5g60 - Revision history

OCA at 13:40, 26 July 2023

2023-07-26T13:40:11Z

←Older revision		Revision as of 13:40, 26 July 2023
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	<StructureSection load='5g60' size='340' side='right'caption='[[5g60]], [[Resolution\|resolution]] 1.99Å' scene=''>		<StructureSection load='5g60' size='340' side='right'caption='[[5g60]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g60]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Strpn Strpn~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G60 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5G60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g60]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G60 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=~~GOL~~:~~GLYCEROL~~'>~~GOL~~</scene>, <scene name='pdbligand=~~NYT~~:~~BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL+~~ALPHA-D-~~GLUCOPYRANOSIDE~~'>~~NYT~~</scene><~~/td~~></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.99Å</td></tr>
-	<~~tr id~~='~~related'><td class~~=~~"sblockLbl"><b>[[Related_structure\|Related~~:~~]]</b~~></td>~~<td class="sblockDat">[[5g5y\|5g5y]], [[5g5z\|5g5z]], [[5g61\|5g61]], [[5g62\|5g62]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FRU:FRUCTOSE'>FRU</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PRD_900044:nystose'>PRD_900044</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5g60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g60 OCA], [~~http~~://pdbe.org/5g60 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5g60 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5g60 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5g60 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g60 OCA], [https://pdbe.org/5g60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g60 RCSB], [https://www.ebi.ac.uk/pdbsum/5g60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g60 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FUSA_STRPN FUSA_STRPN] Part of the ABC transporter complex FusABC-MsmK involved in short- and long-chain fructooligosaccharide (FOS) import. Required for the utilization of long-chain FOSs (PubMed:23264576). Binds kestose, nystose, fructofuranosyl-nystose and inulin, but not sucrose. Has a preference for long-chain FOSs (tetrasaccharides and larger) (PubMed:27939783).<ref>PMID:27939783</ref> <ref>PMID:23264576</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Strpn~~]]	+	[[Category: Streptococcus pneumoniae TIGR4]]
-	[[Category: Culurgioni, S]]	+	[[Category: Culurgioni S]]
-	[[Category: Harris, G]]	+	[[Category: Harris G]]
-	[[Category: King~~, S J~~]]	+	[[Category: King SJ]]
-	[[Category: Singh~~, A K~~]]	+	[[Category: Singh AK]]
-	[[Category: Walsh~~, M A]]~~	+	[[Category: Walsh MA]]
-	~~[[Category: Abc-transporter]]~~	+
-	~~[[Category: Carbohydrate]]~~	+
-	~~[[Category: Fructo-nystose]]~~	+
-	~~[[Category: Fructooligosaccharide]]~~	+
-	~~[[Category: Fusa]]~~	+
-	~~[[Category: Kestose]]~~	+
-	~~[[Category: Nystose]]~~	+
-	~~[[Category: Pneumoniae]]~~	+
-	~~[[Category: Substrate-binding-protein]]~~	+
-	~~[[Category: Sugar]]~~	+
-	~~[[Category: Transport]]~~	+
-	~~[[Category: Transport protein]]~~	+
-	~~[[Category: Transporter~~]]	+

OCA at 06:40, 13 May 2020

2020-05-13T06:40:39Z

←Older revision		Revision as of 06:40, 13 May 2020
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	==S.pneumoniae ABC-transporter substrate binding protein FusA in complex with nystose==		==S.pneumoniae ABC-transporter substrate binding protein FusA in complex with nystose==
-	<StructureSection load='5g60' size='340' side='right' caption='[[5g60]], [[Resolution\|resolution]] 1.99Å' scene=''>	+	<StructureSection load='5g60' size='340' side='right'caption='[[5g60]], [[Resolution\|resolution]] 1.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g60]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G60 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5G60 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g60]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpn Strpn]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G60 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5G60 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NYT:BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL+ALPHA-D-GLUCOPYRANOSIDE'>NYT</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NYT:BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL+ALPHA-D-GLUCOPYRANOSIDE'>NYT</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g5y\|5g5y]], [[5g5z\|5g5z]], [[5g61\|5g61]], [[5g62\|5g62]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g5y\|5g5y]], [[5g5z\|5g5z]], [[5g61\|5g61]], [[5g62\|5g62]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5g60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g60 OCA], [http://pdbe.org/5g60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g60 RCSB], [http://www.ebi.ac.uk/pdbsum/5g60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g60 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5g60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g60 OCA], [http://pdbe.org/5g60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g60 RCSB], [http://www.ebi.ac.uk/pdbsum/5g60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g60 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Strpn]]
	[[Category: Culurgioni, S]]		[[Category: Culurgioni, S]]
	[[Category: Harris, G]]		[[Category: Harris, G]]

