5ivh - Revision history

OCA at 10:33, 6 September 2023

2023-09-06T10:33:22Z

←Older revision		Revision as of 10:33, 6 September 2023
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	<StructureSection load='5ivh' size='340' side='right'caption='[[5ivh]], [[Resolution\|resolution]] 1.71Å' scene=''>		<StructureSection load='5ivh' size='340' side='right'caption='[[5ivh]], [[Resolution\|resolution]] 1.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ivh]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Australian_sheep_blowfly Australian sheep blowfly~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVH OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5IVH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ivh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lucilia_cuprina Lucilia cuprina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IVH FirstGlance]. <br>
-	</td></tr><tr id='~~related~~'><td class="sblockLbl"><b>[[~~Related_structure~~\|~~Related~~:]]</b></td><td class="sblockDat"~~>[[5ivk\|5ivk]], [[5ivd\|5ivd]], [[5ivi\|5ivi]]</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.71Å</td></tr>
-	~~<tr~~ id~~='gene'><td class~~="~~sblockLbl~~">~~<b>~~[[~~Gene~~\|~~Gene:~~]]~~</b></td><td class="sblockDat">LcaE7 ([http://www~~.~~ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info~~&~~srchmode=5&id=7375 Australian sheep blowfly])~~</td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ivh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivh OCA], [https://pdbe.org/5ivh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ivh RCSB], [https://www.ebi.ac.uk/pdbsum/5ivh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivh ProSAT]</span></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ivh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivh OCA], [~~http~~://pdbe.org/5ivh PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ivh RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ivh PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivh ProSAT]</span></td></tr>	+
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/Q25252_LUCCU Q25252_LUCCU]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: Australian sheep blowfly]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Correy, G J~~]]	+	[[Category: Lucilia cuprina]]
-	[[Category: ~~Jackson, C J~~]]	+	[[Category: Correy GJ]]
-	[[Category: ~~Acetylcholinesterase]]~~	+	[[Category: Jackson CJ]]
-	~~[[Category: Carboxylesterase]]~~	+
-	~~[[Category: Hydrolase]]~~	+
-	~~[[Category: Organophosphate]]~~	+
-	~~[[Category: Protein dynamic~~]]	+

OCA at 07:34, 3 June 2020

2020-06-03T07:34:22Z

←Older revision		Revision as of 07:34, 3 June 2020
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-	~~{{Large structure}}~~	+
	==The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: apo-enzyme ensemble refinement==		==The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: apo-enzyme ensemble refinement==
-	<StructureSection load='5ivh' size='340' side='right' caption='[[5ivh]], [[Resolution\|resolution]] 1.71Å' scene=''>	+	<StructureSection load='5ivh' size='340' side='right'caption='[[5ivh]], [[Resolution\|resolution]] 1.71Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ivh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVH OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5IVH FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ivh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Australian_sheep_blowfly Australian sheep blowfly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVH OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IVH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivk\|5ivk]], [[5ivd\|5ivd]], [[5ivi\|5ivi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivk\|5ivk]], [[5ivd\|5ivd]], [[5ivi\|5ivi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ivh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivh OCA], [http://pdbe.org/5ivh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivh RCSB], [http://www.ebi.ac.uk/pdbsum/5ivh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivh ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">LcaE7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7375 Australian sheep blowfly])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ivh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivh OCA], [http://pdbe.org/5ivh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivh RCSB], [http://www.ebi.ac.uk/pdbsum/5ivh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivh ProSAT]</span></td></tr>
	</table>		</table>
-	{{Large structure}}
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</div>		</div>
	<div class="pdbe-citations 5ivh" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ivh" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Carboxylesterase 3D structures\|Carboxylesterase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Australian sheep blowfly]]
		+	[[Category: Large Structures]]
	[[Category: Correy, G J]]		[[Category: Correy, G J]]
	[[Category: Jackson, C J]]		[[Category: Jackson, C J]]

OCA at 02:27, 13 July 2016

2016-07-13T02:27:48Z

←Older revision		Revision as of 02:27, 13 July 2016
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[5ivh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IVH FirstGlance]. <br>		<table><tr><td colspan='2'>[[5ivh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IVH FirstGlance]. <br>
	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivk\|5ivk]], [[5ivd\|5ivd]], [[5ivi\|5ivi]]</td></tr>		</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivk\|5ivk]], [[5ivd\|5ivd]], [[5ivi\|5ivi]]</td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ivh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivh OCA], [http://pdbe.org/5ivh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivh RCSB], [http://www.ebi.ac.uk/pdbsum/5ivh PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ivh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivh OCA], [http://pdbe.org/5ivh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivh RCSB], [http://www.ebi.ac.uk/pdbsum/5ivh PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivh ProSAT]</span></td></tr>
	</table>		</table>
	{{Large structure}}		{{Large structure}}

