5ic1 - Revision history

OCA at 13:45, 30 August 2023

2023-08-30T13:45:16Z

←Older revision		Revision as of 13:45, 30 August 2023
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	<StructureSection load='5ic1' size='340' side='right'caption='[[5ic1]], [[Resolution\|resolution]] 2.20Å' scene=''>		<StructureSection load='5ic1' size='340' side='right'caption='[[5ic1]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ic1]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Lk3_transgenic_mice Lk3 transgenic mice~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ic1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IC1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat">~~<scene name='pdbligand=EDO:1~~,2~~-ETHANEDIOL'>EDO</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.2Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[4w8p\|4w8p]], [[5ic0\|5ic0]]</td></tr>~~	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~"><~~b>[[Gene\|Gene~~:~~]]</b~~></td>~~<td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic1 OCA], [https://pdbe.org/5ic1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ic1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ic1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic1 OCA], [~~http~~://pdbe.org/5ic1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ic1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ic1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic1 ProSAT]</span></td></tr>	+
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.	+	[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Lk3 transgenic mice~~]]	+	[[Category: Mus musculus]]
-	[[Category: Chang, Y ~~C.E~~]]	+	[[Category: Chang Y-CE]]
-	[[Category: Huang, Q Q]]	+	[[Category: Huang Q-Q]]
-	[[Category: Wu, J]]	+	[[Category: Wu J]]
-	[[Category: Zhang, H]]	+	[[Category: Zhang H]]
-	~~[[Category: Alternative]]~~	+
-	~~[[Category: Autoinhibition]]~~	+
-	~~[[Category: Integrin]]~~	+
-	~~[[Category: Peptide binding protein]]~~	+
-	~~[[Category: Riam~~]]	+

OCA at 09:07, 4 December 2019

2019-12-04T09:07:31Z

←Older revision		Revision as of 09:07, 4 December 2019
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	==Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant==		==Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant==
-	<StructureSection load='5ic1' size='340' side='right' caption='[[5ic1]], [[Resolution\|resolution]] 2.20Å' scene=''>	+	<StructureSection load='5ic1' size='340' side='right'caption='[[5ic1]], [[Resolution\|resolution]] 2.20Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ic1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IC1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ic1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IC1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w8p\|4w8p]], [[5ic0\|5ic0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w8p\|4w8p]], [[5ic0\|5ic0]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">Tln1, Tln ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic1 OCA], [http://pdbe.org/5ic1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ic1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ic1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic1 OCA], [http://pdbe.org/5ic1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ic1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ic1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic1 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Lk3 transgenic mice]]
	[[Category: Chang, Y C.E]]		[[Category: Chang, Y C.E]]
	[[Category: Huang, Q Q]]		[[Category: Huang, Q Q]]

OCA at 04:43, 21 September 2017

2017-09-21T04:43:44Z

←Older revision		Revision as of 04:43, 21 September 2017
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	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w8p\|4w8p]], [[5ic0\|5ic0]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w8p\|4w8p]], [[5ic0\|5ic0]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic1 OCA], [http://pdbe.org/5ic1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ic1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ic1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic1 OCA], [http://pdbe.org/5ic1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ic1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ic1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ic1 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5ic1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ic1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Talin\|Talin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 15:55, 1 June 2016

