5glh - Revision history

OCA at 11:35, 2 August 2023

2023-08-02T11:35:15Z

←Older revision		Revision as of 11:35, 2 August 2023
Line 3:		Line 3:
	<StructureSection load='5glh' size='340' side='right'caption='[[5glh]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5glh' size='340' side='right'caption='[[5glh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5glh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GLH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5glh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GLH FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5gli\|5gli]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.8Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">EDNRB ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5glh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glh OCA], [https://pdbe.org/5glh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5glh RCSB], [https://www.ebi.ac.uk/pdbsum/5glh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5glh ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5glh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glh OCA], [~~http~~://pdbe.org/5glh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5glh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5glh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5glh ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Disease ==
		+	[https://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN] Hirschsprung disease;Waardenburg-Shah syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Defects in EDNRB are associated with Waardenburg syndrome 2, with ocular albinism, autosomal recessive: A disorder characterized by the association of features typical of Waardenburg syndrome type 2 with ocular albinism. Patients manifest reduced visual acuity, albinotic fundus, deafness, hypomelanosis.<ref>PMID:28236341</ref>
	== Function ==		== Function ==
-	[[~~http~~://www.uniprot.org/uniprot/~~EDN1_HUMAN EDN1_HUMAN~~]~~] Endothelins are endothelium~~-~~derived vasoconstrictor peptides~~.	+	[https://www.uniprot.org/uniprot/ENLYS_BPT4 ENLYS_BPT4] Endolysin with lysozyme activity that degrades host peptidoglycans and participates with the holin and spanin proteins in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer.<ref>PMID:22389108</ref> [https://www.uniprot.org/uniprot/EDNRB_HUMAN EDNRB_HUMAN] Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.<ref>PMID:7536888</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Dohmae, N]]	+	[[Category: Dohmae N]]
-	[[Category: Doi, T]]	+	[[Category: Doi T]]
-	[[Category: Fujiyoshi, Y]]	+	[[Category: Fujiyoshi Y]]
-	[[Category: Nishizawa, T]]	+	[[Category: Nishizawa T]]
-	[[Category: Nureki, O]]	+	[[Category: Nureki O]]
-	[[Category: Okuta, A]]	+	[[Category: Okuta A]]
-	[[Category: Shihoya, W]]	+	[[Category: Shihoya W]]
-	[[Category: Tani, K]]	+	[[Category: Tani K]]
-	~~[[Category: Alpha helical]]~~	+
-	~~[[Category: Signaling protein~~]]	+

OCA at 10:08, 26 February 2020

2020-02-26T10:08:17Z

←Older revision		Revision as of 10:08, 26 February 2020
Line 1:		Line 1:

	==Human endothelin receptor type-B in complex with ET-1==		==Human endothelin receptor type-B in complex with ET-1==
-	<StructureSection load='5glh' size='340' side='right' caption='[[5glh]], [[Resolution\|resolution]] 2.80Å' scene=''>	+	<StructureSection load='5glh' size='340' side='right'caption='[[5glh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5glh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GLH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5glh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GLH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gli\|5gli]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gli\|5gli]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">EDNRB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5glh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glh OCA], [http://pdbe.org/5glh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5glh RCSB], [http://www.ebi.ac.uk/pdbsum/5glh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5glh ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5glh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glh OCA], [http://pdbe.org/5glh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5glh RCSB], [http://www.ebi.ac.uk/pdbsum/5glh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5glh ProSAT]</span></td></tr>
	</table>		</table>
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Dohmae, N]]		[[Category: Dohmae, N]]
	[[Category: Doi, T]]		[[Category: Doi, T]]

OCA at 06:16, 21 September 2016

2016-09-21T06:16:03Z

←Older revision		Revision as of 06:16, 21 September 2016
Line 1:		Line 1:

-	==~~Crystal Structure of a Protein_1~~==	+	==Human endothelin receptor type-B in complex with ET-1==
	<StructureSection load='5glh' size='340' side='right' caption='[[5glh]], [[Resolution\|resolution]] 2.80Å' scene=''>		<StructureSection load='5glh' size='340' side='right' caption='[[5glh]], [[Resolution\|resolution]] 2.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/EDN1_HUMAN EDN1_HUMAN]] Endothelins are endothelium-derived vasoconstrictor peptides.		[[http://www.uniprot.org/uniprot/EDN1_HUMAN EDN1_HUMAN]] Endothelins are endothelium-derived vasoconstrictor peptides.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Endothelin, a 21-amino-acid peptide, participates in various physiological processes, such as regulation of vascular tone, humoral homeostasis, neural crest cell development and neurotransmission. Endothelin and its G-protein-coupled receptor are involved in the development of various diseases, such as pulmonary arterial hypertension, and thus are important therapeutic targets. Here we report crystal structures of human endothelin type B receptor in the ligand-free form and in complex with the endogenous agonist endothelin-1. The structures and mutation analysis reveal the mechanism for the isopeptide selectivity between endothelin-1 and -3. Transmembrane helices 1, 2, 6 and 7 move and envelop the entire endothelin peptide, in a virtually irreversible manner. The agonist-induced conformational changes are propagated to the receptor core and the cytoplasmic G-protein coupling interface, and probably induce conformational flexibility in TM6. A comparison with the M2 muscarinic receptor suggests a shared mechanism for signal transduction in class A G-protein-coupled receptors.
		+
		+	Activation mechanism of endothelin ETB receptor by endothelin-1.,Shihoya W, Nishizawa T, Okuta A, Tani K, Dohmae N, Fujiyoshi Y, Nureki O, Doi T Nature. 2016 Sep 5;537(7620):363-368. doi: 10.1038/nature19319. PMID:27595334<ref>PMID:27595334</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5glh" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Dohmae, N]]
		+	[[Category: Doi, T]]
	[[Category: Fujiyoshi, Y]]		[[Category: Fujiyoshi, Y]]
	[[Category: Nishizawa, T]]		[[Category: Nishizawa, T]]
		+	[[Category: Nureki, O]]
	[[Category: Okuta, A]]		[[Category: Okuta, A]]
	[[Category: Shihoya, W]]		[[Category: Shihoya, W]]
	[[Category: Tani, K]]		[[Category: Tani, K]]
	[[Category: Alpha helical]]		[[Category: Alpha helical]]
-	[[Category: ~~Cytokine~~]]	+	[[Category: Signaling protein]]

