1 is ON HOLD until Paper Publication Authors: Cekic, N., Heinonen, J.E., Stubbs, K.A., Roth, C., McEachern, E.J., Davies, G.J., Vocadlo, D.J. De...

New page

'''Unreleased structure'''

The entry 5fl1 is ON HOLD until Paper Publication

Authors: Cekic, N., Heinonen, J.E., Stubbs, K.A., Roth, C., McEachern, E.J., Davies, G.J., Vocadlo, D.J.

Description: Structure of a hydrolase with an inhibitor
[[Category: Unreleased Structures]]
[[Category: Davies, G.J]]
[[Category: Cekic, N]]
[[Category: Vocadlo, D.J]]
[[Category: Roth, C]]
[[Category: Mceachern, E.J]]
[[Category: Stubbs, K.A]]
[[Category: Heinonen, J.E]]