5i1m - Revision history

OCA at 12:33, 6 March 2024

2024-03-06T12:33:33Z

←Older revision		Revision as of 12:33, 6 March 2024
Line 9:		Line 9:
	== Function ==		== Function ==
	[https://www.uniprot.org/uniprot/VPP1_YEAST VPP1_YEAST] Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1491220, PubMed:8798414, PubMed:11278748). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1491220, PubMed:11278748). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:8798414, PubMed:11278748).<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>		[https://www.uniprot.org/uniprot/VPP1_YEAST VPP1_YEAST] Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1491220, PubMed:8798414, PubMed:11278748). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1491220, PubMed:11278748). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:8798414, PubMed:11278748).<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>
-	<div style="background-color:#fffaf0;">
-	== Publication Abstract from PubMed ==
-	Rotary ATPases couple ATP synthesis or hydrolysis to proton translocation across a membrane. However, understanding proton translocation has been hampered by a lack of structural information for the membrane-embedded a subunit. The V/A-ATPase from the eubacteriumThermus thermophilusis similar in structure to the eukaryotic V-ATPase but has a simpler subunit composition and functions in vivo to synthesize ATP rather than pump protons. We determined theT. thermophilusV/A-ATPase structure by cryo-EM at 6.4 A resolution. Evolutionary covariance analysis allowed tracing of the a subunit sequence within the map, providing a complete model of the rotary ATPase. Comparing the membrane-embedded regions of theT. thermophilusV/A-ATPase and eukaryotic V-ATPase fromSaccharomyces cerevisiaeallowed identification of the alpha-helices that belong to the a subunit and revealed the existence of previously unknown subunits in the eukaryotic enzyme. Subsequent evolutionary covariance analysis enabled construction of a model of the a subunit in theS. cerevisaeV-ATPase that explains numerous biochemical studies of that enzyme. Comparing the two a subunit structures determined here with a structure of the distantly related a subunit from the bovine F-type ATP synthase revealed a conserved pattern of residues, suggesting a common mechanism for proton transport in all rotary ATPases.
-
-	Models for the a subunits of the Thermus thermophilus V/A-ATPase and Saccharomyces cerevisiae V-ATPase enzymes by cryo-EM and evolutionary covariance.,Schep DG, Zhao J, Rubinstein JL Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3245-50. doi:, 10.1073/pnas.1521990113. Epub 2016 Mar 7. PMID:26951669<ref>PMID:26951669</ref>
-
-	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	</div>
-	<div class="pdbe-citations 5i1m" style="background-color:#fffaf0;"></div>

	==See Also==		==See Also==

OCA at 08:20, 23 August 2023

2023-08-23T08:20:13Z

←Older revision		Revision as of 08:20, 23 August 2023
Line 3:		Line 3:
	<SX load='5i1m' size='340' side='right' viewer='molstar' caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>		<SX load='5i1m' size='340' side='right' viewer='molstar' caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5I1M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5I1M FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[5gar\|5gar]]~~, [[~~5gas~~\|~~5gas~~]]</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 7Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5i1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i1m OCA], [~~http~~://pdbe.org/5i1m PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5i1m RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5i1m PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5i1m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5i1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i1m OCA], [https://pdbe.org/5i1m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5i1m RCSB], [https://www.ebi.ac.uk/pdbsum/5i1m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5i1m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/~~VPH1_YEAST VPH1_YEAST]~~] Subunit of the ~~integral membrane~~ V0 complex of vacuolar ATPase ~~essential~~ for ~~assembly~~ and ~~catalytic activity~~. Is present only in vacuolar V-ATPase complexes~~. Enzymes~~ containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion~~. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells~~.<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>	+	[https://www.uniprot.org/uniprot/VPP1_YEAST VPP1_YEAST] Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (PubMed:1491220, PubMed:8798414, PubMed:11278748). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (PubMed:1491220, PubMed:11278748). Is present only in vacuolar V-ATPase complexes; enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion (PubMed:8798414, PubMed:11278748).<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
Line 27:		Line 27:
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
-	[[Category: Rubinstein~~, J L~~]]	+	[[Category: Rubinstein JL]]
-	[[Category: Schep~~, D G~~]]	+	[[Category: Schep DG]]
-	[[Category: Zhao, J]]	+	[[Category: Zhao J]]
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: V-atpase]]~~	+
-	~~[[Category: Vo region~~]]	+

