5g68 - Revision history

OCA at 13:40, 26 July 2023

2023-07-26T13:40:40Z

←Older revision		Revision as of 13:40, 26 July 2023
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	<StructureSection load='5g68' size='340' side='right'caption='[[5g68]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='5g68' size='340' side='right'caption='[[5g68]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g68]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Bacsu Bacsu~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G68 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5G68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g68]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G68 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5G68 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ML6:7-({[3-(3-FLUOROPHENYL)PROPYL]AMINO}METHYL)QUINOLIN-2-AMINE'>ML6</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.63Å</td></tr>
-	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g65\|5g65]], [[5g66\|5g66]], [[5g67\|5g67]], [[5g69\|5g69]], [[5g6a\|5g6a]], [[5g6b\|5g6b]], [[5g6c\|5g6c]], [[5g6d\|5g6d]], [[5g6e\|5g6e]], [[5g6f\|5g6f]], [[5g6g\|5g6g]], [[5g6h\|5g6h]], [[5g6i\|5g6i]], [[5g6j\|5g6j]], [[5g6k\|5g6k]], [[5g6l\|5g6l]], [[5g6m\|5g6m]], [[5g6n\|5g6n]], [[5g6o\|5g6o]], [[5g6p\|5g6p]], [[5g6q\|5g6q]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ML6:7-({[3-(3-FLUOROPHENYL)PROPYL]AMINO}METHYL)QUINOLIN-2-AMINE'>ML6</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5g68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g68 OCA], [https://pdbe.org/5g68 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5g68 RCSB], [https://www.ebi.ac.uk/pdbsum/5g68 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5g68 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5g68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g68 OCA], [~~http~~://pdbe.org/5g68 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5g68 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5g68 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5g68 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.	+	[https://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU] Catalyzes the production of nitric oxide.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Bacsu~~]]	+	[[Category: Bacillus subtilis subsp. subtilis str. 168]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Holden~~, J K~~]]	+	[[Category: Holden JK]]
-	[[Category: Poulos~~, T L]]~~	+	[[Category: Poulos TL]]
-	~~[[Category: Inhibitor]]~~	+
-	~~[[Category: Nitric oxide synthase]]~~	+
-	~~[[Category: Oxidoreductase~~]]	+

OCA at 08:25, 4 November 2020

2020-11-04T08:25:31Z

←Older revision		Revision as of 08:25, 4 November 2020
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	==Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2- amine==		==Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2- amine==
-	<StructureSection load='5g68' size='340' side='right' caption='[[5g68]], [[Resolution\|resolution]] 1.63Å' scene=''>	+	<StructureSection load='5g68' size='340' side='right'caption='[[5g68]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G68 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5G68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G68 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5G68 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ML6:7-({[3-(3-FLUOROPHENYL)PROPYL]AMINO}METHYL)QUINOLIN-2-AMINE'>ML6</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ML6:7-({[3-(3-FLUOROPHENYL)PROPYL]AMINO}METHYL)QUINOLIN-2-AMINE'>ML6</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g65\|5g65]], [[5g66\|5g66]], [[5g67\|5g67]], [[5g69\|5g69]], [[5g6a\|5g6a]], [[5g6b\|5g6b]], [[5g6c\|5g6c]], [[5g6d\|5g6d]], [[5g6e\|5g6e]], [[5g6f\|5g6f]], [[5g6g\|5g6g]], [[5g6h\|5g6h]], [[5g6i\|5g6i]], [[5g6j\|5g6j]], [[5g6k\|5g6k]], [[5g6l\|5g6l]], [[5g6m\|5g6m]], [[5g6n\|5g6n]], [[5g6o\|5g6o]], [[5g6p\|5g6p]], [[5g6q\|5g6q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g65\|5g65]], [[5g66\|5g66]], [[5g67\|5g67]], [[5g69\|5g69]], [[5g6a\|5g6a]], [[5g6b\|5g6b]], [[5g6c\|5g6c]], [[5g6d\|5g6d]], [[5g6e\|5g6e]], [[5g6f\|5g6f]], [[5g6g\|5g6g]], [[5g6h\|5g6h]], [[5g6i\|5g6i]], [[5g6j\|5g6j]], [[5g6k\|5g6k]], [[5g6l\|5g6l]], [[5g6m\|5g6m]], [[5g6n\|5g6n]], [[5g6o\|5g6o]], [[5g6p\|5g6p]], [[5g6q\|5g6q]]</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5g68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g68 OCA], [http://pdbe.org/5g68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g68 RCSB], [http://www.ebi.ac.uk/pdbsum/5g68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g68 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5g68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g68 OCA], [http://pdbe.org/5g68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g68 RCSB], [http://www.ebi.ac.uk/pdbsum/5g68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g68 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 22:

