5h18 - Revision history

OCA at 11:48, 2 August 2023

2023-08-02T11:48:48Z

←Older revision		Revision as of 11:48, 2 August 2023
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	<StructureSection load='5h18' size='340' side='right'caption='[[5h18]], [[Resolution\|resolution]] 1.40Å' scene=''>		<StructureSection load='5h18' size='340' side='right'caption='[[5h18]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h18]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_10518 Atcc 10518~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H18 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5H18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h18]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermomyces_dupontii Thermomyces dupontii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H18 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5H18 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=~~UPG~~:~~URIDINE-5-DIPHOSPHATE-GLUCOSE~~'>~~UPG~~</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.4Å</td></tr>
-	~~<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=~~MSE~~:~~SELENOMETHIONINE~~'>~~MSE~~</scene></td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5h18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h18 OCA], [~~http~~://pdbe.org/5h18 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5h18 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5h18 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5h18 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5h18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h18 OCA], [https://pdbe.org/5h18 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5h18 RCSB], [https://www.ebi.ac.uk/pdbsum/5h18 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5h18 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/A0A2D0TCJ6_TALTH A0A2D0TCJ6_TALTH]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 10518]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Kamikubo, H]]	+	[[Category: Thermomyces dupontii]]
-	[[Category: Kato, K]]	+	[[Category: Kamikubo H]]
-	[[Category: Satoh, T]]	+	[[Category: Kato K]]
-	[[Category: Toshimori, T]]	+	[[Category: Satoh T]]
-	[[Category: Uchihashi, T]]	+	[[Category: Toshimori T]]
-	[[Category: Zhu, T]]	+	[[Category: Uchihashi T]]
-	~~[[Category: Endoplasmic reticulum]]~~	+	[[Category: Zhu T]]
-	~~[[Category: Folding sensor]]~~	+
-	~~[[Category: Glucosyltransferase]]~~	+
-	~~[[Category: Quality control]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 06:49, 20 May 2020

2020-05-20T06:49:11Z

←Older revision		Revision as of 06:49, 20 May 2020
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	==Crystal structure of catalytic domain of UGGT (UDP-glucose-bound form) from Thermomyces dupontii==		==Crystal structure of catalytic domain of UGGT (UDP-glucose-bound form) from Thermomyces dupontii==
-	<StructureSection load='5h18' size='340' side='right' caption='[[5h18]], [[Resolution\|resolution]] 1.40Å' scene=''>	+	<StructureSection load='5h18' size='340' side='right'caption='[[5h18]], [[Resolution\|resolution]] 1.40Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5h18]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10518 Atcc 10518]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H18 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5H18 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5h18]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10518 Atcc 10518]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H18 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5H18 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>
	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>		<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5h18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h18 OCA], [http://pdbe.org/5h18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h18 RCSB], [http://www.ebi.ac.uk/pdbsum/5h18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h18 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5h18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h18 OCA], [http://pdbe.org/5h18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h18 RCSB], [http://www.ebi.ac.uk/pdbsum/5h18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h18 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</StructureSection>		</StructureSection>
	[[Category: Atcc 10518]]		[[Category: Atcc 10518]]
		+	[[Category: Large Structures]]
	[[Category: Kamikubo, H]]		[[Category: Kamikubo, H]]
	[[Category: Kato, K]]		[[Category: Kato, K]]

OCA at 06:17, 1 November 2017

2017-11-01T06:17:29Z

←Older revision		Revision as of 06:17, 1 November 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5h18 is ~~ON HOLD until Paper~~ Publication	+	==Crystal structure of catalytic domain of UGGT (UDP-glucose-bound form) from Thermomyces dupontii==
		+	<StructureSection load='5h18' size='340' side='right' caption='[[5h18]], [[Resolution\|resolution]] 1.40Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5h18]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_10518 Atcc 10518]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H18 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H18 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene></td></tr>
		+	<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue\|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h18 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h18 OCA], [http://pdbe.org/5h18 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h18 RCSB], [http://www.ebi.ac.uk/pdbsum/5h18 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h18 ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	In the endoplasmic reticulum (ER), a protein quality control system facilitates the efficient folding of newly synthesised proteins. In this system, a series of N-linked glycan intermediates displayed on the protein surface serve as quality tags. The ER folding-sensor enzyme UDP-glucose:glycoprotein glucosyltransferase (UGGT) acts as a gatekeeper in the ER quality control system by specifically catalysing monoglucosylation onto incompletely folded glycoproteins, thereby enabling them to interact with lectin-chaperone complexes. Here we characterise the dynamic structure of this enzyme. Our crystallographic data demonstrate that the sensor region is composed of four thioredoxin-like domains followed by a beta-rich domain, which are arranged into a C-shaped structure with a large central cavity, while the C-terminal catalytic domain undergoes a ligand-dependent conformational alteration. Furthermore, small-angle X-ray scattering, cryo-electron microscopy and high-speed atomic force microscopy have demonstrated that UGGT has a flexible modular structure in which the smaller catalytic domain is tethered to the larger folding-sensor region with variable spatial arrangements. These findings provide structural insights into the working mechanism whereby UGGT operates as a folding-sensor against a variety of glycoprotein substrates through its flexible modular structure possessing extended hydrophobic surfaces for the recognition of unfolded substrates.

-	~~Authors~~:	+	Visualisation of a flexible modular structure of the ER folding-sensor enzyme UGGT.,Satoh T, Song C, Zhu T, Toshimori T, Murata K, Hayashi Y, Kamikubo H, Uchihashi T, Kato K Sci Rep. 2017 Sep 22;7(1):12142. doi: 10.1038/s41598-017-12283-w. PMID:28939828<ref>PMID:28939828</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5h18" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Atcc 10518]]
		+	[[Category: Kamikubo, H]]
		+	[[Category: Kato, K]]
		+	[[Category: Satoh, T]]
		+	[[Category: Toshimori, T]]
		+	[[Category: Uchihashi, T]]
		+	[[Category: Zhu, T]]
		+	[[Category: Endoplasmic reticulum]]
		+	[[Category: Folding sensor]]
		+	[[Category: Glucosyltransferase]]
		+	[[Category: Quality control]]
		+	[[Category: Transferase]]

OCA at 13:37, 9 December 2016

2016-12-09T13:37:59Z

←Older revision		Revision as of 13:37, 9 December 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5h18 is ON HOLD	+	The entry 5h18 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA: Protected "5h18" [edit=sysop:move=sysop]

2016-10-19T12:01:40Z

Protected "5h18" [edit=sysop:move=sysop]

←Older revision

Revision as of 12:01, 19 October 2016

OCA: New page: '''Unreleased structure''' The entry 5h18 is ON HOLD Authors: Description: Category: Unreleased Structures

2016-10-19T12:01:39Z

New page: '''Unreleased structure''' The entry 5h18 is ON HOLD Authors: Description: Category: Unreleased Structures

New page

'''Unreleased structure'''

The entry 5h18 is ON HOLD

Authors:

Description:
[[Category: Unreleased Structures]]