5icr - Revision history

OCA at 13:45, 30 August 2023

2023-08-30T13:45:58Z

←Older revision		Revision as of 13:45, 30 August 2023
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	<StructureSection load='5icr' size='340' side='right'caption='[[5icr]], [[Resolution\|resolution]] 2.25Å' scene=''>		<StructureSection load='5icr' size='340' side='right'caption='[[5icr]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5icr]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Mycs2 Mycs2~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICR OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5ICR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5icr]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_smegmatis_MC2_155 Mycolicibacterium smegmatis MC2 155]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5ICR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=649:5-O-[(11-PHENOXYUNDECANOYL)SULFAMOYL]ADENOSINE'>649</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.25Å</td></tr>
-	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadD32, MSMEG_6393, MSMEI_6225 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=649:5-O-[(11-PHENOXYUNDECANOYL)SULFAMOYL]ADENOSINE'>649</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5icr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icr OCA], [~~http~~://pdbe.org/5icr PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5icr RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5icr PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5icr ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5icr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icr OCA], [https://pdbe.org/5icr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5icr RCSB], [https://www.ebi.ac.uk/pdbsum/5icr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5icr ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/FAA32_MYCS2 FAA32_MYCS2] Involved in the biosynthesis of mycolic acids (By similarity). Catalyzes the activation of long-chain fatty acids as acyl-adenylates (acyl-AMP), which are then transferred to the phosphopantetheine arm of the polyketide synthase Pks13 for further chain extension (By similarity). Can use decanoate (C10), dodecanoate (C12) and tetradecanoate (C14) (PubMed:23364516, PubMed:26900152).[UniProtKB:O53580]<ref>PMID:23364516</ref> <ref>PMID:26900152</ref>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Mycs2~~]]	+	[[Category: Mycolicibacterium smegmatis MC2 155]]
-	[[Category: Anderson~~, W F]]~~	+	[[Category: Anderson WF]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Dubrovska I]]
-	[[Category: Dubrovska, I]]	+	[[Category: Edelstein J]]
-	[[Category: Edelstein, J]]	+	[[Category: Fisher SL]]
-	[[Category: Fisher~~, S L~~]]	+	[[Category: Hung D]]
-	[[Category: Hung, D]]	+	[[Category: Kiryukhina O]]
-	[[Category: Kiryukhina, O]]	+	[[Category: Minasov G]]
-	[[Category: Minasov, G]]	+	[[Category: Shuvalova L]]
-	[[Category: Shuvalova, L]]	+
-	~~[[Category: Csgid]]~~	+
-	~~[[Category: Fadd32]]~~	+
-	~~[[Category: Fatty-acid-coa ligase]]~~	+
-	~~[[Category: Ligase-ligase inhibitor complex~~]]	+

OCA at 07:13, 3 June 2020

2020-06-03T07:13:22Z

←Older revision		Revision as of 07:13, 3 June 2020
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	==2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine.==		==2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine.==
-	<StructureSection load='5icr' size='340' side='right' caption='[[5icr]], [[Resolution\|resolution]] 2.25Å' scene=''>	+	<StructureSection load='5icr' size='340' side='right'caption='[[5icr]], [[Resolution\|resolution]] 2.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5icr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICR OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ICR FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5icr]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycs2 Mycs2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICR OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5ICR FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=649:5-O-[(11-PHENOXYUNDECANOYL)SULFAMOYL]ADENOSINE'>649</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=649:5-O-[(11-PHENOXYUNDECANOYL)SULFAMOYL]ADENOSINE'>649</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5icr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icr OCA], [http://pdbe.org/5icr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icr RCSB], [http://www.ebi.ac.uk/pdbsum/5icr PDBsum]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">fadD32, MSMEG_6393, MSMEI_6225 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=246196 MYCS2])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5icr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icr OCA], [http://pdbe.org/5icr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icr RCSB], [http://www.ebi.ac.uk/pdbsum/5icr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5icr ProSAT]</span></td></tr>
	</table>		</table>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Mycs2]]
	[[Category: Anderson, W F]]		[[Category: Anderson, W F]]
	[[Category: Structural genomic]]		[[Category: Structural genomic]]