	==See Also==		==See Also==
-	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]	+	*[[Nitric Oxide Synthase 3D structures\|Nitric Oxide Synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 28:		Line 28:
	</StructureSection>		</StructureSection>
	[[Category: Bacsu]]		[[Category: Bacsu]]
		+	[[Category: Large Structures]]
	[[Category: Holden, J K]]		[[Category: Holden, J K]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 09:18, 30 January 2019

2019-01-30T09:18:37Z

←Older revision		Revision as of 09:18, 30 January 2019
Line 3:		Line 3:
	<StructureSection load='5g68' size='340' side='right' caption='[[5g68]], [[Resolution\|resolution]] 1.63Å' scene=''>		<StructureSection load='5g68' size='340' side='right' caption='[[5g68]], [[Resolution\|resolution]] 1.63Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5g68]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G68 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5g68]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacsu Bacsu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G68 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ML6:7-({[3-(3-FLUOROPHENYL)PROPYL]AMINO}METHYL)QUINOLIN-2-AMINE'>ML6</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ML6:7-({[3-(3-FLUOROPHENYL)PROPYL]AMINO}METHYL)QUINOLIN-2-AMINE'>ML6</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g65\|5g65]], [[5g66\|5g66]], [[5g67\|5g67]], [[5g69\|5g69]], [[5g6a\|5g6a]], [[5g6b\|5g6b]], [[5g6c\|5g6c]], [[5g6d\|5g6d]], [[5g6e\|5g6e]], [[5g6f\|5g6f]], [[5g6g\|5g6g]], [[5g6h\|5g6h]], [[5g6i\|5g6i]], [[5g6j\|5g6j]], [[5g6k\|5g6k]], [[5g6l\|5g6l]], [[5g6m\|5g6m]], [[5g6n\|5g6n]], [[5g6o\|5g6o]], [[5g6p\|5g6p]], [[5g6q\|5g6q]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g65\|5g65]], [[5g66\|5g66]], [[5g67\|5g67]], [[5g69\|5g69]], [[5g6a\|5g6a]], [[5g6b\|5g6b]], [[5g6c\|5g6c]], [[5g6d\|5g6d]], [[5g6e\|5g6e]], [[5g6f\|5g6f]], [[5g6g\|5g6g]], [[5g6h\|5g6h]], [[5g6i\|5g6i]], [[5g6j\|5g6j]], [[5g6k\|5g6k]], [[5g6l\|5g6l]], [[5g6m\|5g6m]], [[5g6n\|5g6n]], [[5g6o\|5g6o]], [[5g6p\|5g6p]], [[5g6q\|5g6q]]</td></tr>
Line 20:		Line 20:
	</div>		</div>
	<div class="pdbe-citations 5g68" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5g68" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Nitric Oxide Synthase\|Nitric Oxide Synthase]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Bacsu]]
	[[Category: Holden, J K]]		[[Category: Holden, J K]]
	[[Category: Poulos, T L]]		[[Category: Poulos, T L]]

