5ja0 - Revision history

OCA at 10:56, 6 September 2023

2023-09-06T10:56:21Z

←Older revision		Revision as of 10:56, 6 September 2023
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	<StructureSection load='5ja0' size='340' side='right'caption='[[5ja0]], [[Resolution\|resolution]] 1.90Å' scene=''>		<StructureSection load='5ja0' size='340' side='right'caption='[[5ja0]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ja0]] is a 1 chain structure with sequence from [~~http~~://en.wikipedia.org/wiki/~~Human Human~~]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JA0 OCA]. For a <b>guided tour on the structure components</b> use [~~http~~://proteopedia.org/fgij/fg.htm?mol=5JA0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ja0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5JA0 FirstGlance]. <br>
-	</td></tr><tr id='~~ligand~~'><td class="sblockLbl"><b>[[~~Ligand~~\|~~Ligands~~:]]</b></td><td class="sblockDat" id="~~ligandDat~~">~~<scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>~~, ~~<scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>~~</td></tr>	+	</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models\|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution\|Resolution]] 1.9Å</td></tr>
-	<tr id='~~gene~~'><td class="sblockLbl"><b>[[~~Gene~~\|~~Gene~~:]]</b></td><td class="sblockDat">~~FDPS, FPS, KIAA1293 ([http~~:/~~/www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode~~=~~Info&srchmode~~=~~5&id=9606 HUMAN])~~</td></tr>	+	<tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[~~http~~://proteopedia.org/fgij/fg.htm?mol=5ja0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ja0 OCA], [~~http~~://pdbe.org/5ja0 PDBe], [~~http~~://www.rcsb.org/pdb/explore.do?structureId=5ja0 RCSB], [~~http~~://www.ebi.ac.uk/pdbsum/5ja0 PDBsum], [~~http~~://prosat.h-its.org/prosat/prosatexe?pdbcode=5ja0 ProSAT]</span></td></tr>	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ja0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ja0 OCA], [https://pdbe.org/5ja0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ja0 RCSB], [https://www.ebi.ac.uk/pdbsum/5ja0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ja0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
-	[~~[http~~://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.	+	[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
	<div style="background-color:#fffaf0;">		<div style="background-color:#fffaf0;">
	== Publication Abstract from PubMed ==		== Publication Abstract from PubMed ==
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	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
-	[[Category: ~~Human~~]]	+	[[Category: Homo sapiens]]
	[[Category: Large Structures]]		[[Category: Large Structures]]
-	[[Category: Berghuis~~, A M~~]]	+	[[Category: Berghuis AM]]
-	[[Category: Park, J]]	+	[[Category: Park J]]
-	[[Category: Tsantrizos~~, Y S~~]]	+	[[Category: Tsantrizos YS]]
-	[[Category: Zielinski, M]]	+	[[Category: Zielinski M]]
-	~~[[Category: Transferase~~]]	+

OCA at 07:39, 10 June 2020

2020-06-10T07:39:23Z

←Older revision		Revision as of 07:39, 10 June 2020
Line 1:		Line 1:

	==Crystal structure of human FPPS with allosterically bound FPP==		==Crystal structure of human FPPS with allosterically bound FPP==
-	<StructureSection load='5ja0' size='340' side='right' caption='[[5ja0]], [[Resolution\|resolution]] 1.90Å' scene=''>	+	<StructureSection load='5ja0' size='340' side='right'caption='[[5ja0]], [[Resolution\|resolution]] 1.90Å' scene=''>
	== Structural highlights ==		== Structural highlights ==
-	<table><tr><td colspan='2'>[[5ja0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JA0 OCA]. For a <b>guided tour on the structure components</b> use [http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5JA0 FirstGlance]. <br>	+	<table><tr><td colspan='2'>[[5ja0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JA0 OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5JA0 FirstGlance]. <br>
-	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://~~oca~~.~~weizmann.ac.il/oca-docs~~/fgij/fg.htm?mol=5ja0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ja0 OCA], [http://pdbe.org/5ja0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ja0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ja0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ja0 ProSAT]</span></td></tr>	+	<tr id='gene'><td class="sblockLbl"><b>[[Gene\|Gene:]]</b></td><td class="sblockDat">FDPS, FPS, KIAA1293 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
		+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ja0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ja0 OCA], [http://pdbe.org/5ja0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ja0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ja0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ja0 ProSAT]</span></td></tr>
	</table>		</table>
	== Function ==		== Function ==
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	</div>		</div>
	<div class="pdbe-citations 5ja0" style="background-color:#fffaf0;"></div>		<div class="pdbe-citations 5ja0" style="background-color:#fffaf0;"></div>
		+
		+	==See Also==
		+	*[[Farnesyl diphosphate synthase 3D structures\|Farnesyl diphosphate synthase 3D structures]]
	== References ==		== References ==
	<references/>		<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>
		+	[[Category: Human]]
		+	[[Category: Large Structures]]
	[[Category: Berghuis, A M]]		[[Category: Berghuis, A M]]
	[[Category: Park, J]]		[[Category: Park, J]]

