5ide - Revision history

OCA at 13:46, 30 August 2023

2023-08-30T13:46:47Z

←Older revision		Revision as of 13:46, 30 August 2023
Line 3:		Line 3:
	<SX load='5ide' size='340' side='right' viewer='molstar' caption='[[5ide]], [[Resolution\|resolution]] 8.25Å' scene=''>		<SX load='5ide' size='340' side='right' viewer='molstar' caption='[[5ide]], [[Resolution\|resolution]] 8.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IDE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IDE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ide FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ide OCA], [~~http~~://pdbe.org/5ide PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ide RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ide PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ide ProSAT]</span></td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution\|Resolution]] 8.25Å</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ide FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ide OCA], [https://pdbe.org/5ide PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ide RCSB], [https://www.ebi.ac.uk/pdbsum/5ide PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ide ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> [[http://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).	+	[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</SX>		</SX>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Fernandez-Leiro, R]]	+	[[Category: Rattus norvegicus]]
-	[[Category: Garcia-Nafria, J]]	+	[[Category: Fernandez-Leiro R]]
-	[[Category: Greger~~, I H~~]]	+	[[Category: Garcia-Nafria J]]
-	[[Category: Herguedas, B]]	+	[[Category: Greger IH]]
-	~~[[Category: Ampa glutamate receptor]]~~	+	[[Category: Herguedas B]]
-	~~[[Category: Signaling protein~~]]	+

OCA at 20:13, 10 April 2020

2020-04-10T20:13:18Z

←Older revision		Revision as of 20:13, 10 April 2020
Line 3:		Line 3:
	<SX load='5ide' size='340' side='right' viewer='molstar' caption='[[5ide]], [[Resolution\|resolution]] 8.25Å' scene=''>		<SX load='5ide' size='340' side='right' viewer='molstar' caption='[[5ide]], [[Resolution\|resolution]] 8.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IDE FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IDE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ide FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ide OCA], [http://pdbe.org/5ide PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ide RCSB], [http://www.ebi.ac.uk/pdbsum/5ide PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ide ProSAT]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ide FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ide OCA], [http://pdbe.org/5ide PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ide RCSB], [http://www.ebi.ac.uk/pdbsum/5ide PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ide ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 18:33, 6 March 2020

2020-03-06T18:33:23Z

←Older revision		Revision as of 18:33, 6 March 2020
Line 1:		Line 1:

	==Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I)==		==Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I)==
-	<~~StructureSection~~ load='5ide' size='340' side='right' caption='[[5ide]], [[Resolution\|resolution]] 8.25Å' scene=''>	+	<SX load='5ide' size='340' side='right' viewer='molstar' caption='[[5ide]], [[Resolution\|resolution]] 8.25Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IDE FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IDE FirstGlance]. <br>
Line 17:		Line 17:
	</div>		</div>
	<div class="pdbe-citations 5ide" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ide" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Glutamate receptor 3D structures\|Glutamate receptor 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
-	</~~StructureSection~~>	+	</SX>
		+	[[Category: Large Structures]]
	[[Category: Fernandez-Leiro, R]]		[[Category: Fernandez-Leiro, R]]
	[[Category: Garcia-Nafria, J]]		[[Category: Garcia-Nafria, J]]

OCA at 09:48, 12 October 2017

2017-10-12T09:48:03Z

←Older revision		Revision as of 09:48, 12 October 2017
Line 4:		Line 4:
	== Structural highlights ==		== Structural highlights ==
	<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IDE FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IDE FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ide FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ide OCA], [http://pdbe.org/5ide PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ide RCSB], [http://www.ebi.ac.uk/pdbsum/5ide PDBsum]</span></td></tr>	+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ide FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ide OCA], [http://pdbe.org/5ide PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ide RCSB], [http://www.ebi.ac.uk/pdbsum/5ide PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ide ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==

