5ig1 - Revision history

OCA at 13:50, 30 August 2023

2023-08-30T13:50:10Z

←Older revision		Revision as of 13:50, 30 August 2023
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	<StructureSection load='5ig1' size='340' side='right'caption='[[5ig1]], [[Resolution\|resolution]] 2.90Å' scene=''>		<StructureSection load='5ig1' size='340' side='right'caption='[[5ig1]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ig1]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Proterospongia_sp._atcc_50818 Proterospongia sp. atcc 50818~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IG1 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IG1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ig1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salpingoeca_rosetta Salpingoeca rosetta]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IG1 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat"~~><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.9Å</td></tr>
-	~~<tr~~ id~~='related'><td class~~="~~sblockLbl~~">~~<b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig0\|5ig0]]~~, [[~~5ig3~~\|~~5ig3]], [[5ig4\|5ig4]], [[5ig5\|5ig5~~]]</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~PTSG_10090 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=946362 Proterospongia sp. ATCC 50818])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ig1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig1 OCA], [https://pdbe.org/5ig1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ig1 RCSB], [https://www.ebi.ac.uk/pdbsum/5ig1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ig1 ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ig1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig1 OCA], [~~http~~://pdbe.org/5ig1 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ig1 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ig1 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ig1 ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/F2UPG5_SALR5 F2UPG5_SALR5]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5ig1" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ig1" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Calcium/calmodulin dependent protein kinase 3D structures\|Calcium/calmodulin dependent protein kinase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Proterospongia sp. atcc 50818~~]]	+	[[Category: Salpingoeca rosetta]]
-	[[Category: Barros, T]]	+	[[Category: Barros T]]
-	[[Category: Bhattacharyya, M]]	+	[[Category: Bhattacharyya M]]
-	[[Category: Gee~~, C L~~]]	+	[[Category: Gee CL]]
-	[[Category: Kuriyan, J]]	+	[[Category: Kuriyan J]]
-	~~[[Category: Ca2+/cam-dependent kinase]]~~	+
-	~~[[Category: Choanoflagellate]]~~	+
-	~~[[Category: Transferase~~]]	+

OCA at 16:17, 20 November 2019

2019-11-20T16:17:15Z

←Older revision		Revision as of 16:17, 20 November 2019
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	==Crystal structure of S. rosetta CaMKII kinase domain==		==Crystal structure of S. rosetta CaMKII kinase domain==
-	<StructureSection load='5ig1' size='340' side='right' caption='[[5ig1]], [[Resolution\|resolution]] 2.90Å' scene=''>	+	<StructureSection load='5ig1' size='340' side='right'caption='[[5ig1]], [[Resolution\|resolution]] 2.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ig1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IG1 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ig1]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Proterospongia_sp._atcc_50818 Proterospongia sp. atcc 50818]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IG1 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig0\|5ig0]], [[5ig3\|5ig3]], [[5ig4\|5ig4]], [[5ig5\|5ig5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig0\|5ig0]], [[5ig3\|5ig3]], [[5ig4\|5ig4]], [[5ig5\|5ig5]]</td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">PTSG_10090 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=946362 Proterospongia sp. ATCC 50818])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ig1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig1 OCA], [http://pdbe.org/5ig1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ig1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ig1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ig1 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ig1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig1 OCA], [http://pdbe.org/5ig1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ig1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ig1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ig1 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Proterospongia sp. atcc 50818]]
	[[Category: Barros, T]]		[[Category: Barros, T]]
	[[Category: Bhattacharyya, M]]		[[Category: Bhattacharyya, M]]

OCA at 03:06, 13 July 2016

2016-07-13T03:06:20Z

←Older revision		Revision as of 03:06, 13 July 2016
Line 6:		Line 6:
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig0\|5ig0]], [[5ig3\|5ig3]], [[5ig4\|5ig4]], [[5ig5\|5ig5]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig0\|5ig0]], [[5ig3\|5ig3]], [[5ig4\|5ig4]], [[5ig5\|5ig5]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ig1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig1 OCA], [http://pdbe.org/5ig1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ig1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ig1 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ig1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig1 OCA], [http://pdbe.org/5ig1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ig1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ig1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ig1 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 16:36, 10 May 2016

