5fr9 - Revision history

OCA at 13:19, 26 July 2023

2023-07-26T13:19:52Z

←Older revision		Revision as of 13:19, 26 July 2023
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	<StructureSection load='5fr9' size='340' side='right'caption='[[5fr9]], [[Resolution\|resolution]] 2.81Å' scene=''>		<StructureSection load='5fr9' size='340' side='right'caption='[[5fr9]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fr9]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Artsp Artsp~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR9 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fr9]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Arthrobacter_sp. Arthrobacter sp.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FR9 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=9HC:[4~~-[~~3-(4-BROMOPHENYL)-3-OXIDANYLIDENE-PROPYL~~]~~-6-METHYL-5-OXIDANYL-PYRIDIN-3-YL~~]~~METHYL+PHOSPHATE'>9HC</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.81Å</td></tr>
-	<tr id='~~activity~~'><td class="sblockLbl"><b>~~Activity~~:</b></td><td class="sblockDat"><~~span class~~='~~plainlinks'>~~[~~http://en.wikipedia.org/wiki/Beta~~-~~alanine~~--~~pyruvate_transaminase Beta~~-~~alanine~~--~~pyruvate transaminase~~]~~, with EC number [http://www.brenda~~-~~enzymes.info/php/result_flat.php4?ecno=2.~~6~~.1.18 2.6.1.18~~] </~~span~~></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9HC:[4-[3-(4-BROMOPHENYL)-3-OXIDANYLIDENE-PROPYL]-6-METHYL-5-OXIDANYL-PYRIDIN-3-YL]METHYL+PHOSPHATE'>9HC</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr9 OCA], [~~http~~://pdbe.org/5fr9 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fr9 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fr9 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fr9 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr9 OCA], [https://pdbe.org/5fr9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fr9 RCSB], [https://www.ebi.ac.uk/pdbsum/5fr9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fr9 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F7J696_9MICC F7J696_9MICC]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Artsp]]~~	+	[[Category: Arthrobacter sp]]
-	~~[[Category: Beta-alanine--pyruvate transaminase~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cuetos, A]]	+	[[Category: Cuetos A]]
-	[[Category: Grogan, G]]	+	[[Category: Grogan G]]
-	[[Category: Kroutil, W]]	+	[[Category: Kroutil W]]
-	[[Category: Lavandera, I]]	+	[[Category: Lavandera I]]
-	~~[[Category: Aminotransferase]]~~	+
-	~~[[Category: Fluoroamine]]~~	+
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Plp]]~~	+
-	~~[[Category: Transferase]]~~	+
-	~~[[Category: Transminase~~]]	+

OCA at 07:33, 6 May 2020

2020-05-06T07:33:20Z

←Older revision		Revision as of 07:33, 6 May 2020
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	==Structure of transaminase ATA-117 arRmut11 from Arthrobacter sp. KNK168 inhibited with 1-(4-Bromophenyl)-2-fluoroethylamine==		==Structure of transaminase ATA-117 arRmut11 from Arthrobacter sp. KNK168 inhibited with 1-(4-Bromophenyl)-2-fluoroethylamine==
-	<StructureSection load='5fr9' size='340' side='right' caption='[[5fr9]], [[Resolution\|resolution]] 2.81Å' scene=''>	+	<StructureSection load='5fr9' size='340' side='right'caption='[[5fr9]], [[Resolution\|resolution]] 2.81Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fr9]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR9 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FR9 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fr9]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Artsp Artsp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR9 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FR9 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9HC:[4-[3-(4-BROMOPHENYL)-3-OXIDANYLIDENE-PROPYL]-6-METHYL-5-OXIDANYL-PYRIDIN-3-YL]METHYL+PHOSPHATE'>9HC</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=9HC:[4-[3-(4-BROMOPHENYL)-3-OXIDANYLIDENE-PROPYL]-6-METHYL-5-OXIDANYL-PYRIDIN-3-YL]METHYL+PHOSPHATE'>9HC</scene></td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-alanine--pyruvate_transaminase Beta-alanine--pyruvate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.18 2.6.1.18] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-alanine--pyruvate_transaminase Beta-alanine--pyruvate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.18 2.6.1.18] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr9 OCA], [http://pdbe.org/5fr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fr9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fr9 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr9 OCA], [http://pdbe.org/5fr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fr9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fr9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fr9 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Artsp]]
	[[Category: Beta-alanine--pyruvate transaminase]]		[[Category: Beta-alanine--pyruvate transaminase]]
		+	[[Category: Large Structures]]
	[[Category: Cuetos, A]]		[[Category: Cuetos, A]]
	[[Category: Grogan, G]]		[[Category: Grogan, G]]