OCA at 20:13, 10 April 2020

2020-04-10T20:13:00Z

←Older revision		Revision as of 20:13, 10 April 2020
Line 3:		Line 3:
	<SX load='5i1m' size='340' side='right' viewer='molstar' caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>		<SX load='5i1m' size='340' side='right' viewer='molstar' caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5I1M FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5I1M FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gar\|5gar]], [[5gas\|5gas]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gar\|5gar]], [[5gas\|5gas]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5i1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i1m OCA], [http://pdbe.org/5i1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i1m RCSB], [http://www.ebi.ac.uk/pdbsum/5i1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i1m ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5i1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i1m OCA], [http://pdbe.org/5i1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i1m RCSB], [http://www.ebi.ac.uk/pdbsum/5i1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i1m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:33, 6 March 2020

2020-03-06T18:33:14Z

←Older revision		Revision as of 18:33, 6 March 2020
Line 1:		Line 1:

	==Yeast V-ATPase average of densities, a subunit segment==		==Yeast V-ATPase average of densities, a subunit segment==
-	<~~StructureSection~~ load='5i1m' size='340' side='right'caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>	+	<SX load='5i1m' size='340' side='right' viewer='molstar' caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I1M FirstGlance]. <br>		<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I1M FirstGlance]. <br>
Line 24:		Line 24:
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]

OCA at 08:50, 18 December 2019

2019-12-18T08:50:31Z

←Older revision		Revision as of 08:50, 18 December 2019
Line 1:		Line 1:

	==Yeast V-ATPase average of densities, a subunit segment==		==Yeast V-ATPase average of densities, a subunit segment==
-	<StructureSection load='5i1m' size='340' side='right' caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>	+	<StructureSection load='5i1m' size='340' side='right'caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I1M FirstGlance]. <br>		<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I1M FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gar\|5gar]], [[5gas\|5gas]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gar\|5gar]], [[5gas\|5gas]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i1m OCA], [http://pdbe.org/5i1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i1m RCSB], [http://www.ebi.ac.uk/pdbsum/5i1m PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i1m OCA], [http://pdbe.org/5i1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i1m RCSB], [http://www.ebi.ac.uk/pdbsum/5i1m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5i1m ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 18:		Line 18:
	</div>		</div>
	<div class="pdbe-citations 5i1m" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5i1m" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[ATPase 3D structures\|ATPase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Saccharomyces cerevisiae]]		[[Category: Saccharomyces cerevisiae]]
	[[Category: Rubinstein, J L]]		[[Category: Rubinstein, J L]]

OCA at 17:59, 10 May 2016

2016-05-10T17:59:07Z

←Older revision		Revision as of 17:59, 10 May 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/VPH1_YEAST VPH1_YEAST]] Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in vacuolar V-ATPase complexes. Enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>		[[http://www.uniprot.org/uniprot/VPH1_YEAST VPH1_YEAST]] Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in vacuolar V-ATPase complexes. Enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Rotary ATPases couple ATP synthesis or hydrolysis to proton translocation across a membrane. However, understanding proton translocation has been hampered by a lack of structural information for the membrane-embedded a subunit. The V/A-ATPase from the eubacteriumThermus thermophilusis similar in structure to the eukaryotic V-ATPase but has a simpler subunit composition and functions in vivo to synthesize ATP rather than pump protons. We determined theT. thermophilusV/A-ATPase structure by cryo-EM at 6.4 A resolution. Evolutionary covariance analysis allowed tracing of the a subunit sequence within the map, providing a complete model of the rotary ATPase. Comparing the membrane-embedded regions of theT. thermophilusV/A-ATPase and eukaryotic V-ATPase fromSaccharomyces cerevisiaeallowed identification of the alpha-helices that belong to the a subunit and revealed the existence of previously unknown subunits in the eukaryotic enzyme. Subsequent evolutionary covariance analysis enabled construction of a model of the a subunit in theS. cerevisaeV-ATPase that explains numerous biochemical studies of that enzyme. Comparing the two a subunit structures determined here with a structure of the distantly related a subunit from the bovine F-type ATP synthase revealed a conserved pattern of residues, suggesting a common mechanism for proton transport in all rotary ATPases.
		+
		+	Models for the a subunits of the Thermus thermophilus V/A-ATPase and Saccharomyces cerevisiae V-ATPase enzymes by cryo-EM and evolutionary covariance.,Schep DG, Zhao J, Rubinstein JL Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3245-50. doi:, 10.1073/pnas.1521990113. Epub 2016 Mar 7. PMID:26951669<ref>PMID:26951669</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5i1m" style="background-color:#fffaf0;"></div>
	== References ==		== References ==
	<references/>		<references/>