OCA at 04:12, 12 May 2016

2016-05-12T04:12:36Z

←Older revision		Revision as of 04:12, 12 May 2016
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-	'''Unreleased structure'''

-	~~The entry 5icr is ON HOLD until Apr 05 2017~~	+	==2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine.==
-		+	<StructureSection load='5icr' size='340' side='right' caption='[[5icr]], [[Resolution\|resolution]] 2.25Å' scene=''>
-	~~Authors: Minasov, G., Shuvalova, L., Hung, D., Fisher, S.L., Edelstein, J., Kiryukhina, O., Dubrovska, I., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5icr]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5ICR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ICR FirstGlance]. <br>
-	~~Description:~~ 2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine.	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=649:5-O-[(11-PHENOXYUNDECANOYL)SULFAMOYL]ADENOSINE'>649</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5icr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5icr OCA], [http://pdbe.org/5icr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5icr RCSB], [http://www.ebi.ac.uk/pdbsum/5icr PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Anderson, W F]]
		+	[[Category: Structural genomic]]
	[[Category: Dubrovska, I]]		[[Category: Dubrovska, I]]
-	[[Category: Minasov, G]]
	[[Category: Edelstein, J]]		[[Category: Edelstein, J]]
		+	[[Category: Fisher, S L]]
	[[Category: Hung, D]]		[[Category: Hung, D]]
-	[[Category: Fisher, S.L]]
	[[Category: Kiryukhina, O]]		[[Category: Kiryukhina, O]]
-	[[Category: ~~Anderson~~, ~~W.F]]~~	+	[[Category: Minasov, G]]
-	~~[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)~~]]	+
	[[Category: Shuvalova, L]]		[[Category: Shuvalova, L]]
		+	[[Category: Csgid]]
		+	[[Category: Fadd32]]
		+	[[Category: Fatty-acid-coa ligase]]
		+	[[Category: Ligase-ligase inhibitor complex]]

OCA at 02:07, 10 March 2016

2016-03-10T02:07:40Z

←Older revision		Revision as of 02:07, 10 March 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5icr is ON HOLD	+	The entry 5icr is ON HOLD until Apr 05 2017

	Authors: Minasov, G., Shuvalova, L., Hung, D., Fisher, S.L., Edelstein, J., Kiryukhina, O., Dubrovska, I., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)		Authors: Minasov, G., Shuvalova, L., Hung, D., Fisher, S.L., Edelstein, J., Kiryukhina, O., Dubrovska, I., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

OCA: Protected "5icr" [edit=sysop:move=sysop]

2016-03-02T13:44:48Z

Protected "5icr" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:44, 2 March 2016

OCA: New page: '''Unreleased structure''' The entry 5icr is ON HOLD Authors: Minasov, G., Shuvalova, L., Hung, D., Fisher, S.L., Edelstein, J., Kiryukhina, O., Dubrovska, I., Anderson, W.F., Center fo...

2016-03-02T13:44:46Z

New page: '''Unreleased structure''' The entry 5icr is ON HOLD Authors: Minasov, G., Shuvalova, L., Hung, D., Fisher, S.L., Edelstein, J., Kiryukhina, O., Dubrovska, I., Anderson, W.F., Center fo...

New page

'''Unreleased structure'''

The entry 5icr is ON HOLD

Authors: Minasov, G., Shuvalova, L., Hung, D., Fisher, S.L., Edelstein, J., Kiryukhina, O., Dubrovska, I., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)

Description: 2.25 Angstrom Resolution Crystal Structure of Fatty-Acid-CoA Ligase (FadD32) from Mycobacterium smegmatis in complex with Inhibitor 5'-O-[(11-phenoxyundecanoyl)sulfamoyl]adenosine.
[[Category: Unreleased Structures]]
[[Category: Dubrovska, I]]
[[Category: Minasov, G]]
[[Category: Edelstein, J]]
[[Category: Hung, D]]
[[Category: Fisher, S.L]]
[[Category: Kiryukhina, O]]
[[Category: Anderson, W.F]]
[[Category: Center For Structural Genomics Of Infectious Diseases (Csgid)]]
[[Category: Shuvalova, L]]