5fn0 - Revision history

OCA at 06:58, 19 July 2023

2023-07-19T06:58:31Z

←Older revision		Revision as of 06:58, 19 July 2023
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	<StructureSection load='5fn0' size='340' side='right'caption='[[5fn0]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='5fn0' size='340' side='right'caption='[[5fn0]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fn0]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus~~ fluorescens ~~liquefaciens" flugge 1886~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FN0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fn0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_fluorescens Pseudomonas fluorescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FN0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=JHY:3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC+ACID'>JHY</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.19Å</td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=JHY:3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC+ACID'>JHY</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn0 OCA], [~~http~~://pdbe.org/5fn0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fn0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fn0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fn0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn0 OCA], [https://pdbe.org/5fn0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fn0 RCSB], [https://www.ebi.ac.uk/pdbsum/5fn0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fn0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.	+	[https://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Monooxygenase\|Monooxygenase]]	+	*[[Monooxygenase 3D structures\|Monooxygenase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
-	[[Category: Kynurenine 3-monooxygenase]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Ancellin, N]]	+	[[Category: Pseudomonas fluorescens]]
-	[[Category: Baily~~, J E~~]]	+	[[Category: Ancellin N]]
-	[[Category: Beaufils, B]]	+	[[Category: Baily JE]]
-	[[Category: Beneton, V]]	+	[[Category: Beaufils B]]
-	[[Category: Binnie, M]]	+	[[Category: Beneton V]]
-	[[Category: Garden~~, O J~~]]	+	[[Category: Binnie M]]
-	[[Category: Haslam, C]]	+	[[Category: Garden OJ]]
-	[[Category: Holmes, D]]	+	[[Category: Haslam C]]
-	[[Category: Homer~~, N Z.M~~]]	+	[[Category: Holmes D]]
-	[[Category: Howie~~, S E.M~~]]	+	[[Category: Homer NZM]]
-	[[Category: Hughes, J]]	+	[[Category: Howie SEM]]
-	[[Category: Hutchinson~~, J P~~]]	+	[[Category: Hughes J]]
-	[[Category: Iredale~~, J P~~]]	+	[[Category: Hutchinson JP]]
-	[[Category: Liddle, J]]	+	[[Category: Iredale JP]]
-	[[Category: McBride, A]]	+	[[Category: Liddle J]]
-	[[Category: Mirguet, O]]	+	[[Category: McBride A]]
-	[[Category: Mole~~, D J~~]]	+	[[Category: Mirguet O]]
-	[[Category: Mowat~~, C G~~]]	+	[[Category: Mole DJ]]
-	[[Category: Rowland, P]]	+	[[Category: Mowat CG]]
-	[[Category: Sharp~~, M G.F~~]]	+	[[Category: Rowland P]]
-	[[Category: Trottet, L]]	+	[[Category: Sharp MGF]]
-	[[Category: Uings, I]]	+	[[Category: Trottet L]]
-	[[Category: Walker, A]]	+	[[Category: Uings I]]
-	[[Category: Webster~~, S P~~]]	+	[[Category: Walker A]]
-	[[Category: Wilkinson, M]]	+	[[Category: Webster SP]]
-	[[Category: Wilson, K]]	+	[[Category: Wilkinson M]]
-	[[Category: Zheng, X]]	+	[[Category: Wilson K]]
-	~~[[Category: Kmo]]~~	+	[[Category: Zheng X]]
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 13:00, 10 May 2019

2019-05-10T13:00:14Z

←Older revision		Revision as of 13:00, 10 May 2019
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	==Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180==		==Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180==
-	<StructureSection load='5fn0' size='340' side='right' caption='[[5fn0]], [[Resolution\|resolution]] 3.19Å' scene=''>	+	<StructureSection load='5fn0' size='340' side='right'caption='[[5fn0]], [[Resolution\|resolution]] 3.19Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fn0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FN0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fn0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_fluorescens_liquefaciens"_flugge_1886 "bacillus fluorescens liquefaciens" flugge 1886]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FN0 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=JHY:3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC+ACID'>JHY</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=JHY:3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC+ACID'>JHY</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn0 OCA], [http://pdbe.org/5fn0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fn0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fn0 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn0 OCA], [http://pdbe.org/5fn0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fn0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fn0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fn0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5fn0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fn0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Monooxygenase\|Monooxygenase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacillus fluorescens liquefaciens flugge 1886]]
	[[Category: Kynurenine 3-monooxygenase]]		[[Category: Kynurenine 3-monooxygenase]]
		+	[[Category: Large Structures]]
	[[Category: Ancellin, N]]		[[Category: Ancellin, N]]
	[[Category: Baily, J E]]		[[Category: Baily, J E]]

OCA at 06:42, 2 March 2016

2016-03-02T06:42:09Z

←Older revision		Revision as of 06:42, 2 March 2016
Line 1:		Line 1:
		+
	==Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180==		==Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180==
	<StructureSection load='5fn0' size='340' side='right' caption='[[5fn0]], [[Resolution\|resolution]] 3.19Å' scene=''>		<StructureSection load='5fn0' size='340' side='right' caption='[[5fn0]], [[Resolution\|resolution]] 3.19Å' scene=''>