OCA at 04:00, 10 March 2016

2016-03-10T04:00:14Z

←Older revision		Revision as of 04:00, 10 March 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5i1m is ~~ON HOLD~~	+	==Yeast V-ATPase average of densities, a subunit segment==
-		+	<StructureSection load='5i1m' size='340' side='right' caption='[[5i1m]], [[Resolution\|resolution]] 7.00Å' scene=''>
-	~~Authors~~: ~~Schep~~, D.G., ~~Zhao~~, J., ~~Rubinstein, J~~.L.	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5i1m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5I1M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5I1M FirstGlance]. <br>
-	~~Description~~: ~~Yeast~~ V-ATPase ~~average~~ of ~~densities,~~ a ~~subunit segment~~	+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5gar\|5gar]], [[5gas\|5gas]]</td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5i1m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5i1m OCA], [http://pdbe.org/5i1m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5i1m RCSB], [http://www.ebi.ac.uk/pdbsum/5i1m PDBsum]</span></td></tr>
-	[[Category: ~~Schep~~, ~~D.G~~]]	+	</table>
-	[[Category: ~~Rubinstein~~, ~~J.L~~]]	+	== Function ==
		+	[[http://www.uniprot.org/uniprot/VPH1_YEAST VPH1_YEAST]] Subunit of the integral membrane V0 complex of vacuolar ATPase essential for assembly and catalytic activity. Is present only in vacuolar V-ATPase complexes. Enzymes containing this subunit have a 4-fold higher ratio of proton transport to ATP hydrolysis than complexes containing the Golgi/endosomal isoform and undergo reversible dissociation of V1 and V0 in response to glucose depletion. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.<ref>PMID:11278748</ref> <ref>PMID:1491220</ref> <ref>PMID:8798414</ref>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Saccharomyces cerevisiae]]
		+	[[Category: Rubinstein, J L]]
		+	[[Category: Schep, D G]]
	[[Category: Zhao, J]]		[[Category: Zhao, J]]
		+	[[Category: Membrane protein]]
		+	[[Category: V-atpase]]
		+	[[Category: Vo region]]

OCA: Protected "5i1m" [edit=sysop:move=sysop]

2016-02-21T01:25:59Z

Protected "5i1m" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:25, 21 February 2016

OCA: New page: '''Unreleased structure''' The entry 5i1m is ON HOLD Authors: Schep, D.G., Zhao, J., Rubinstein, J.L. Description: Yeast V-ATPase average of densities, a subunit segment [[Category: Un...

2016-02-21T01:25:57Z

New page: '''Unreleased structure''' The entry 5i1m is ON HOLD Authors: Schep, D.G., Zhao, J., Rubinstein, J.L. Description: Yeast V-ATPase average of densities, a subunit segment [[Category: Un...

New page

'''Unreleased structure'''

The entry 5i1m is ON HOLD

Authors: Schep, D.G., Zhao, J., Rubinstein, J.L.

Description: Yeast V-ATPase average of densities, a subunit segment
[[Category: Unreleased Structures]]
[[Category: Schep, D.G]]
[[Category: Rubinstein, J.L]]
[[Category: Zhao, J]]