5ii8 - Revision history

OCA at 13:53, 30 August 2023

2023-08-30T13:53:56Z

←Older revision		Revision as of 13:53, 30 August 2023
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	<StructureSection load='5ii8' size='340' side='right'caption='[[5ii8]], [[Resolution\|resolution]] 0.99Å' scene=''>		<StructureSection load='5ii8' size='340' side='right'caption='[[5ii8]], [[Resolution\|resolution]] 0.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ii8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5II8 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5II8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ii8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Haliotis_rufescens Haliotis rufescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5II8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5II8 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=MES:2~~-~~(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>~~, ~~<scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 0.99Å</td></tr>
-	<tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat">~~[[1lis\|1lis]]~~, ~~[[2lis\|2lis]], [[1lyn\|1lyn]], [[2lyn\|2lyn]], [[5ii7\|5ii7]], [[5ii9\|5ii9]], [[5iia\|5iia]], [[5iib\|5iib]]~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ii8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ii8 OCA], [~~http~~://pdbe.org/5ii8 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ii8 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ii8 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ii8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ii8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ii8 OCA], [https://pdbe.org/5ii8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ii8 RCSB], [https://www.ebi.ac.uk/pdbsum/5ii8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ii8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/ELYS_HALRU ELYS_HALRU]] Dissolves the egg vitelline layer nonenzymatically during fertilization. It creates a hole of about 3 mu-m in diameter through which the sperm pass.	+	[https://www.uniprot.org/uniprot/ELYS_HALRU ELYS_HALRU] Dissolves the egg vitelline layer nonenzymatically during fertilization. It creates a hole of about 3 mu-m in diameter through which the sperm pass.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	==See Also==		==See Also==
-	*[[Lysin\|Lysin]]	+	*[[Lysin 3D structures\|Lysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Haliotis rufescens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Al-Hosseini, H Sadat~~]]	+	[[Category: De Sanctis D]]
-	[[Category: Jovine, L]]	+	[[Category: Jovine L]]
-	[[Category: Nishimura, K]]	+	[[Category: Nishimura K]]
-	[[Category: Raj, I]]	+	[[Category: Raj I]]
-	[[Category: ~~Sanctis, D De]]~~	+	[[Category: Sadat Al-Hosseini H]]
-	~~[[Category: Acrosomal protein]]~~	+
-	~~[[Category: Cell adhesion]]~~	+
-	~~[[Category: Crystal dehydration]]~~	+
-	~~[[Category: Egg coat penetration]]~~	+
-	~~[[Category: Egg~~-~~binding protein]]~~	+
-	~~[[Category: Egg-sperm interaction]]~~	+
-	~~[[Category: Fertilization]]~~	+
-	~~[[Category: Gamete recognition~~]]	+

OCA at 07:19, 3 June 2020

2020-06-03T07:19:25Z

←Older revision		Revision as of 07:19, 3 June 2020
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	==Orthorhombic crystal structure of red abalone lysin at 0.99 A resolution==		==Orthorhombic crystal structure of red abalone lysin at 0.99 A resolution==
-	<StructureSection load='5ii8' size='340' side='right' caption='[[5ii8]], [[Resolution\|resolution]] 0.99Å' scene=''>	+	<StructureSection load='5ii8' size='340' side='right'caption='[[5ii8]], [[Resolution\|resolution]] 0.99Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ii8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5II8 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5II8 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ii8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5II8 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5II8 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lis\|1lis]], [[2lis\|2lis]], [[1lyn\|1lyn]], [[2lyn\|2lyn]], [[5ii7\|5ii7]], [[5ii9\|5ii9]], [[5iia\|5iia]], [[5iib\|5iib]]</td></tr>		<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lis\|1lis]], [[2lis\|2lis]], [[1lyn\|1lyn]], [[2lyn\|2lyn]], [[5ii7\|5ii7]], [[5ii9\|5ii9]], [[5iia\|5iia]], [[5iib\|5iib]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ii8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ii8 OCA], [http://pdbe.org/5ii8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ii8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ii8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ii8 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ii8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ii8 OCA], [http://pdbe.org/5ii8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ii8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ii8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ii8 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5ii8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ii8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lysin\|Lysin]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
	[[Category: Al-Hosseini, H Sadat]]		[[Category: Al-Hosseini, H Sadat]]
	[[Category: Jovine, L]]		[[Category: Jovine, L]]

OCA at 12:41, 6 November 2017

2017-11-06T12:41:55Z

←Older revision		Revision as of 12:41, 6 November 2017
Line 19:		Line 19:
	</div>		</div>
	<div class="pdbe-citations 5ii8" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ii8" style="background-color:#fffaf0;"></div>
-
-	==See Also==
-	*[[Lysin\|Lysin]]
	== References ==		== References ==
	<references/>		<references/>