OCA at 08:39, 20 January 2016

2016-01-20T08:39:54Z

←Older revision		Revision as of 08:39, 20 January 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.		[[http://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Acute pancreatitis (AP) is a common and devastating inflammatory condition of the pancreas that is considered to be a paradigm of sterile inflammation leading to systemic multiple organ dysfunction syndrome (MODS) and death. Acute mortality from AP-MODS exceeds 20% (ref. 3), and the lifespans of those who survive the initial episode are typically shorter than those of the general population. There are no specific therapies available to protect individuals from AP-MODS. Here we show that kynurenine-3-monooxygenase (KMO), a key enzyme of tryptophan metabolism, is central to the pathogenesis of AP-MODS. We created a mouse strain that is deficient for Kmo (encoding KMO) and that has a robust biochemical phenotype that protects against extrapancreatic tissue injury to the lung, kidney and liver in experimental AP-MODS. A medicinal chemistry strategy based on modifications of the kynurenine substrate led to the discovery of the oxazolidinone GSK180 as a potent and specific inhibitor of KMO. The binding mode of the inhibitor in the active site was confirmed by X-ray co-crystallography at 3.2 A resolution. Treatment with GSK180 resulted in rapid changes in the levels of kynurenine pathway metabolites in vivo, and it afforded therapeutic protection against MODS in a rat model of AP. Our findings establish KMO inhibition as a novel therapeutic strategy in the treatment of AP-MODS, and they open up a new area for drug discovery in critical illness.
		+
		+	Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.,Mole DJ, Webster SP, Uings I, Zheng X, Binnie M, Wilson K, Hutchinson JP, Mirguet O, Walker A, Beaufils B, Ancellin N, Trottet L, Beneton V, Mowat CG, Wilkinson M, Rowland P, Haslam C, McBride A, Homer NZ, Baily JE, Sharp MG, Garden OJ, Hughes J, Howie SE, Holmes DS, Liddle J, Iredale JP Nat Med. 2016 Jan 11. doi: 10.1038/nm.4020. PMID:26752518<ref>PMID:26752518</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5fn0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 20:37, 13 January 2016

2016-01-13T20:37:33Z

←Older revision		Revision as of 20:37, 13 January 2016
Line 1:		Line 1:
-	'''~~Unreleased structure~~'''	+	==Crystal structure of Pseudomonas fluorescens kynurenine-3- monooxygenase (KMO) in complex with GSK180==
-		+	<StructureSection load='5fn0' size='340' side='right' caption='[[5fn0]], [[Resolution\|resolution]] 3.19Å' scene=''>
-	~~The entry~~ 5fn0 is ~~ON HOLD until Paper Publication~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fn0]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FN0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FN0 FirstGlance]. <br>
-	~~Authors~~: ~~Mole, D~~.J.~~, Webster, S~~.P.~~, Uings, I~~.~~, Zheng, X~~.~~, Binnie, M~~.~~, Wilson, K~~.~~, Hutchinson, J.P~~., ~~Mirguet~~, O.~~, Walker, A~~., ~~Beaufils, B~~.~~, Ancellin, N~~.~~, Trottet, L~~.~~, Beneton, V~~.~~, Mowat, C~~.G.~~, Wilkinson, M~~.~~, Rowland, P~~.~~, Haslam, C~~.~~, McBride, A~~.~~, Homer, N~~.Z.M., ~~Baily, J~~.E.~~, Sharp, M.G.F~~., ~~Garden, O~~.~~J., Hughes~~, J.~~, Howie, S~~.~~E.M~~., ~~Holmes, D~~.~~, Liddle, J~~.~~, Iredale, J.P~~.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=JHY:3-(5,6-DICHLORO-2-OXOBENZO[D]OXAZOL-3(2H)-YL)PROPANOIC+ACID'>JHY</scene></td></tr>
-		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Kynurenine_3-monooxygenase Kynurenine 3-monooxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.9 1.14.13.9] </span></td></tr>
-	~~Description~~: ~~Crystal structure~~ of ~~Pseudomonas fluorescens~~ kynurenine-3-~~monooxygenase~~ (~~KMO~~) ~~in complex with GSK180~~	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fn0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fn0 OCA], [http://pdbe.org/5fn0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fn0 RCSB], [http://www.ebi.ac.uk/pdbsum/5fn0 PDBsum]</span></td></tr>
-	~~[[Category: Unreleased Structures]]~~	+	</table>
-	~~[[Category: Iredale, J~~.~~P]]~~	+	== Function ==
-	~~[[Category: Beaufils, B]]~~	+	[[http://www.uniprot.org/uniprot/KMO_PSEFL KMO_PSEFL]] Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Probably required for the synthesis of quinolinic acid and the siderophore quinolobactin.
-	~~[[Category: Mole, D~~.~~J]]~~	+	__TOC__
-	~~[[Category: Garden, O.J]]~~	+	</StructureSection>
-	~~[[Category: Mowat, C.G]]~~	+	[[Category: Kynurenine 3-monooxygenase]]
-	[[Category: ~~Zheng, X]]~~	+
-	~~[[Category: Hughes, J]]~~	+
-	~~[[Category: Binnie, M]]~~	+
-	~~[[Category: Mcbride, A~~]]	+
	[[Category: Ancellin, N]]		[[Category: Ancellin, N]]
-	[[Category: ~~Sharp~~, ~~M.G.F~~]]	+	[[Category: Baily, J E]]
-	[[Category: ~~Wilson~~, K]]	+	[[Category: Beaufils, B]]
	[[Category: Beneton, V]]		[[Category: Beneton, V]]
		+	[[Category: Binnie, M]]
		+	[[Category: Garden, O J]]
	[[Category: Haslam, C]]		[[Category: Haslam, C]]
-	[[Category: Uings, I]]
-	[[Category: Wilkinson, M]]
-	[[Category: Hutchinson, J.P]]
-	[[Category: Liddle, J]]
-	[[Category: Walker, A]]
-	[[Category: Webster, S.P]]
	[[Category: Holmes, D]]		[[Category: Holmes, D]]
-	[[Category: ~~Trottet~~, L]]	+	[[Category: Homer, N Z.M]]
-	[[Category: Howie, S.E.M]]	+	[[Category: Howie, S E.M]]
-	[[Category: ~~Baily~~, J.E]]	+	[[Category: Hughes, J]]
-	[[Category: ~~Rowland~~, P]]	+	[[Category: Hutchinson, J P]]
-	[[Category: ~~Homer~~, ~~N.Z.M~~]]	+	[[Category: Iredale, J P]]
		+	[[Category: Liddle, J]]
		+	[[Category: McBride, A]]
	[[Category: Mirguet, O]]		[[Category: Mirguet, O]]
		+	[[Category: Mole, D J]]
		+	[[Category: Mowat, C G]]
		+	[[Category: Rowland, P]]
		+	[[Category: Sharp, M G.F]]
		+	[[Category: Trottet, L]]
		+	[[Category: Uings, I]]
		+	[[Category: Walker, A]]
		+	[[Category: Webster, S P]]
		+	[[Category: Wilkinson, M]]
		+	[[Category: Wilson, K]]
		+	[[Category: Zheng, X]]
		+	[[Category: Kmo]]
		+	[[Category: Oxidoreductase]]

