5fzg - Revision history

OCA at 13:33, 26 July 2023

2023-07-26T13:33:16Z

←Older revision		Revision as of 13:33, 26 July 2023
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	<StructureSection load='5fzg' size='340' side='right'caption='[[5fzg]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='5fzg' size='340' side='right'caption='[[5fzg]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fzg]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZG OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5FZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fzg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5FZG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7IA:[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETIC+ACID'>7IA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.96Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7IA:[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETIC+ACID'>7IA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5fzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzg OCA], [~~http~~://pdbe.org/5fzg PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5fzg RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5fzg PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5fzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzg OCA], [https://pdbe.org/5fzg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5fzg RCSB], [https://www.ebi.ac.uk/pdbsum/5fzg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>	+	[https://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>

	==See Also==		==See Also==
Line 18:		Line 18:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	[[Category: Burgess-Brown~~, N A]]~~	+	[[Category: Burgess-Brown NA]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Gileadi C]]
-	[[Category: Gileadi, C]]	+	[[Category: Johansson C]]
-	[[Category: Johansson, C]]	+	[[Category: Krojer T]]
-	[[Category: Krojer, T]]	+	[[Category: Kupinska K]]
-	[[Category: Kupinska, K]]	+	[[Category: Mai A]]
-	[[Category: Mai, A]]	+	[[Category: Nowak R]]
-	[[Category: Nowak, R]]	+	[[Category: Oppermann U]]
-	[[Category: Oppermann, U]]	+	[[Category: Rotili D]]
-	[[Category: Rotili, D]]	+	[[Category: Srikannathasan V]]
-	[[Category: Srikannathasan, V]]	+	[[Category: Strain-Damerell C]]
-	[[Category: Strain-Damerell, C]]	+	[[Category: Szykowska A]]
-	[[Category: Szykowska, A]]	+	[[Category: Von Delft F]]
-	[[Category: ~~Jarid1b]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Plu1~~]]	+

OCA at 06:31, 13 May 2020

2020-05-13T06:31:44Z

←Older revision		Revision as of 06:31, 13 May 2020
Line 1:		Line 1:

	==Crystal structure of the catalytic domain of human JARID1B in complex with MC3948==		==Crystal structure of the catalytic domain of human JARID1B in complex with MC3948==
-	<StructureSection load='5fzg' size='340' side='right' caption='[[5fzg]], [[Resolution\|resolution]] 1.96Å' scene=''>	+	<StructureSection load='5fzg' size='340' side='right'caption='[[5fzg]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZG OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5FZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZG OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5FZG FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7IA:[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETIC+ACID'>7IA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7IA:[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETIC+ACID'>7IA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5fzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzg OCA], [http://pdbe.org/5fzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzg RCSB], [http://www.ebi.ac.uk/pdbsum/5fzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzg ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5fzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzg OCA], [http://pdbe.org/5fzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzg RCSB], [http://www.ebi.ac.uk/pdbsum/5fzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzg ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>		[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
		+
		+	==See Also==
		+	*[[Jumonji domain-containing protein 3D structures\|Jumonji domain-containing protein 3D structures]]
		+	*[[Lysine-specific histone demethylase 3D structures\|Lysine-specific histone demethylase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 15:		Line 19:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 20:34, 24 January 2018

2018-01-24T20:34:00Z

←Older revision		Revision as of 20:34, 24 January 2018
Line 3:		Line 3:
	<StructureSection load='5fzg' size='340' side='right' caption='[[5fzg]], [[Resolution\|resolution]] 1.96Å' scene=''>		<StructureSection load='5fzg' size='340' side='right' caption='[[5fzg]], [[Resolution\|resolution]] 1.96Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5fzg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZG FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5fzg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZG FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7IA:[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETIC+ACID'>7IA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7IA:[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETIC+ACID'>7IA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>
Line 14:		Line 14:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]
	[[Category: Burgess-Brown, N A]]		[[Category: Burgess-Brown, N A]]
-	[[Category: Delft, F ~~Von~~]]	+	[[Category: Delft, F von]]
	[[Category: Edwards, A M]]		[[Category: Edwards, A M]]
	[[Category: Gileadi, C]]		[[Category: Gileadi, C]]

