5fnu - Revision history

OCA at 07:00, 19 July 2023

2023-07-19T07:00:31Z

←Older revision		Revision as of 07:00, 19 July 2023
Line 3:		Line 3:
	<StructureSection load='5fnu' size='340' side='right'caption='[[5fnu]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='5fnu' size='340' side='right'caption='[[5fnu]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fnu]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FNU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fnu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FNU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L6I:(3S)-3-(7-METHOXY-1-METHYL-1H-BENZO[D][1,2,3]TRIAZOL-5-YL)-3-(4-METHYL-3-(((R)-4-METHYL-1,1-DIOXIDO-3,4-DIHYDRO-2H-BENZO[B][1,4,5]OXATHIAZEPIN-2-YL)METHYL)PHENYL)PROPANOIC+ACID'>L6I</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.78Å</td></tr>
-	~~<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fnq\|5fnq]], [[5fnr\|5fnr]], [[5fns\|5fns]], [[5fnt\|5fnt]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L6I:(3S)-3-(7-METHOXY-1-METHYL-1H-BENZO[D][1,2,3]TRIAZOL-5-YL)-3-(4-METHYL-3-(((R)-4-METHYL-1,1-DIOXIDO-3,4-DIHYDRO-2H-BENZO[B][1,4,5]OXATHIAZEPIN-2-YL)METHYL)PHENYL)PROPANOIC+ACID'>L6I</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnu OCA], [~~http~~://pdbe.org/5fnu PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fnu RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fnu PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnu OCA], [https://pdbe.org/5fnu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fnu RCSB], [https://www.ebi.ac.uk/pdbsum/5fnu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>	+	[https://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Bolognese~~, B J~~]]	+	[[Category: Bolognese BJ]]
-	[[Category: Callahan~~, J F~~]]	+	[[Category: Callahan JF]]
-	[[Category: Cottom~~, J E~~]]	+	[[Category: Cottom JE]]
-	[[Category: Coyle~~, J E~~]]	+	[[Category: Coyle JE]]
-	[[Category: Davies~~, T G~~]]	+	[[Category: Davies TG]]
-	[[Category: Feldser~~, H G~~]]	+	[[Category: Feldser HG]]
-	[[Category: Foley~~, J P~~]]	+	[[Category: Foley JP]]
-	[[Category: Griffiths-Jones, C]]	+	[[Category: Griffiths-Jones C]]
-	[[Category: Hearn, K]]	+	[[Category: Hearn K]]
-	[[Category: Heightman~~, T D~~]]	+	[[Category: Heightman TD]]
-	[[Category: Kerns~~, J K~~]]	+	[[Category: Kerns JK]]
-	[[Category: Kou, J]]	+	[[Category: Kou J]]
-	[[Category: Logan, G]]	+	[[Category: Logan G]]
-	[[Category: McMenamin, R]]	+	[[Category: McMenamin R]]
-	[[Category: Norton, D]]	+	[[Category: Norton D]]
-	[[Category: Podolin~~, P L~~]]	+	[[Category: Podolin PL]]
-	[[Category: Rich~~, S J~~]]	+	[[Category: Rich SJ]]
-	[[Category: Richardson, C]]	+	[[Category: Richardson C]]
-	[[Category: Sanchez, Y]]	+	[[Category: Sanchez Y]]
-	[[Category: Saxty, G]]	+	[[Category: Saxty G]]
-	[[Category: Willems~~, H M.G~~]]	+	[[Category: Willems HMG]]
-	[[Category: Wixted~~, W E~~]]	+	[[Category: Wixted WE]]
-	[[Category: Woolford~~, A J~~]]	+	[[Category: Woolford AJ]]
-	[[Category: Yan, H]]	+	[[Category: Yan H]]
-	[[Category: Yonchuk~~, J G]]~~	+	[[Category: Yonchuk JG]]
-	~~[[Category: Keap1]]~~	+
-	~~[[Category: Nrf2]]~~	+
-	~~[[Category: Oxidative stress]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:27, 6 May 2020

2020-05-06T07:27:18Z

←Older revision		Revision as of 07:27, 6 May 2020
Line 1:		Line 1:

	==Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.==		==Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.==
-	<StructureSection load='5fnu' size='340' side='right' caption='[[5fnu]], [[Resolution\|resolution]] 1.78Å' scene=''>	+	<StructureSection load='5fnu' size='340' side='right'caption='[[5fnu]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fnu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FNU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fnu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FNU FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L6I:(3S)-3-(7-METHOXY-1-METHYL-1H-BENZO[D][1,2,3]TRIAZOL-5-YL)-3-(4-METHYL-3-(((R)-4-METHYL-1,1-DIOXIDO-3,4-DIHYDRO-2H-BENZO[B][1,4,5]OXATHIAZEPIN-2-YL)METHYL)PHENYL)PROPANOIC+ACID'>L6I</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L6I:(3S)-3-(7-METHOXY-1-METHYL-1H-BENZO[D][1,2,3]TRIAZOL-5-YL)-3-(4-METHYL-3-(((R)-4-METHYL-1,1-DIOXIDO-3,4-DIHYDRO-2H-BENZO[B][1,4,5]OXATHIAZEPIN-2-YL)METHYL)PHENYL)PROPANOIC+ACID'>L6I</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fnq\|5fnq]], [[5fnr\|5fnr]], [[5fns\|5fns]], [[5fnt\|5fnt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fnq\|5fnq]], [[5fnr\|5fnr]], [[5fns\|5fns]], [[5fnt\|5fnt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnu OCA], [http://pdbe.org/5fnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnu RCSB], [http://www.ebi.ac.uk/pdbsum/5fnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnu ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnu OCA], [http://pdbe.org/5fnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnu RCSB], [http://www.ebi.ac.uk/pdbsum/5fnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 21:		Line 21:

	==See Also==		==See Also==
-	*[[Kelch-like protein\|Kelch-like protein]]	+	*[[Kelch-like protein 3D structures\|Kelch-like protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Lk3 transgenic mice]]		[[Category: Lk3 transgenic mice]]
	[[Category: Bolognese, B J]]		[[Category: Bolognese, B J]]

OCA at 06:46, 4 April 2018

2018-04-04T06:46:26Z

←Older revision		Revision as of 06:46, 4 April 2018
Line 3:		Line 3:
	<StructureSection load='5fnu' size='340' side='right' caption='[[5fnu]], [[Resolution\|resolution]] 1.78Å' scene=''>		<StructureSection load='5fnu' size='340' side='right' caption='[[5fnu]], [[Resolution\|resolution]] 1.78Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fnu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FNU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fnu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FNU FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L6I:(3S)-3-(7-METHOXY-1-METHYL-1H-BENZO[D][1,2,3]TRIAZOL-5-YL)-3-(4-METHYL-3-(((R)-4-METHYL-1,1-DIOXIDO-3,4-DIHYDRO-2H-BENZO[B][1,4,5]OXATHIAZEPIN-2-YL)METHYL)PHENYL)PROPANOIC+ACID'>L6I</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L6I:(3S)-3-(7-METHOXY-1-METHYL-1H-BENZO[D][1,2,3]TRIAZOL-5-YL)-3-(4-METHYL-3-(((R)-4-METHYL-1,1-DIOXIDO-3,4-DIHYDRO-2H-BENZO[B][1,4,5]OXATHIAZEPIN-2-YL)METHYL)PHENYL)PROPANOIC+ACID'>L6I</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fnq\|5fnq]], [[5fnr\|5fnr]], [[5fns\|5fns]], [[5fnt\|5fnt]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fnq\|5fnq]], [[5fnr\|5fnr]], [[5fns\|5fns]], [[5fnt\|5fnt]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnu OCA], [http://pdbe.org/5fnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnu RCSB], [http://www.ebi.ac.uk/pdbsum/5fnu PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnu OCA], [http://pdbe.org/5fnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnu RCSB], [http://www.ebi.ac.uk/pdbsum/5fnu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fnu ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5fnu" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fnu" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Kelch-like protein\|Kelch-like protein]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Bolognese, B J]]		[[Category: Bolognese, B J]]
	[[Category: Callahan, J F]]		[[Category: Callahan, J F]]

