5hys - Revision history

OCA at 11:00, 16 August 2023

2023-08-16T11:00:42Z

←Older revision		Revision as of 11:00, 16 August 2023
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	<StructureSection load='5hys' size='340' side='right'caption='[[5hys]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5hys' size='340' side='right'caption='[[5hys]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hys]] is a 12 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYS OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5HYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hys]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HYS FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.5Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEL-214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGHE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5hys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hys OCA], [~~http~~://pdbe.org/5hys PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5hys RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5hys PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5hys ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hys OCA], [https://pdbe.org/5hys PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hys RCSB], [https://www.ebi.ac.uk/pdbsum/5hys PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hys ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/IGHE_HUMAN IGHE_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Jardetzky~~, T S~~]]	+	[[Category: Jardetzky TS]]
-	[[Category: Pennington~~, L F~~]]	+	[[Category: Pennington LF]]
-	[[Category: Sathiyamoorthy, K]]	+	[[Category: Sathiyamoorthy K]]
-	[[Category: Tarchevskaya~~, S S]]~~	+	[[Category: Tarchevskaya SS]]
-	~~[[Category: Immune system~~]]	+

OCA at 07:39, 10 April 2019

2019-04-10T07:39:47Z

←Older revision		Revision as of 07:39, 10 April 2019
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	==Structure of IgE complexed with omalizumab==		==Structure of IgE complexed with omalizumab==
-	<StructureSection load='5hys' size='340' side='right' caption='[[5hys]], [[Resolution\|resolution]] 2.50Å' scene=''>	+	<StructureSection load='5hys' size='340' side='right'caption='[[5hys]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5hys]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYS FirstGlance]. <br>		<table><tr><td colspan='2'>[[5hys]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYS FirstGlance]. <br>
Line 22:		Line 22:
	</StructureSection>		</StructureSection>
	[[Category: Human]]		[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Jardetzky, T S]]		[[Category: Jardetzky, T S]]
	[[Category: Pennington, L F]]		[[Category: Pennington, L F]]

OCA at 17:31, 15 November 2017

2017-11-15T17:31:01Z

←Older revision		Revision as of 17:31, 15 November 2017
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	<StructureSection load='5hys' size='340' side='right' caption='[[5hys]], [[Resolution\|resolution]] 2.50Å' scene=''>		<StructureSection load='5hys' size='340' side='right' caption='[[5hys]], [[Resolution\|resolution]] 2.50Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5hys]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYS FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5hys]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYS FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hys OCA], [http://pdbe.org/5hys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hys RCSB], [http://www.ebi.ac.uk/pdbsum/5hys PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">HEL-214 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IGHE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hys OCA], [http://pdbe.org/5hys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hys RCSB], [http://www.ebi.ac.uk/pdbsum/5hys PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hys ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
Line 20:		Line 21:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
	[[Category: Jardetzky, T S]]		[[Category: Jardetzky, T S]]
	[[Category: Pennington, L F]]		[[Category: Pennington, L F]]

OCA at 15:34, 1 June 2016

2016-06-01T15:34:00Z

←Older revision		Revision as of 15:34, 1 June 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5hys is ~~ON HOLD~~	+	==Structure of IgE complexed with omalizumab==
		+	<StructureSection load='5hys' size='340' side='right' caption='[[5hys]], [[Resolution\|resolution]] 2.50Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5hys]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HYS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HYS FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hys OCA], [http://pdbe.org/5hys PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hys RCSB], [http://www.ebi.ac.uk/pdbsum/5hys PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Omalizumab is a widely used therapeutic anti-IgE antibody. Here we report the crystal structure of the omalizumab-Fab in complex with an IgE-Fc fragment. This structure reveals the mechanism of omalizumab-mediated inhibition of IgE interactions with both high- and low-affinity IgE receptors, and explains why omalizumab selectively binds free IgE. The structure of the complex also provides mechanistic insight into a class of disruptive IgE inhibitors that accelerate the dissociation of the high-affinity IgE receptor from IgE. We use this structural data to generate a mutant IgE-Fc fragment that is resistant to omalizumab binding. Treatment with this omalizumab-resistant IgE-Fc fragment, in combination with omalizumab, promotes the exchange of cell-bound full-length IgE with omalizumab-resistant IgE-Fc fragments on human basophils. This combination treatment also blocks basophil activation more efficiently than either agent alone, providing a novel approach to probe regulatory mechanisms underlying IgE hypersensitivity with implications for therapeutic interventions.

-	~~Authors: Pennington, L.F~~., ~~Tarchevskaya~~, S~~.S.~~, ~~Sathiyamoorthy~~, K., ~~Jardetzky~~, T.S.	+	Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange.,Pennington LF, Tarchevskaya S, Brigger D, Sathiyamoorthy K, Graham MT, Nadeau KC, Eggel A, Jardetzky TS Nat Commun. 2016 May 19;7:11610. doi: 10.1038/ncomms11610. PMID:27194387<ref>PMID:27194387</ref>

-	~~Description: Structure~~ of ~~IgE complexed with omalizumab~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Pennington, L.F]]~~	+	<div class="pdbe-citations 5hys" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Tarchevskaya~~, S.S]]	+	== References ==
-	[[Category: ~~Jardetzky~~, ~~T.S~~]]	+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Jardetzky, T S]]
		+	[[Category: Pennington, L F]]
	[[Category: Sathiyamoorthy, K]]		[[Category: Sathiyamoorthy, K]]
		+	[[Category: Tarchevskaya, S S]]
		+	[[Category: Immune system]]

OCA: Protected "5hys" [edit=sysop:move=sysop]

2016-02-10T15:55:19Z

Protected "5hys" [edit=sysop:move=sysop]

←Older revision

Revision as of 15:55, 10 February 2016

OCA: New page: '''Unreleased structure''' The entry 5hys is ON HOLD Authors: Pennington, L.F., Tarchevskaya, S.S., Sathiyamoorthy, K., Jardetzky, T.S. Description: Structure of IgE complexed with oma...

2016-02-10T15:55:18Z

New page: '''Unreleased structure''' The entry 5hys is ON HOLD Authors: Pennington, L.F., Tarchevskaya, S.S., Sathiyamoorthy, K., Jardetzky, T.S. Description: Structure of IgE complexed with oma...

New page

'''Unreleased structure'''

The entry 5hys is ON HOLD

Authors: Pennington, L.F., Tarchevskaya, S.S., Sathiyamoorthy, K., Jardetzky, T.S.

Description: Structure of IgE complexed with omalizumab
[[Category: Unreleased Structures]]
[[Category: Pennington, L.F]]
[[Category: Tarchevskaya, S.S]]
[[Category: Jardetzky, T.S]]
[[Category: Sathiyamoorthy, K]]