5gkr - Revision history

OCA at 11:34, 2 August 2023

2023-08-02T11:34:37Z

←Older revision		Revision as of 11:34, 2 August 2023
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	<StructureSection load='5gkr' size='340' side='right'caption='[[5gkr]], [[Resolution\|resolution]] 2.10Å' scene=''>		<StructureSection load='5gkr' size='340' side='right'caption='[[5gkr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gkr]] is a 5 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GKR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gkr]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GKR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GKR FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">[[~~5gks~~\|~~5gks~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.1Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5gkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gkr OCA], [~~http~~://pdbe.org/5gkr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gkr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gkr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gkr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gkr OCA], [https://pdbe.org/5gkr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gkr RCSB], [https://www.ebi.ac.uk/pdbsum/5gkr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gkr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arimori, T]]	+	[[Category: Arimori T]]
-	[[Category: Kikutani, H]]	+	[[Category: Kikutani H]]
-	[[Category: Sakakibara, S]]	+	[[Category: Sakakibara S]]
-	[[Category: Takagi, J]]	+	[[Category: Takagi J]]
-	~~[[Category: Antibody]]~~	+
-	~~[[Category: Dna]]~~	+
-	~~[[Category: Fab]]~~	+
-	~~[[Category: Immune system-dna complex]]~~	+
-	~~[[Category: Lupus~~]]	+

OCA at 06:45, 13 May 2020

2020-05-13T06:45:20Z

←Older revision		Revision as of 06:45, 13 May 2020
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	==Crystal structure of SLE patient-derived anti-DNA antibody in complex with oligonucleotide==		==Crystal structure of SLE patient-derived anti-DNA antibody in complex with oligonucleotide==
-	<StructureSection load='5gkr' size='340' side='right' caption='[[5gkr]], [[Resolution\|resolution]] 2.10Å' scene=''>	+	<StructureSection load='5gkr' size='340' side='right'caption='[[5gkr]], [[Resolution\|resolution]] 2.10Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gkr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GKR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GKR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gkr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GKR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GKR FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gks\|5gks]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gks\|5gks]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gkr OCA], [http://pdbe.org/5gkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gkr RCSB], [http://www.ebi.ac.uk/pdbsum/5gkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gkr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gkr OCA], [http://pdbe.org/5gkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gkr RCSB], [http://www.ebi.ac.uk/pdbsum/5gkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gkr ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arimori, T]]		[[Category: Arimori, T]]
	[[Category: Kikutani, H]]		[[Category: Kikutani, H]]

OCA at 07:32, 6 December 2017

2017-12-06T07:32:41Z

←Older revision		Revision as of 07:32, 6 December 2017
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gkr OCA], [http://pdbe.org/5gkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gkr RCSB], [http://www.ebi.ac.uk/pdbsum/5gkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gkr ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gkr OCA], [http://pdbe.org/5gkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gkr RCSB], [http://www.ebi.ac.uk/pdbsum/5gkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gkr ProSAT]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The evolutional process of disease-associated autoantibodies in systemic lupus erythematosus (SLE) remains to be established. Here we show intraclonal diversification and affinity maturation of anti-nuclear antibody (ANA)-producing B cells in SLE. We identified a panel of monoclonal ANAs recognizing nuclear antigens, such as double-stranded DNA (dsDNA) and ribonucleoproteins (RNPs) from acute SLE subjects. These ANAs had relatively few, but nonetheless critical mutations. High-throughput immunoglobulin sequencing of blood lymphocytes disclosed the existence of sizable ANA lineages shearing critical mutations intraclonally. We further focused on anti-DNA antibodies, which are capable to bind to both single-stranded (ss) and dsDNA at high affinity. Crystal structure and biochemical analysis confirmed a direct role of the mutations in the acquisition of DNA reactivity and also revealed that these anti-DNA antibodies recognized an unpaired region within DNA duplex. Our study unveils the unique properties of high-affinity anti-DNA antibodies that are generated through antigen-driven affinity maturation in acute phase of SLE.
		+
		+	Clonal evolution and antigen recognition of anti-nuclear antibodies in acute systemic lupus erythematosus.,Sakakibara S, Arimori T, Yamashita K, Jinzai H, Motooka D, Nakamura S, Li S, Takeda K, Katayama J, El Hussien MA, Narazaki M, Tanaka T, Standley DM, Takagi J, Kikutani H Sci Rep. 2017 Nov 27;7(1):16428. doi: 10.1038/s41598-017-16681-y. PMID:29180749<ref>PMID:29180749</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5gkr" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 06:23, 16 November 2017

2017-11-16T06:23:57Z

←Older revision		Revision as of 06:23, 16 November 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5gkr is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of SLE patient-derived anti-DNA antibody in complex with oligonucleotide==
-		+	<StructureSection load='5gkr' size='340' side='right' caption='[[5gkr]], [[Resolution\|resolution]] 2.10Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5gkr]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GKR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GKR FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gks\|5gks]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gkr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gkr OCA], [http://pdbe.org/5gkr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gkr RCSB], [http://www.ebi.ac.uk/pdbsum/5gkr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gkr ProSAT]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Arimori, T]]
		+	[[Category: Kikutani, H]]
		+	[[Category: Sakakibara, S]]
		+	[[Category: Takagi, J]]
		+	[[Category: Antibody]]
		+	[[Category: Dna]]
		+	[[Category: Fab]]
		+	[[Category: Immune system-dna complex]]
		+	[[Category: Lupus]]

OCA at 10:32, 27 July 2016

2016-07-27T10:32:54Z

←Older revision		Revision as of 10:32, 27 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5gkr is ON HOLD	+	The entry 5gkr is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5gkr" [edit=sysop:move=sysop]

2016-07-14T06:38:08Z

Protected "5gkr" [edit=sysop:move=sysop]

←Older revision

Revision as of 06:38, 14 July 2016

OCA: New page: '''Unreleased structure''' The entry 5gkr is ON HOLD Authors: Description: Category: Unreleased Structures

2016-07-14T06:38:06Z

New page: '''Unreleased structure''' The entry 5gkr is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5gkr is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]