5igm - Revision history

OCA at 13:51, 30 August 2023

2023-08-30T13:51:50Z

←Older revision		Revision as of 13:51, 30 August 2023
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	<StructureSection load='5igm' size='340' side='right'caption='[[5igm]], [[Resolution\|resolution]] 1.60Å' scene=''>		<StructureSection load='5igm' size='340' side='right'caption='[[5igm]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5igm]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGM OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IGM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5igm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IGM FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=BMF:BROMOSPORINE'>BMF</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.6Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~BRD9, UNQ3040/PRO9856 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMF:BROMOSPORINE'>BMF</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igm OCA], [~~http~~://pdbe.org/5igm PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5igm RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5igm PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5igm ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igm OCA], [https://pdbe.org/5igm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5igm RCSB], [https://www.ebi.ac.uk/pdbsum/5igm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5igm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.	+	[https://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN] May play a role in chromatin remodeling and regulation of transcription.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Arrowsmith~~, C H~~]]	+	[[Category: Arrowsmith CH]]
-	[[Category: Bountra, C]]	+	[[Category: Bountra C]]
-	~~[[Category: Delft, F von~~]]	+	[[Category: Edwards AM]]
-	[[Category: Edwards~~, A M~~]]	+	[[Category: Filippakopoulos P]]
-	[[Category: Filippakopoulos, P]]	+	[[Category: Knapp S]]
-	[[Category: Knapp, S]]	+	[[Category: Nunez-Alonso G]]
-	[[Category: Nunez-Alonso, G]]	+	[[Category: Picaud S]]
-	[[Category: Picaud, S]]	+	[[Category: Tallant C]]
-	~~[[Category: Structural genomic~~]]	+	[[Category: Von Delft F]]
-	[[Category: Tallant, C]]	+
-	[[Category: ~~Chromatin remodeling]]~~	+
-	~~[[Category: Sgc]]~~	+
-	~~[[Category: Transcription~~]]	+

OCA at 07:18, 3 June 2020

2020-06-03T07:18:04Z

←Older revision		Revision as of 07:18, 3 June 2020
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	==Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (BSP)==		==Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (BSP)==
-	<StructureSection load='5igm' size='340' side='right' caption='[[5igm]], [[Resolution\|resolution]] 1.60Å' scene=''>	+	<StructureSection load='5igm' size='340' side='right'caption='[[5igm]], [[Resolution\|resolution]] 1.60Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5igm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGM OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IGM FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5igm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGM OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IGM FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMF:BROMOSPORINE'>BMF</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMF:BROMOSPORINE'>BMF</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igm OCA], [http://pdbe.org/5igm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5igm RCSB], [http://www.ebi.ac.uk/pdbsum/5igm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5igm ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">BRD9, UNQ3040/PRO9856 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igm OCA], [http://pdbe.org/5igm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5igm RCSB], [http://www.ebi.ac.uk/pdbsum/5igm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5igm ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5igm" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5igm" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Bromodomain-containing protein 3D structures\|Bromodomain-containing protein 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Arrowsmith, C H]]		[[Category: Arrowsmith, C H]]
	[[Category: Bountra, C]]		[[Category: Bountra, C]]

OCA at 11:15, 2 November 2016

2016-11-02T11:15:23Z

←Older revision		Revision as of 11:15, 2 November 2016
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	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.		[[http://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Bromodomains (BRDs) have emerged as compelling targets for cancer therapy. The development of selective and potent BET (bromo and extra-terminal) inhibitors and their significant activity in diverse tumor models have rapidly translated into clinical studies and have motivated drug development efforts targeting non-BET BRDs. However, the complex multidomain/subunit architecture of BRD protein complexes complicates predictions of the consequences of their pharmacological targeting. To address this issue, we developed a promiscuous BRD inhibitor [bromosporine (BSP)] that broadly targets BRDs (including BETs) with nanomolar affinity, creating a tool for the identification of cellular processes and diseases where BRDs have a regulatory function. As a proof of principle, we studied the effects of BSP on leukemic cell lines known to be sensitive to BET inhibition and found, as expected, strong antiproliferative activity. Comparison of the modulation of transcriptional profiles by BSP after a short exposure to the inhibitor resulted in a BET inhibitor signature but no significant additional changes in transcription that could account for inhibition of other BRDs. Thus, nonselective targeting of BRDs identified BETs, but not other BRDs, as master regulators of context-dependent primary transcription response.
		+
		+	Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia.,Picaud S, Leonards K, Lambert JP, Dovey O, Wells C, Fedorov O, Monteiro O, Fujisawa T, Wang CY, Lingard H, Tallant C, Nikbin N, Guetzoyan L, Ingham R, Ley SV, Brennan P, Muller S, Samsonova A, Gingras AC, Schwaller J, Vassiliou G, Knapp S, Filippakopoulos P Sci Adv. 2016 Oct 12;2(10):e1600760. eCollection 2016 Oct. PMID:27757418<ref>PMID:27757418</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5igm" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 00:58, 20 October 2016

