5gou - Revision history

OCA at 11:38, 2 August 2023

2023-08-02T11:38:20Z

←Older revision		Revision as of 11:38, 2 August 2023
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	<StructureSection load='5gou' size='340' side='right'caption='[[5gou]], [[Resolution\|resolution]] 2.91Å' scene=''>		<StructureSection load='5gou' size='340' side='right'caption='[[5gou]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gou]] is a 16 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOU OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5GOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gou]] is a 16 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5GOU FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat"~~>FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&~~id~~=9606 HUMAN])</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.91Å</td></tr>
-	~~<tr id='activity'><td class~~="~~sblockLbl~~">~~<b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>~~[~~http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase~~]~~, with EC number [http://www~~.~~brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span>~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5gou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gou OCA], [https://pdbe.org/5gou PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5gou RCSB], [https://www.ebi.ac.uk/pdbsum/5gou PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5gou ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5gou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gou OCA], [~~http~~://pdbe.org/5gou PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5gou RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5gou PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5gou ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).	+	[https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Ferroxidase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Wang, H]]	+	[[Category: Wang H]]
-	[[Category: Wang, W]]	+	[[Category: Wang W]]
-	[[Category: Zang, J]]	+	[[Category: Zang J]]
-	[[Category: Zhang, S]]	+	[[Category: Zhang S]]
-	[[Category: Zhao, G]]	+	[[Category: Zhao G]]
-	~~[[Category: 16-mer nanocage]]~~	+
-	~~[[Category: Ferritin]]~~	+
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Subunit interface redesign~~]]	+

OCA at 06:49, 13 May 2020

2020-05-13T06:49:03Z

←Older revision		Revision as of 06:49, 13 May 2020
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	==Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign==		==Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign==
-	<StructureSection load='5gou' size='340' side='right' caption='[[5gou]], [[Resolution\|resolution]] 2.91Å' scene=''>	+	<StructureSection load='5gou' size='340' side='right'caption='[[5gou]], [[Resolution\|resolution]] 2.91Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5gou]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOU OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5GOU FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5gou]] is a 16 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOU OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5GOU FirstGlance]. <br>
-	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FTH1, FTH, FTHL6, OK/SW-cl.84, PIG15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5gou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gou OCA], [http://pdbe.org/5gou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gou RCSB], [http://www.ebi.ac.uk/pdbsum/5gou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gou ProSAT]</span></td></tr>	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5gou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gou OCA], [http://pdbe.org/5gou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gou RCSB], [http://www.ebi.ac.uk/pdbsum/5gou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gou ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5gou" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5gou" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Ferritin 3D structures\|Ferritin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Ferroxidase]]		[[Category: Ferroxidase]]
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Wang, H]]		[[Category: Wang, H]]
	[[Category: Wang, W]]		[[Category: Wang, W]]

OCA at 01:31, 11 March 2017

2017-03-11T01:31:24Z

←Older revision		Revision as of 01:31, 11 March 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5gou is ~~ON HOLD until Paper~~ Publication	+	==Structure of a 16-mer protein nanocage fabricated from its 24-mer analogue by subunit interface redesign==
		+	<StructureSection load='5gou' size='340' side='right' caption='[[5gou]], [[Resolution\|resolution]] 2.91Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5gou]] is a 16 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5GOU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5GOU FirstGlance]. <br>
		+	</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5gou FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5gou OCA], [http://pdbe.org/5gou PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5gou RCSB], [http://www.ebi.ac.uk/pdbsum/5gou PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5gou ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Protein assemblies with high symmetry are widely distributed in nature. Most efforts so far have focused on repurposing these protein assemblies, a strategy that is ultimately limited by the structures available. To overcome this limitation, methods for fabricating novel self-assembling proteins have received intensive interest. Herein, by reengineering the key subunit interfaces of native 24-mer protein cage with octahedral symmetry through amino acid residues insertion, we fabricated a 16-mer lenticular nanocage whose structure is unique among all known protein cages. This newly non-native protein can be used for encapsulation of bioactive compounds and exhibits high uptake efficiency by cancer cells. More importantly, the above strategy could be applied to other naturally occurring protein assemblies with high symmetry, leading to the generation of new proteins with unexplored functions.

-	~~Authors~~:	+	Conversion of the Native 24-mer Ferritin Nanocage into Its Non-Native 16-mer Analogue by Insertion of Extra Amino Acid Residues.,Zhang S, Zang J, Wang W, Chen H, Zhang X, Wang F, Wang H, Zhao G Angew Chem Int Ed Engl. 2016 Dec 23;55(52):16064-16070. doi:, 10.1002/anie.201609517. Epub 2016 Nov 25. PMID:27885765<ref>PMID:27885765</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5gou" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ferroxidase]]
		+	[[Category: Wang, H]]
		+	[[Category: Wang, W]]
		+	[[Category: Zang, J]]
		+	[[Category: Zhang, S]]
		+	[[Category: Zhao, G]]
		+	[[Category: 16-mer nanocage]]
		+	[[Category: Ferritin]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Subunit interface redesign]]

OCA at 08:28, 21 September 2016

2016-09-21T08:28:09Z

←Older revision		Revision as of 08:28, 21 September 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5gou is ON HOLD	+	The entry 5gou is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5gou" [edit=sysop:move=sysop]

2016-08-03T23:22:33Z

Protected "5gou" [edit=sysop:move=sysop]

←Older revision

Revision as of 23:22, 3 August 2016

OCA: New page: '''Unreleased structure''' The entry 5gou is ON HOLD Authors: Description: Category: Unreleased Structures

2016-08-03T23:22:32Z

New page: '''Unreleased structure''' The entry 5gou is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5gou is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]