2016-06-01T15:55:24Z

←Older revision		Revision as of 15:55, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ic1 is ~~ON HOLD until Paper~~ Publication	+	==Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant==
		+	<StructureSection load='5ic1' size='340' side='right' caption='[[5ic1]], [[Resolution\|resolution]] 2.20Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ic1]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IC1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[4w8p\|4w8p]], [[5ic0\|5ic0]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ic1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ic1 OCA], [http://pdbe.org/5ic1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ic1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ic1 PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE]] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Talin plays an important role in regulating integrin-mediated signaling. Talin function is autoinhibited by intramolecular interactions between the integrin-binding F3 domain and the autoinhibitory domain (R9). We determined the crystal structure of a triple-domain fragment, R7R8R9, which contains R9 and the RIAM (Rap1-interacting adaptor molecule) binding domain (R8). The structure reveals a crystallographic contact between R9 and a symmetrically related R8 domain, representing a homodimeric interaction in talin. Strikingly, we demonstrated that the alpha5 helix of R9 also interacts with the F3 domain, despite no interdomain contact involving the alpha5 helix in the crystal structure of an F2F3:R9 autoinhibitory complex reported previously. Mutations on the alpha5 helix significantly diminish the F3:R9 association and lead to elevated talin activity. Our results offer biochemical and functional evidence of the existence of a new talin autoinhibitory configuration, thus providing a more comprehensive understanding of talin autoinhibition, regulation, and quaternary structure assembly.

-	~~Authors~~:	+	Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.,Zhang H, Chang YC, Huang Q, Brennan ML, Wu J Structure. 2016 May 3;24(5):721-9. doi: 10.1016/j.str.2016.02.020. Epub 2016 Apr , 14. PMID:27150043<ref>PMID:27150043</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ic1" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Chang, Y C.E]]
		+	[[Category: Huang, Q Q]]
		+	[[Category: Wu, J]]
		+	[[Category: Zhang, H]]
		+	[[Category: Alternative]]
		+	[[Category: Autoinhibition]]
		+	[[Category: Integrin]]
		+	[[Category: Peptide binding protein]]
		+	[[Category: Riam]]

OCA at 14:18, 15 May 2016

2016-05-15T14:18:59Z

←Older revision		Revision as of 14:18, 15 May 2016
Line 3:		Line 3:
	The entry 5ic1 is ON HOLD until Paper Publication		The entry 5ic1 is ON HOLD until Paper Publication

-	Authors: ~~Wu, J., Chang, Y.-C.E., Zhang, H., Huang, Q.-Q.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Zhang, H]]
-	[[Category: Wu, J]]
-	[[Category: Huang, Q.-Q]]
-	[[Category: Chang, Y.-C.E]]

OCA at 00:22, 11 May 2016

2016-05-11T00:22:29Z

←Older revision		Revision as of 00:22, 11 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ic1 is ON HOLD	+	The entry 5ic1 is ON HOLD until Paper Publication

-	Authors: Wu, J., Chang, Y.-C.E., Zhang, H., Huang, Q.-Q~~., Brennan, M.L~~.	+	Authors: Wu, J., Chang, Y.-C.E., Zhang, H., Huang, Q.-Q.

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Zhang, H]]		[[Category: Zhang, H]]
-	[[Category: Brennan, M.L]]
	[[Category: Wu, J]]		[[Category: Wu, J]]
	[[Category: Huang, Q.-Q]]		[[Category: Huang, Q.-Q]]
	[[Category: Chang, Y.-C.E]]		[[Category: Chang, Y.-C.E]]

OCA: Protected "5ic1" [edit=sysop:move=sysop]

2016-03-02T13:42:37Z

Protected "5ic1" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:42, 2 March 2016

OCA: New page: '''Unreleased structure''' The entry 5ic1 is ON HOLD Authors: Wu, J., Chang, Y.-C.E., Zhang, H., Huang, Q.-Q., Brennan, M.L. Description: Category: Unreleased Structures [[Categor...

2016-03-02T13:42:35Z

New page: '''Unreleased structure''' The entry 5ic1 is ON HOLD Authors: Wu, J., Chang, Y.-C.E., Zhang, H., Huang, Q.-Q., Brennan, M.L. Description: Category: Unreleased Structures [[Categor...

New page

'''Unreleased structure'''

The entry 5ic1 is ON HOLD

Authors: Wu, J., Chang, Y.-C.E., Zhang, H., Huang, Q.-Q., Brennan, M.L.

Description:
[[Category: Unreleased Structures]]
[[Category: Zhang, H]]
[[Category: Brennan, M.L]]
[[Category: Wu, J]]
[[Category: Huang, Q.-Q]]
[[Category: Chang, Y.-C.E]]