5hpb - Revision history

OCA at 10:49, 16 August 2023

2023-08-16T10:49:45Z

←Older revision		Revision as of 10:49, 16 August 2023
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	<StructureSection load='5hpb' size='340' side='right'caption='[[5hpb]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='5hpb' size='340' side='right'caption='[[5hpb]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hpb]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPB OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hpb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HPB FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63W:5-METHYL-6-{[4-(TRIFLUOROMETHYL)PHENYL]SULFANYL}THIENO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>63W</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene~~></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.65Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=63W:5-METHYL-6-{[4-(TRIFLUOROMETHYL)PHENYL]SULFANYL}THIENO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>63W</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpb OCA], [https://pdbe.org/5hpb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hpb RCSB], [https://www.ebi.ac.uk/pdbsum/5hpb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpb ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpb OCA], [~~http~~://pdbe.org/5hpb PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hpb RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hpb PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpb ProSAT]</span></td></tr>	+
	</table>		</table>
	== Disease ==		== Disease ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[~~http~~://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[https://omim.org/entry/613839 613839]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>	+	[https://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>

	==See Also==		==See Also==
Line 20:		Line 19:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Dihydrofolate reductase]]~~	+	[[Category: Homo sapiens]]
-	~~[[Category: Human~~]]	+
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Cody, V]]	+	[[Category: Cody V]]
-	[[Category: Ganjee, A]]	+	[[Category: Ganjee A]]
-	~~[[Category: Oxidoreductase]]~~	+
-	~~[[Category: Oxidoreductase ternary complex with trifluoromethyl inhibitor]]~~	+
-	~~[[Category: Oxidoreductase-oxidoreductase inhibitor complex~~]]	+

OCA at 16:13, 11 December 2019

2019-12-11T16:13:39Z

←Older revision		Revision as of 16:13, 11 December 2019
Line 1:		Line 1:

	==human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine==		==human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine==
-	<StructureSection load='5hpb' size='340' side='right' caption='[[5hpb]], [[Resolution\|resolution]] 1.65Å' scene=''>	+	<StructureSection load='5hpb' size='340' side='right'caption='[[5hpb]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5hpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HPB FirstGlance]. <br>		<table><tr><td colspan='2'>[[5hpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HPB FirstGlance]. <br>
Line 13:		Line 13:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>		[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
		+
		+	==See Also==
		+	*[[Dihydrofolate reductase 3D structures\|Dihydrofolate reductase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
Line 19:		Line 22:
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Cody, V]]		[[Category: Cody, V]]
	[[Category: Ganjee, A]]		[[Category: Ganjee, A]]

OCA at 17:27, 15 November 2017

2017-11-15T17:27:06Z

←Older revision		Revision as of 17:27, 15 November 2017
Line 3:		Line 3:
	<StructureSection load='5hpb' size='340' side='right' caption='[[5hpb]], [[Resolution\|resolution]] 1.65Å' scene=''>		<StructureSection load='5hpb' size='340' side='right' caption='[[5hpb]], [[Resolution\|resolution]] 1.65Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hpb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HPB FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hpb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HPB FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63W:5-METHYL-6-{[4-(TRIFLUOROMETHYL)PHENYL]SULFANYL}THIENO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>63W</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63W:5-METHYL-6-{[4-(TRIFLUOROMETHYL)PHENYL]SULFANYL}THIENO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>63W</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>		<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpb OCA], [http://pdbe.org/5hpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hpb RCSB], [http://www.ebi.ac.uk/pdbsum/5hpb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpb ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpb OCA], [http://pdbe.org/5hpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hpb RCSB], [http://www.ebi.ac.uk/pdbsum/5hpb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpb ProSAT]</span></td></tr>
Line 17:		Line 18:
	</StructureSection>		</StructureSection>
	[[Category: Dihydrofolate reductase]]		[[Category: Dihydrofolate reductase]]
		+	[[Category: Human]]
	[[Category: Cody, V]]		[[Category: Cody, V]]
	[[Category: Ganjee, A]]		[[Category: Ganjee, A]]

OCA at 23:42, 25 January 2017

2017-01-25T23:42:05Z

←Older revision		Revision as of 23:42, 25 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry 5hpb is ON HOLD until Paper Publication~~	+	==human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine==
-		+	<StructureSection load='5hpb' size='340' side='right' caption='[[5hpb]], [[Resolution\|resolution]] 1.65Å' scene=''>
-	~~Authors: Cody, V., Ganjee, A.~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5hpb]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HPB FirstGlance]. <br>
-	~~Description:~~ human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=63W:5-METHYL-6-{[4-(TRIFLUOROMETHYL)PHENYL]SULFANYL}THIENO[2,3-D]PYRIMIDINE-2,4-DIAMINE'>63W</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hpb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hpb OCA], [http://pdbe.org/5hpb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hpb RCSB], [http://www.ebi.ac.uk/pdbsum/5hpb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hpb ProSAT]</span></td></tr>
		+	</table>
		+	== Disease ==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Defects in DHFR are the cause of megaloblastic anemia due to dihydrofolate reductase deficiency (DHFRD) [MIM:[http://omim.org/entry/613839 613839]]. DHFRD is an inborn error of metabolism, characterized by megaloblastic anemia and/or pancytopenia, severe cerebral folate deficiency, and cerebral tetrahydrobiopterin deficiency. Clinical features include variable neurologic symptoms, ranging from severe developmental delay and generalized seizures in infancy, to childhood absence epilepsy with learning difficulties, to lack of symptoms.<ref>PMID:21310276</ref> <ref>PMID:21310277</ref>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/DYR_HUMAN DYR_HUMAN]] Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1.<ref>PMID:21876188</ref> <ref>PMID:12096917</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dihydrofolate reductase]]
	[[Category: Cody, V]]		[[Category: Cody, V]]
	[[Category: Ganjee, A]]		[[Category: Ganjee, A]]
		+	[[Category: Oxidoreductase]]
		+	[[Category: Oxidoreductase ternary complex with trifluoromethyl inhibitor]]
		+	[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

OCA at 14:07, 3 February 2016

2016-02-03T14:07:09Z

←Older revision		Revision as of 14:07, 3 February 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5hpb is ON HOLD	+	The entry 5hpb is ON HOLD until Paper Publication

	Authors: Cody, V., Ganjee, A.		Authors: Cody, V., Ganjee, A.

OCA: Protected "5hpb" [edit=sysop:move=sysop]

2016-01-28T01:02:02Z

Protected "5hpb" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:02, 28 January 2016

OCA: New page: '''Unreleased structure''' The entry 5hpb is ON HOLD Authors: Cody, V., Ganjee, A. Description: human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluorom...

2016-01-28T01:02:00Z

New page: '''Unreleased structure''' The entry 5hpb is ON HOLD Authors: Cody, V., Ganjee, A. Description: human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluorom...

New page

'''Unreleased structure'''

The entry 5hpb is ON HOLD

Authors: Cody, V., Ganjee, A.

Description: human dihydrofolate reductase complex with NADPH and 5-methyl-6-(phenylthio-4'trifluoromethyl)thieno[2,3-d]pyrimidine-2,4-diamine
[[Category: Unreleased Structures]]
[[Category: Cody, V]]
[[Category: Ganjee, A]]