OCA at 17:20, 10 May 2016

2016-05-10T17:20:50Z

←Older revision		Revision as of 17:20, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ide is ~~ON HOLD~~	+	==Cryo-EM structure of GluA2/3 AMPA receptor heterotetramer (model I)==
		+	<StructureSection load='5ide' size='340' side='right' caption='[[5ide]], [[Resolution\|resolution]] 8.25Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ide]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IDE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IDE FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ide FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ide OCA], [http://pdbe.org/5ide PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ide RCSB], [http://www.ebi.ac.uk/pdbsum/5ide PDBsum]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref> [[http://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT]] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	AMPA-type glutamate receptors (AMPARs), which are central mediators of rapid neurotransmission and synaptic plasticity, predominantly exist as heteromers of the subunits GluA1 to GluA4. Here we report the first AMPAR heteromer structures, which deviate substantially from existing GluA2 homomer structures. Crystal structures of the GluA2/3 and GluA2/4 N-terminal domains reveal a novel compact conformation with an alternating arrangement of the four subunits around a central axis. This organization is confirmed by cysteine cross-linking in full-length receptors, and it permitted us to determine the structure of an intact GluA2/3 receptor by cryogenic electron microscopy. Two models in the ligand-free state, at resolutions of 8.25 and 10.3 angstroms, exhibit substantial vertical compression and close associations between domain layers, reminiscent of N-methyl-D-aspartate receptors. Model 1 resembles a resting state and model 2 a desensitized state, thus providing snapshots of gating transitions in the nominal absence of ligand. Our data reveal organizational features of heteromeric AMPARs and provide a framework to decipher AMPAR architecture and signaling.

-	~~Authors: Herguedas~~, B., Garcia-Nafria, J., Fernandez-Leiro, R., ~~Greger~~, I.H.	+	Structure and organization of heteromeric AMPA-type glutamate receptors.,Herguedas B, Garcia-Nafria J, Cais O, Fernandez-Leiro R, Krieger J, Ho H, Greger IH Science. 2016 Apr 29;352(6285):aad3873. doi: 10.1126/science.aad3873. Epub 2016, Mar 10. PMID:26966189<ref>PMID:26966189</ref>

-	~~Description:~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Greger, I.H]]~~	+	<div class="pdbe-citations 5ide" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Fernandez-Leiro, R]]		[[Category: Fernandez-Leiro, R]]
	[[Category: Garcia-Nafria, J]]		[[Category: Garcia-Nafria, J]]
		+	[[Category: Greger, I H]]
	[[Category: Herguedas, B]]		[[Category: Herguedas, B]]
		+	[[Category: Ampa glutamate receptor]]
		+	[[Category: Signaling protein]]

OCA at 02:09, 10 March 2016

2016-03-10T02:09:08Z

←Older revision		Revision as of 02:09, 10 March 2016
Line 3:		Line 3:
	The entry 5ide is ON HOLD		The entry 5ide is ON HOLD

-	Authors: Herguedas, B., Garcia-Nafria, J,, Fernandez-Leiro, R., Greger, I.H.	+	Authors: Herguedas, B., Garcia-Nafria, J., Fernandez-Leiro, R., Greger, I.H.

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
	[[Category: Greger, I.H]]		[[Category: Greger, I.H]]
-	[[Category: Garcia-Nafria, J~~,, Fernandez-Leiro, R~~]]	+	[[Category: Fernandez-Leiro, R]]
		+	[[Category: Garcia-Nafria, J]]
	[[Category: Herguedas, B]]		[[Category: Herguedas, B]]

OCA: Protected "5ide" [edit=sysop:move=sysop]

2016-03-02T13:47:07Z

Protected "5ide" [edit=sysop:move=sysop]

←Older revision

Revision as of 13:47, 2 March 2016

OCA: New page: '''Unreleased structure''' The entry 5ide is ON HOLD Authors: Herguedas, B., Garcia-Nafria, J,, Fernandez-Leiro, R., Greger, I.H. Description: Category: Unreleased Structures [[Ca...

2016-03-02T13:47:06Z

New page: '''Unreleased structure''' The entry 5ide is ON HOLD Authors: Herguedas, B., Garcia-Nafria, J,, Fernandez-Leiro, R., Greger, I.H. Description: Category: Unreleased Structures [[Ca...

New page

'''Unreleased structure'''

The entry 5ide is ON HOLD

Authors: Herguedas, B., Garcia-Nafria, J,, Fernandez-Leiro, R., Greger, I.H.

Description:
[[Category: Unreleased Structures]]
[[Category: Greger, I.H]]
[[Category: Garcia-Nafria, J,, Fernandez-Leiro, R]]
[[Category: Herguedas, B]]