5j81 - Revision history

OCA at 10:53, 6 September 2023

2023-09-06T10:53:05Z

←Older revision		Revision as of 10:53, 6 September 2023
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	<StructureSection load='5j81' size='340' side='right'caption='[[5j81]], [[Resolution\|resolution]] 1.80Å' scene=''>		<StructureSection load='5j81' size='340' side='right'caption='[[5j81]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j81]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Puump Puump~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J81 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5J81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j81]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Puumala_virus_p360 Puumala virus p360]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J81 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>~~</td></tr>~~	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.8Å</td></tr>
-	~~<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39001 PUUMP])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5j81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j81 OCA], [~~http~~://pdbe.org/5j81 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5j81 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5j81 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5j81 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j81 OCA], [https://pdbe.org/5j81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j81 RCSB], [https://www.ebi.ac.uk/pdbsum/5j81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/GP_PUUMP GP_PUUMP]] Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).	+	[https://www.uniprot.org/uniprot/GP_PUUMP GP_PUUMP] Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	</StructureSection>		</StructureSection>
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: ~~Puump~~]]	+	[[Category: Puumala virus p360]]
-	[[Category: Dessau, M]]	+	[[Category: Dessau M]]
-	[[Category: Willensky, S]]	+	[[Category: Willensky S]]
-	~~[[Category: Class ii]]~~	+
-	~~[[Category: Glycoprotein]]~~	+
-	~~[[Category: Membrane fusion]]~~	+
-	~~[[Category: Viral protein]]~~	+
-	~~[[Category: Virus~~]]	+

OCA at 07:32, 10 June 2020

2020-06-10T07:32:53Z

←Older revision		Revision as of 07:32, 10 June 2020
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	==Crystal structure of Glycoprotein C from Puumala virus in the post-fusion conformation (pH 6.0)==		==Crystal structure of Glycoprotein C from Puumala virus in the post-fusion conformation (pH 6.0)==
-	<StructureSection load='5j81' size='340' side='right' caption='[[5j81]], [[Resolution\|resolution]] 1.80Å' scene=''>	+	<StructureSection load='5j81' size='340' side='right'caption='[[5j81]], [[Resolution\|resolution]] 1.80Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5j81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J81 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5J81 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5j81]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Puump Puump]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J81 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5J81 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5j81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j81 OCA], [http://pdbe.org/5j81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j81 RCSB], [http://www.ebi.ac.uk/pdbsum/5j81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j81 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">GP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=39001 PUUMP])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5j81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j81 OCA], [http://pdbe.org/5j81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j81 RCSB], [http://www.ebi.ac.uk/pdbsum/5j81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j81 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
Line 22:		Line 23:
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Large Structures]]
		+	[[Category: Puump]]
	[[Category: Dessau, M]]		[[Category: Dessau, M]]
	[[Category: Willensky, S]]		[[Category: Willensky, S]]

OCA at 20:07, 9 December 2016

2016-12-09T20:07:28Z

←Older revision		Revision as of 20:07, 9 December 2016
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/GP_PUUMP GP_PUUMP]] Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).		[[http://www.uniprot.org/uniprot/GP_PUUMP GP_PUUMP]] Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Hantaviruses are important emerging human pathogens and are the causative agents of serious diseases in humans with high mortality rates. Like other members in the Bunyaviridae family their M segment encodes two glycoproteins, GN and GC, which are responsible for the early events of infection. Hantaviruses deliver their tripartite genome into the cytoplasm by fusion of the viral and endosomal membranes in response to the reduced pH of the endosome. Unlike phleboviruses (e.g. Rift valley fever virus), that have an icosahedral glycoprotein envelope, hantaviruses display a pleomorphic virion morphology as GN and GC assemble into spikes with apparent four-fold symmetry organized in a grid-like pattern on the viral membrane. Here we present the crystal structure of glycoprotein C (GC) from Puumala virus (PUUV), a representative member of the Hantavirus genus. The crystal structure shows GC as the membrane fusion effector of PUUV and it presents a class II membrane fusion protein fold. Furthermore, GC was crystallized in its post-fusion trimeric conformation that until now had been observed only in Flavi- and Togaviridae family members. The PUUV GC structure together with our functional data provides intriguing evolutionary and mechanistic insights into class II membrane fusion proteins and reveals new targets for membrane fusion inhibitors against these important pathogens.
		+
		+	Crystal Structure of Glycoprotein C from a Hantavirus in the Post-fusion Conformation.,Willensky S, Bar-Rogovsky H, Bignon EA, Tischler ND, Modis Y, Dessau M PLoS Pathog. 2016 Oct 26;12(10):e1005948. doi: 10.1371/journal.ppat.1005948., eCollection 2016 Oct. PMID:27783673<ref>PMID:27783673</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5j81" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 21:29, 5 October 2016

2016-10-05T21:29:57Z

←Older revision		Revision as of 21:29, 5 October 2016
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5j81 is ~~ON HOLD~~	+	==Crystal structure of Glycoprotein C from Puumala virus in the post-fusion conformation (pH 6.0)==
-		+	<StructureSection load='5j81' size='340' side='right' caption='[[5j81]], [[Resolution\|resolution]] 1.80Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5j81]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J81 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J81 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=P33:3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL'>P33</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j81 OCA], [http://pdbe.org/5j81 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j81 RCSB], [http://www.ebi.ac.uk/pdbsum/5j81 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j81 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/GP_PUUMP GP_PUUMP]] Glycoprotein N and Glycoprotein C interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promote fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Glycoprotein N contains an ITAM motif which is likely to dysregulate normal immune and endothelial cell responses and contribute to virus pathogenesis (By similarity).
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Dessau, M]]
		+	[[Category: Willensky, S]]
		+	[[Category: Class ii]]
		+	[[Category: Glycoprotein]]
		+	[[Category: Membrane fusion]]
		+	[[Category: Viral protein]]
		+	[[Category: Virus]]

OCA at 15:09, 15 May 2016

2016-05-15T15:09:19Z

←Older revision		Revision as of 15:09, 15 May 2016
Line 3:		Line 3:
	The entry 5j81 is ON HOLD		The entry 5j81 is ON HOLD

-	Authors: ~~Willensky, S., Dessau, M.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Dessau, M]]
-	[[Category: Willensky, S]]

OCA: Protected "5j81" [edit=sysop:move=sysop]

2016-05-11T01:39:19Z

Protected "5j81" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:39, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5j81 is ON HOLD Authors: Willensky, S., Dessau, M. Description: Category: Unreleased Structures Category: Dessau, M [[Category: Willensky,...

2016-05-11T01:39:18Z

New page: '''Unreleased structure''' The entry 5j81 is ON HOLD Authors: Willensky, S., Dessau, M. Description: Category: Unreleased Structures Category: Dessau, M [[Category: Willensky,...

New page

'''Unreleased structure'''

The entry 5j81 is ON HOLD

Authors: Willensky, S., Dessau, M.

Description:
[[Category: Unreleased Structures]]
[[Category: Dessau, M]]
[[Category: Willensky, S]]