OCA at 05:44, 11 May 2016

2016-05-11T05:44:26Z

←Older revision		Revision as of 05:44, 11 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fnu is ~~ON HOLD~~ ~~until Paper~~ Publication	+	==Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.==
		+	<StructureSection load='5fnu' size='340' side='right' caption='[[5fnu]], [[Resolution\|resolution]] 1.78Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fnu]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FNU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FNU FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=L6I:(3S)-3-(7-METHOXY-1-METHYL-1H-BENZO[D][1,2,3]TRIAZOL-5-YL)-3-(4-METHYL-3-(((R)-4-METHYL-1,1-DIOXIDO-3,4-DIHYDRO-2H-BENZO[B][1,4,5]OXATHIAZEPIN-2-YL)METHYL)PHENYL)PROPANOIC+ACID'>L6I</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fnq\|5fnq]], [[5fnr\|5fnr]], [[5fns\|5fns]], [[5fnt\|5fnt]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fnu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fnu OCA], [http://pdbe.org/5fnu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fnu RCSB], [http://www.ebi.ac.uk/pdbsum/5fnu PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KEAP1_MOUSE KEAP1_MOUSE]] Retains NFE2L2/NRF2 in the cytosol. Functions as substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1. Targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. May also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome (By similarity).<ref>PMID:9887101</ref> <ref>PMID:12682069</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	KEAP1 is the key regulator of the NRF2-mediated cytoprotective response, and increasingly recognized as a target for diseases involving oxidative stress. Pharmacological intervention has focused on molecules that decrease NRF2-ubiquitination through covalent modification of KEAP1 cysteine residues, but such electrophilic compounds lack selectivity and may be associated with off-target toxicity. We report here the first use of a fragment-based approach to directly target the KEAP1 Kelch-NRF2 interaction. X-ray crystallographic screening identified three distinct "hot-spots" for fragment binding within the NRF2 binding pocket of KEAP1, allowing progression of a weak fragment hit to molecules with nanomolar affinity for KEAP1 while maintaining drug-like properties. This work resulted in a promising lead compound which exhibits tight and selective binding to KEAP1, and activates the NRF2 antioxidant response in cellular and in vivo models, thereby providing a high quality chemical probe to explore the therapeutic potential of disrupting the KEAP1-NRF2 interaction.

-	~~Authors~~: Davies~~, T.G.~~, Wixted~~, W.E.~~, Coyle~~, J.E.~~, Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich~~, S.J.~~, Richardson, C., Saxty, G., Willems~~, H.M.G.~~, Woolford~~, A.J.~~, Cottom~~, J.E.~~, Kou~~, J.~~, Yonchuk~~, J.G.~~, Feldser~~, H.G.~~, Sanchez, Y., Foley~~, J.P.~~, Bolognese~~, B.J.~~, Logan, G., Podolin~~, P.L.~~, Yan, H., Callahan, J.F.~~, Heightman, T~~.D., ~~Kerns, J.K~~.	+	Monoacidic Inhibitors of the Kelch-like ECH-Associated Protein 1: Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1:NRF2) Protein-Protein Interaction with High Cell Potency Identified by Fragment-Based Discovery.,Davies TG, Wixted WE, Coyle JE, Griffiths-Jones C, Hearn K, McMenamin R, Norton D, Rich SJ, Richardson C, Saxty G, Willems HM, Woolford AJ, Cottom JE, Kou JP, Yonchuk JG, Feldser HG, Sanchez Y, Foley JP, Bolognese BJ, Logan G, Podolin PL, Yan H, Callahan JF, Heightman TD, Kerns JK J Med Chem. 2016 Apr 28;59(8):3991-4006. doi: 10.1021/acs.jmedchem.6b00228. Epub , 2016 Apr 12. PMID:27031670<ref>PMID:27031670</ref>