OCA at 13:49, 21 September 2016

2016-09-21T13:49:27Z

←Older revision		Revision as of 13:49, 21 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5g68 is ~~ON HOLD until Paper~~ Publication	+	==Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2- amine==
		+	<StructureSection load='5g68' size='340' side='right' caption='[[5g68]], [[Resolution\|resolution]] 1.63Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5g68]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5G68 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5G68 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ML6:7-({[3-(3-FLUOROPHENYL)PROPYL]AMINO}METHYL)QUINOLIN-2-AMINE'>ML6</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5g65\|5g65]], [[5g66\|5g66]], [[5g67\|5g67]], [[5g69\|5g69]], [[5g6a\|5g6a]], [[5g6b\|5g6b]], [[5g6c\|5g6c]], [[5g6d\|5g6d]], [[5g6e\|5g6e]], [[5g6f\|5g6f]], [[5g6g\|5g6g]], [[5g6h\|5g6h]], [[5g6i\|5g6i]], [[5g6j\|5g6j]], [[5g6k\|5g6k]], [[5g6l\|5g6l]], [[5g6m\|5g6m]], [[5g6n\|5g6n]], [[5g6o\|5g6o]], [[5g6p\|5g6p]], [[5g6q\|5g6q]]</td></tr>
		+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Nitric-oxide_synthase_(NAD(P)H-dependent) Nitric-oxide synthase (NAD(P)H-dependent)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.165 1.14.13.165] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5g68 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5g68 OCA], [http://pdbe.org/5g68 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5g68 RCSB], [http://www.ebi.ac.uk/pdbsum/5g68 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5g68 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/NOSO_BACSU NOSO_BACSU]] Catalyzes the production of nitric oxide.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Nitric oxide (NO) is produced in Gram-positive pathogens Bacillus anthracis and Staphylococcus aureus by the bacterial isoform of nitric oxide synthase (NOS). Inhibition of bacterial nitric oxide synthase (bNOS) has been identified as a promising antibacterial strategy for targeting methicillin-resistant Staphylocoocus aureus1. One class of NOS inhibitors that demonstrates antimicrobial efficacy utilizes an aminoquinoline scaffold. Here we report on a variety of aminoquinolines that target the bacterial NOS active site, in part, by binding to a hydrophobic patch that is unique to bNOS. Through mutagenesis and crystallographic studies, our findings demonstrate that aminoquinolines are an excellent scaffold to further aid in the development of bNOS-specific inhibitors.

-	~~Authors:~~ Holden, ~~J.K.~~, ~~Poulos~~, T.L.	+	Targeting Bacterial Nitric Oxide Synthase with Aminoquinoline-based Inhibitors.,Holden JK, Lewis MC, Cinelli MA, Abdullatif Z, Pensa AV, Silverman RB, Poulos TL Biochemistry. 2016 Sep 8. PMID:27607918<ref>PMID:27607918</ref>

-	~~Description: Structure~~ of ~~Bacillus subtilis Nitric Oxide Synthase in complex with 7~~-(2-~~(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2-amine~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: Poulos, T.L]]	+	<div class="pdbe-citations 5g68" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Holden, J.K~~]]	+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Holden, J K]]
		+	[[Category: Poulos, T L]]
		+	[[Category: Inhibitor]]
		+	[[Category: Nitric oxide synthase]]
		+	[[Category: Oxidoreductase]]

OCA at 10:03, 14 September 2016

2016-09-14T10:03:11Z

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-	The entry 5g68 is ON HOLD	+	The entry 5g68 is ON HOLD until Paper Publication

	Authors: Holden, J.K., Poulos, T.L.		Authors: Holden, J.K., Poulos, T.L.

OCA: Protected "5g68" [edit=sysop:move=sysop]

2016-07-12T21:29:28Z

Protected "5g68" [edit=sysop:move=sysop]

←Older revision

Revision as of 21:29, 12 July 2016

OCA: New page: '''Unreleased structure''' The entry 5g68 is ON HOLD Authors: Holden, J.K., Poulos, T.L. Description: Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(2-(3-(3-Fl...

2016-07-12T21:29:27Z

New page: '''Unreleased structure''' The entry 5g68 is ON HOLD Authors: Holden, J.K., Poulos, T.L. Description: Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(2-(3-(3-Fl...

New page

'''Unreleased structure'''

The entry 5g68 is ON HOLD

Authors: Holden, J.K., Poulos, T.L.

Description: Structure of Bacillus subtilis Nitric Oxide Synthase in complex with 7-(2-(3-(3-Fluorophenyl(propylamino)methyl))quinolin-2-amine
[[Category: Unreleased Structures]]
[[Category: Poulos, T.L]]
[[Category: Holden, J.K]]