OCA at 15:03, 2 March 2016

2016-03-02T15:03:32Z

←Older revision		Revision as of 15:03, 2 March 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fr9 is ~~ON HOLD~~	+	==Structure of transaminase ATA-117 arRmut11 from Arthrobacter sp. KNK168 inhibited with 1-(4-Bromophenyl)-2-fluoroethylamine==
		+	<StructureSection load='5fr9' size='340' side='right' caption='[[5fr9]], [[Resolution\|resolution]] 2.81Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fr9]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FR9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FR9 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=9HC:[4-[3-(4-BROMOPHENYL)-3-OXIDANYLIDENE-PROPYL]-6-METHYL-5-OXIDANYL-PYRIDIN-3-YL]METHYL+PHOSPHATE'>9HC</scene></td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-alanine--pyruvate_transaminase Beta-alanine--pyruvate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.18 2.6.1.18] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fr9 OCA], [http://pdbe.org/5fr9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fr9 RCSB], [http://www.ebi.ac.uk/pdbsum/5fr9 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Transaminases are valuable enzymes for industrial biocatalysis and enable the preparation of optically pure amines. For these transformations they require either an amine donor (amination of ketones) or an amine acceptor (deamination of racemic amines). Herein transaminases are shown to react with aromatic beta-fluoroamines, thus leading to simultaneous enantioselective dehalogenation and deamination to form the corresponding acetophenone derivatives in the absence of an amine acceptor. A series of racemic beta-fluoroamines was resolved in a kinetic resolution by tandem hydrodefluorination/deamination, thus giving the corresponding amines with up to greater than 99 % ee. This protocol is the first example of exploiting the catalytic promiscuity of transaminases as a tool for novel transformations.

-	~~Authors~~: Cuetos, A., ~~Kroutil~~, W., Lavandera, I., ~~Grogan, G~~.	+	Catalytic Promiscuity of Transaminases: Preparation of Enantioenriched beta-Fluoroamines by Formal Tandem Hydrodefluorination/Deamination.,Cuetos A, Garcia-Ramos M, Fischereder EM, Diaz-Rodriguez A, Grogan G, Gotor V, Kroutil W, Lavandera I Angew Chem Int Ed Engl. 2016 Feb;55(9):3144-7. doi: 10.1002/anie.201510554. Epub , 2016 Feb 2. PMID:26836037<ref>PMID:26836037</ref>

-	~~Description: Structure~~ of ~~transaminase ATA-117 arRmut11 from Arthrobacter sp~~. ~~KNK168 inhibited with 1-(4~~-~~Bromophenyl)~~-~~2-fluoroethylamine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	[[Category: ~~Kroutil, W~~]]	+	<div class="pdbe-citations 5fr9" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Beta-alanine--pyruvate transaminase]]
	[[Category: Cuetos, A]]		[[Category: Cuetos, A]]
-	[[Category: Lavandera, I]]
	[[Category: Grogan, G]]		[[Category: Grogan, G]]
		+	[[Category: Kroutil, W]]
		+	[[Category: Lavandera, I]]
		+	[[Category: Aminotransferase]]
		+	[[Category: Fluoroamine]]
		+	[[Category: Inhibitor]]
		+	[[Category: Plp]]
		+	[[Category: Transferase]]
		+	[[Category: Transminase]]

OCA at 18:19, 30 December 2015

2015-12-30T18:19:15Z

←Older revision		Revision as of 18:19, 30 December 2015
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fr9 is ON HOLD ~~until sometime in the future~~	+	The entry 5fr9 is ON HOLD

	Authors: Cuetos, A., Kroutil, W., Lavandera, I., Grogan, G.		Authors: Cuetos, A., Kroutil, W., Lavandera, I., Grogan, G.

OCA: Protected "5fr9" [edit=sysop:move=sysop]

2015-12-23T11:51:05Z

Protected "5fr9" [edit=sysop:move=sysop]

←Older revision

Revision as of 11:51, 23 December 2015

OCA: New page: '''Unreleased structure''' The entry 5fr9 is ON HOLD until sometime in the future Authors: Cuetos, A., Kroutil, W., Lavandera, I., Grogan, G. Description: Structure of transaminase ATA...

2015-12-23T11:51:04Z

New page: '''Unreleased structure''' The entry 5fr9 is ON HOLD until sometime in the future Authors: Cuetos, A., Kroutil, W., Lavandera, I., Grogan, G. Description: Structure of transaminase ATA...

New page

'''Unreleased structure'''

The entry 5fr9 is ON HOLD until sometime in the future

Authors: Cuetos, A., Kroutil, W., Lavandera, I., Grogan, G.

Description: Structure of transaminase ATA-117 arRmut11 from Arthrobacter sp. KNK168 inhibited with 1-(4-Bromophenyl)-2-fluoroethylamine
[[Category: Unreleased Structures]]
[[Category: Kroutil, W]]
[[Category: Cuetos, A]]
[[Category: Lavandera, I]]
[[Category: Grogan, G]]