2016-10-20T00:58:51Z

←Older revision		Revision as of 00:58, 20 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5igm is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (BSP)==
-		+	<StructureSection load='5igm' size='340' side='right' caption='[[5igm]], [[Resolution\|resolution]] 1.60Å' scene=''>
-	~~Authors~~: ~~Tallant, C~~.~~, Filippakopoulos, P~~.~~, Picaud, S~~., ~~Nunez~~-~~Alonso~~, G., ~~von Delft, F~~., ~~Edwards, A~~.M., Arrowsmith, C.H., Bountra, C., ~~Knapp~~, ~~S., Structural Genomics Consortium (SGC)~~	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5igm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IGM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IGM FirstGlance]. <br>
-	~~Description~~: ~~Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (BSP)~~	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMF:BROMOSPORINE'>BMF</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5igm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5igm OCA], [http://pdbe.org/5igm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5igm RCSB], [http://www.ebi.ac.uk/pdbsum/5igm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5igm ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/BRD9_HUMAN BRD9_HUMAN]] May play a role in chromatin remodeling and regulation of transcription.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Arrowsmith, C H]]
		+	[[Category: Bountra, C]]
		+	[[Category: Delft, F von]]
		+	[[Category: Edwards, A M]]
		+	[[Category: Filippakopoulos, P]]
		+	[[Category: Knapp, S]]
	[[Category: Nunez-Alonso, G]]		[[Category: Nunez-Alonso, G]]
	[[Category: Picaud, S]]		[[Category: Picaud, S]]
-	~~[[Category: Knapp, S]]~~	+	[[Category: Structural genomic]]
-	~~[[Category: Bountra, C]]~~	+
-	~~[[Category: Arrowsmith, C.H]]~~	+
-	~~[[Category: Von Delft, F]]~~	+
-	~~[[Category: Filippakopoulos, P]]~~	+
-	~~[[Category: Edwards, A.M]]~~	+
-	[[Category: Structural ~~Genomics Consortium (Sgc)~~]]	+
	[[Category: Tallant, C]]		[[Category: Tallant, C]]
		+	[[Category: Chromatin remodeling]]
		+	[[Category: Sgc]]
		+	[[Category: Transcription]]

OCA: Protected "5igm" [edit=sysop:move=sysop]

2016-03-10T02:17:04Z

Protected "5igm" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:17, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5igm is ON HOLD until Paper Publication Authors: Tallant, C., Filippakopoulos, P., Picaud, S., Nunez-Alonso, G., von Delft, F., Edwards, A.M., Arrow...

2016-03-10T02:17:02Z

New page: '''Unreleased structure''' The entry 5igm is ON HOLD until Paper Publication Authors: Tallant, C., Filippakopoulos, P., Picaud, S., Nunez-Alonso, G., von Delft, F., Edwards, A.M., Arrow...

New page

'''Unreleased structure'''

The entry 5igm is ON HOLD until Paper Publication

Authors: Tallant, C., Filippakopoulos, P., Picaud, S., Nunez-Alonso, G., von Delft, F., Edwards, A.M., Arrowsmith, C.H., Bountra, C., Knapp, S., Structural Genomics Consortium (SGC)

Description: Crystal structure of the bromodomain of human BRD9 in complex with bromosporine (BSP)
[[Category: Unreleased Structures]]
[[Category: Nunez-Alonso, G]]
[[Category: Picaud, S]]
[[Category: Knapp, S]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Von Delft, F]]
[[Category: Filippakopoulos, P]]
[[Category: Edwards, A.M]]
[[Category: Structural Genomics Consortium (Sgc)]]
[[Category: Tallant, C]]