OCA at 11:14, 1 February 2017

2017-02-01T11:14:39Z

←Older revision		Revision as of 11:14, 1 February 2017
Line 9:		Line 9:
	== Function ==		== Function ==
	[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.		[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
		+	<div style="background-color:#fffaf0;">
		+	== Publication Abstract from PubMed ==
		+	Farnesyl pyrophosphate synthase (FPPS) is an enzyme of the mevalonate pathway and a well-established therapeutic target. Recent research has focused around a newly identified druggable pocket near the enzyme's active site. Pharmacological exploitation of this pocket is deemed promising; however, its natural biological function, if any, is yet unknown. Here we report that the product of FPPS, farnesyl pyrophosphate (FPP), can bind to this pocket and lock the enzyme in an inactive state. The Kd for this binding is 5-6 muM, within a catalytically relevant range. These results indicate that FPPS activity is sensitive to the product concentration. Kinetic analysis shows that the enzyme is inhibited through FPP accumulation. Having a specific physiological effector, FPPS is a bona fide allosteric enzyme. This allostery offers an exquisite mechanism for controlling prenyl pyrophosphate levels in vivo and thus contributes an additional layer of regulation to the mevalonate pathway.
		+
		+	Human farnesyl pyrophosphate synthase is allosterically inhibited by its own product.,Park J, Zielinski M, Magder A, Tsantrizos YS, Berghuis AM Nat Commun. 2017 Jan 18;8:14132. doi: 10.1038/ncomms14132. PMID:28098152<ref>PMID:28098152</ref>
		+
		+	From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
		+	</div>
		+	<div class="pdbe-citations 5ja0" style="background-color:#fffaf0;"></div>
		+	== References ==
		+	<references/>
	__TOC__		__TOC__
	</StructureSection>		</StructureSection>

OCA at 23:44, 25 January 2017

2017-01-25T23:44:05Z

←Older revision		Revision as of 23:44, 25 January 2017
Line 1:		Line 1:
-	'''Unreleased structure'''

-	~~The entry~~ 5ja0 is ~~ON HOLD until Paper Publication~~	+	==Crystal structure of human FPPS with allosterically bound FPP==
-		+	<StructureSection load='5ja0' size='340' side='right' caption='[[5ja0]], [[Resolution\|resolution]] 1.90Å' scene=''>
-	~~Authors~~:	+	== Structural highlights ==
-		+	<table><tr><td colspan='2'>[[5ja0]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5JA0 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5JA0 FirstGlance]. <br>
-	~~Description~~:	+	</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand\|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FPP:FARNESYL+DIPHOSPHATE'>FPP</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-	[[Category: ~~Unreleased Structures~~]]	+	<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ja0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ja0 OCA], [http://pdbe.org/5ja0 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ja0 RCSB], [http://www.ebi.ac.uk/pdbsum/5ja0 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ja0 ProSAT]</span></td></tr>
		+	</table>
		+	== Function ==
		+	[[http://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN]] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
		+	__TOC__
		+	</StructureSection>
		+	[[Category: Berghuis, A M]]
		+	[[Category: Park, J]]
		+	[[Category: Tsantrizos, Y S]]
		+	[[Category: Zielinski, M]]
		+	[[Category: Transferase]]

OCA at 15:12, 15 May 2016

2016-05-15T15:12:45Z

←Older revision		Revision as of 15:12, 15 May 2016
Line 1:		Line 1:
	'''Unreleased structure'''		'''Unreleased structure'''

-	The entry 5ja0 is ON HOLD	+	The entry 5ja0 is ON HOLD until Paper Publication

-	Authors: ~~Park, J., Zielinski, M., Tsantrizos, Y.S., Berghuis, A.M.~~	+	Authors:

	Description:		Description:
	[[Category: Unreleased Structures]]		[[Category: Unreleased Structures]]
-	[[Category: Zielinski, M]]
-	[[Category: Park, J]]
-	[[Category: Berghuis, A.M]]
-	[[Category: Tsantrizos, Y.S]]

OCA: Protected "5ja0" [edit=sysop:move=sysop]

2016-05-11T01:44:30Z

Protected "5ja0" [edit=sysop:move=sysop]

←Older revision

Revision as of 01:44, 11 May 2016

OCA: New page: '''Unreleased structure''' The entry 5ja0 is ON HOLD Authors: Park, J., Zielinski, M., Tsantrizos, Y.S., Berghuis, A.M. Description: Category: Unreleased Structures [[Category: Zi...

2016-05-11T01:44:29Z

New page: '''Unreleased structure''' The entry 5ja0 is ON HOLD Authors: Park, J., Zielinski, M., Tsantrizos, Y.S., Berghuis, A.M. Description: Category: Unreleased Structures [[Category: Zi...

New page

'''Unreleased structure'''

The entry 5ja0 is ON HOLD

Authors: Park, J., Zielinski, M., Tsantrizos, Y.S., Berghuis, A.M.

Description:
[[Category: Unreleased Structures]]
[[Category: Zielinski, M]]
[[Category: Park, J]]
[[Category: Berghuis, A.M]]
[[Category: Tsantrizos, Y.S]]