-	~~Description: Structure~~ of the ~~Keap1 Kelch domain in complex with a small molecule inhibitor~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Kou~~, J]]	+	<div class="pdbe-citations 5fnu" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Willems~~, ~~H.M.G~~]]	+	== References ==
-	[[Category: Coyle, J.E]]	+	<references/>
-	[[Category: ~~Cottom~~, ~~J.E~~]]	+	__TOC__
-	[[Category: ~~Woolford~~, ~~A.J~~]]	+	</StructureSection>
-	[[Category: ~~Podolin~~, P.L]]	+	[[Category: Bolognese, B J]]
		+	[[Category: Callahan, J F]]
		+	[[Category: Cottom, J E]]
		+	[[Category: Coyle, J E]]
		+	[[Category: Davies, T G]]
		+	[[Category: Feldser, H G]]
		+	[[Category: Foley, J P]]
		+	[[Category: Griffiths-Jones, C]]
	[[Category: Hearn, K]]		[[Category: Hearn, K]]
-	[[Category: ~~Yonchuk~~, J.G]]	+	[[Category: Heightman, T D]]
		+	[[Category: Kerns, J K]]
		+	[[Category: Kou, J]]
		+	[[Category: Logan, G]]
		+	[[Category: McMenamin, R]]
		+	[[Category: Norton, D]]
		+	[[Category: Podolin, P L]]
		+	[[Category: Rich, S J]]
		+	[[Category: Richardson, C]]
	[[Category: Sanchez, Y]]		[[Category: Sanchez, Y]]
-	[[Category: Bolognese, B.J]]
-	[[Category: Mcmenamin, R]]
-	[[Category: Heightman, T.D]]
-	[[Category: Foley, J.P]]
-	[[Category: Griffiths-Jones, C]]
-	[[Category: Feldser, H.G]]
	[[Category: Saxty, G]]		[[Category: Saxty, G]]
-	[[Category: ~~Davies~~, T.G]]	+	[[Category: Willems, H M.G]]
-	[[Category: ~~Callahan~~, ~~J.F~~]]	+	[[Category: Wixted, W E]]
-	[[Category: ~~Norton, D]]~~	+	[[Category: Woolford, A J]]
-	~~[[Category: Kerns~~, J.K]]	+
	[[Category: Yan, H]]		[[Category: Yan, H]]
-	[[Category: ~~Rich~~, S.J]]	+	[[Category: Yonchuk, J G]]
-	[[Category: ~~Logan, G~~]]	+	[[Category: Keap1]]
-	[[Category: ~~Wixted, W.E~~]]	+	[[Category: Nrf2]]
-	[[Category: ~~Richardson, C~~]]	+	[[Category: Oxidative stress]]
		+	[[Category: Transcription]]

OCA at 15:22, 2 December 2015

2015-12-02T15:22:34Z

←Older revision		Revision as of 15:22, 2 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fnu is ON HOLD	+	The entry 5fnu is ON HOLD until Paper Publication

	Authors: Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.		Authors: Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.

OCA: Protected "5fnu" [edit=sysop:move=sysop]

2015-12-01T03:42:48Z

Protected "5fnu" [edit=sysop:move=sysop]

←Older revision

Revision as of 03:42, 1 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fnu is ON HOLD Authors: Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson,...

2015-12-01T03:42:46Z

New page: '''Unreleased structure''' The entry 5fnu is ON HOLD Authors: Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson,...

New page

'''Unreleased structure'''

The entry 5fnu is ON HOLD

Authors: Davies, T.G., Wixted, W.E., Coyle, J.E., Griffiths-Jones, C., Hearn, K., McMenamin, R., Norton, D., Rich, S.J., Richardson, C., Saxty, G., Willems, H.M.G., Woolford, A.J., Cottom, J.E., Kou, J., Yonchuk, J.G., Feldser, H.G., Sanchez, Y., Foley, J.P., Bolognese, B.J., Logan, G., Podolin, P.L., Yan, H., Callahan, J.F., Heightman, T.D., Kerns, J.K.

Description: Structure of the Keap1 Kelch domain in complex with a small molecule inhibitor.
[[Category: Unreleased Structures]]
[[Category: Kou, J]]
[[Category: Willems, H.M.G]]
[[Category: Coyle, J.E]]
[[Category: Cottom, J.E]]
[[Category: Woolford, A.J]]
[[Category: Podolin, P.L]]
[[Category: Hearn, K]]
[[Category: Yonchuk, J.G]]
[[Category: Sanchez, Y]]
[[Category: Bolognese, B.J]]
[[Category: Mcmenamin, R]]
[[Category: Heightman, T.D]]
[[Category: Foley, J.P]]
[[Category: Griffiths-Jones, C]]
[[Category: Feldser, H.G]]
[[Category: Saxty, G]]
[[Category: Davies, T.G]]
[[Category: Callahan, J.F]]
[[Category: Norton, D]]
[[Category: Kerns, J.K]]
[[Category: Yan, H]]
[[Category: Rich, S.J]]
[[Category: Logan, G]]
[[Category: Wixted, W.E]]
[[Category: Richardson, C]]