OCA at 16:13, 18 January 2017

2017-01-18T16:13:22Z

←Older revision		Revision as of 16:13, 18 January 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5g60 is ~~ON HOLD until Paper~~ Publication	+	==S.pneumoniae ABC-transporter substrate binding protein FusA in complex with nystose==
		+	<StructureSection load='5g60' size='340' side='right' caption='[[5g60]], [[Resolution\|resolution]] 1.99Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5g60]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G60 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G60 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NYT:BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL-(2- 1)-BETA-D-FRUCTOFURANOSYL+ALPHA-D-GLUCOPYRANOSIDE'>NYT</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g5y\|5g5y]], [[5g5z\|5g5z]], [[5g61\|5g61]], [[5g62\|5g62]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g60 OCA], [http://pdbe.org/5g60 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g60 RCSB], [http://www.ebi.ac.uk/pdbsum/5g60 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g60 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Streptococcus pneumoniae is dependent on carbohydrate uptake for colonization and pathogenesis, and dedicates over a third of its transport systems to their uptake. The ability of the pneumococcus to utilize fructooligosaccharides (FOSs) is attributed to the presence of one of two types of FOS ATP-binding cassette (ABC) transporters. Strains encoding SfuABC are only able to utilize short-chain FOSs, while strains encoding FusABC can utilize both short- and long-chain FOSs. The crystal structures of the substrate-binding protein FusA in its open and closed conformations bound to FOSs, and solution scattering data of SfuA, delineate the structural basis for import of short- and long-chain FOSs. The structure of FusA identifies an EF hand-like calcium-binding motif. This is shown to be essential for translocation of FOSs in FusABC and forms the basis for the definition of a new class of substrate-binding proteins that regulate substrate translocation by calcium.

-	~~Authors: Culurgioni~~, S., Harris, G., Singh~~, A.K.~~, King, S.J.~~, Walsh, M~~.A.	+	Structural Basis for Regulation and Specificity of Fructooligosaccharide Import in Streptococcus pneumoniae.,Culurgioni S, Harris G, Singh AK, King SJ, Walsh MA Structure. 2017 Jan 3;25(1):79-93. doi: 10.1016/j.str.2016.11.008. Epub 2016 Dec , 8. PMID:27939783<ref>PMID:27939783</ref>

-	~~Description:~~ S.~~pneumoniae ABC-transporter substrate binding protein FusA in complex with nystose~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category~~: ~~Unreleased Structures]]~~	+	</div>
		+	<div class="pdbe-citations 5g60" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Culurgioni, S]]		[[Category: Culurgioni, S]]
-	[[Category: Walsh, M.A]]
-	[[Category: King, S.J]]
	[[Category: Harris, G]]		[[Category: Harris, G]]
-	[[Category: Singh, A.K]]	+	[[Category: King, S J]]
		+	[[Category: Singh, A K]]
		+	[[Category: Walsh, M A]]
		+	[[Category: Abc-transporter]]
		+	[[Category: Carbohydrate]]
		+	[[Category: Fructo-nystose]]
		+	[[Category: Fructooligosaccharide]]
		+	[[Category: Fusa]]
		+	[[Category: Kestose]]
		+	[[Category: Nystose]]
		+	[[Category: Pneumoniae]]
		+	[[Category: Substrate-binding-protein]]
		+	[[Category: Sugar]]
		+	[[Category: Transport]]
		+	[[Category: Transport protein]]
		+	[[Category: Transporter]]

OCA at 06:26, 14 July 2016

2016-07-14T06:26:25Z

←Older revision		Revision as of 06:26, 14 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5g60 is ON HOLD	+	The entry 5g60 is ON HOLD until Paper Publication

	Authors: Culurgioni, S., Harris, G., Singh, A.K., King, S.J., Walsh, M.A.		Authors: Culurgioni, S., Harris, G., Singh, A.K., King, S.J., Walsh, M.A.

OCA at 21:28, 12 July 2016

2016-07-12T21:28:40Z

←Older revision		Revision as of 21:28, 12 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5g60 is ON HOLD ~~until sometime in the future~~	+	The entry 5g60 is ON HOLD

	Authors: Culurgioni, S., Harris, G., Singh, A.K., King, S.J., Walsh, M.A.		Authors: Culurgioni, S., Harris, G., Singh, A.K., King, S.J., Walsh, M.A.

OCA: Protected "5g60" [edit=sysop:move=sysop]

2016-06-23T18:39:36Z

Protected "5g60" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:39, 23 June 2016

OCA: New page: '''Unreleased structure''' The entry 5g60 is ON HOLD until sometime in the future Authors: Culurgioni, S., Harris, G., Singh, A.K., King, S.J., Walsh, M.A. Description: S.pneumoniae AB...

2016-06-23T18:39:35Z

New page: '''Unreleased structure''' The entry 5g60 is ON HOLD until sometime in the future Authors: Culurgioni, S., Harris, G., Singh, A.K., King, S.J., Walsh, M.A. Description: S.pneumoniae AB...

New page

'''Unreleased structure'''

The entry 5g60 is ON HOLD until sometime in the future

Authors: Culurgioni, S., Harris, G., Singh, A.K., King, S.J., Walsh, M.A.

Description: S.pneumoniae ABC-transporter substrate binding protein FusA in complex with nystose
[[Category: Unreleased Structures]]
[[Category: Culurgioni, S]]
[[Category: Walsh, M.A]]
[[Category: King, S.J]]
[[Category: Harris, G]]
[[Category: Singh, A.K]]