5fvp - Revision history

OCA at 13:28, 26 July 2023

2023-07-26T13:28:50Z

←Older revision		Revision as of 13:28, 26 July 2023
Line 3:		Line 3:
	<StructureSection load='5fvp' size='340' side='right'caption='[[5fvp]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5fvp' size='340' side='right'caption='[[5fvp]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fvp]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVP OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FVP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fvp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FVP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=WOS:4-METHYL-6-[2-(5-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYL]PYRIDIN-2-AMINE'>WOS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.099Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvs\|5fvs]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=WOS:4-METHYL-6-[2-(5-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYL]PYRIDIN-2-AMINE'>WOS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvp OCA], [https://pdbe.org/5fvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fvp RCSB], [https://www.ebi.ac.uk/pdbsum/5fvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvp ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvp OCA], [~~http~~://pdbe.org/5fvp PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fvp RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fvp PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvp ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.	+	[https://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 26:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Li, H~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Poulos, T L~~]]	+	[[Category: Li H]]
-	[[Category: ~~Inhibitor complex]]~~	+	[[Category: Poulos TL]]
-	~~[[Category: Nitric oxide synthase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 07:39, 6 May 2020

2020-05-06T07:39:32Z

←Older revision		Revision as of 07:39, 6 May 2020
Line 1:		Line 1:

	==Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-[2-(5-morpholin-4-ylpyridin-3-yl)ethyl]pyridin-2-amine==		==Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-[2-(5-morpholin-4-ylpyridin-3-yl)ethyl]pyridin-2-amine==
-	<StructureSection load='5fvp' size='340' side='right' caption='[[5fvp]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5fvp' size='340' side='right'caption='[[5fvp]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fvp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVP OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FVP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fvp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVP OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FVP FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=WOS:4-METHYL-6-[2-(5-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYL]PYRIDIN-2-AMINE'>WOS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=WOS:4-METHYL-6-[2-(5-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYL]PYRIDIN-2-AMINE'>WOS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvs\|5fvs]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvs\|5fvs]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvp OCA], [http://pdbe.org/5fvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvp RCSB], [http://www.ebi.ac.uk/pdbsum/5fvp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvp ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvp OCA], [http://pdbe.org/5fvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvp RCSB], [http://www.ebi.ac.uk/pdbsum/5fvp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5fvp" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5fvp" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 25:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Buffalo rat]]		[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 12:37, 16 November 2017

2017-11-16T12:37:17Z

←Older revision		Revision as of 12:37, 16 November 2017
Line 3:		Line 3:
	<StructureSection load='5fvp' size='340' side='right' caption='[[5fvp]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5fvp' size='340' side='right' caption='[[5fvp]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fvp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FVP FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fvp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FVP FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=WOS:4-METHYL-6-[2-(5-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYL]PYRIDIN-2-AMINE'>WOS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=WOS:4-METHYL-6-[2-(5-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYL]PYRIDIN-2-AMINE'>WOS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvs\|5fvs]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvs\|5fvs]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvp OCA], [http://pdbe.org/5fvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvp RCSB], [http://www.ebi.ac.uk/pdbsum/5fvp PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvp OCA], [http://pdbe.org/5fvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvp RCSB], [http://www.ebi.ac.uk/pdbsum/5fvp PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fvp ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 24:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
	[[Category: Li, H]]		[[Category: Li, H]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 18:45, 12 May 2016

