5imw - Revision history

OCA at 14:01, 30 August 2023

2023-08-30T14:01:57Z

←Older revision		Revision as of 14:01, 30 August 2023
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	<StructureSection load='5imw' size='340' side='right'caption='[[5imw]], [[Resolution\|resolution]] 2.89Å' scene=''>		<StructureSection load='5imw' size='340' side='right'caption='[[5imw]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5imw]] is a 2 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Atcc_27335 Atcc 27335~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMW OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IMW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5imw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_intermedius Streptococcus intermedius]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IMW FirstGlance]. <br>
-	</td></tr><tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~ily (~~[~~http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=1338 ATCC 27335])~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 2.89Å</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5imw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imw OCA], [~~http~~://pdbe.org/5imw PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5imw RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5imw PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5imw ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5imw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imw OCA], [https://pdbe.org/5imw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5imw RCSB], [https://www.ebi.ac.uk/pdbsum/5imw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5imw ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q9LCB8_STRIT Q9LCB8_STRIT]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Atcc 27335]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Feil, S C~~]]	+	[[Category: Streptococcus intermedius]]
-	[[Category: ~~Lawrence, S L~~]]	+	[[Category: Feil SC]]
-	[[Category: ~~Morton, C J~~]]	+	[[Category: Lawrence SL]]
-	[[Category: ~~Parker, M W~~]]	+	[[Category: Morton CJ]]
-	[[Category: ~~Locked]]~~	+	[[Category: Parker MW]]
-	~~[[Category: Toxin~~]]	+

OCA at 07:24, 3 June 2020

2020-06-03T07:24:31Z

←Older revision		Revision as of 07:24, 3 June 2020
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	==Trapped Toxin==		==Trapped Toxin==
-	<StructureSection load='5imw' size='340' side='right' caption='[[5imw]], [[Resolution\|resolution]] 2.89Å' scene=''>	+	<StructureSection load='5imw' size='340' side='right'caption='[[5imw]], [[Resolution\|resolution]] 2.89Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5imw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMW OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IMW FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5imw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_27335 Atcc 27335]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IMW FirstGlance]. <br>
-	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5imw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imw OCA], [http://pdbe.org/5imw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5imw RCSB], [http://www.ebi.ac.uk/pdbsum/5imw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5imw ProSAT]</span></td></tr>	+	</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ily ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1338 ATCC 27335])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5imw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imw OCA], [http://pdbe.org/5imw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5imw RCSB], [http://www.ebi.ac.uk/pdbsum/5imw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5imw ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
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	</div>		</div>
	<div class="pdbe-citations 5imw" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5imw" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Cytolysin 3D structures\|Cytolysin 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Atcc 27335]]
		+	[[Category: Large Structures]]
	[[Category: Feil, S C]]		[[Category: Feil, S C]]
	[[Category: Lawrence, S L]]		[[Category: Lawrence, S L]]

OCA at 06:51, 10 September 2016

2016-09-10T06:51:49Z

←Older revision		Revision as of 06:51, 10 September 2016
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-	'''Unreleased structure'''

-	~~The entry~~ 5imw is ~~ON HOLD until Paper~~ Publication	+	==Trapped Toxin==
		+	<StructureSection load='5imw' size='340' side='right' caption='[[5imw]], [[Resolution\|resolution]] 2.89Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5imw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IMW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IMW FirstGlance]. <br>
		+	</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5imw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5imw OCA], [http://pdbe.org/5imw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5imw RCSB], [http://www.ebi.ac.uk/pdbsum/5imw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5imw ProSAT]</span></td></tr>
		+	</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Cholesterol-dependent cytolysins (CDCs) are a family of pore-forming toxins that punch holes in the outer membrane of eukaryotic cells. Cholesterol serves as the receptor, but a subclass of CDCs first binds to human CD59. Here we describe the crystal structures of vaginolysin and intermedilysin complexed to CD59. These studies, together with small-angle X-ray scattering, reveal that CD59 binds to each at different, though overlapping, sites, consistent with molecular dynamics simulations and binding studies. The CDC consensus undecapeptide motif, which for the CD59-responsive CDCs has a proline instead of a tryptophan in the motif, adopts a strikingly different conformation between the structures; our data suggest that the proline acts as a selectivity switch to ensure CD59-dependent CDCs bind their protein receptor first in preference to cholesterol. The structural data suggest a detailed model of how these water-soluble toxins assemble as prepores on the cell surface.

-	~~Authors:~~ Lawrence, ~~S.L.~~, Feil, ~~S.C.~~, Morton, C.J.~~, Parker, M~~.W.	+	Structural Basis for Receptor Recognition by the Human CD59-Responsive Cholesterol-Dependent Cytolysins.,Lawrence SL, Gorman MA, Feil SC, Mulhern TD, Kuiper MJ, Ratner AJ, Tweten RK, Morton CJ, Parker MW Structure. 2016 Sep 6;24(9):1488-1498. doi: 10.1016/j.str.2016.06.017. Epub 2016 , Aug 4. PMID:27499440<ref>PMID:27499440</ref>

-	~~Description~~: ~~Trapped Toxin~~	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-	[[Category: ~~Unreleased Structures~~]]	+	</div>
-	[[Category: ~~Feil~~, S.C]]	+	<div class="pdbe-citations 5imw" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Lawrence~~, ~~S.L~~]]	+	== References ==
-	[[Category: Parker, M.W]]	+	<references/>
-	[[Category: ~~Morton, C.J~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Feil, S C]]
		+	[[Category: Lawrence, S L]]
		+	[[Category: Morton, C J]]
		+	[[Category: Parker, M W]]
		+	[[Category: Locked]]
		+	[[Category: Toxin]]

OCA at 22:36, 12 July 2016

2016-07-12T22:36:41Z

←Older revision		Revision as of 22:36, 12 July 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5imw is ON HOLD	+	The entry 5imw is ON HOLD until Paper Publication

	Authors: Lawrence, S.L., Feil, S.C., Morton, C.J., Parker, M.W.		Authors: Lawrence, S.L., Feil, S.C., Morton, C.J., Parker, M.W.

OCA: Protected "5imw" [edit=sysop:move=sysop]

2016-05-11T00:40:25Z

Protected "5imw" [edit=sysop:move=sysop]

←Older revision

Revision as of 00:40, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5imw is ON HOLD Authors: Lawrence, S.L., Feil, S.C., Morton, C.J., Parker, M.W. Description: Trapped Toxin Category: Unreleased Structures [[Ca...

2016-05-11T00:40:24Z

New page: '''Unreleased structure''' The entry 5imw is ON HOLD Authors: Lawrence, S.L., Feil, S.C., Morton, C.J., Parker, M.W. Description: Trapped Toxin Category: Unreleased Structures [[Ca...

New page

'''Unreleased structure'''

The entry 5imw is ON HOLD

Authors: Lawrence, S.L., Feil, S.C., Morton, C.J., Parker, M.W.

Description: Trapped Toxin
[[Category: Unreleased Structures]]
[[Category: Feil, S.C]]
[[Category: Lawrence, S.L]]
[[Category: Parker, M.W]]
[[Category: Morton, C.J]]