OCA at 08:24, 3 August 2017

2017-08-03T08:24:05Z

←Older revision		Revision as of 08:24, 3 August 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ii8 is ~~ON HOLD until Paper~~ Publication	+	==Orthorhombic crystal structure of red abalone lysin at 0.99 A resolution==
		+	<StructureSection load='5ii8' size='340' side='right' caption='[[5ii8]], [[Resolution\|resolution]] 0.99Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ii8]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5II8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5II8 FirstGlance]. <br>
		+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
		+	<tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[1lis\|1lis]], [[2lis\|2lis]], [[1lyn\|1lyn]], [[2lyn\|2lyn]], [[5ii7\|5ii7]], [[5ii9\|5ii9]], [[5iia\|5iia]], [[5iib\|5iib]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ii8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ii8 OCA], [http://pdbe.org/5ii8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ii8 RCSB], [http://www.ebi.ac.uk/pdbsum/5ii8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ii8 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/ELYS_HALRU ELYS_HALRU]] Dissolves the egg vitelline layer nonenzymatically during fertilization. It creates a hole of about 3 mu-m in diameter through which the sperm pass.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Recognition between sperm and the egg surface marks the beginning of life in all sexually reproducing organisms. This fundamental biological event depends on the species-specific interaction between rapidly evolving counterpart molecules on the gametes. We report biochemical, crystallographic, and mutational studies of domain repeats 1-3 of invertebrate egg coat protein VERL and their interaction with cognate sperm protein lysin. VERL repeats fold like the functionally essential N-terminal repeat of mammalian sperm receptor ZP2, whose structure is also described here. Whereas sequence-divergent repeat 1 does not bind lysin, repeat 3 binds it non-species specifically via a high-affinity, largely hydrophobic interface. Due to its intermediate binding affinity, repeat 2 selectively interacts with lysin from the same species. Exposure of a highly positively charged surface of VERL-bound lysin suggests that complex formation both disrupts the organization of egg coat filaments and triggers their electrostatic repulsion, thereby opening a hole for sperm penetration and fusion.

-	~~Authors~~:	+	Structural Basis of Egg Coat-Sperm Recognition at Fertilization.,Raj I, Sadat Al Hosseini H, Dioguardi E, Nishimura K, Han L, Villa A, de Sanctis D, Jovine L Cell. 2017 Jun 15;169(7):1315-1326.e17. doi: 10.1016/j.cell.2017.05.033. PMID:28622512<ref>PMID:28622512</ref>

-	~~Description~~:	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
		+	<div class="pdbe-citations 5ii8" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Lysin\|Lysin]]
		+	== References ==
		+	<references/>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Al-Hosseini, H Sadat]]
		+	[[Category: Jovine, L]]
		+	[[Category: Nishimura, K]]
		+	[[Category: Raj, I]]
		+	[[Category: Sanctis, D De]]
		+	[[Category: Acrosomal protein]]
		+	[[Category: Cell adhesion]]
		+	[[Category: Crystal dehydration]]
		+	[[Category: Egg coat penetration]]
		+	[[Category: Egg-binding protein]]
		+	[[Category: Egg-sperm interaction]]
		+	[[Category: Fertilization]]
		+	[[Category: Gamete recognition]]

OCA at 12:36, 1 June 2016

2016-06-01T12:36:32Z

←Older revision		Revision as of 12:36, 1 June 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ii8 is ON HOLD	+	The entry 5ii8 is ON HOLD until Paper Publication

	Authors:		Authors:

OCA at 14:27, 15 May 2016

2016-05-15T14:27:00Z

←Older revision		Revision as of 14:27, 15 May 2016
Line 3:		Line 3:
	The entry 5ii8 is ON HOLD		The entry 5ii8 is ON HOLD

-	Authors: ~~Sadat Al-Hosseini, H., Raj, I., Nishimura, K., De Sanctis, D., Jovine, L.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Sadat Al-Hosseini, H]]
-	[[Category: Raj, I]]
-	[[Category: De Sanctis, D]]
-	[[Category: Nishimura, K]]
-	[[Category: Jovine, L]]

OCA: Protected "5ii8" [edit=sysop:move=sysop]

2016-03-10T02:22:11Z

Protected "5ii8" [edit=sysop:move=sysop]

←Older revision

Revision as of 02:22, 10 March 2016

OCA: New page: '''Unreleased structure''' The entry 5ii8 is ON HOLD Authors: Sadat Al-Hosseini, H., Raj, I., Nishimura, K., De Sanctis, D., Jovine, L. Description: [[Category: Unreleased Structures]...

2016-03-10T02:22:10Z

New page: '''Unreleased structure''' The entry 5ii8 is ON HOLD Authors: Sadat Al-Hosseini, H., Raj, I., Nishimura, K., De Sanctis, D., Jovine, L. Description: [[Category: Unreleased Structures]...

New page

'''Unreleased structure'''

The entry 5ii8 is ON HOLD

Authors: Sadat Al-Hosseini, H., Raj, I., Nishimura, K., De Sanctis, D., Jovine, L.

Description:
[[Category: Unreleased Structures]]
[[Category: Sadat Al-Hosseini, H]]
[[Category: Raj, I]]
[[Category: De Sanctis, D]]
[[Category: Nishimura, K]]
[[Category: Jovine, L]]