5hfd - Revision history

OCA at 09:18, 27 September 2023

2023-09-27T09:18:44Z

←Older revision		Revision as of 09:18, 27 September 2023
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	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>		[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
		+
		+	==See Also==
		+	*[[Postsynaptic density protein 3D structures\|Postsynaptic density protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 07:34, 9 August 2023

2023-08-09T07:34:10Z

←Older revision		Revision as of 07:34, 9 August 2023
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	<StructureSection load='5hfd' size='340' side='right'caption='[[5hfd]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5hfd' size='340' side='right'caption='[[5hfd]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hfd]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Buffalo_rat Buffalo rat~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFD OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5HFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hfd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HFD FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[1bfe\|1bfe]], [[5hdy\|5hdy]], [[5heb\|5heb]], [[5hed\|5hed]], [[5het\|5het]], [[5hey\|5hey]], [[5hf1\|5hf1]], [[5hf4\|5hf4]], [[5hfb\|5hfb]], [[5hfc\|5hfc]], [[5hfe\|5hfe]], [[5hff\|5hff]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">Dlg4, Dlgh4, Psd95 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=10116 Buffalo rat])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfd OCA], [https://pdbe.org/5hfd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hfd RCSB], [https://www.ebi.ac.uk/pdbsum/5hfd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfd ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfd OCA], [~~http~~://pdbe.org/5hfd PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hfd RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hfd PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfd ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>	+	[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Buffalo rat]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Raman, A S~~]]	+	[[Category: Rattus norvegicus]]
-	[[Category: ~~Ranganathan, R~~]]	+	[[Category: Raman AS]]
-	[[Category: ~~White, K I~~]]	+	[[Category: Ranganathan R]]
-	[[Category: ~~Adhesion]]~~	+	[[Category: White KI]]
-	~~[[Category: Dhr]]~~	+
-	~~[[Category: Glgf]]~~	+
-	~~[[Category: Pdz]]~~	+
-	~~[[Category: Peptide binding protein]]~~	+
-	~~[[Category: Peptide-binding domain]]~~	+
-	~~[[Category: Synapse]]~~	+
-	~~[[Category: Synaptic density~~]]	+

OCA at 07:03, 20 May 2020

2020-05-20T07:03:44Z

←Older revision		Revision as of 07:03, 20 May 2020
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	==The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)==		==The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)==
-	<StructureSection load='5hfd' size='340' side='right' caption='[[5hfd]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5hfd' size='340' side='right'caption='[[5hfd]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hfd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFD OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HFD FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hfd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFD OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HFD FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bfe\|1bfe]], [[5hdy\|5hdy]], [[5heb\|5heb]], [[5hed\|5hed]], [[5het\|5het]], [[5hey\|5hey]], [[5hf1\|5hf1]], [[5hf4\|5hf4]], [[5hfb\|5hfb]], [[5hfc\|5hfc]], [[5hfe\|5hfe]], [[5hff\|5hff]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bfe\|1bfe]], [[5hdy\|5hdy]], [[5heb\|5heb]], [[5hed\|5hed]], [[5het\|5het]], [[5hey\|5hey]], [[5hf1\|5hf1]], [[5hf4\|5hf4]], [[5hfb\|5hfb]], [[5hfc\|5hfc]], [[5hfe\|5hfe]], [[5hff\|5hff]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfd OCA], [http://pdbe.org/5hfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfd RCSB], [http://www.ebi.ac.uk/pdbsum/5hfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfd ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Dlg4, Dlgh4, Psd95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfd OCA], [http://pdbe.org/5hfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfd RCSB], [http://www.ebi.ac.uk/pdbsum/5hfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfd ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Buffalo rat]]
		+	[[Category: Large Structures]]
	[[Category: Raman, A S]]		[[Category: Raman, A S]]
	[[Category: Ranganathan, R]]		[[Category: Ranganathan, R]]

OCA at 16:27, 18 January 2017

2017-01-18T16:27:05Z

←Older revision		Revision as of 16:27, 18 January 2017
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-	'''Unreleased structure'''

-	The ~~entry~~ 5hfd is ~~ON HOLD~~ ~~until Paper Publication~~	+	==The third PDZ domain from the synaptic protein PSD-95 (G330T, H372A double mutant)==
-		+	<StructureSection load='5hfd' size='340' side='right' caption='[[5hfd]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5hfd]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HFD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HFD FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1bfe\|1bfe]], [[5hdy\|5hdy]], [[5heb\|5heb]], [[5hed\|5hed]], [[5het\|5het]], [[5hey\|5hey]], [[5hf1\|5hf1]], [[5hf4\|5hf4]], [[5hfb\|5hfb]], [[5hfc\|5hfc]], [[5hfe\|5hfe]], [[5hff\|5hff]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hfd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hfd OCA], [http://pdbe.org/5hfd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hfd RCSB], [http://www.ebi.ac.uk/pdbsum/5hfd PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hfd ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Raman, A S]]
		+	[[Category: Ranganathan, R]]
		+	[[Category: White, K I]]
		+	[[Category: Adhesion]]
		+	[[Category: Dhr]]
		+	[[Category: Glgf]]
		+	[[Category: Pdz]]
		+	[[Category: Peptide binding protein]]
		+	[[Category: Peptide-binding domain]]
		+	[[Category: Synapse]]
		+	[[Category: Synaptic density]]

OCA at 13:35, 15 May 2016

2016-05-15T13:35:22Z

←Older revision		Revision as of 13:35, 15 May 2016
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	The entry 5hfd is ON HOLD until Paper Publication		The entry 5hfd is ON HOLD until Paper Publication

-	Authors: ~~White, K.I., Raman, A.S., Ranganathan, R.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Ranganathan, R]]
-	[[Category: Raman, A.S]]
-	[[Category: White, K.I]]

OCA at 00:37, 28 January 2016

2016-01-28T00:37:27Z

←Older revision		Revision as of 00:37, 28 January 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hfd is ON HOLD	+	The entry 5hfd is ON HOLD until Paper Publication

	Authors: White, K.I., Raman, A.S., Ranganathan, R.		Authors: White, K.I., Raman, A.S., Ranganathan, R.

OCA: Protected "5hfd" [edit=sysop:move=sysop]

2016-01-13T18:58:27Z

Protected "5hfd" [edit=sysop:move=sysop]

←Older revision

Revision as of 18:58, 13 January 2016

OCA: New page: '''Unreleased structure''' The entry 5hfd is ON HOLD Authors: White, K.I., Raman, A.S., Ranganathan, R. Description: Category: Unreleased Structures Category: Ranganathan, R [...

2016-01-13T18:58:26Z

New page: '''Unreleased structure''' The entry 5hfd is ON HOLD Authors: White, K.I., Raman, A.S., Ranganathan, R. Description: Category: Unreleased Structures Category: Ranganathan, R [...

New page

'''Unreleased structure'''

The entry 5hfd is ON HOLD

Authors: White, K.I., Raman, A.S., Ranganathan, R.

Description:
[[Category: Unreleased Structures]]
[[Category: Ranganathan, R]]
[[Category: Raman, A.S]]
[[Category: White, K.I]]