5j67 - Revision history

OCA at 10:50, 6 September 2023

2023-09-06T10:50:50Z

←Older revision		Revision as of 10:50, 6 September 2023
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	<StructureSection load='5j67' size='340' side='right'caption='[[5j67]], [[Resolution\|resolution]] 3.16Å' scene=''>		<StructureSection load='5j67' size='340' side='right'caption='[[5j67]], [[Resolution\|resolution]] 3.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j67]] is a 4 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J67 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5J67 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j67]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J67 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J67 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 3.16Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASTN2, KIAA0634 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [~~http~~://pdbe.org/5j67 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5j67 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5j67 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [https://pdbe.org/5j67 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [https://www.ebi.ac.uk/pdbsum/5j67 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j67 ProSAT]</span></td></tr>
	</table>		</table>
		+	== Function ==
		+	[https://www.uniprot.org/uniprot/ASTN2_HUMAN ASTN2_HUMAN]
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Gilbert~~, R J.C~~]]	+	[[Category: Gilbert RJC]]
-	[[Category: Harlos, K]]	+	[[Category: Harlos K]]
-	[[Category: Ni, T]]	+	[[Category: Ni T]]
-	~~[[Category: Annexin-like]]~~	+
-	~~[[Category: Fibronectin]]~~	+
-	~~[[Category: Macpf]]~~	+
-	~~[[Category: Membrane protein]]~~	+
-	~~[[Category: Neural guidance~~]]	+

OCA at 07:58, 3 April 2019

2019-04-03T07:58:29Z

←Older revision		Revision as of 07:58, 3 April 2019
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	==Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development==		==Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development==
-	<StructureSection load='5j67' size='340' side='right' caption='[[5j67]], [[Resolution\|resolution]] 3.16Å' scene=''>	+	<StructureSection load='5j67' size='340' side='right'caption='[[5j67]], [[Resolution\|resolution]] 3.16Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j67]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J67 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j67]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J67 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
		+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">ASTN2, KIAA0634 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [http://pdbe.org/5j67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [http://www.ebi.ac.uk/pdbsum/5j67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j67 ProSAT]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [http://pdbe.org/5j67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [http://www.ebi.ac.uk/pdbsum/5j67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j67 ProSAT]</span></td></tr>
	</table>		</table>
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Gilbert, R J.C]]		[[Category: Gilbert, R J.C]]
	[[Category: Harlos, K]]		[[Category: Harlos, K]]

OCA at 07:21, 6 October 2017

2017-10-06T07:21:29Z

←Older revision		Revision as of 07:21, 6 October 2017
Line 5:		Line 5:
	<table><tr><td colspan='2'>[[5j67]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J67 FirstGlance]. <br>		<table><tr><td colspan='2'>[[5j67]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J67 FirstGlance]. <br>
	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>		</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [http://pdbe.org/5j67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [http://www.ebi.ac.uk/pdbsum/5j67 PDBsum]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [http://pdbe.org/5j67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [http://www.ebi.ac.uk/pdbsum/5j67 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j67 ProSAT]</span></td></tr>
	</table>		</table>
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">

OCA at 07:45, 20 June 2016

2016-06-20T07:45:14Z

←Older revision		Revision as of 07:45, 20 June 2016
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	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [http://pdbe.org/5j67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [http://www.ebi.ac.uk/pdbsum/5j67 PDBsum]</span></td></tr>		<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [http://pdbe.org/5j67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [http://www.ebi.ac.uk/pdbsum/5j67 PDBsum]</span></td></tr>
	</table>		</table>
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	The vertebrate-specific proteins astrotactin-1 and 2 (ASTN-1 and ASTN-2) are integral membrane perforin-like proteins known to play critical roles in neurodevelopment, while ASTN-2 has been linked to the planar cell polarity pathway in hair cells. Genetic variations associated with them are linked to a variety of neurodevelopmental disorders and other neurological pathologies, including an advanced onset of Alzheimer's disease. Here we present the structure of the majority endosomal region of ASTN-2, showing it to consist of a unique combination of polypeptide folds: a perforin-like domain, a minimal epidermal growth factor-like module, a unique form of fibronectin type III domain and an annexin-like domain. The perforin-like domain differs from that of other members of the membrane attack complex-perforin (MACPF) protein family in ways that suggest ASTN-2 does not form pores. Structural and biophysical data show that ASTN-2 (but not ASTN-1) binds inositol triphosphates, suggesting a mechanism for membrane recognition or secondary messenger regulation of its activity. The annexin-like domain is closest in fold to repeat three of human annexin V and similarly binds calcium, and yet shares no sequence homology with it. Overall, our structure provides the first atomic-resolution description of a MACPF protein involved in development, while highlighting distinctive features of ASTN-2 responsible for its activity.
		+
		+	Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development.,Ni T, Harlos K, Gilbert R Open Biol. 2016 May;6(5). pii: 160053. doi: 10.1098/rsob.160053. Epub 2016 May 4. PMID:27249642<ref>PMID:27249642</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5j67" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 23:03, 1 June 2016

2016-06-01T23:03:29Z

←Older revision		Revision as of 23:03, 1 June 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5j67 is ~~ON HOLD until Paper Publication~~	+	==Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development==
-		+	<StructureSection load='5j67' size='340' side='right' caption='[[5j67]], [[Resolution\|resolution]] 3.16Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5j67]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J67 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J67 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=I3P:D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE'>I3P</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j67 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j67 OCA], [http://pdbe.org/5j67 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j67 RCSB], [http://www.ebi.ac.uk/pdbsum/5j67 PDBsum]</span></td></tr>
		+	</table>
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Gilbert, R J.C]]
		+	[[Category: Harlos, K]]
		+	[[Category: Ni, T]]
		+	[[Category: Annexin-like]]
		+	[[Category: Fibronectin]]
		+	[[Category: Macpf]]
		+	[[Category: Membrane protein]]
		+	[[Category: Neural guidance]]

OCA at 15:05, 15 May 2016

2016-05-15T15:05:56Z

←Older revision		Revision as of 15:05, 15 May 2016
Line 3:		Line 3:
	The entry 5j67 is ON HOLD until Paper Publication		The entry 5j67 is ON HOLD until Paper Publication

-	Authors: ~~Ni, T., Harlos, K., Gilbert, R.J.C.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Gilbert, R.J.C]]
-	[[Category: Harlos, K]]
-	[[Category: Ni, T]]

OCA: Protected "5j67" [edit=sysop:move=sysop]

2016-05-11T01:32:50Z

Protected "5j67" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:32, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5j67 is ON HOLD until Paper Publication Authors: Ni, T., Harlos, K., Gilbert, R.J.C. Description: Category: Unreleased Structures [[Category: ...

2016-05-11T01:32:48Z

New page: '''Unreleased structure''' The entry 5j67 is ON HOLD until Paper Publication Authors: Ni, T., Harlos, K., Gilbert, R.J.C. Description: Category: Unreleased Structures [[Category: ...

New page

'''Unreleased structure'''

The entry 5j67 is ON HOLD until Paper Publication

Authors: Ni, T., Harlos, K., Gilbert, R.J.C.

Description:
[[Category: Unreleased Structures]]
[[Category: Gilbert, R.J.C]]
[[Category: Harlos, K]]
[[Category: Ni, T]]