2016-05-10T16:36:51Z

←Older revision		Revision as of 16:36, 10 May 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ig1 is ~~ON HOLD~~	+	==Crystal structure of S. rosetta CaMKII kinase domain==
		+	<StructureSection load='5ig1' size='340' side='right' caption='[[5ig1]], [[Resolution\|resolution]] 2.90Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ig1]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IG1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IG1 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ig0\|5ig0]], [[5ig3\|5ig3]], [[5ig4\|5ig4]], [[5ig5\|5ig5]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ig1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ig1 OCA], [http://pdbe.org/5ig1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ig1 RCSB], [http://www.ebi.ac.uk/pdbsum/5ig1 PDBsum]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Activation triggers the exchange of subunits in Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an oligomeric enzyme that is critical for learning, memory, and cardiac function. The mechanism by which subunit exchange occurs remains elusive. We show that the human CaMKII holoenzyme exists in dodecameric and tetradecameric forms, and that the calmodulin (CaM)-binding element of CaMKII can bind to the hub of the holoenzyme and destabilize it to release dimers. The structures of CaMKII from two distantly diverged organisms suggest that the CaM-binding element of activated CaMKII acts as a wedge by docking at intersubunit interfaces in the hub. This converts the hub into a spiral form that can release or gain CaMKII dimers. Our data reveal a three-way competition for the CaM-binding element, whereby phosphorylation biases it towards the hub interface, away from the kinase domain and calmodulin, thus unlocking the ability of activated CaMKII holoenzymes to exchange dimers with unactivated ones.

-	~~Authors: Bhattacharyya~~, M., ~~Gee~~, C., ~~Barros~~, T., ~~Kuriyan~~, J.	+	Molecular mechanism of activation-triggered subunit exchange in Ca(2+)/calmodulin-dependent protein kinase II.,Bhattacharyya M, Stratton MM, Going CC, McSpadden ED, Huang Y, Susa AC, Elleman A, Cao YM, Pappireddi N, Burkhardt P, Gee CL, Barros T, Schulman H, Williams ER, Kuriyan J Elife. 2016 Mar 7;5. pii: e13405. doi: 10.7554/eLife.13405. PMID:26949248<ref>PMID:26949248</ref>

-	~~Description:~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	~~[[Category: Unreleased Structures]]~~	+	</div>
-	~~[[Category~~: ~~Gee, C]]~~	+	<div class="pdbe-citations 5ig1" style="background-color:#fffaf0;"></div>
-	~~[[Category: Kuriyan, J]]~~	+	== References ==
-	~~[[Category: Bhattacharyya, M]]~~	+	<references/>
		+	__TOC__
		+	</StructureSection>
	[[Category: Barros, T]]		[[Category: Barros, T]]
		+	[[Category: Bhattacharyya, M]]
		+	[[Category: Gee, C L]]
		+	[[Category: Kuriyan, J]]
		+	[[Category: Ca2+/cam-dependent kinase]]
		+	[[Category: Choanoflagellate]]
		+	[[Category: Transferase]]

OCA: Protected "5ig1" [edit=sysop:move=sysop]

2016-03-10T02:15:54Z

Protected "5ig1" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:15, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5ig1 is ON HOLD Authors: Bhattacharyya, M., Gee, C., Barros, T., Kuriyan, J. Description: Category: Unreleased Structures Category: Gee, C...

2016-03-10T02:15:53Z

New page: '''Unreleased structure''' The entry 5ig1 is ON HOLD Authors: Bhattacharyya, M., Gee, C., Barros, T., Kuriyan, J. Description: Category: Unreleased Structures Category: Gee, C...

New page

'''Unreleased structure'''

The entry 5ig1 is ON HOLD

Authors: Bhattacharyya, M., Gee, C., Barros, T., Kuriyan, J.

Description:
[[Category: Unreleased Structures]]
[[Category: Gee, C]]
[[Category: Kuriyan, J]]
[[Category: Bhattacharyya, M]]
[[Category: Barros, T]]