OCA at 23:08, 23 June 2016

2016-06-23T23:08:38Z

←Older revision		Revision as of 23:08, 23 June 2016
Line 1:		Line 1:
-	'''~~Unreleased~~ structure'''	+	{{Large structure}}
		+	==The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: apo-enzyme ensemble refinement==
		+	<StructureSection load='5ivh' size='340' side='right' caption='[[5ivh]], [[Resolution\|resolution]] 1.71Å' scene=''>
		+	== Structural highlights ==
		+	<table><tr><td colspan='2'>[[5ivh]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IVH FirstGlance]. <br>
		+	</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure\|Related:]]</b></td><td class="sblockDat">[[5ivk\|5ivk]], [[5ivd\|5ivd]], [[5ivi\|5ivi]]</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ivh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivh OCA], [http://pdbe.org/5ivh PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivh RCSB], [http://www.ebi.ac.uk/pdbsum/5ivh PDBsum]</span></td></tr>
		+	</table>
		+	{{Large structure}}
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The proper function of enzymes often depends upon their efficient interconversion between particular conformational sub-states on a free-energy landscape. Experimentally characterizing these sub-states is challenging, which has limited our understanding of the role of protein dynamics in many enzymes. Here, we have used a combination of kinetic crystallography and detailed analysis of crystallographic protein ensembles to map the accessible conformational landscape of an insect carboxylesterase (LcalphaE7) as it traverses all steps in its catalytic cycle. LcalphaE7 is of special interest because of its evolving role in organophosphate insecticide resistance. Our results reveal that a dynamically coupled network of residues extends from the substrate-binding site to a surface loop. Interestingly, the coupling of this network that is apparent in the apoenzyme appears to be reduced in the phosphorylated enzyme intermediate. Altogether, the results of this work highlight the importance of protein dynamics to enzyme function and the evolution of new activity.

-	~~The entry 5ivh is ON HOLD~~	+	Mapping the Accessible Conformational Landscape of an Insect Carboxylesterase Using Conformational Ensemble Analysis and Kinetic Crystallography.,Correy GJ, Carr PD, Meirelles T, Mabbitt PD, Fraser NJ, Weik M, Jackson CJ Structure. 2016 Jun 7;24(6):977-87. doi: 10.1016/j.str.2016.04.009. Epub 2016 May, 19. PMID:27210287<ref>PMID:27210287</ref>

-	~~Authors: Correy~~, G.J.~~, Jackson, C.J~~.	+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
-		+	</div>
-	~~Description: The alpha~~-~~esterase~~-~~7 carboxylesterase, E3, from the blowfly Lucilia cuprina~~: ~~apo-enzyme ensemble refinement~~	+	<div class="pdbe-citations 5ivh" style="background-color:#fffaf0;"></div>
-	[[Category: ~~Unreleased Structures~~]]	+	== References ==
-	[[Category: Jackson, C.J]]	+	<references/>
-	[[Category: ~~Correy, G.J~~]]	+	__TOC__
		+	</StructureSection>
		+	[[Category: Correy, G J]]
		+	[[Category: Jackson, C J]]
		+	[[Category: Acetylcholinesterase]]
		+	[[Category: Carboxylesterase]]
		+	[[Category: Hydrolase]]
		+	[[Category: Organophosphate]]
		+	[[Category: Protein dynamic]]

OCA: Protected "5ivh" [edit=sysop:move=sysop]

2016-05-11T01:01:29Z

Protected "5ivh" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:01, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5ivh is ON HOLD Authors: Correy, G.J., Jackson, C.J. Description: The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: apo-...

2016-05-11T01:01:28Z

New page: '''Unreleased structure''' The entry 5ivh is ON HOLD Authors: Correy, G.J., Jackson, C.J. Description: The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: apo-...

New page

'''Unreleased structure'''

The entry 5ivh is ON HOLD

Authors: Correy, G.J., Jackson, C.J.

Description: The alpha-esterase-7 carboxylesterase, E3, from the blowfly Lucilia cuprina: apo-enzyme ensemble refinement
[[Category: Unreleased Structures]]
[[Category: Jackson, C.J]]
[[Category: Correy, G.J]]