5hmb - Revision history

OCA at 10:47, 16 August 2023

2023-08-16T10:47:00Z

←Older revision		Revision as of 10:47, 16 August 2023
Line 3:		Line 3:
	<StructureSection load='5hmb' size='340' side='right'caption='[[5hmb]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='5hmb' size='340' side='right'caption='[[5hmb]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hmb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Streg Streg~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HMB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5HMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hmb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sahachiroi Streptomyces sahachiroi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HMB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HMB FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.151Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5hmc\|5hmc]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">azi13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285525 STREG])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hmb OCA], [https://pdbe.org/5hmb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hmb RCSB], [https://www.ebi.ac.uk/pdbsum/5hmb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hmb ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5hmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hmb OCA], [~~http~~://pdbe.org/5hmb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hmb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hmb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hmb ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/B4XYA6_STREG B4XYA6_STREG]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 23:		Line 24:
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Streg~~]]	+	[[Category: Streptomyces sahachiroi]]
-	[[Category: Ealick~~, S E~~]]	+	[[Category: Ealick SE]]
-	[[Category: Erb~~, M S~~]]	+	[[Category: Erb MS]]
-	[[Category: Zhang, Y]]	+	[[Category: Zhang Y]]
-	~~[[Category: Azinomycin biosynthesis]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Naphthoate]]~~	+
-	~~[[Category: Polyketide synthase]]~~	+
-	~~[[Category: Thioesterase~~]]	+

OCA at 08:22, 27 May 2020

2020-05-27T08:22:57Z

←Older revision		Revision as of 08:22, 27 May 2020
Line 1:		Line 1:

	==Crystal structure of S. sahachiroi AziG==		==Crystal structure of S. sahachiroi AziG==
-	<StructureSection load='5hmb' size='340' side='right' caption='[[5hmb]], [[Resolution\|resolution]] 2.15Å' scene=''>	+	<StructureSection load='5hmb' size='340' side='right'caption='[[5hmb]], [[Resolution\|resolution]] 2.15Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hmb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HMB OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HMB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hmb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streg Streg]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HMB OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5HMB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hmc\|5hmc]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hmc\|5hmc]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hmb OCA], [http://pdbe.org/5hmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hmb RCSB], [http://www.ebi.ac.uk/pdbsum/5hmb PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">azi13 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=285525 STREG])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5hmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hmb OCA], [http://pdbe.org/5hmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hmb RCSB], [http://www.ebi.ac.uk/pdbsum/5hmb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hmb ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 21:		Line 22:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Streg]]
	[[Category: Ealick, S E]]		[[Category: Ealick, S E]]
	[[Category: Erb, M S]]		[[Category: Erb, M S]]

OCA at 19:11, 20 February 2016

2016-02-20T19:11:30Z

←Older revision		Revision as of 19:11, 20 February 2016
Line 1:		Line 1:
		+
	==Crystal structure of S. sahachiroi AziG==		==Crystal structure of S. sahachiroi AziG==
	<StructureSection load='5hmb' size='340' side='right' caption='[[5hmb]], [[Resolution\|resolution]] 2.15Å' scene=''>		<StructureSection load='5hmb' size='340' side='right' caption='[[5hmb]], [[Resolution\|resolution]] 2.15Å' scene=''>

OCA at 15:45, 3 February 2016

2016-02-03T15:45:26Z

←Older revision		Revision as of 15:45, 3 February 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	==Crystal structure of S. sahachiroi AziG==
		+	<StructureSection load='5hmb' size='340' side='right' caption='[[5hmb]], [[Resolution\|resolution]] 2.15Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5hmb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HMB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HMB FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5hmc\|5hmc]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hmb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hmb OCA], [http://pdbe.org/5hmb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hmb RCSB], [http://www.ebi.ac.uk/pdbsum/5hmb PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The azinomycins are a family of potent antitumor agents with the ability to form interstrand cross-links with DNA. This study reports on the unusual biosynthetic formation of the 5-methyl naphthoate moiety, which is essential for effective DNA association. While sequence analysis predicts that the polyketide synthase (AziB) catalyzes the formation of this naphthoate, 2-methylbenzoic acid, a truncated single-ring product, is formed instead. We demonstrate that the thioesterase (AziG) acts as a chain elongation and cyclization (CEC) domain and is required for the additional two rounds of chain extension to form the expected product.

-	~~The entry 5hmb is ON HOLD~~	+	Polyketide Ring Expansion Mediated by a Thioesterase, Chain Elongation and Cyclization Domain, in Azinomycin Biosynthesis: Characterization of AziB and AziG.,Mori S, Simkhada D, Zhang H, Erb MS, Zhang Y, Williams H, Fedoseyenko D, Russell WK, Kim D, Fleer N, Ealick SE, Watanabe CM Biochemistry. 2016 Feb 2;55(4):704-14. doi: 10.1021/acs.biochem.5b01050. Epub, 2016 Jan 19. PMID:26731610<ref>PMID:26731610</ref>

-	~~Authors: Erb~~, M.S.~~, Zhang, Y., Ealick, S.E~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description~~: ~~Crystal structure of S. sahachiroi AziG~~	+	<div class="pdbe-citations 5hmb" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: Erb, M.S]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Ealick, S E]]
		+	[[Category: Erb, M S]]
	[[Category: Zhang, Y]]		[[Category: Zhang, Y]]
-	[[Category: ~~Ealick, S.E~~]]	+	[[Category: Azinomycin biosynthesis]]
		+	[[Category: Hydrolase]]
		+	[[Category: Naphthoate]]
		+	[[Category: Polyketide synthase]]
		+	[[Category: Thioesterase]]

OCA: Protected "5hmb" [edit=sysop:move=sysop]

2016-01-28T00:52:47Z

Protected "5hmb" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:52, 28 January 2016

OCA: New page: '''Unreleased structure''' The entry 5hmb is ON HOLD Authors: Erb, M.S., Zhang, Y., Ealick, S.E. Description: Crystal structure of S. sahachiroi AziG [[Category: Unreleased Structures]...

2016-01-28T00:52:46Z

New page: '''Unreleased structure''' The entry 5hmb is ON HOLD Authors: Erb, M.S., Zhang, Y., Ealick, S.E. Description: Crystal structure of S. sahachiroi AziG [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 5hmb is ON HOLD

Authors: Erb, M.S., Zhang, Y., Ealick, S.E.

Description: Crystal structure of S. sahachiroi AziG
[[Category: Unreleased Structures]]
[[Category: Erb, M.S]]
[[Category: Zhang, Y]]
[[Category: Ealick, S.E]]