2016-05-12T18:45:30Z

←Older revision		Revision as of 18:45, 12 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fvp is ~~ON HOLD until Paper~~ Publication	+	==Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-[2-(5-morpholin-4-ylpyridin-3-yl)ethyl]pyridin-2-amine==
		+	<StructureSection load='5fvp' size='340' side='right' caption='[[5fvp]], [[Resolution\|resolution]] 2.10Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5fvp]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FVP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FVP FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=WOS:4-METHYL-6-[2-(5-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYL]PYRIDIN-2-AMINE'>WOS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fvo\|5fvo]], [[5fvq\|5fvq]], [[5fvr\|5fvr]], [[5fvs\|5fvs]], [[5fvt\|5fvt]], [[5fvu\|5fvu]], [[5fvv\|5fvv]], [[5fvw\|5fvw]], [[5fvx\|5fvx]], [[5fvy\|5fvy]], [[5fvz\|5fvz]], [[5fw0\|5fw0]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NADPH_dependent) Nitric-oxide synthase (NADPH dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.39 1.14.13.39] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fvp OCA], [http://pdbe.org/5fvp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fvp RCSB], [http://www.ebi.ac.uk/pdbsum/5fvp PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOS1_RAT NOS1_RAT]] Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR. Inhibitory transmitter for non-adrenergic and non-cholinergic nerves in the colorectum.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Neuronal nitric oxide synthase (nNOS) is an important therapeutic target for the treatment of various neurodegenerative disorders. A major challenge in the design of nNOS inhibitors focuses on potency in humans and selectivity over other NOS isoforms. Here we report potent and selective human nNOS inhibitors based on the 2-aminopyridine scaffold with a central pyridine linker. Compound 14j, the most promising inhibitor in this study, exhibits excellent potency for rat nNOS (Ki = 16 nM) with 828-fold n/e and 118-fold n/i selectivity with a Ki value of 13 nM against human nNOS with 1761-fold human n/e selectivity. Compound 14j also displayed good metabolic stability in human liver microsomes, low plasma protein binding, and minimal binding to cytochromes P450 (CYPs), although it had little to no Caco-2 permeability.

-	~~Authors: Li~~, H., Poulos, T.L.	+	Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.,Wang HY, Qin Y, Li H, Roman LJ, Martasek P, Poulos TL, Silverman RB J Med Chem. 2016 Apr 20. PMID:27050842<ref>PMID:27050842</ref>

-	~~Description: Structure~~ of ~~rat neuronal nitric oxide synthase heme domain in complex with 4~~-~~methyl~~-~~6-[2-(5-morpholin-4-ylpyridin-3-yl)ethyl]pyridin-2-amine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
-	~~[[Category: Poulos, T.L]]~~	+	<div class="pdbe-citations 5fvp" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Li, H]]		[[Category: Li, H]]
		+	[[Category: Poulos, T L]]
		+	[[Category: Inhibitor complex]]
		+	[[Category: Nitric oxide synthase]]
		+	[[Category: Oxidoreductase]]

OCA at 12:15, 2 March 2016

2016-03-02T12:15:13Z

←Older revision		Revision as of 12:15, 2 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5fvp is ON HOLD	+	The entry 5fvp is ON HOLD until Paper Publication

	Authors: Li, H., Poulos, T.L.		Authors: Li, H., Poulos, T.L.

-	Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with ~~HW49~~	+	Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-[2-(5-morpholin-4-ylpyridin-3-yl)ethyl]pyridin-2-amine
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Poulos, T.L]]		[[Category: Poulos, T.L]]
	[[Category: Li, H]]		[[Category: Li, H]]

OCA: Protected "5fvp" [edit=sysop:move=sysop]

2016-02-21T00:28:22Z

Protected "5fvp" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:28, 21 February 2016

OCA: New page: '''Unreleased structure''' The entry 5fvp is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with HW49 [[Categ...

2016-02-21T00:28:20Z

New page: '''Unreleased structure''' The entry 5fvp is ON HOLD Authors: Li, H., Poulos, T.L. Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with HW49 [[Categ...

New page

'''Unreleased structure'''

The entry 5fvp is ON HOLD

Authors: Li, H., Poulos, T.L.

Description: Structure of rat neuronal nitric oxide synthase heme domain in complex with HW49
[[Category: Unreleased Structures]]
[[Category: Poulos, T.L]]
[[Category: Li, H]]