5gnh - Revision history

OCA at 11:37, 2 August 2023

2023-08-02T11:37:26Z

←Older revision		Revision as of 11:37, 2 August 2023
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	==Myotubularin-related protein 2==		==Myotubularin-related protein 2==
-	<StructureSection load='5gnh' size='340' side='right' caption='[[5gnh]], [[Resolution\|resolution]] 2.60Å' scene=''>	+	<StructureSection load='5gnh' size='340' side='right'caption='[[5gnh]], [[Resolution\|resolution]] 2.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gnh]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GNH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gnh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GNH FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name~~=~~'pdbligand=PO4:PHOSPHATE+ION'>PO4</scene~~></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~MTMR2, KIAA1073 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gnh OCA], [~~http~~://pdbe.org/5gnh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gnh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gnh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gnh ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gnh OCA], [https://pdbe.org/5gnh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gnh RCSB], [https://www.ebi.ac.uk/pdbsum/5gnh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gnh ProSAT]</span></td></tr>
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/MTMR2_HUMAN MTMR2_HUMAN]] Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1) [MIM:[~~http~~://omim.org/entry/601382 601382]]. CMT4B1 is a recessive, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.<ref>PMID:10802647</ref> <ref>PMID:12398840</ref>	+	[https://www.uniprot.org/uniprot/MTMR2_HUMAN MTMR2_HUMAN] Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1) [MIM:[https://omim.org/entry/601382 601382]. CMT4B1 is a recessive, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.<ref>PMID:10802647</ref> <ref>PMID:12398840</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/MTMR2_HUMAN MTMR2_HUMAN]] Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.<ref>PMID:12668758</ref> <ref>PMID:21372139</ref>	+	[https://www.uniprot.org/uniprot/MTMR2_HUMAN MTMR2_HUMAN] Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.<ref>PMID:12668758</ref> <ref>PMID:21372139</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
-	[[Category: ~~Bong, S M~~]]	+	[[Category: Large Structures]]
-	[[Category: ~~Lee, B I~~]]	+	[[Category: Bong SM]]
-	[[Category: ~~Hydrolase]]~~	+	[[Category: Lee BI]]
-	~~[[Category: Mtmr2]]~~	+
-	~~[[Category: Myotubularin-related protein]]~~	+
-	~~[[Category: Pi~~]]	+

OCA at 04:34, 16 November 2017

2017-11-16T04:34:30Z

←Older revision		Revision as of 04:34, 16 November 2017
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-	'''Unreleased structure'''

-	~~The entry~~ 5gnh is ~~ON HOLD until Paper Publication~~	+	==Myotubularin-related protein 2==
-		+	<StructureSection load='5gnh' size='340' side='right' caption='[[5gnh]], [[Resolution\|resolution]] 2.60Å' scene=''>
-	~~Authors~~: ~~Lee~~, B.I., ~~Bong~~, S.M.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5gnh]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GNH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GNH FirstGlance]. <br>
-	~~Description~~: ~~Myotubularin~~-~~related protein 2~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">MTMR2, KIAA1073 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	[[Category: Lee, B.I]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gnh OCA], [http://pdbe.org/5gnh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gnh RCSB], [http://www.ebi.ac.uk/pdbsum/5gnh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gnh ProSAT]</span></td></tr>
-	[[Category: ~~Bong, S.M~~]]	+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/MTMR2_HUMAN MTMR2_HUMAN]] Defects in MTMR2 are the cause of Charcot-Marie-Tooth disease type 4B1 (CMT4B1) [MIM:[http://omim.org/entry/601382 601382]]. CMT4B1 is a recessive, severe form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy and primary peripheral axonal neuropathy. Demyelinating CMT neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention, autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.<ref>PMID:10802647</ref> <ref>PMID:12398840</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/MTMR2_HUMAN MTMR2_HUMAN]] Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate.<ref>PMID:12668758</ref> <ref>PMID:21372139</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Bong, S M]]
		+	[[Category: Lee, B I]]
		+	[[Category: Hydrolase]]
		+	[[Category: Mtmr2]]
		+	[[Category: Myotubularin-related protein]]
		+	[[Category: Pi]]

OCA at 06:46, 4 May 2017

2017-05-04T06:46:07Z

←Older revision		Revision as of 06:46, 4 May 2017
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	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5gnh is ON HOLD	+	The entry 5gnh is ON HOLD until Paper Publication

	Authors: Lee, B.I., Bong, S.M.		Authors: Lee, B.I., Bong, S.M.

OCA at 09:00, 9 March 2017

2017-03-09T09:00:46Z

←Older revision		Revision as of 09:00, 9 March 2017
Line 7:		Line 7:
	Description: Myotubularin-related protein 2		Description: Myotubularin-related protein 2
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Bong, S.M]]
	[[Category: Lee, B.I]]		[[Category: Lee, B.I]]
		+	[[Category: Bong, S.M]]

OCA: Protected "5gnh" [edit=sysop:move=sysop]

2016-07-27T10:39:32Z

Protected "5gnh" [edit=sysop:move=sysop]

←Older revision

Revision as of 10:39, 27 July 2016

OCA: New page: '''Unreleased structure''' The entry 5gnh is ON HOLD Authors: Lee, B.I., Bong, S.M. Description: Myotubularin-related protein 2 Category: Unreleased Structures [[Category: Bong, S....

2016-07-27T10:39:31Z

New page: '''Unreleased structure''' The entry 5gnh is ON HOLD Authors: Lee, B.I., Bong, S.M. Description: Myotubularin-related protein 2 Category: Unreleased Structures [[Category: Bong, S....

New page

'''Unreleased structure'''

The entry 5gnh is ON HOLD

Authors: Lee, B.I., Bong, S.M.

Description: Myotubularin-related protein 2
[[Category: Unreleased Structures]]
[[Category: Bong, S.M]]
[[Category: Lee, B.I]]