OCA at 13:42, 29 March 2017

2017-03-29T13:42:37Z

←Older revision		Revision as of 13:42, 29 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5fzg is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the catalytic domain of human JARID1B in complex with MC3948==
-		+	<StructureSection load='5fzg' size='340' side='right' caption='[[5fzg]], [[Resolution\|resolution]] 1.96Å' scene=''>
-	~~Authors~~: ~~Nowak~~, R., ~~Krojer~~, T., ~~Johansson~~, C., ~~Gileadi~~, C., ~~Kupinska~~, K., ~~Strain-Damerell~~, C., ~~Szykowska~~, A., ~~Srikannathasan~~, V., ~~Von Delft~~, F., ~~Burgess~~-~~Brown~~, N.A., ~~Arrowsmith~~, C.H., ~~Bountra~~, C., ~~Edwards~~, A.M., ~~Rotili, D~~., ~~Mai~~, A., ~~Oppermann~~, U.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5fzg]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FZG FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the catalytic domain of human JARID1B in complex with MC3948~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7IA:[(6-OXO-4-PHENYL-1,6-DIHYDROPYRIMIDIN-2-YL)SULFANYL]ACETIC+ACID'>7IA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5fyc\|5fyc]], [[5fyh\|5fyh]], [[5fyi\|5fyi]], [[5fym\|5fym]], [[5fys\|5fys]], [[5fyt\|5fyt]], [[5fyu\|5fyu]], [[5fyv\|5fyv]], [[5fyy\|5fyy]], [[5fyz\|5fyz]], [[5fz0\|5fz0]], [[5fz1\|5fz1]], [[5fz3\|5fz3]], [[5fz4\|5fz4]], [[5fz6\|5fz6]], [[5fz7\|5fz7]], [[5fz8\|5fz8]], [[5fz9\|5fz9]], [[5fza\|5fza]], [[5fzb\|5fzb]], [[5fzc\|5fzc]], [[5fzd\|5fzd]], [[5fze\|5fze]], [[5fzf\|5fzf]], [[5fzh\|5fzh]], [[5fzi\|5fzi]], [[5fzk\|5fzk]], [[5fzl\|5fzl]], [[5fzm\|5fzm]], [[5fzo\|5fzo]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fzg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fzg OCA], [http://pdbe.org/5fzg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fzg RCSB], [http://www.ebi.ac.uk/pdbsum/5fzg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fzg ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/KDM5B_HUMAN KDM5B_HUMAN]] Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.<ref>PMID:12657635</ref> <ref>PMID:16645588</ref> <ref>PMID:17320161</ref> <ref>PMID:17363312</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Burgess-Brown, N A]]
		+	[[Category: Delft, F Von]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Gileadi, C]]
		+	[[Category: Johansson, C]]
		+	[[Category: Krojer, T]]
		+	[[Category: Kupinska, K]]
		+	[[Category: Mai, A]]
	[[Category: Nowak, R]]		[[Category: Nowak, R]]
-	[[Category: Arrowsmith, C.H]]
-	[[Category: Gileadi, C]]
	[[Category: Oppermann, U]]		[[Category: Oppermann, U]]
	[[Category: Rotili, D]]		[[Category: Rotili, D]]
		+	[[Category: Srikannathasan, V]]
		+	[[Category: Strain-Damerell, C]]
	[[Category: Szykowska, A]]		[[Category: Szykowska, A]]
-	[[Category: ~~Burgess-Brown, N.A~~]]	+	[[Category: Jarid1b]]
-	[[Category: ~~Von Delft, F~~]]	+	[[Category: Oxidoreductase]]
-	[[Category: ~~Edwards, A.M]]~~	+	[[Category: Plu1]]
-	~~[[Category: Johansson, C]]~~	+
-	~~[[Category: Mai, A]]~~	+
-	~~[[Category: Strain-Damerell, C]]~~	+
-	~~[[Category: Krojer, T]]~~	+
-	~~[[Category: Srikannathasan, V]]~~	+
-	~~[[Category: Bountra, C]]~~	+
-	~~[[Category: Kupinska, K~~]]	+

OCA at 08:45, 9 March 2017

2017-03-09T08:45:47Z

←Older revision		Revision as of 08:45, 9 March 2017
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	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Nowak, R]]		[[Category: Nowak, R]]
-	[[Category: Rotili, D]]
-	[[Category: Burgess-Brown, N.A]]
-	[[Category: Krojer, T]]
-	[[Category: Bountra, C]]
-	[[Category: Kupinska, K]]
	[[Category: Arrowsmith, C.H]]		[[Category: Arrowsmith, C.H]]
	[[Category: Gileadi, C]]		[[Category: Gileadi, C]]
	[[Category: Oppermann, U]]		[[Category: Oppermann, U]]
		+	[[Category: Rotili, D]]
	[[Category: Szykowska, A]]		[[Category: Szykowska, A]]
		+	[[Category: Burgess-Brown, N.A]]
	[[Category: Von Delft, F]]		[[Category: Von Delft, F]]
	[[Category: Edwards, A.M]]		[[Category: Edwards, A.M]]
Line 22:		Line 19:
	[[Category: Mai, A]]		[[Category: Mai, A]]
	[[Category: Strain-Damerell, C]]		[[Category: Strain-Damerell, C]]
		+	[[Category: Krojer, T]]
	[[Category: Srikannathasan, V]]		[[Category: Srikannathasan, V]]
		+	[[Category: Bountra, C]]
		+	[[Category: Kupinska, K]]

OCA: Protected "5fzg" [edit=sysop:move=sysop]

2016-05-10T23:15:58Z

Protected "5fzg" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:15, 10 May 2016

OCA: New page: '''Unreleased structure''' The entry 5fzg is ON HOLD until Paper Publication Authors: Nowak, R., Krojer, T., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A....

2016-05-10T23:15:57Z

New page: '''Unreleased structure''' The entry 5fzg is ON HOLD until Paper Publication Authors: Nowak, R., Krojer, T., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A....

New page

'''Unreleased structure'''

The entry 5fzg is ON HOLD until Paper Publication

Authors: Nowak, R., Krojer, T., Johansson, C., Gileadi, C., Kupinska, K., Strain-Damerell, C., Szykowska, A., Srikannathasan, V., Von Delft, F., Burgess-Brown, N.A., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Rotili, D., Mai, A., Oppermann, U.

Description: Crystal structure of the catalytic domain of human JARID1B in complex with MC3948
[[Category: Unreleased Structures]]
[[Category: Nowak, R]]
[[Category: Rotili, D]]
[[Category: Burgess-Brown, N.A]]
[[Category: Krojer, T]]
[[Category: Bountra, C]]
[[Category: Kupinska, K]]
[[Category: Arrowsmith, C.H]]
[[Category: Gileadi, C]]
[[Category: Oppermann, U]]
[[Category: Szykowska, A]]
[[Category: Von Delft, F]]
[[Category: Edwards, A.M]]
[[Category: Johansson, C]]
[[Category: Mai, A]]
[[Category: Strain-Damerell, C]]
[[Category: Srikannathasan, V]]