OCA: Protected "5fn0" [edit=sysop:move=sysop]

2015-12-01T03:38:56Z

Protected "5fn0" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:38, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fn0 is ON HOLD until Paper Publication Authors: Mole, D.J., Webster, S.P., Uings, I., Zheng, X., Binnie, M., Wilson, K., Hutchinson, J.P., Mirguet,...

2015-12-01T03:38:55Z

New page: '''Unreleased structure''' The entry 5fn0 is ON HOLD until Paper Publication Authors: Mole, D.J., Webster, S.P., Uings, I., Zheng, X., Binnie, M., Wilson, K., Hutchinson, J.P., Mirguet,...

New page

'''Unreleased structure'''

The entry 5fn0 is ON HOLD until Paper Publication

Authors: Mole, D.J., Webster, S.P., Uings, I., Zheng, X., Binnie, M., Wilson, K., Hutchinson, J.P., Mirguet, O., Walker, A., Beaufils, B., Ancellin, N., Trottet, L., Beneton, V., Mowat, C.G., Wilkinson, M., Rowland, P., Haslam, C., McBride, A., Homer, N.Z.M., Baily, J.E., Sharp, M.G.F., Garden, O.J., Hughes, J., Howie, S.E.M., Holmes, D., Liddle, J., Iredale, J.P.

Description: Crystal structure of Pseudomonas fluorescens kynurenine-3-monooxygenase (KMO) in complex with GSK180
[[Category: Unreleased Structures]]
[[Category: Iredale, J.P]]
[[Category: Beaufils, B]]
[[Category: Mole, D.J]]
[[Category: Garden, O.J]]
[[Category: Mowat, C.G]]
[[Category: Zheng, X]]
[[Category: Hughes, J]]
[[Category: Binnie, M]]
[[Category: Mcbride, A]]
[[Category: Ancellin, N]]
[[Category: Sharp, M.G.F]]
[[Category: Wilson, K]]
[[Category: Beneton, V]]
[[Category: Haslam, C]]
[[Category: Uings, I]]
[[Category: Wilkinson, M]]
[[Category: Hutchinson, J.P]]
[[Category: Liddle, J]]
[[Category: Walker, A]]
[[Category: Webster, S.P]]
[[Category: Holmes, D]]
[[Category: Trottet, L]]
[[Category: Howie, S.E.M]]
[[Category: Baily, J.E]]
[[Category: Rowland, P]]
[[Category: Homer, N.Z.M]]
[[Category: Mirguet, O]]