OCA at 21:05, 10 September 2016

2016-09-10T21:05:57Z

←Older revision		Revision as of 21:05, 10 September 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5glh is ~~ON HOLD~~	+	==Crystal Structure of a Protein_1==
-		+	<StructureSection load='5glh' size='340' side='right' caption='[[5glh]], [[Resolution\|resolution]] 2.80Å' scene=''>
-	~~Authors~~: ~~Shihoya~~, W., ~~Nishizawa, T~~., ~~Okuta, A~~., ~~Tani, K~~., ~~Fujiyoshi, Y~~.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5glh]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GLH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GLH FirstGlance]. <br>
-	~~Description~~: ~~Crystal Structure of a Protein_1~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gli\|5gli]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5glh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5glh OCA], [http://pdbe.org/5glh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5glh RCSB], [http://www.ebi.ac.uk/pdbsum/5glh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5glh ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/EDN1_HUMAN EDN1_HUMAN]] Endothelins are endothelium-derived vasoconstrictor peptides.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Fujiyoshi, Y]]
		+	[[Category: Nishizawa, T]]
	[[Category: Okuta, A]]		[[Category: Okuta, A]]
		+	[[Category: Shihoya, W]]
	[[Category: Tani, K]]		[[Category: Tani, K]]
-	[[Category: ~~Nishizawa, T~~]]	+	[[Category: Alpha helical]]
-	[[Category: ~~Shihoya, W]]~~	+	[[Category: Cytokine]]
-	~~[[Category: Fujiyoshi, Y~~]]	+

OCA at 10:34, 27 July 2016

2016-07-27T10:34:23Z

←Older revision		Revision as of 10:34, 27 July 2016
Line 3:		Line 3:
	The entry 5glh is ON HOLD		The entry 5glh is ON HOLD

-	Authors: Shihoya W., Nishizawa T., Okuta A., Tani K., Fujiyoshi Y.	+	Authors: Shihoya, W., Nishizawa, T., Okuta, A., Tani, K., Fujiyoshi, Y.

	Description: Crystal Structure of a Protein_1		Description: Crystal Structure of a Protein_1
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: ~~Tani K~~]]	+	[[Category: Okuta, A]]
-	[[Category: ~~Okuta A~~]]	+	[[Category: Tani, K]]
-	[[Category: Nishizawa T]]	+	[[Category: Nishizawa, T]]
-	[[Category: ~~Fujiyoshi Y~~]]	+	[[Category: Shihoya, W]]
-	[[Category: ~~Shihoya W~~]]	+	[[Category: Fujiyoshi, Y]]

OCA: Protected "5glh" [edit=sysop:move=sysop]

2016-07-26T09:43:41Z

Protected "5glh" [edit=sysop:move=sysop]

←Older revision

Revision as of 09:43, 26 July 2016

OCA: New page: '''Unreleased structure''' The entry 5glh is ON HOLD Authors: Shihoya W., Nishizawa T., Okuta A., Tani K., Fujiyoshi Y. Description: Crystal Structure of a Protein_1 [[Category: Unrele...

2016-07-26T09:43:39Z

New page: '''Unreleased structure''' The entry 5glh is ON HOLD Authors: Shihoya W., Nishizawa T., Okuta A., Tani K., Fujiyoshi Y. Description: Crystal Structure of a Protein_1 [[Category: Unrele...

New page

'''Unreleased structure'''

The entry 5glh is ON HOLD

Authors: Shihoya W., Nishizawa T., Okuta A., Tani K., Fujiyoshi Y.

Description: Crystal Structure of a Protein_1
[[Category: Unreleased Structures]]
[[Category: Tani K]]
[[Category: Okuta A]]
[[Category: Nishizawa T]]
[[Category: Fujiyoshi Y]]
[[Category: Shihoya W]]